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Volumn 100, Issue , 2011, Pages 483-498

Demise of the flies: Why Drosophila models still matter

Author keywords

Amyloid; Ataxin; Drosophila; Neurodegeneration; Parkin; Superoxide dismutase; Tau; TDP 43; Synuclein

Indexed keywords


EID: 79952416755     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-384878-9.00011-X     Document Type: Chapter
Times cited : (6)

References (87)
  • 1
    • 0034837386 scopus 로고    scopus 로고
    • A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
    • DOI 10.1101/gr.169101
    • L.T. Reiter, L. Potocki, S. Chien, M. Gribskov, and E. Bier A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster Genome Res 11 2001 1114 1125 (Pubitemid 32834555)
    • (2001) Genome Research , vol.11 , Issue.6 , pp. 1114-1125
    • Reiter, L.T.1    Potocki, L.2    Chien, S.3    Gribskov, M.4    Bier, E.5
  • 2
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • DOI 10.1038/nrg1503
    • E. Bier Drosophila, the golden bug, emerges as a tool for human genetics Nat Rev Genet 6 2005 9 23 (Pubitemid 39657894)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.1 , pp. 9-23
    • Bier, E.1
  • 5
    • 36148942524 scopus 로고    scopus 로고
    • Transgenesis upgrades for Drosophila melanogaster
    • DOI 10.1242/dev.005686
    • K.J. Venken, and H.J. Bellen Transgenesis upgrades for Drosophila melanogaster Development 134 2007 3571 3584 (Pubitemid 350107703)
    • (2007) Development , vol.134 , Issue.20 , pp. 3571-3584
    • Venken, K.J.T.1    Bellen, H.J.2
  • 6
    • 0032956145 scopus 로고    scopus 로고
    • A fly's eye view of biology
    • DOI 10.1016/S0168-9525(99)01720-5, PII S0168952599017205
    • B.J. Thomas, and D.A. Wassarman A fly's eye view of biology Trends Genet 15 1999 184 190 (Pubitemid 29217068)
    • (1999) Trends in Genetics , vol.15 , Issue.5 , pp. 184-190
    • Thomas, B.J.1    Wassarman, D.A.2
  • 7
    • 0026664105 scopus 로고
    • Mosaic analysis gives an estimate of the extent of genomic involvement in the development of the visual system in Drosophila melanogaster
    • H.M. Thaker, and D.R. Kankel Mosaic analysis gives an estimate of the extent of genomic involvement in the development of the visual system in Drosophila melanogaster Genetics 131 1992 883 894
    • (1992) Genetics , vol.131 , pp. 883-894
    • Thaker, H.M.1    Kankel, D.R.2
  • 8
    • 0028234124 scopus 로고
    • Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder
    • DOI 10.1016/0197-4580(94)90032-9
    • H. Braak, and E. Braak Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder Neurobiol Aging 15 1994 355 356 (discussion 37980) (Pubitemid 24194878)
    • (1994) Neurobiology of Aging , vol.15 , Issue.3 , pp. 355-356
    • Braak, H.1    Braak, E.2
  • 10
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • DOI 10.1038/nrn2194, PII NRN2194
    • C. Ballatore, V.M. Lee, and J.Q. Trojanowski Tau-mediated neurodegeneration in Alzheimer's disease and related disorders Nat Rev Neurosci 8 2007 663 672 (Pubitemid 47283144)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.9 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 11
    • 70549084415 scopus 로고    scopus 로고
    • Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
    • W. Satake, Y. Nakabayashi, I. Mizuta, Y. Hirota, C. Ito, and M. Kubo Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease Nat Genet 41 2009 1303 1307
    • (2009) Nat Genet , vol.41 , pp. 1303-1307
    • Satake, W.1    Nakabayashi, Y.2    Mizuta, I.3    Hirota, Y.4    Ito, C.5    Kubo, M.6
  • 12
