Mechanisms of intragastric pH sensing

Current Gastroenterology Reports

Volumn 12, Issue 6, 2010, Pages 465-470

  Goo, Tyralee ^a,e   Akiba, Yasutada ^a,b,c,d   Kaunitz, Jonathan D ^a,b,c,d  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Brentwood Biomedical Research Institute Los Angeles   (United States)

^e CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Acid sensing ion channel; Amino acid; Calcitonin gene related peptide; Calcium sensing receptor; Gastrin; Parietal cell, G cell, D cell; Somatostatin; Transient receptor potential vanilloid subtype 1 (TRPV1)

Indexed keywords

AMINO ACID; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ION; CALCIUM SENSING RECEPTOR; GASTRIN; MAGNESIUM ION;

BIOSENSOR; CELL PH; FEEDBACK SYSTEM; FUNCTIONAL ANATOMY; GASTRIN RELEASE; HUMAN; NONHUMAN; PARATHYROID GLAND; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SENSORY NERVE; STOMACH ACID SECRETION; STOMACH PH;

AMINO ACIDS; ANIMALS; FEEDBACK, PHYSIOLOGICAL; GASTRIC ACID; GASTRIC MUCOSA; GASTRIN-SECRETING CELLS; GASTRINS; HUMANS; HYDROGEN-ION CONCENTRATION; NEURONS, AFFERENT; RECEPTORS, CALCIUM-SENSING; SOMATOSTATIN-SECRETING CELLS;

EID: 78649908085     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-010-0147-7     Document Type: Review

References (37)

