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Volumn 12, Issue 3, 2010, Pages 340-349

Cancer therapy with bispecific antibodies: Clinical experience

Author keywords

Bispecific antibody; Cytotoxic T lymphocyte; Fc receptor; Immunotherapy; MAb; T cell; Targeted T cell; Tumor antigen

Indexed keywords

ANTIHISTAMINIC AGENT; ANTINEOPLASTIC AGENT; ANTIPYRETIC AGENT; BISPECIFIC ANTIBODY; BLINATUMOMAB; CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY; CATUMAXOMAB; CD16 ANTIGEN; CD19 ANTIBODY; CD20 ANTIBODY; CD3 ANTIBODY; CD30 ANTIGEN; DEXAMETHASONE; ERTUMAXOMAB; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; MDX 210; MDX 447; MDX H210; MELANOMA ASSOCIATED PROTEOGLYCAN; MONOCLONAL ANTIBODY CD28; MONOCLONAL ANTIBODY CD3; MT 103; MT 110; OKT 3; OVARIAN CANCER ASSOCIATED ANTIGEN; PETHIDINE; UNCLASSIFIED DRUG;

EID: 77953188563     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (60)

References (103)
  • 2
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D, Robert NJ, Scholl S, Fehrenbacher L, Wolter JM, Paton V, Shak S, Lieberman G, Slamon DJ: Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol (1999) 17(9):2639-2648.
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3    Robert, N.J.4    Scholl, S.5    Fehrenbacher, L.6    Wolter, J.M.7    Paton, V.8    Shak, S.9    Lieberman, G.10    Slamon, D.J.11
  • 3
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J, Kimby E, Björkholm M, Broliden PA, Celsing F, Hjalmar V, Möllgard L, Rebello P, Hale G, Waldmann H, Mellstedt H et al: Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood (2002) 100(3):768-773.
    • (2002) Blood , vol.100 , Issue.3 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Björkholm, M.3    Broliden, P.A.4    Celsing, F.5    Hjalmar, V.6    Möllgard, L.7    Rebello, P.8    Hale, G.9    Waldmann, H.10    Mellstedt, H.11
  • 4
    • 0028127304 scopus 로고
    • Phase i clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma
    • Maloney DG, Liles TM, Czerwinski DK, Waldichuk C, Rosenberg J, Grillo-Lopez A, Levy R: Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. Blood (1994) 84(8):2457-2466.
    • (1994) Blood , vol.84 , Issue.8 , pp. 2457-2466
    • Maloney, D.G.1    Liles, T.M.2    Czerwinski, D.K.3    Waldichuk, C.4    Rosenberg, J.5    Grillo-Lopez, A.6    Levy, R.7
  • 9
  • 11
    • 0029063312 scopus 로고
    • Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies
    • Lindhofer H, Mocikat R, Steipe B, Thierfelder S: Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. J Immunol (1995) 155(1):219-225.
    • (1995) J Immunol , vol.155 , Issue.1 , pp. 219-225
    • Lindhofer, H.1    Mocikat, R.2    Steipe, B.3    Thierfelder, S.4
  • 13
    • 37649020163 scopus 로고    scopus 로고
    • Multifunctional antibodies by the dock-and-lock method for improved cancer imaging and therapy by pretargeting
    • Goldenberg DM, Rossi EA, Sharkey RM, McBride WJ, Chang CH: Multifunctional antibodies by the dock-and-lock method for improved cancer imaging and therapy by pretargeting. J Nucl Med (2008) 49(1):158-163.
    • (2008) J Nucl Med , vol.49 , Issue.1 , pp. 158-163
    • Goldenberg, D.M.1    Rossi, E.A.2    Sharkey, R.M.3    McBride, W.J.4    Chang, C.H.5
  • 14
    • 0013974537 scopus 로고
    • Effect of leukocytes on transplantability of human cancer
    • Southam CM, Brunschwig A, Levin AG, Dizon QS: Effect of leukocytes on transplantability of human cancer. Cancer (1966) 19(11):1743-1753.
    • (1966) Cancer , vol.19 , Issue.11 , pp. 1743-1753
    • Southam, C.M.1    Brunschwig, A.2    Levin, A.G.3    Dizon, Q.S.4
  • 15
    • 0023039208 scopus 로고
    • Interleukin 2-activated human killer cells are derived from phenotypically heterogeneous precursors
    • Damle NK, Doyle LV, Bradley EC: Interleukin 2-activated human killer cells are derived from phenotypically heterogeneous precursors. J Immunol (1986) 137(9):2814-2822.
    • (1986) J Immunol , vol.137 , Issue.9 , pp. 2814-2822
    • Damle, N.K.1    Doyle, L.V.2    Bradley, E.C.3
  • 16
    • 0022914307 scopus 로고
    • Human lymphokine-activated killer cells (LAK cells) as a potential immunotherapeutic modality
    • Grimm EA: Human lymphokine-activated killer cells (LAK cells) as a potential immunotherapeutic modality. Biochim Biophys Acta (1986) 865(3):267-279.