    • 70549088602 scopus 로고    scopus 로고
    • Genome-wide association study reveals genetic risk underlying Parkinson's disease
    • J. Simon-Sanchez, C. Schulte, J.M. Bras, M. Sharma, J.R. Gibbs, and D. Berg Genome-wide association study reveals genetic risk underlying Parkinson's disease Nat Genet 41 2009 1308 1312
    • (2009) Nat Genet , vol.41 , pp. 1308-1312
    • Simon-Sanchez, J.1    Schulte, C.2    Bras, J.M.3    Sharma, M.4    Gibbs, J.R.5    Berg, D.6
  • 13
    • 77951185469 scopus 로고    scopus 로고
    • Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
    • T.L. Edwards, W.K. Scott, C. Almonte, A. Burt, E.H. Powell, and G.W. Beecham Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease Ann Hum Genet 74 2010 97 109
    • (2010) Ann Hum Genet , vol.74 , pp. 97-109
    • Edwards, T.L.1    Scott, W.K.2    Almonte, C.3    Burt, A.4    Powell, E.H.5    Beecham, G.W.6
  • 14
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • A.H. Brand, and N. Perrimon Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401 415 (Pubitemid 23214028)
    • (1993) Development , vol.118 , Issue.2 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 15
    • 0034716223 scopus 로고    scopus 로고
    • Tau and tau reporters disrupt central projections of sensory neurons in Drosophila
    • D.W. Williams, M. Tyrer, and D. Shepherd Tau and tau reporters disrupt central projections of sensory neurons in Drosophila J Comp Neurol 428 2000 630 640
    • (2000) J Comp Neurol , vol.428 , pp. 630-640
    • Williams, D.W.1    Tyrer, M.2    Shepherd, D.3
  • 17
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • DOI 10.1016/S0896-6273(02)00706-7
    • G.R. Jackson, M. Wiedau-Pazos, T.-K. Sang, N. Wagle, C.A. Brown, and S. Massachi Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila Neuron 34 2002 509 519 (Pubitemid 34628749)
    • (2002) Neuron , vol.34 , Issue.4 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.-K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 18
    • 0346361872 scopus 로고    scopus 로고
    • Genetic Modifiers of Tauopathy in Drosophila
    • J.M. Shulman, and M.B. Feany Genetic modifiers of tauopathy in Drosophila Genetics 165 2003 1233 1242 (Pubitemid 38020245)
    • (2003) Genetics , vol.165 , Issue.3 , pp. 1233-1242
    • Shulman, J.M.1    Feany, M.B.2
  • 21
    • 57649203362 scopus 로고    scopus 로고
    • Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK and Cdk5 in a Drosophila model
    • S. Chatterjee, T.K. Sang, G.M. Lawless, and G.R. Jackson Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model Hum Mol Genet 18 2009 164 177
    • (2009) Hum Mol Genet , vol.18 , pp. 164-177
    • Chatterjee, S.1    Sang, T.K.2    Lawless, G.M.3    Jackson, G.R.4
  • 22
    • 77950940279 scopus 로고    scopus 로고
    • Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein
    • S. Feuillette, L. Miguel, T. Frbourg, D. Campion, and M. Lecourtois Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein J Neurochem 113 2010 895 903
    • (2010) J Neurochem , vol.113 , pp. 895-903
    • Feuillette, S.1    Miguel, L.2    Frbourg, T.3    Campion, D.4    Lecourtois, M.5
  • 23
    • 77953249839 scopus 로고    scopus 로고
    • Disruption of neuronal function by soluble hyperphosphorylated tau in a Drosophila model of tauopathy
    • C.M. Cowan, F. Chee, D. Shepherd, and A. Mudher Disruption of neuronal function by soluble hyperphosphorylated tau in a Drosophila model of tauopathy Biochem Soc Trans 38 2010 564 570
    • (2010) Biochem Soc Trans , vol.38 , pp. 564-570
    • Cowan, C.M.1    Chee, F.2    Shepherd, D.3    Mudher, A.4