1. S Andersson L Olbe 1964 Inhibition of gastric acid response to sham feeding in pavlov pouch dogs by acidification of antrum Acta Physiol Scand 61 55 64 1:CAS:528:DyaF2cXkslynt7w%3D 10.1111/j.1748-1716.1964.tb02942.x 14168047
2. RF Barreras 1973 Calcium and gastric secretion Gastroenterology 64 1168 1184 1:CAS:528:DyaE3sXkt1OktLk%3D 4574679
3. J Behar M Hitchings RD Smyth 1977 Calcium stimulation of gastrin and gastric acid secretion: effect of small doses of calcium carbonate Gut 18 442 448 1:CAS:528:DyaE2sXksl2ju7g%3D 10.1136/gut.18.6.442 873325 (Pubitemid 8139293)
4. GE Feurle 1975 Effect of rising intragastric pH induced by several antacids on serum gastrin concentrations in duodenal ulcer patients and in a control group Gastroenterology 68 1 7 1:CAS:528:DyaE2MXhsV2ntLY%3D 234900
5. G Mazzacca F Cascione G Budillon, et al. 1978 Parietal cell hyperplasia induced by long-term administration of antacids to rats Gut 19 798 801 1:CAS:528:DyaE1MXhs1ensw%3D%3D 10.1136/gut.19.9.798 710969
6. ML Schubert DA Peura 2008 Control of gastric acid secretion in health and disease Gastroenterology 134 1842 1860 1:CAS:528:DC%2BD1cXosFGltr4%3D 10.1053/j.gastro.2008.05.021 18474247 This article provides a comprehensive review of cellular anatomy and physiologic control of gastric acid secretion in the normal state and describes the pathologic clinical presentations of abnormal acid states (Pubitemid 351783299)
7. Shulkes A, Baldwin GS, Giraud AS: Regulation of gastric acid secretion. In Physiology of the Gastrointestinal Tract. Edited by Johnson LR. New York: Academic Press; 2006:1223-1258.
8. RV Campos AM Buchan RM Meloche, et al. 1990 Gastrin secretion from human antral G cells in culture Gastroenterology 99 36 44 1:CAS:528:DyaK3MXisVSqu7w%3D 1971610
9. N Zeng C Athmann T Kang, et al. 1999 PACAP type I receptor activation regulates ECL cells and gastric acid secretion J Clin Invest 104 1383 1391 1:CAS:528:DyaK1MXntlyru7c%3D 10.1172/JCI7537 10562300
10. SA Wank 1999 PACAP upsets stomach theory J Clin Invest 104 1341 1342 1:CAS:528:DyaK1MXntlyru7o%3D 10.1172/JCI8732 10562295
11. CT Richardson JH Walsh MI Hicks JS Fordtran 1976 Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects J Clin Invest 58 623 631 1:CAS:528:DyaE28Xlt1Srtb0%3D 10.1172/JCI108509 956391
12. ML Schubert MJ Jong GM Makhlouf 1991 Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus Am J Physiol 261 G885 G889 1:CAS:528:DyaK38Xhs1Sqtg%3D%3D 1683168
13. JH Walsh CT Richardson JS Fordtran 1975 pH dependence of acid secretion and gastrin release in normal and ulcer subjects J Clin Invest 55 462 468 1:CAS:528:DyaE2MXht1arsLY%3D 10.1172/JCI107952 1167869
14. FD Manela J Ren J Gao, et al. 1995 Calcitonin gene-related peptide modulates acid-mediated regulation of somatostatin and gastrin release from rat antrum Gastroenterology 109 701 706 1:CAS:528:DyaK2MXos1Grtbc%3D 10.1016/0016-5085(95)90376-3 7657098
15. Holst JJ: Differences in the control of somatostatin release from antrum and fundus. In The Stomach as an Endocrine Organ. Edited by Hankanson R, Sundler F. Amsterdam: Elsevier Science Publishers; 1991:244-250.
16. AK Sandvik R Dimaline ER Forster, et al. 1993 Differential control of somatostatin messenger RNA in rat gastric corpus and antrum. Role of acid, food, and capsaicin-sensitive afferent neurons J Clin Invest 91 244 250 1:CAS:528:DyaK3sXpsVOjuw%3D%3D 10.1172/JCI116177 8093704
17. J Ren ST Dunn Y Tang, et al. 1998 Effects of calcitonin gene-related peptide on somatostatin and gastrin gene expression in rat antrum Regul Pept 73 75 82 1:CAS:528:DyaK1cXhsl2itb4%3D 10.1016/S0167-0115(97)01039-2 9533810 (Pubitemid 28083420)
18. P Holzer 2002 Sensory neurone responses to mucosal noxae in the upper gut: relevance to mucosal integrity and gastrointestinal pain Neurogastroenterol Motil 14 459 475 1:STN:280:DC%2BD38vpvVCqsA%3D%3D 10.1046/j.1365-2982.2002. 00353.x 12358674 (Pubitemid 35216329)
19. K Lamb YM Kang GF Gebhart K Bielefeldt 2003 Gastric inflammation triggers hypersensitivity to acid in awake rats Gastroenterology 125 1410 1418 10.1016/j.gastro.2003.07.010 14598257 (Pubitemid 37409761)
20. T Sugiura K Dang K Lamb, et al. 2005 Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach J Neurosci 25 2617 2627 1:CAS:528:DC%2BD2MXis1ygsL4%3D 10.1523/JNEUROSCI.2894-04.2005 15758172 (Pubitemid 40365173)
21. MJ Caterina TA Rosen M Tominaga, et al. 1999 A capsaicin-receptor homologue with a high threshold for noxious heat Nature 398 436 441 1:CAS:528:DyaK1MXisFGks7c%3D 10.1038/18906 10201375 (Pubitemid 29180377)