    • (1986) Biochim Biophys Acta , vol.865 , Issue.3 , pp. 267-279
    • Grimm, E.A.1
  • 17
    • 0022968481 scopus 로고
    • Optimal methods for generating expanded lymphokine activated killer cells capable of reducing established murine tumors in vivo
    • Lafreniere R, Rosenstein MS, Rosenberg SA: Optimal methods for generating expanded lymphokine activated killer cells capable of reducing established murine tumors in vivo. J Immunol Methods (1986) 94(1-2):37-49.
    • (1986) J Immunol Methods , vol.94 , Issue.1-2 , pp. 37-49
    • Lafreniere, R.1    Rosenstein, M.S.2    Rosenberg, S.A.3
  • 18
    • 0022455906 scopus 로고
    • Similarities and distinctions between murine natural killer cells and lymphokine-activated killer cells
    • Merluzzi VJ, Smith MD, Last-Barney K: Similarities and distinctions between murine natural killer cells and lymphokine-activated killer cells. Cell Immunol (1986) 100(2):563-569.
    • (1986) Cell Immunol , vol.100 , Issue.2 , pp. 563-569
    • Merluzzi, V.J.1    Smith, M.D.2    Last-Barney, K.3
  • 19
    • 0022501035 scopus 로고
    • Lymphokine-activated killer cells. Analysis of progenitors and effectors
    • Ortaldo JR, Mason A, Overton R: Lymphokine-activated killer cells. Analysis of progenitors and effectors. J Exp Med (1986) 164(4):1193-1205.
    • (1986) J Exp Med , vol.164 , Issue.4 , pp. 1193-1205
    • Ortaldo, J.R.1    Mason, A.2    Overton, R.3
  • 20
    • 0022876525 scopus 로고
    • Phenotypic characterization of murine lymphokine-activated killer cells
    • Owen-Schaub LB, Abraham SR, Hemstreet GP 3rd: Phenotypic characterization of murine lymphokine-activated killer cells. Cell Immunol (1986) 103(2):272-286.
    • (1986) Cell Immunol , vol.103 , Issue.2 , pp. 272-286
    • Owen-Schaub, L.B.1    Abraham, S.R.2    Hemstreet III, G.P.3
  • 21
    • 0022536155 scopus 로고
    • A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2
    • Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Vetto JT, Seipp CA, Simpson C: A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2. Surgery (1986) 100(2):262-272.
    • (1986) Surgery , vol.100 , Issue.2 , pp. 262-272
    • Rosenberg, S.A.1    Lotze, M.T.2    Muul, L.M.3    Leitman, S.4    Chang, A.E.5    Vetto, J.T.6    Seipp, C.A.7    Simpson, C.8
  • 23
    • 0022501663 scopus 로고
    • Murine lymphokine-activated killer (LAK) cells: Phenotypic characterization of the precursor and effector cells
    • Yang JC, Mule JJ, Rosenberg SA: Murine lymphokine-activated killer (LAK) cells: Phenotypic characterization of the precursor and effector cells. J Immunol (1986) 137(2):715-722.
    • (1986) J Immunol , vol.137 , Issue.2 , pp. 715-722
    • Yang, J.C.1    Mule, J.J.2    Rosenberg, S.A.3
  • 27
    • 0030986821 scopus 로고    scopus 로고
    • Adoptive immunotherapy with donor lymphocyte transfusions
    • Kolb HJ, Holler E: Adoptive immunotherapy with donor lymphocyte transfusions. Curr Opin Oncol (1997) 9(2):139-145.
    • (1997) Curr Opin Oncol , vol.9 , Issue.2 , pp. 139-145
    • Kolb, H.J.1    Holler, E.2
  • 28
    • 0025678601 scopus 로고
    • Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients
    • Kolb HJ, Mittermuller J, Clemm C, Holler E, Ledderose G, Brehm G, Heim M, Wilmanns W: Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood (1990) 76(12):2462-2465.
    • (1990) Blood , vol.76 , Issue.12 , pp. 2462-2465
    • Kolb, H.J.1    Mittermuller, J.2    Clemm, C.3    Holler, E.4    Ledderose, G.5    Brehm, G.6    Heim, M.7    Wilmanns, W.8
  • 29
    • 0036357480 scopus 로고    scopus 로고
    • Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the prevention and treatment of EBV-associated post-transplant lymphomas
    • Liu Z, Savoldo B, Huls H, Lopez T, Gee A, Wilson J, Brenner MK, Heslop HE, Rooney CM: Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the prevention and treatment of EBV-associated post-transplant lymphomas. Recent Results Cancer Res (2002) 159:123-133.
    • (2002) Recent Results Cancer Res , vol.159 , pp. 123-133
    • Liu, Z.1    Savoldo, B.2    Huls, H.3    Lopez, T.4    Gee, A.5    Wilson, J.6    Brenner, M.K.7    Heslop, H.E.8    Rooney, C.M.9
  • 30
    • 0038297196 scopus 로고    scopus 로고
    • A recombinant bispecific single-chain antibody induces targeted, supra-agonistic CD28-stimulation and tumor cell killing
    • Grosse-Hovest L, Hartlapp I, Marwan W, Brem G, Rammensee HG, Jung G: A recombinant bispecific single-chain antibody induces targeted, supra-agonistic CD28-stimulation and tumor cell killing. Eur J Immunol (2003) 33(5):1334-1340.