  • 24
    • 74949109318 scopus 로고    scopus 로고
    • Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila
    • S. Kosmidis, S. Grammenoudi, K. Papanikolopoulou, and E.M.C. Skoulakis Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila J Neurosci 30 2010 464 477
    • (2010) J Neurosci , vol.30 , pp. 464-477
    • Kosmidis, S.1    Grammenoudi, S.2    Papanikolopoulou, K.3    Skoulakis, E.M.C.4
  • 25
    • 72949116144 scopus 로고    scopus 로고
    • Drosophila notal bristle as a novel assessment tool for pathogenic study of Tau toxicity and screening of therapeutic compounds
    • P.-A. Yeh, J.-Y. Chien, C.-C. Chou, Y.-F. Huang, C.-Y. Tang, and H.-Y. Wang Drosophila notal bristle as a novel assessment tool for pathogenic study of Tau toxicity and screening of therapeutic compounds Biochem Biophys Res Commun 391 2010 510 516
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 510-516
    • Yeh, P.-A.1    Chien, J.-Y.2    Chou, C.-C.3    Huang, Y.-F.4    Tang, C.-Y.5    Wang, H.-Y.6
  • 26
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: Back to the future
    • L. Bertram, C.M. Lill, and R.E. Tanzi The genetics of Alzheimer disease: back to the future Neuron 68 2010 270 281
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 27
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis - An update and reappraisal
    • J. Hardy Alzheimer's disease: The amyloid cascade hypothesis: an update and reappraisal J Alzheimers Dis 9 2006 151 153 (Pubitemid 44253307)
    • (2006) Journal of Alzheimer's Disease , vol.9 , Issue.SUPPL. 3 , pp. 151-153
    • Hardy, J.1
  • 28
    • 0038360879 scopus 로고    scopus 로고
    • Different cofactor activities in γ-secretase assembly: Evidence for a nicastrin - Aph-1 subcomplex
    • DOI 10.1083/jcb.200304014
    • Y. Hu, and M.E. Fortini Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex J Cell Biol 161 2003 685 690 (Pubitemid 36648751)
    • (2003) Journal of Cell Biology , vol.161 , Issue.4 , pp. 685-690
    • Hu, Y.1    Fortini, M.E.2
  • 29
    • 58149503769 scopus 로고    scopus 로고
    • Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
    • K. Carmine-Simmen, T. Proctor, J. Tschpe, B. Poeck, T. Triphan, and R. Strauss Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function Neurobiol Dis 33 2009 274 281
    • (2009) Neurobiol Dis , vol.33 , pp. 274-281
    • Carmine-Simmen, K.1    Proctor, T.2    Tschpe, J.3    Poeck, B.4    Triphan, T.5    Strauss, R.6
  • 30
    • 0026783241 scopus 로고
    • Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene
    • L. Luo, T. Tully, and K. White Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene Neuron 9 1992 595 605
    • (1992) Neuron , vol.9 , pp. 595-605
    • Luo, L.1    Tully, T.2    White, K.3
  • 32
    • 77951060396 scopus 로고    scopus 로고
    • PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila
    • H.-C. Chiang, L. Wang, Z. Xie, A. Yau, and Y. Zhong PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila Proc Natl Acad Sci USA 107 2010 7060 7065
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7060-7065
    • Chiang, H.-C.1    Wang, L.2    Xie, Z.3    Yau, A.4    Zhong, Y.5
  • 33
    • 15044339964 scopus 로고    scopus 로고
    • Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease
    • DOI 10.1016/j.neuroscience.2004.12.025
    • D.C. Crowther, K.J. Kinghorn, E. Miranda, R. Page, J.A. Curry, and F.A.I. Duthie Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease Neuroscience 132 2005 123 135 (Pubitemid 40380720)
    • (2005) Neuroscience , vol.132 , Issue.1 , pp. 123-135
