Two ligands for a GPCR, proton vs lysolipid

Acta Pharmacologica Sinica

Volumn 26, Issue 12, 2005, Pages 1435-1441

  Im, Dong Soon ^a  

^a Pusan National University   (South Korea)

Author keywords

G protein coupled receptor; Lysolipid; Lysophosphatidylcholine; Proton; Psychosine; Sphingosylphosphorylcholine

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LIGAND; LIPID; LYSOLIPID; OVARIAN CANCER G PROTEIN COUPLED RECEPTOR 1; PROTON; RECEPTOR; UNCLASSIFIED DRUG;

NONHUMAN; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; HUMANS; LIGANDS; LYSOPHOSPHATIDYLCHOLINES; MOLECULAR SEQUENCE DATA; PHOSPHORYLCHOLINE; PROTONS; PSYCHOSINE; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 29044447488     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00237.x     Document Type: Review

References (54)

1. Im DS. Orphan G protein-coupled receptors and beyond. Jpn J Pharmacol 2002; 90: 101-6.
2. Perez DM. From plants to man: the GPCR "tree of life". Mol Pharmacol 2005; 67: 1383-4.
3. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, et al. The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci USA 2003; 100: 4903-8.
4. Kostenis E. A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands. Pharmacol Ther 2004; 102: 243-57.
5. Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999; 399: 789-93.
6. Yokomizo T, Izumi T, Chang K, Takuwa Y, Shimizu T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 1997; 387: 620-4.
7. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 573-85.
8. Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 1996; 135: 1071-83.
9. Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 1998; 279: 1552-5.
10. Ahern GP, Brooks IM, Miyares RL, Wang XB. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci 2005; 25: 5109-16.
11. Voilley N. Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-inflammatory drugs (NSAIDs). Curr Drug Targets Inflamm Allergy 2004; 3: 71-9.
12. Xu Y, Zhu K, Hong G, Wu W, Baudhuin LM, Xiao Y, et al. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol 2000; 2: 261-7.
13. Zhu K, Baudhuin LM, Hong G, Williams FS, Cristina KL, Kabarowski JH, et al. Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. J Biol Chem 2001; 276: 41325-35.
14. Im DS, Heise CE, Nguyen T, O'Dowd BF, Lynch KR. Identification of a molecular target of psychosine and its role in globoid cell formation. J Cell Biol 2001; 153: 429-34.
15. Xu Y, Fang XJ, Casey G, Mills GB. Lysophospholipids activate ovarian and breast cancer cells. Biochem J 1995; 309 (Pt 3): 933-40.
16. Weng Z, Fluckiger AC, Nisitani S, Wahl MI, Le LQ, Hunter CA, et al. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc Natl Acad Sci USA 1998; 95: 12334-9.
17. Radu CG, Yang LV, Riedinger M, Au M, Witte ON. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci USA 2004; 101: 245-50.
18. Yang LV, Radu CG, Wang L, Riedinger M, Witte ON. Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood 2005; 105: 1127-34.
19. Wang L, Radu CG, Yang LV, Bentolila LA, Riedinger M, Witte ON. Lysophosphatidylcholine-induced Surface Redistribution Regulates Signaling of the Murine G Protein-coupled Receptor G2A. Mol Biol Cell 2005; 16: 2234-47.
20. Han KH, Hong KH, Ko J, Rhee KS, Hong MK, Kim JJ, et al. Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells. J Leukoc Biol 2004; 76: 195-202.
21. Murakami N, Yokomizo T, Okuno T, Shimizu T. G2A is a proton-sensing G-protein coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem 2004; 279: 42484-91.
22. Lin P, Ye RD. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. J Biol Chem 2003; 278: 14379-86.
23. Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, et al. Secretory phospholipase A2 induces neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor. J Biol Chem 2005; 280: 28044-52.
24. Lum H, Qiao J, Walter RJ, Huang F, Subbaiah PV, Kim KS, et al. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. Am J Physiol Heart Circ Physiol 2003; 285: H1786-9.