    • (2003) Eur J Immunol , vol.33 , Issue.5 , pp. 1334-1340
    • Grosse-Hovest, L.1    Hartlapp, I.2    Marwan, W.3    Brem, G.4    Rammensee, H.G.5    Jung, G.6
  • 32
    • 0019462963 scopus 로고
    • Hybrid antibodies with dual specificity for the delivery of ricin to immunoglobulin-bearing target cells
    • Raso V, Griffin T: Hybrid antibodies with dual specificity for the delivery of ricin to immunoglobulin-bearing target cells. Cancer Res (1981) 41(6):2073-2078.
    • (1981) Cancer Res , vol.41 , Issue.6 , pp. 2073-2078
    • Raso, V.1    Griffin, T.2
  • 34
    • 0023629058 scopus 로고
    • Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo
    • Titus JA, Perez P, Kaubisch A, Garrido MA, Segal DM: Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo. J Immunol (1987) 139(9):3153-3158.
    • (1987) J Immunol , vol.139 , Issue.9 , pp. 3153-3158
    • Titus, J.A.1    Perez, P.2    Kaubisch, A.3    Garrido, M.A.4    Segal, D.M.5
  • 35
    • 0020518331 scopus 로고
    • Hybrid hybridomas and their use in immunohistochemistry
    • Milstein C, Cuello AC: Hybrid hybridomas and their use in immunohistochemistry. Nature (1983) 305(5934):537-540.
    • (1983) Nature , vol.305 , Issue.5934 , pp. 537-540
    • Milstein, C.1    Cuello, A.C.2
  • 36
    • 0022508883 scopus 로고
    • Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity
    • Staerz UD, Bevan MJ: Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity. Proc Natl Acad Sci USA (1986) 83(5):1453-1457.
    • (1986) Proc Natl Acad Sci USA , vol.83 , Issue.5 , pp. 1453-1457
    • Staerz, U.D.1    Bevan, M.J.2
  • 37
    • 0022437660 scopus 로고
    • Targeting cells for attack by cytotoxic T lymphocytes using heteroconjugates of monoclonal antibodies
    • Staerz UD, Bevan MJ: Targeting cells for attack by cytotoxic T lymphocytes using heteroconjugates of monoclonal antibodies. Symp Fundam Cancer Res (1986) 38:31-34.
    • (1986) Symp Fundam Cancer Res , vol.38 , pp. 31-34
    • Staerz, U.D.1    Bevan, M.J.2
  • 43
    • 33646477258 scopus 로고    scopus 로고
    • Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting
    • Rossi EA, Goldenberg DM, Cardillo TM, McBride WJ, Sharkey RM, Chang CH: Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting. Proc Natl Acad Sci USA (2006) 103(18): 6841-6846.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.18 , pp. 6841-6846
    • Rossi, E.A.1    Goldenberg, D.M.2    Cardillo, T.M.3    McBride, W.J.4    Sharkey, R.M.5    Chang, C.H.6
  • 45
    • 0346156081 scopus 로고    scopus 로고
    • Recombinant singlechain antibody fusion construct targeting human melanoma cells and containing tumor necrosis factor
    • Liu Y, Cheung LH, Marks JW, Rosenblum MG: Recombinant singlechain antibody fusion construct targeting human melanoma cells and containing tumor necrosis factor. Int J Cancer (2004) 108(4):549-557.
    • (2004) Int J Cancer , vol.108 , Issue.4 , pp. 549-557
    • Liu, Y.1    Cheung, L.H.2    Marks, J.W.3    Rosenblum, M.G.4
  • 46
    • 33744799701 scopus 로고    scopus 로고
    • The antimelanoma immunocytokine scFvMEL/TNF shows reduced toxicity and potent antitumor activity against human tumor xenografts
    • Liu Y, Zhang W, Cheung LH, Niu T, Wu Q, Li C, Van Pelt CS, Rosenblum MG: The antimelanoma immunocytokine scFvMEL/TNF shows reduced toxicity and potent antitumor activity against human tumor xenografts. Neoplasia (2006) 8(5):384-393.
    • (2006) Neoplasia , vol.8 , Issue.5 , pp. 384-393
    • Liu, Y.1    Zhang, W.2    Cheung, L.H.3    Niu, T.4    Wu, Q.5    Li, C.6    Van Pelt, C.S.7    Rosenblum, M.G.8
  • 47
    • 33644777800 scopus 로고    scopus 로고
    • A trimeric anti-HER2/neu ScFv and tumor necrosis factor-α fusion protein induces HER2/neu signaling and facilitates repair of injured epithelia
    • Huang TH, Morrison SL: A trimeric anti-HER2/neu ScFv and tumor necrosis factor-α fusion protein induces HER2/neu signaling and facilitates repair of injured epithelia. J Pharmacol Exp Ther (2006) 316(3):983-991.
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.3 , pp. 983-991
    • Huang, T.H.1    Morrison, S.L.2
  • 48
    • 0042674300 scopus 로고    scopus 로고
    • Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin
    • Rosenblum MG, Cheung LH, Liu Y, Marks JW 3rd: Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin. Cancer Res (2003) 63(14):3995-4002.
