Duodenal chemosensing and mucosal defenses

Digestion

Volumn 83, Issue SUPPL.1, 2011, Pages 25-31

  Akiba, Yasutada ^a   Kaunitz, Jonathan D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acid sensor; Carbonic anhydrase; G protein coupled receptors; Luminal nutrient; Vanilloid receptor

Indexed keywords

BILE ACID; CALCIUM SENSING RECEPTOR; CARBON DIOXIDE; CARBONATE DEHYDRATASE; FATTY ACID; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR 1; HETERODIMER; PROSTAGLANDIN SYNTHASE;

ABSORPTION; CONFERENCE PAPER; DIGESTION; DUODENUM; DUODENUM MUCOSA; ENTEROENDOCRINE CELL; HUMAN; ION TRANSPORT; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; SECRETION; SENSORY NERVE; STOMACH ACID;

AMINO ACIDS; BICARBONATES; CARBON DIOXIDE; CHEMORECEPTOR CELLS; DUODENUM; ESOPHAGUS; GASTRIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL MUCOSA; RECEPTORS, CALCIUM-SENSING; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PURINERGIC P2Y;

EID: 79952517839     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000323401     Document Type: Conference Paper

References (71)

1. Akiba Y, Kaunitz JD: Luminal chemosensing and upper gastrointestinal mucosal defenses. Am J Clin Nutr 2009;90:826S-831S.
2. Akiba Y, Nakamura M, Nagata H, Kaunitz JD, Ishii H: Acid-sensing pathways in rat gastrointestinal mucosa. J Gastroenterol 2002;37:133-138. (Pubitemid 35385945)
3. Andersson S: Inhibitory effects of hydrochloric acid in the duodenum on gastrinstimulated gastric secretion in Heidenhain pouch dogs. Acta Physiol Scand 1960;50:105-112.
4. Kaunitz JD, Akiba Y: Acid-sensing protective mechanisms of duodenum. J Physiol Pharmacol 2003;54:19-26.
5. Kaunitz JD, Akiba Y: Duodenal carbonic anhydrase: mucosal protection, luminal chemosensing, and gastric acid disposal. Keio J Med 2006;55:96-106. (Pubitemid 44544851)
6. Rune SJ, Henriksen FW: Carbon dioxide tensions in the proximal part of the canine gastrointestinal tract. Gastroenterology 1969;56:758-762.
7. Sugai N, Okamura H, Tsunoda R: Histochemical localization of carbonic anhydrase in the rat duodenal epithelium. Fukushima J Med Sci 1994;40:103-117.
8. 2 and pH regulation in rat duodenal mucosa. J Physiol 2006;573:827-842.
9. 2 in rat duodenum. Gastroenterology 2006;131:142-152.
10. Gamble JL, Ross SG: The factors in the dehydration following pyloric obstruction. J Clin Invest 1925;1:403-423.
11. Rune SJ: The metabolic alkalosis following aspiration of gastric acid secretion. Scand J Clin Lab Invest 1965;17:305-310.
12. - secretion in rats. Med Sci Monit 2009;15:BR349-BR356.
13. - supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci USA 2009;106:13094-13099.
14. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K: Proton-sensing G-protein-coupled receptors. Nature 2003;425:93-98. (Pubitemid 37101724)
15. Im DS: Two ligands for a GPCR, proton vs. lysolipid. Acta Pharmacol Sin 2005;26:1435-1441.
16. Im DS: New intercellular lipid mediators and their GPCRs: an update. Prostaglandins Other Lipid Mediat 2009;89:53-56.
17. Huang CW, Tzeng JN, Chen YJ, Tsai WF, Chen CC, Sun WH: Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors. Mol Cell Neurosci 2007;36:195-210.
18. Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON: Vascular abnormalities in mice deficient for the G-protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol 2007;27:1334-1347. (Pubitemid 46239816)
19. Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F: Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol 2009;182:3243-3251.
20. Akiba Y, Mizumori M, Guth PH, Engel E, Kaunitz JD: Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats. Am J Physiol Gastrointest Liver Physiol 2007;293:G1223-G1233. (Pubitemid 350255037)
21. Mizumori M, Ham M, Guth PH, Engel E, Kaunitz JD, Akiba Y: Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum. J Physiol 2009;587:3651-3663.