25. Kim KS, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, et al. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB J 2005; 19: 819-21.
26. Maghazachi AA, Knudsen E, Jin Y, Jenstad M, Chaudhry FA. D-galactosyl-beta1-1'-sphingosine and D-glucosyl-beta1-1'-sphingosine induce human natural killer cell apoptosis. Biochem Biophys Res Commun 2004; 320: 810-5.
27. Malone MH, Wang Z, Distelhorst CW. The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. J Biol Chem 2004; 279: 52850-9.
28. Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, et al. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol 2003; 15: 741-9.
29. Le LQ, Kabarowski JH, Weng Z, Satterthwaite AB, Harvill ET, Jensen ER, et al. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity 2001; 14: 561-71.
30. Yan JJ, Jung JS, Lee JE, Lee J, Huh SO, Kim HS, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med 2004; 10: 161-7.
31. Zohn IE, Klinger M, Karp X, Kirk H, Symons M, Chrzanowska-Wodnicka M, et al. G2A is an oncogenic G protein-coupled receptor. Oncogene 2000; 19: 3866-77.
32. Sin WC, Zhang Y, Zhong W, Adhikarakunnathu S, Powers S, Hoey T, et al. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. Oncogene 2004; 23: 6299-303.
33. Bektas M, Barak LS, Jolly PS, Liu H, Lynch KR, Lacana E, et al. The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry 2003; 42: 12181-91.
34. 2A. Science 2001; 293: 702-5.
35. Retraction in: Witte ON, Kabarowski JH, Xu Y, Le LQ, Zhu K. Retraction. Science 2005; 307: 206.
36. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, et al. Proton-sensing G-protein-coupled receptors. Nature 2003; 425: 93-8.
37. Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K, et al. TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J Biol Chem 2004; 279: 45626-33.
38. Ishii S, Kihara Y, Shimizu T. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J Biol Chem 2005; 280: 9083-7.
39. Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A 2005; 102: 1632-7.
40. Conner AC, Simms J, Hay DL, Mahmoud K, Howitt SG, Wheatley M, et al. Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin. Biochem Soc Trans 2004; 32: 843-6.
41. Wike-Hooley JL, Haveman J, Reinhold HS. The relevance of tumour pH to the treatment of malignant disease. Radiother Oncol 1984; 2: 343-66.
42. Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TA, et al. Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med 2000; 161: 694-9.
43. Naghavi M, John R, Naguib S, Siadaty MS, Grasu R, Kurian KC, et al. pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque. Atherosclerosis 2002; 164: 27-35.
44. Christensen BN, Kochukov MY, McNearney TA, Taglialatela G, Westlund KN. A Proton-Sensing G-Protein Coupled Receptor Mobilizes Calcium in Human Synovial Cells. Am J Physiol Cell Physiol 2005; 289: C601-8.
45. Krieger NS, Frick KK, Bushinsky DA. Mechanism of acid-induced bone resorption. Curr Opin Nephrol Hypertens 2004; 13: 423-36.
46. Kenakin TP. Drug-receptor theory. In: Kenakin TP. Pharmacological analysis of drug-receptor interaction. New York: Raven Press; 1987. p 1-30.
47. Strange PG. Mechanisms of inverse agonism at G-protein-coupled receptors. Trends Pharmacol Sci 2002; 23: 89-95.
48. Tryoen-Toth P, Decaillot FM, Filliol D, Befort K, Lazarus LH, Schiller PW, et al. Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors. J Pharmacol Exp Ther 2005; 313: 410-21.
49. Wildman SS, Unwin RJ, King BF. Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions. Br J Pharmacol 2003; 140: 1177-86.
50. Quinn SJ, Bai M, Brown EM. pH Sensing by the calcium-sensing receptor. J Biol Chem 2004; 279: 37241-9.
51. Lagnado L, Baylor D. Signal flow in visual transduction. Neuron 1992; 8: 995-1002.
52. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000; 289: 739-45.
53. Nagy I, Santha P, Jancso G, Urban L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol. 2004; 500: 351-69.
54. Xu Y, Casey G. Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. Genomics 1996; 35: 397-402.