    • Crowther, D.C.1    Kinghorn, K.J.2    Miranda, E.3    Page, R.4    Curry, J.A.5    Duthie, F.A.I.6    Gubb, D.C.7    Lomas, D.A.8
  • 34
    • 77957254409 scopus 로고    scopus 로고
    • Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
    • K. Iijima, A. Gatt, and K. Iijima-Ando Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease Hum Mol Genet 19 2010 2947 2957
    • (2010) Hum Mol Genet , vol.19 , pp. 2947-2957
    • Iijima, K.1    Gatt, A.2    Iijima-Ando, K.3
  • 35
    • 41149163183 scopus 로고    scopus 로고
    • Parkinson's disease: Clinical features and diagnosis
    • DOI 10.1136/jnnp.2007.131045
    • J. Jankovic Parkinson's disease: clinical features and diagnosis J Neurol Neurosurg Psychiatry 79 2008 368 376 (Pubitemid 351441488)
    • (2008) Journal of Neurology, Neurosurgery and Psychiatry , vol.79 , Issue.4 , pp. 368-376
    • Jankovic, J.1
  • 36
  • 38
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • R. Krüger, W. Kuhn, T. Müller, D. Woitalla, M. Graeber, and S. Ksel Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease Nat Genet 18 1998 106 108
    • (1998) Nat Genet , vol.18 , pp. 106-108
    • Krüger, R.1    Kuhn, W.2    Müller, T.3    Woitalla, D.4    Graeber, M.5    Ksel, S.6
  • 40
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between α-synuclein gene duplication and familial Parkinson's disease
    • DOI 10.1016/S0140-6736(04)17104-3, PII S0140673604171043
    • P. Ibez, A.-M. Bonnet, B. Dbarges, E. Lohmann, F. Tison, and P. Pollak Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease Lancet 364 2004 1169 1171 (Pubitemid 39296605)
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1169-1171
    • Ibanez, P.1    Bonnet, A.-M.2    Debarges, B.3    Lohmann, E.4    Tison, F.5    Pollak, P.6    Agid, Y.7    Durr, A.8    Brice, P.A.9
  • 42
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • DOI 10.1038/35006074
    • M.B. Feany, and W.W. Bender A Drosophila model of Parkinson's disease Nature 404 2000 394 398 (Pubitemid 30164341)
    • (2000) Nature , vol.404 , Issue.6776 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 43
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
    • DOI 10.1126/science.1067389
    • P.K. Auluck, H.Y. Chan, J.Q. Trojanowski, V.M. Lee, and N.M. Bonini Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease Science 295 2002 865 868 (Pubitemid 34118369)
    • (2002) Science , vol.295 , Issue.5556 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.E.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4    Bonini, N.M.5
  • 47
    • 34547885021 scopus 로고    scopus 로고
    • Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
    • DOI 10.1523/JNEUROSCI.0218-07.2007
    • C. Wang, R. Lu, X. Ouyang, M.W.L. Ho, W. Chia, and F. Yu Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities J Neurosci 27 2007 8563 8570 (Pubitemid 47254271)
    • (2007) Journal of Neuroscience , vol.27 , Issue.32 , pp. 8563-8570
    • Wang, C.1    Lu, R.2    Ouyang, X.3    Ho, M.W.L.4    Chia, W.5    Yu, F.6    Lim, K.-L.7
  • 49
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • DOI 10.1038/nature04779, PII N04779
    • I.E. Clark, M.W. Dodson, C. Jiang, J.H. Cao, J.R. Huh, and J.H. Seol Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 441 2006 1162 1166 (Pubitemid 43990738)
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 54
    • 70350461833 scopus 로고    scopus 로고
    • LRRK2 in Parkinson's disease: In vivo models and approaches for understanding pathogenic roles