    • (2003) Cancer Res , vol.63 , Issue.14 , pp. 3995-4002
    • Rosenblum, M.G.1    Cheung, L.H.2    Liu, Y.3    Marks III, J.W.4
  • 49
    • 0345365618 scopus 로고    scopus 로고
    • HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor
    • Elsasser D, Valerius T, Repp R, Weiner GJ, Deo Y, Kalden JR, van de Winkel JG, Stevenson GT, Glennie MJ, Gramatzki M: HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor. Blood (1996) 87(9):3803-3812.
    • (1996) Blood , vol.87 , Issue.9 , pp. 3803-3812
    • Elsasser, D.1    Valerius, T.2    Repp, R.3    Weiner, G.J.4    Deo, Y.5    Kalden, J.R.6    Van De Winkel, J.G.7    Stevenson, G.T.8    Glennie, M.J.9    Gramatzki, M.10
  • 50
    • 0035251812 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of the bispecific antibody MDX-H210 when administered in combination with interferon ?: A multiple-dose phase-I study in patients with advanced cancer which overexpresses HER-2/neu
    • Lewis LD, Cole BF, Wallace PK, Fisher JL, Waugh M, Guyre PM, Fanger MW, Curnow RT, Kaufman PA, Ernstoff MS: Pharmacokinetic-pharmacodynamic relationships of the bispecific antibody MDX-H210 when administered in combination with interferon ?: A multiple-dose phase-I study in patients with advanced cancer which overexpresses HER-2/neu. J Immunol Methods (2001) 248(1-2):149-165.
    • (2001) J Immunol Methods , vol.248 , Issue.1-2 , pp. 149-165
    • Lewis, L.D.1    Cole, B.F.2    Wallace, P.K.3    Fisher, J.L.4    Waugh, M.5    Guyre, P.M.6    Fanger, M.W.7    Curnow, R.T.8    Kaufman, P.A.9    Ernstoff, M.S.10
  • 51
    • 0030829805 scopus 로고    scopus 로고
    • Clinical evaluation of the bispecific antibody MDX-H210 (anti-Fc γ RI x anti-HER-2/neu) in combination with granulocyte-colony-stimulating factor (filgrastim) for treatment of advanced breast cancer
    • van Ojik HH, Repp R, Groenewegen G, Valerius T, van de Winkel JG: Clinical evaluation of the bispecific antibody MDX-H210 (anti-Fc γ RI x anti-HER-2/neu) in combination with granulocyte-colony-stimulating factor (filgrastim) for treatment of advanced breast cancer. Cancer Immunol Immunother (1997) 45(3-4):207-209.
    • (1997) Cancer Immunol Immunother , vol.45 , Issue.3-4 , pp. 207-209
    • Van Ojik, H.H.1    Repp, R.2    Groenewegen, G.3    Valerius, T.4    Van De Winkel, J.G.5
  • 53
    • 0025161953 scopus 로고
    • Preliminary trial of specific targeting therapy against malignant glioma
    • Nitta T, Sato K, Yagita H, Okumura K, Ishii S: Preliminary trial of specific targeting therapy against malignant glioma. Lancet (1990) 335(8686):368-371.
    • (1990) Lancet , vol.335 , Issue.8686 , pp. 368-371
    • Nitta, T.1    Sato, K.2    Yagita, H.3    Okumura, K.4    Ishii, S.5
  • 54
    • 0026840358 scopus 로고
    • Initial trial of bispecific antibody-mediated immunotherapy of CD15-bearing tumors: Cytotoxicity of human tumor cells using a bispecific antibody comprised of anti-CD15 (MoAb PM81) and anti-CD64/Fc γ RI (MoAb 32)
    • Ball ED, Guyre PM, Mills L, Fisher J, Dinces NB, Fanger MW: Initial trial of bispecific antibody-mediated immunotherapy of CD15-bearing tumors: Cytotoxicity of human tumor cells using a bispecific antibody comprised of anti-CD15 (MoAb PM81) and anti-CD64/Fc γ RI (MoAb 32). J Hematother (1992) 1(1):85-94.
    • (1992) J Hematother , vol.1 , Issue.1 , pp. 85-94
    • Ball, E.D.1    Guyre, P.M.2    Mills, L.3    Fisher, J.4    Dinces, N.B.5    Fanger, M.W.6
  • 60
    • 0034940408 scopus 로고    scopus 로고
    • A phase II study of the bispecific antibody MDX-H210 (anti-HER2 x CD64) with GM-CSF in HER2+ advanced prostate cancer
    • James ND, Atherton PJ, Jones J, Howie AJ, Tchekmedyian S, Curnow RT: A phase II study of the bispecific antibody MDX-H210 (anti-HER2 x CD64) with GM-CSF in HER2+ advanced prostate cancer. Br J Cancer (2001) 85(2):152-156.
    • (2001) Br J Cancer , vol.85 , Issue.2 , pp. 152-156
    • James, N.D.1    Atherton, P.J.2    Jones, J.3    Howie, A.J.4    Tchekmedyian, S.5    Curnow, R.T.6
  • 62
    • 0042326327 scopus 로고    scopus 로고
    • Bispecific antibodies for polyclonal T-cell engagement
    • Baeuerle PA, Kufer P, Lutterbuse R: Bispecific antibodies for polyclonal T-cell engagement. Curr Opin Mol Ther (2003) 5(4): 413-419.