22. Ham M, Mizumori M, Watanabe C, Wang J, Inoue T, Nakano T, Guth PH, Engel E, Kaunitz JD, Akiba Y: Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther 2010;335:607-613.
23. Kaunitz JD, Akiba Y: Purinergic regulation of duodenal surface pH and ATP concentration: implications for mucosal defence, lipid uptake and cystic fibrosis. Acta Physiol (Oxf) 2011;201:109-116.
24. 2 chemosensing in rat oesophagus. Gut 2008;57:1654-1664.
25. Chandrashekar J, Yarmolinsky D, von BL, Oka Y, Sly W, Ryba NJ, Zuker CS: The taste of carbonation. Science 2009;326:443-445.
26. Goo T, Akiba Y, Kaunitz JD: Mechanisms of intragastric pH sensing. Curr Gastroenterol Rep 2010;12:465-470.
27. Buchan AM, Squires PE, Ring M, Meloche RM: Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 2001;120:1128-1139. (Pubitemid 32246667)
28. Quinn SJ, Bai M, Brown EM: pH sensing by the calcium-sensing receptor. J Biol Chem 2004;279:37241-37249. (Pubitemid 39195430)
29. Busque SM, Kerstetter JE, Geibel JP, Insogna K: L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol 2005;289:G664-G669. (Pubitemid 41377172)
30. Feng J, Lu M, Anthony S, Petersen CD, Wank SA: The calcium-sensing receptor mediates meal stimulated gastrin secretion. Gastroenterology 2007;132:A101.
31. Schicho R, Florian W, Liebmann I, Holzer P, Lippe IT: Increased expression of TRPV1 receptor in dorsal root ganglia by acid insult of the rat gastric mucosa. Eur J Neurosci 2004;19:1811-1818. (Pubitemid 38482568)
32. Holzer P: Neural emergency system in the stomach. Gastroenterology 1998;114:823-839.
33. Lindemann B: Receptors and transduction in taste. Nature 2001;413:219-225.
34. Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP: Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 2005;33:302-305. (Pubitemid 40313828)
35. +-glucose co-transporter 1. Proc Natl Acad Sci USA 2007;104:15075-15080.
36. Mace OJ, Affleck J, Patel N, Kellett GL: Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 2007;582:379-392. (Pubitemid 46993582)
37. Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E: Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci USA 2002;99:2392-2397. (Pubitemid 34169071)
38. Raybould HE: Nutrient tasting and signaling mechanisms in the gut. I. Sensing of lipid by the intestinal mucosa. Am J Physiol 1999;277:G751-G755.
39. Rozengurt E: Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and α-gustducin in the mammalian gut. Am J Physiol Gastrointest Liver Physiol 2006;291:G171-G177.
40. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS: An aminoacid taste receptor. Nature 2002;416:199-202.
41. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS: The receptors for mammalian sweet and umami taste. Cell 2003;115:255-266. (Pubitemid 37487700)
42. Chaudhari N, Landin AM, Roper SD: A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci 2000;3:113-119. (Pubitemid 30126325)
43. Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K: Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell Tissue Res 2003;313:29-35. (Pubitemid 36976473)
44. San Gabriel AM, Maekawa T, Uneyama H, Yoshie S, Torii K: mGluR1 in the fundic glands of rat stomach. FEBS Lett 2007;581:1119-1123. (Pubitemid 46385934)
45. 2+-sensing receptor in rat intestine. Am J Physiol 1998;274:G122-G130.
46. Uneyama H, Niijima A, San GA, Torii K: Luminal amino acid sensing in the rat gastric mucosa. Am J Physiol Gastrointest Liver Physiol 2006;291:G1163- G1170. (Pubitemid 44904171)
47. Akiba Y, Kaunitz JD: Luminal chemosensing in the duodenal mucosa. Acta Physiol (Oxf) 2011;201:77-84.
48. Akiba Y, Watanabe C, Mizumori M, Kaunitz JD: Luminal L -glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol 2009;297:G781-G791.
