Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers

Journal of Immunology

Volumn 170, Issue 2, 2003, Pages 870-877

  Reddy, Jayagopala ^a   Bettelli, Estelle ^a   Nicholson, Lindsay ^a   Waldner, Hanspeter ^a   Jang, Mei Huei ^a   Wucherpfennig, Kai W ^a   Kuchroo, Vijay K ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN; PROTEIN 139-151; PROTEOLIPID PROTEIN; SIALIDASE; T LYMPHOCYTE RECEPTOR; TETRAMER; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; BIOASSAY; CALCIUM TRANSPORT; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; MOUSE; NONHUMAN; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; SENSITIVITY AND SPECIFICITY; STAINING; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0037438615     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.2.870     Document Type: Article

References (33)

1. Crawford, F., H. Kozono, J. White, P. Marrack, and J. Kappler. 1998. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 8:675.
2. g7 tetramers. Proc. Natl. Acad. Sci. USA 97:14596.
3. + T cells by HLA-DR1 oligomers is dependent on the T cell activation state. J. Immunol. 166:741.
4. Kwok, W. W., A. W. Liu, E. J. Novak, J. A. Gebe, R. A. Ettinger, G. T. Nepom, S. N. Reymond, and D. M. Koelle. 2000. HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells. J. Immunol. 164:4244.
5. Meyer, A. L., C. Trollmo, F. Crawford, P. Marrack, A. C. Steere, B. T. Huber, J. Kappler, and D. A. Hafler. 2000, Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc. Natl. Acad. Sci. USA 97:11433.
6. Janeway, C. A., Jr. 1994. Thymic selection: two pathways to life and two to death. Immunity 1:3.
7. Kruisbeek, A. M., J. Zuniga-Pflucker, S. Marusic-Galesic, M. A. Weston, L. Tentori, and D. L. Longo. 1988. Thymic selection of the T-cell repertoire. Immunol. Res. 7:318.
8. Lee, D. S., C. Ahn, B. Ernst, J. Sprent, and C. D. Surh. 1999. Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells. Immunity 10:83.
9. von Boehmer, H. 1992. Thymic selection: a matter of life and death. Immunol. Today 13:454.
10. g7 molecules from non-obese diabetic mice are poor peptide binders. J. Immunol. 156:450.
11. g7 class II molecule. Res. Immunol. 148:291.
12. u. Immunity 17:83.
13. Tuohy, V. K., Z. Lu, R. A. Sobel, R. A. Laursen, and M. B. Lees. 1989. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 142:1523.
14. Whitham, R. H., D. N. Bourdette, G. A. Hashim, R. M. Herndon, R. C. Ilg, A. A. Vandenbark, and H. Offner. 1991. Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis. J. Immunol. 146:101.
15. Greer, J. M., V. K. Kuchroo, R. A. Sobel, and M. B. Lees. 1992. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J. Immunol. 149:783.
16. Greer, J. M., R. A. Sobel, A. Sette, S. Southwood, M. B. Lees, and V. K. Kuchroo. 1996. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. J. Immunol. 156:371.
17. Anderson, A. C., L. B. Nicholson, K. L. Legge, V. Turchin, H. Zaghouani, and V. K. Kuchroo. 2000. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191:761.
18. Waldner, H., M. J. Whitters, R. A. Sobel, M. Collins, and V. K. Kuchroo. 2000. Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor. Proc. Natl. Acad. Sci. USA 97:3412.
19. g7 molecule: rapid release of CLIP at an endosomal pH. J. Exp. Med. 189:1723.
20. Gerety, S. J., R. J. Clatch, H. L. Lipton, R. G. Goswami, M. K. Rundell, and S. D. Miller. 1991. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice. J. Immunol. 146:2401.
21. Gerety, S. J., W. J. Karpus, A. R. Cubbon, R. G. Goswami, M. K. Rundell, J. D. Peterson, and S. D. Miller. 1994. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice. J. Immunol. 152:908.
22. Krieger, J., D. M. Jenis, R. W. Chesnut, and H. M. Grey. 1988. Studies on the capacity of intact cells and purified IA from different B cell sources to function in antigen presentation to T cells. J. Immunol. 140:388.
23. Robinson, J. P., Z. D., P. N. Dean, A. Orfao, P. S. Rabinovitch, H. J. Tanke, and L. L. Wheeless. 2000. Current protocols in cytometry. In Measurement of Intracellular Calcium Ions by Flow Cytometry. C. H. June, R. Abe, and P. S. Rabinovitch, eds. Wiley, New York.
24. Daniels, M. A., L. Devine, J. D. Miller, J. M. Moser, A. E. Lukacher, J. D. Altman, P. Kavathas, K. A. Hogquist, and S. C. Jameson. 2001. CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Immunity 15:1051.
25. high, proliferating subset. Int. Immunol. 13:799.
26. Diliberto, P. A., A. Periasamy, and B. Herman. 1991. Distinct oscillations in cytosolic and nuclear free calcium in single intact living cells demonstrated by confocal microscopy. In Proceedings of the 49th Annual Meeting of the Electron Microscopy Society of America. G. W. Bailey and E. L. Hall, eds. San Francisco Press, San Francisco. p. 228.
27. Yu, B., L. Gauthier, D. H. Hausmann, and K. W. Wucherpfennig. 2000. Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes. Eur. J. Immunol. 30:2497.
28. Kalandadze, A., M. Galleno, L. Foncerrada, J. L. Strominger, and K. W. Wucherpfennig. 1996. Expression of recombinant HLA-DR2 molecules: replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR αβ heterodimers. J. Biol. Chem. 271:20156.
29. Reichstetter, S., R. A. Ettinger, A. W. Liu, J. A. Gebe, G. T. Nepom, and W. W. Kwok. 2000. Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response. J. Immunol. 165:6994.
30. Reijonen, H., E. J. Novak, S. Kochik, A. Heninger, A. W. Liu, W. W. Kwok, and G. T. Nepom. 2002. Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type I diabetic patients and at-risk subjects. Diabetes 51:1375.
31. + T cells proliferating in response to influenza A antigen. J. Clin. Invest. 104:R63.
32. u mice using peptide-MHC multimers. Int. Immunol. 12:1553.
33. Cowing, C., and J. M. Chapdelaine. 1983. T cells discriminate between IA antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on IA molecules. Proc. Natl. Acad. Sci. USA 80:6000.