    • (2003) Curr Opin Mol Ther , vol.5 , Issue.4 , pp. 413-419
    • Baeuerle, P.A.1    Kufer, P.2    Lutterbuse, R.3
  • 63
    • 0037446782 scopus 로고    scopus 로고
    • T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct
    • Dreier T, Baeuerle PA, Fichtner I, Grun M, Schlereth B, Lorenczewski G, Kufer P, Lutterbuse R, Riethmuller G, Gjorstrup P, Bargou RC: T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct. J Immunol (2003) 170(8):4397-4402.
    • (2003) J Immunol , vol.170 , Issue.8 , pp. 4397-4402
    • Dreier, T.1    Baeuerle, P.A.2    Fichtner, I.3    Grun, M.4    Schlereth, B.5    Lorenczewski, G.6    Kufer, P.7    Lutterbuse, R.8    Riethmuller, G.9    Gjorstrup, P.10    Bargou, R.C.11
  • 64
    • 0343415665 scopus 로고    scopus 로고
    • A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
    • Loffler A, Kufer P, Lutterbuse R, Zettl F, Daniel PT, Schwenkenbecher JM, Riethmuller G, Dorken B, Bargou RC: A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood (2000) 95(6):2098-2103.
    • (2000) Blood , vol.95 , Issue.6 , pp. 2098-2103
    • Loffler, A.1    Kufer, P.2    Lutterbuse, R.3    Zettl, F.4    Daniel, P.T.5    Schwenkenbecher, J.M.6    Riethmuller, G.7    Dorken, B.8    Bargou, R.C.9
  • 66
    • 67449119748 scopus 로고    scopus 로고
    • Treatment with anti-CD19 BiTE antibody blinatumomab (MT103/MEDI-538) is able to eliminate minimal residual disease (MRD) in patients with B-precursor acute lymphoblastic leukemia (ALL): First results of an ongoing phase II study
    • Abs 1926
    • Topp M, Goekbuget N, Kufer P, Zugmaier G, Degenhard E, Neumann S, Horst HA, Viardot A, Schmid M, Ottmann OG, Schmidt M et al: Treatment with anti-CD19 BiTE antibody blinatumomab (MT103/MEDI-538) is able to eliminate minimal residual disease (MRD) in patients with B-precursor acute lymphoblastic leukemia (ALL): First results of an ongoing phase II study. Blood (2008) 112(Suppl):Abs 1926.
    • (2008) Blood , vol.112 , Issue.SUPPL.
    • Topp, M.1    Goekbuget, N.2    Kufer, P.3    Zugmaier, G.4    Degenhard, E.5    Neumann, S.6    Horst, H.A.7    Viardot, A.8    Schmid, M.9    Ottmann, O.G.10    Schmidt, M.11
  • 67
    • 67449156132 scopus 로고    scopus 로고
    • Bispecific T-cell engaging antibodies for cancer therapy
    • Baeuerle PA, Reinhardt C: Bispecific T-cell engaging antibodies for cancer therapy. Cancer Res (2009) 69(12):4941-4944.
    • (2009) Cancer Res , vol.69 , Issue.12 , pp. 4941-4944
    • Baeuerle, P.A.1    Reinhardt, C.2
  • 68
    • 0034051390 scopus 로고    scopus 로고
    • The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells
    • Zeidler R, Mysliwietz J, Csanady M, Walz A, Ziegler I, Schmitt B, Wollenberg B, Lindhofer H: The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br J Cancer (2000) 83(2):261-266.
    • (2000) Br J Cancer , vol.83 , Issue.2 , pp. 261-266
    • Zeidler, R.1    Mysliwietz, J.2    Csanady, M.3    Walz, A.4    Ziegler, I.5    Schmitt, B.6    Wollenberg, B.7    Lindhofer, H.8
  • 69
    • 0033178740 scopus 로고    scopus 로고
    • Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing
    • Zeidler R, Reisbach G, Wollenberg B, Lang S, Chaubal S, Schmitt B, Lindhofer H: Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing. J Immunol (1999) 163(3):1246-1252.
    • (1999) J Immunol , vol.163 , Issue.3 , pp. 1246-1252
    • Zeidler, R.1    Reisbach, G.2    Wollenberg, B.3    Lang, S.4    Chaubal, S.5    Schmitt, B.6    Lindhofer, H.7
  • 75
    • 0642306102 scopus 로고    scopus 로고
    • Future prospects for patient care utilizing autologous lymphoid and hematopoietic stem cells
    • Lum LG, Rathore R, Quesenberry PJ, Elfenbein GJ: Future prospects for patient care utilizing autologous lymphoid and hematopoietic stem cells. Med Health R I (2003) 86(8): 247-248.