22. K Bielefeldt BM Davis 2008 Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice Am J Physiol Gastrointest Liver Physiol 294 G130 G138 1:CAS:528:DC%2BD1cXhtVWrtr4%3D 10.1152/ajpgi.00388.2007 17975130 This in vitro study of knock-out mice examined vagal afferent nerve activation and demonstrated both TRPV1 and ASIC3 play an important role in luminal chemosensing of gastric acidification. TRPV1 also is important in mechanosensation of luminal distension, whereas the ASIC3 contribution appears to be less significant
23. T Wultsch E Painsipp A Shahbazian, et al. 2008 Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis Pain 134 245 253 1:CAS:528:DC%2BD1cXlt1Kruw%3D%3D 10.1016/j.pain.2007.04.025 17531389 This study of ASIC2 and ASIC3 knock-out mice demonstrated the ASIC3 l to play an important role in gastric acid hyperresponsiveness after experimentally induced gastritis. The ASIC2 function appears to attenuate gastric acid signaling by sensory neurons to the NTS
24. J Auer PW Reeh MJM Fischer 2010 Acid-induced CGRP release from the stomach does not depend on TRPV1 or ASIC3 Neurogastroenterol Motil 22 680 687 1:CAS:528:DC%2BC3cXotVWhs7k%3D 10.1111/j.1365-2982.2009.01459.x 20100279 This study investigated the sensory response to acid load in the isolated everted mouse stomach by measuring CGRP as a marker for neuronal activation in wild-type and TRPV1 or ASIC3 knock-outs. A direct linear relationship was found between rising CGRP levels and decreasing extracellular pH. However, this response was found to be independent of TRPV1 or ASIC3 channels, suggesting existence of another acid-sensing pathway yet to be determined
25. 2+-sensing receptor from bovine parathyroid Nature 366 575 580 1:CAS:528:DyaK2cXhvVGmtLs%3D 10.1038/366575a0 8255296 (Pubitemid 24035999)
26. JP Geibel CA Wagner R Caroppo, et al. 2001 The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion J Biol Chem 276 39549 39552 1:CAS:528:DC%2BD3MXotFGisbo%3D 10.1074/jbc.M107315200 11507103
27. 2+-sensing receptor in normal human gastric mucous epithelial cells Am J Physiol 277 G662 G670 1:CAS:528:DyaK1MXmt1alt7w%3D 10484392
28. JM Ray PE Squires SB Curtis, et al. 1997 Expression of the calcium-sensing receptor on human antral gastrin cells in culture J Clin Invest 99 2328 2333 1:CAS:528:DyaK2sXjsVGqsb0%3D 10.1172/JCI119413 9153273
29. E Nakamura M Hasumura AS Gabriel, et al. 2010 Functional role of calcium-sensing receptor on somatostatin release from rat gastric mucosa [abstract] Gastroenterology 138 S404 These investigators presented work on fractioned rat gastric cells that measured mRNA expression for CaSR on individual cell types, identifying CaSR expression to be predominantly found on D cells inducing activating response with somatostatin release. This action was verified with CaSR synthetic agonist calcitonin and antagonized with NPS2143
30. J Feng M Lu S Anthony, et al. 2007 The calcium-sensing receptor (CaSR) mediates meal stimulated gastrin secretion [abstract] Gastroenterology 132 A101 This abstract provided the initial data supporting the hypothesis that the CaSR is the antral pH sensor
31. MM Dufner P Kirchhoff C Remy, et al. 2005 The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands Am J Physiol Gastrointest Liver Physiol 289 G1084 G1090 1:CAS:528:DC%2BD28XlslOisw%3D%3D 10.1152/ajpgi.00571.2004 16109841 (Pubitemid 41740614)
32. AM Buchan PE Squires M Ring RM Meloche 2001 Mechanism of action of the calcium-sensing receptor in human antral gastrin cells Gastroenterology 120 1128 1139 1:CAS:528:DC%2BD3MXjtVeqsLg%3D 10.1053/gast.2001.23246 11266377
33. L Ceglia SS Harris HM Rasmussen B Dawson-Hughes 2009 Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants Osteoporos Int 20 71 78 1:CAS:528:DC%2BD1cXhsVegu73M 10.1007/s00198-008-0637-8 18536954 This double-blind, randomized, placebo-controlled study was the first in vivo human study to demonstrate the actions of of CaSR. Subjects on fixed metabolic diet who were given the CaSR agonist cinacalcet were shown to have increased serum gastrin and basal gastric acid output compared to placebo
34. JI Isenberg V Maxwell 1978 Intravenous infusion of amino acids stimulates gastric acid secretion in man N Engl J Med 298 27 29 1:CAS:528: DyaE1cXntlersA%3D%3D 10.1056/NEJM197801052980106 618447
35. SM Busque JE Kerstetter JP Geibel K Insogna 2005 L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells Am J Physiol Gastrointest Liver Physiol 289 G664 G669 1:CAS:528:DC%2BD2MXhtFensL%2FP 15961860
36. P Kirchhoff MH Dave C Remy, et al. 2006 An amino acid transporter involved in gastric acid secretion Pflugers Arch 451 738 748 1:CAS:528:DC%2BD28Xhtlegtr4%3D 10.1007/s00424-005-1507-2 16308696 (Pubitemid 43228057)
37. SJ Quinn M Bai EM Brown 2004 pH sensing by the calcium-sensing receptor J Biol Chem 279 37241 37249 1:CAS:528:DC%2BD2cXntFSgtLk%3D 10.1074/jbc.M404520200 15201280 (Pubitemid 39195430)