49. Akiba Y, Furukawa O, Guth PH, Engel E, Nastaskin I, Sassani P, Dukkipatis R, Pushkin A, Kurtz I, Kaunitz JD: Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury. J Clin Invest 2001;108:1807-1816. (Pubitemid 34015126)
50. Sato M, Yamashita S, Ogawa H: Potentiation of gustatory response to monosodium glutamate in rat chorda tympani fibers by addition of 5′-ribonucleotides. Jpn J Physiol 1970;20:444-464.
51. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM: Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci USA 2007;104:15069-15074. (Pubitemid 47619594)
52. Bezencon C, le Coutre J, Damak S: Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 2007;32:41-49. (Pubitemid 46017873)
53. Mace OJ, Lister N, Morgan E, Shepherd E, Affleck J, Helliwell P, Bronk JR, Kellett GL, Meredith D, Boyd R, Pieri M, Bailey PD, Pettcrew R, Foley D: An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. J Physiol 2009;587:195-210.
54. Adibi SA, Mercer DW: Protein digestion in human intestine as reflected in luminal, mucosal, and plasma amino acid concentrations after meals. J Clin Invest 1973;52:1586-1594.
55. Marcus CS, Lengemann FW: Absorption of Ca45 and Sr85 from solid and liquid food at various levels of the alimentary tract of the rat. J Nutr 1962;77:155-160.
56. Bronner F: Recent developments in intestinal calcium absorption. Nutr Rev 2009;67:109-113.
57. Balesaria S, Sangha S, Walters JR: Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol 2009;297:G1193-G1197.
58. Barley NF, Howard A, O'Callaghan D, Legon S, Walters JR: Epithelial calcium transporter expression in human duodenum. Am J Physiol Gastrointest Liver Physiol 2001;280:G285-G290.
59. Engelstoft MS, Egerod KL, Holst B, Schwartz TW: A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab 2008;8:447-449.
60. Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ, Gribble FM: Glucose sensing in L cells: a primary cell study. Cell Metab 2008;8:532-539.
61. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G: Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 2005;11:90-94. (Pubitemid 40215843)
62. Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI: Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G-protein-coupled receptor, Gpr41. Proc Natl Acad Sci USA 2008;105:16767-16772.
63. Liou AP, Lu X, Sei Y, Zhao X, Pechhold S, Carrero RJ, Raybould HE, Wank S: The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. Gastroenterology 2010 (in press).
64. Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K: TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009;10:167-177.
65. Baldassano S, Liu S, Qu MH, Mule F, Wood JD: Glucagon-like peptide-2 modulates neurally-evoked mucosal chloride secretion in guinea pig small intestine in vitro. Am J Physiol Gastrointest Liver Physiol 2009;297:G800-G805.
66. Tsai CH, Hill M, Asa SL, Brubaker PL, Drucker DJ: Intestinal growth-promoting properties of glucagon-like peptide-2 in mice. Am J Physiol 1997;273:E77-E84.
67. Wang JH, Akiba Y, Engel E, Guth PH, Kaunitz JD: Umami receptor activation increases duodenal bicarbonate secretion via GLP-2 release in rats. Gastroenterology 2010;138:S405.
68. Dubé PE, Brubaker PL: Frontiers in glucagon-like peptide-2: multiple actions, multiple mediators. Am J Physiol Endocrinol Metab 2007;293:E460-E465. (Pubitemid 47205088)
69. Van Boxel OS, Ter Linde JJ, Siersema PD, Smout AJ: Role of chemical stimulation of the duodenum in dyspeptic symptom generation. Am J Gastroenterol 2010;105:803-811.
70. Tanimura T, Adachi K, Furuta K, Ohara S, Morita T, Koshino K, Miki M, Kinoshita Y: Usefulness of catheterless radiotelemetry pH monitoring system to examine the relationship between duodenal acidity and upper-GI symptoms. J Gastroenterol Hepatol 2011;26:98-103.
71. Akiba Y, Kaunitz JD: Duodenal chemosensing: master control for epigastric sensation? J Gastroenterol Hepatol 2011;26:6-7.