    • (2003) Med Health R i , vol.86 , Issue.8 , pp. 247-248
    • Lum, L.G.1    Rathore, R.2    Quesenberry, P.J.3    Elfenbein, G.J.4
  • 76
    • 6344294885 scopus 로고    scopus 로고
    • Anti-CD3 x anti-HER2 bispecific antibody effectively redirects armed T cells to inhibit tumor development and growth in hormone-refractory prostate cancer-bearing severe combined immunodeficient beige mice
    • Davol PA, Smith JA, Kouttab N, Elfenbein GJ, Lum LG: Anti-CD3 x anti-HER2 bispecific antibody effectively redirects armed T cells to inhibit tumor development and growth in hormone-refractory prostate cancer-bearing severe combined immunodeficient beige mice. Clin Prostate Cancer (2004) 3(2):112-121.
    • (2004) Clin Prostate Cancer , vol.3 , Issue.2 , pp. 112-121
    • Davol, P.A.1    Smith, J.A.2    Kouttab, N.3    Elfenbein, G.J.4    Lum, L.G.5
  • 77
    • 0026518418 scopus 로고
    • CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes
    • Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL: CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J Exp Med (1992) 175(2):353-360.
    • (1992) J Exp Med , vol.175 , Issue.2 , pp. 353-360
    • Azuma, M.1    Cayabyab, M.2    Buck, D.3    Phillips, J.H.4    Lanier, L.L.5
  • 78
    • 0025049870 scopus 로고
    • Enhanced in vitro lysis of human ovarian carcinomas with activated peripheral blood lymphocytes and bifunctional immune heteroaggregates
    • Donohue JH, Ramsey PS, Kerr LA, Segal DM, McKean DJ: Enhanced in vitro lysis of human ovarian carcinomas with activated peripheral blood lymphocytes and bifunctional immune heteroaggregates. Cancer Res (1990) 50(20):6508-6514.
    • (1990) Cancer Res , vol.50 , Issue.20 , pp. 6508-6514
    • Donohue, J.H.1    Ramsey, P.S.2    Kerr, L.A.3    Segal, D.M.4    McKean, D.J.5
  • 79
  • 80
    • 0022530989 scopus 로고
    • Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis
    • Phillips JH, Lanier LL: Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis. J Exp Med (1986) 164(3):814-825.
    • (1986) J Exp Med , vol.164 , Issue.3 , pp. 814-825
    • Phillips, J.H.1    Lanier, L.L.2
  • 81
    • 0023219897 scopus 로고
    • Induction of cytotoxicity in human peripheral blood mononuclear cells by monoclonal antibody OKT3
    • Jung G, Martin DE, Muller-Eberhard HJ: Induction of cytotoxicity in human peripheral blood mononuclear cells by monoclonal antibody OKT3. J Immunol (1987) 139(2):639-644.
    • (1987) J Immunol , vol.139 , Issue.2 , pp. 639-644
    • Jung, G.1    Martin, D.E.2    Muller-Eberhard, H.J.3
  • 82
    • 0021269685 scopus 로고
    • Human T lymphocyte activation by monoclonal antibodies; OKT3, but not UCHT1, triggers mitogenesis via an interleukin 2-dependent mechanism
    • Van Wauwe JP, Goossens JG, Beverley PC: Human T lymphocyte activation by monoclonal antibodies; OKT3, but not UCHT1, triggers mitogenesis via an interleukin 2-dependent mechanism. J Immunol (1984) 133(1):129-132.
    • (1984) J Immunol , vol.133 , Issue.1 , pp. 129-132
    • Van Wauwe, J.P.1    Goossens, J.G.2    Beverley, P.C.3
  • 83
    • 0027493811 scopus 로고
    • Phase I/II study of low-dose intravenous OKT3 and subcutaneous interleukin-2 in metastatic cancer
    • Buter J, Janssen RA, Martens A, Sleijfer DT, de Leij L, Mulder NH: Phase I/II study of low-dose intravenous OKT3 and subcutaneous interleukin-2 in metastatic cancer. Eur J Cancer (1993) 29A(15):2108-2113.
    • (1993) Eur J Cancer , vol.29 A , Issue.15 , pp. 2108-2113
    • Buter, J.1    Janssen, R.A.2    Martens, A.3    Sleijfer, D.T.4    De Leij, L.5    Mulder, N.H.6
  • 85
    • 0024322888 scopus 로고
    • Systemic reaction to the anti-T-cell monoclonal antibody OKT3 in relation to serum levels of tumor necrosis factor and interferon-?
    • Chatenoud L, Ferran C, Reuter A, Legendre C, Gevaert Y, Kreis H, Franchimont P, Bach JF: Systemic reaction to the anti-T-cell monoclonal antibody OKT3 in relation to serum levels of tumor necrosis factor and interferon-?. N Engl J Med (1989) 320(21):1420-1421.
    • (1989) N Engl J Med , vol.320 , Issue.21 , pp. 1420-1421
    • Chatenoud, L.1    Ferran, C.2    Reuter, A.3    Legendre, C.4    Gevaert, Y.5    Kreis, H.6    Franchimont, P.7    Bach, J.F.8
  • 86
    • 0027197842 scopus 로고
    • Phase IB clinical trial of anti-CD3 followed by high-dose bolus interleukin-2 in patients with metastatic melanoma and advanced renal cell carcinoma: Clinical and immunologic effects
    • Sosman JA, Weiss GR, Margolin KA, Aronson FR, Sznol M, Atkins MB, O'Boyle K, Fisher RI, Boldt DH, Doroshow J: Phase IB clinical trial of anti-CD3 followed by high-dose bolus interleukin-2 in patients with metastatic melanoma and advanced renal cell carcinoma: Clinical and immunologic effects. J Clin Oncol (1993) 11(8):1496-1505.
    • (1993) J Clin Oncol , vol.11 , Issue.8 , pp. 1496-1505
    • Sosman, J.A.1    Weiss, G.R.2    Margolin, K.A.3    Aronson, F.R.4    Sznol, M.5    Atkins, M.B.6    O'Boyle, K.7    Fisher, R.I.8    Boldt, D.H.9    Doroshow, J.10
  • 87
    • 0028044986 scopus 로고
    • Poor induction of interleukin-2 receptor expression on CD8bright+ cells in whole blood cell cultures with CD3 mAb. Implications for immunotherapy with CD3 mAb
    • Janssen RA, Heijn AA, The TH, de Leij L: Poor induction of interleukin-2 receptor expression on CD8bright+ cells in whole blood cell cultures with CD3 mAb. Implications for immunotherapy with CD3 mAb. Cancer Immunol Immunother (1994) 38(1):53-60.
    • (1994) Cancer Immunol Immunother , vol.38 , Issue.1 , pp. 53-60
    • Janssen, R.A.1    Heijn, A.A.2    The, T.H.3    De Leij, L.4
  • 88
    • 52649087072 scopus 로고    scopus 로고
    • Induction of immune responses and improved survival after infusions of T cells armed with anti-CD3 x anti-HER2/neu bispecific antibody in stage IV breast cancer patients (phase i
    • Abs 2747
    • Lum LG, Rathore R, Dizon D, Wang D, Al-Kadhimi Z, Uberti JP, Ratanatharathorn V: Induction of immune responses and improved survival after infusions of T cells armed with anti-CD3 x anti-HER2/neu bispecific antibody in stage IV breast cancer patients (phase I). Blood (2007) 110(11 Pt 1): Abs 2747.
    • (2007) Blood , vol.110 , Issue.11 PART 1
    • Lum, L.G.1    Rathore, R.2    Dizon, D.3    Wang, D.4    Al-Kadhimi, Z.5    Uberti, J.P.6    Ratanatharathorn, V.7
  • 89
    • 31544434016 scopus 로고    scopus 로고
    • Human T cells armed with HER2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation
    • Grabert RC, Cousens LP, Smith JA, Olson S, Gall J, Young WB, Davol PA, Lum LG: Human T cells armed with HER2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation. Clin Cancer Res (2006) 12(2):569-576.
    • (2006) Clin Cancer Res , vol.12 , Issue.2 , pp. 569-576
    • Grabert, R.C.1    Cousens, L.P.2    Smith, J.A.3    Olson, S.4    Gall, J.5    Young, W.B.6    Davol, P.A.7    Lum, L.G.8
  • 90
    • 30344457881 scopus 로고    scopus 로고
    • The new face of bispecific antibodies: Targeting cancer and much more
    • Lum LG, Davol PA, Lee RJ: The new face of bispecific antibodies: Targeting cancer and much more. Exp Hematol (2006) 34(1):1-6.
    • (2006) Exp Hematol , vol.34 , Issue.1 , pp. 1-6
    • Lum, L.G.1    Davol, P.A.2    Lee, R.J.3
  • 91
    • 30344441648 scopus 로고    scopus 로고
    • Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model
    • Reusch U, Sundaram M, Davol PA, Olson SD, Davis JB, Demel K, Nissim J, Rathore R, Liu PY, Lum LG: Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model. Clin Cancer Res (2006) 12(1):183-190.
    • (2006) Clin Cancer Res , vol.12 , Issue.1 , pp. 183-190
    • Reusch, U.1    Sundaram, M.2    Davol, P.A.3    Olson, S.D.4    Davis, J.B.5    Demel, K.6    Nissim, J.7    Rathore, R.8    Liu, P.Y.9    Lum, L.G.10
  • 93
    • 0031806536 scopus 로고    scopus 로고
    • Anti-CD3-based bispecific antibody designed for therapy of human B-cell malignancy can induce T-cell activation by antigen-dependent and antigen-independent mechanisms
    • Link BK, Kostelny SA, Cole MS, Fusselman WP, Tso JY, Weiner GJ: Anti-CD3-based bispecific antibody designed for therapy of human B-cell malignancy can induce T-cell activation by antigen-dependent and antigen-independent mechanisms. Int J Cancer (1998) 77(2):251-256.
    • (1998) Int J Cancer , vol.77 , Issue.2 , pp. 251-256
    • Link, B.K.1    Kostelny, S.A.2    Cole, M.S.3    Fusselman, W.P.4    Tso, J.Y.5    Weiner, G.J.6
  • 95
    • 0030992051 scopus 로고    scopus 로고
    • Effective tumor vaccines generated by in vitro modification of tumor cells with cytokines and bispecific monoclonal antibodies
    • Guo YJ, Che XY, Shen F, Xie TP, Ma J, Wang XN, Wu SG, Anthony DD, Wu MC: Effective tumor vaccines generated by in vitro modification of tumor cells with cytokines and bispecific monoclonal antibodies. Nat Med (1997) 3(4):451-455.
    • (1997) Nat Med , vol.3 , Issue.4 , pp. 451-455
    • Guo, Y.J.1    Che, X.Y.2    Shen, F.3    Xie, T.P.4    Ma, J.5    Wang, X.N.6    Wu, S.G.7    Anthony, D.D.8    Wu, M.C.9
  • 96
    • 77953211695 scopus 로고    scopus 로고
    • Enhanced anti-breast cancer cytotoxicity after autologous peripheral blood stem cell transplant (PBSCT) by boosting with multiple infusions of activated T cells (ATC) armed with anti-CD3 x anti-HER2 bispecific antibody (HER2Bi) prior to PBSCT
    • Abs 2748
    • Lum LG, Al-Kadhimi Z, Skuba C, Ratanatharathorn V, Uberti JP: Enhanced anti-breast cancer cytotoxicity after autologous peripheral blood stem cell transplant (PBSCT) by boosting with multiple infusions of activated T cells (ATC) armed with anti-CD3 x anti-HER2 bispecific antibody (HER2Bi) prior to PBSCT. Blood (2007) 110(11 Pt 1):Abs 2748.
    • (2007) Blood , vol.110 , Issue.11 PART 1
    • Lum, L.G.1    Al-Kadhimi, Z.2    Skuba, C.3    Ratanatharathorn, V.4    Uberti, J.P.5
  • 97
    • 0031434631 scopus 로고    scopus 로고
    • Specific activation of resting T cells against CA19-9+ tumor cells by an anti-CD3/ca19-9 bispecific antibody in combination with a costimulatory anti- CD28 antibody
    • Hombach A, Tillmann T, Jensen M, Heuser C, Sircar R, Diehl V, Kruis W, Pohl C: Specific activation of resting T cells against CA19-9+ tumor cells by an anti-CD3/CA19-9 bispecific antibody in combination with a costimulatory anti-CD28 antibody. J Immunother (1997) 20(5):325-333. (Pubitemid 28011528)
    • (1997) Journal of Immunotherapy , vol.20 , Issue.5 , pp. 325-333
    • Hombach, A.1    Tillmann, T.2    Jensen, M.3    Heuser, C.4    Sircar, R.5    Diehl, V.6    Kruis, W.7    Pohl, C.8
  • 98
    • 0029911298 scopus 로고    scopus 로고
    • A mouse/human-chimeric bispecific antibody reactive with human carcinoembryonic antigen-expressing cells and human T-lymphocytes
    • Kuwahara M, Kuroki M, Arakawa F, Senba T, Matsuoka Y, Hideshima T, Yamashita Y, Kanda H: A mouse/human-chimeric bispecific antibody reactive with human carcinoembryonic antigen-expressing cells and human T-lymphocytes. nticancer Res (1996) 16(5A):2661-2667.
    • (1996) Nticancer Res , vol.16 , Issue.5 A , pp. 2661-2667
    • Kuwahara, M.1    Kuroki, M.2    Arakawa, F.3    Senba, T.4    Matsuoka, Y.5    Hideshima, T.6    Yamashita, Y.7    Kanda, H.8
  • 99
    • 33947264398 scopus 로고    scopus 로고
    • Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes
    • Compte M, Blanco B, Serrano F, Cuesta AM, Sanz L, Bernad A, Holliger P, Alvarez-Vallina L: Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes. Cancer Gene Ther (2007) 14(4):380-388.
    • (2007) Cancer Gene Ther , vol.14 , Issue.4 , pp. 380-388
    • Compte, M.1    Blanco, B.2    Serrano, F.3    Cuesta, A.M.4    Sanz, L.5    Bernad, A.6    Holliger, P.7    Alvarez-Vallina, L.8
  • 102
    • 34247586058 scopus 로고    scopus 로고
    • Induction of adaptive anti-HER2/neu immune responses in a phase 1B/2 trial of 2B1 bispecific murine monoclonal antibody in metastatic breast cancer(E3194): A trial coordinated by the Eastern Cooperative Oncology Group
    • Borghaei H, Alpaugh RK, Bernardo P, Palazzo IE, Dutcher JP, Venkatraj U, Wood WC, Goldstein L, Weiner LM: Induction of adaptive anti-HER2/neu immune responses in a phase 1B/2 trial of 2B1 bispecific murine monoclonal antibody in metastatic breast cancer (E3194): A trial coordinated by the Eastern Cooperative Oncology Group. J Immunother (2007) 30(4):455-467.
    • (2007) J Immunother , vol.30 , Issue.4 , pp. 455-467
    • Borghaei, H.1    Alpaugh, R.K.2    Bernardo, P.3    Palazzo, I.E.4    Dutcher, J.P.5    Venkatraj, U.6    Wood, W.C.7    Goldstein, L.8    Weiner, L.M.9
  • 103
    • 36348965935 scopus 로고    scopus 로고
    • A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors
    • Fury MG, Lipton A, Smith KM, Winston CB, Pfister DG: A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors. Cancer Immunol Immunother (2008) 57(2):155-163.
    • (2008) Cancer Immunol Immunother , vol.57 , Issue.2 , pp. 155-163
    • Fury, M.G.1    Lipton, A.2    Smith, K.M.3    Winston, C.B.4    Pfister, D.G.5


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