    • Z. Yue LRRK2 in Parkinson's disease: in vivo models and approaches for understanding pathogenic roles FEBS J 276 2009 6445 6454
    • (2009) FEBS J , vol.276 , pp. 6445-6454
    • Yue, Z.1
  • 56
    • 70349103837 scopus 로고    scopus 로고
    • Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila
    • C.-H. Ng, S.Z.S. Mok, C. Koh, X. Ouyang, M.L. Fivaz, and E.-K. Tan Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila J Neurosci 29 2009 11257 11262
    • (2009) J Neurosci , vol.29 , pp. 11257-11262
    • Ng, C.-H.1    Mok, S.Z.S.2    Koh, C.3    Ouyang, X.4    Fivaz, M.L.5    Tan, E.-K.6
  • 57
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • Y. Imai, S. Gehrke, H.-Q. Wang, R. Takahashi, K. Hasegawa, and E. Oota Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila EMBO J 27 2008 2432 2443
    • (2008) EMBO J , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.-Q.3    Takahashi, R.4    Hasegawa, K.5    Oota, E.6
  • 59
    • 24044472010 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
    • DOI 10.1016/j.cub.2005.07.064, PII S0960982205008481
    • M. Meulener, A.J. Whitworth, C.E. Armstrong-Gold, P. Rizzu, P. Heutink, and P.D. Wes Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease Curr Biol 15 2005 1572 1577 (Pubitemid 41219597)
    • (2005) Current Biology , vol.15 , Issue.17 , pp. 1572-1577
    • Meulener, M.1    Whitworth, A.J.2    Armstrong-Gold, C.E.3    Rizzu, P.4    Heutink, P.5    Wes, P.D.6    Pallanck, L.J.7    Bonini, N.M.8
  • 60
    • 24044506249 scopus 로고    scopus 로고
    • Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
    • DOI 10.1016/j.cub.2005.07.036, PII S0960982205007918
    • F.M. Menzies, S.C. Yenisetti, and K.-T. Min Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress Curr Biol 15 2005 1578 1582 (Pubitemid 41219598)
    • (2005) Current Biology , vol.15 , Issue.17 , pp. 1578-1582
    • Menzies, F.M.1    Yenisetti, S.C.2    Min, K.-T.3
  • 62
    • 0033080367 scopus 로고    scopus 로고
    • Glutamine repeats and neurodegenerative diseases: Molecular aspects
    • DOI 10.1016/S0968-0004(98)01350-4, PII S0968000498013504
    • M.F. Perutz Glutamine repeats and neurodegenerative diseases: molecular aspects Trends Biochem Sci 24 1999 58 63 (Pubitemid 29346574)
    • (1999) Trends in Biochemical Sciences , vol.24 , Issue.2 , pp. 58-63
    • Perutz, M.F.1
  • 63
    • 0034703863 scopus 로고    scopus 로고
    • Mechanisms of chaperone suppression of polyglutamine disease: Selectivity, synergy and modulation of protein solubility in Drosophila
    • H.Y. Chan, J.M. Warrick, G.L. Gray-Board, H.L. Paulson, and N.M. Bonini Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila Hum Mol Genet 9 2000 2811 2820
    • (2000) Hum Mol Genet , vol.9 , pp. 2811-2820
    • Chan, H.Y.1    Warrick, J.M.2    Gray-Board, G.L.3    Paulson, H.L.4    Bonini, N.M.5
  • 65
    • 13644260686 scopus 로고    scopus 로고
    • Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis
    • DOI 10.1093/hmg/ddi032
    • T.-K. Sang, C. Li, W. Liu, A. Rodriguez, J.M. Abrams, and S.L. Zipursky Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis Hum Mol Genet 14 2005 357 372 (Pubitemid 40227371)
    • (2005) Human Molecular Genetics , vol.14 , Issue.3 , pp. 357-372
    • Sang, T.-K.1    Li, C.2    Liu, W.3    Rodriguez, A.4    Abrams, J.M.5    Zipursky, S.L.6    Jackson, G.R.7
  • 66
    • 0032727617 scopus 로고    scopus 로고
    • Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
    • J.M. Warrick, H.Y. Chan, G.L. Gray-Board, Y. Chai, H.L. Paulson, and N.M. Bonini Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 Nat Genet 23 1999 425 428
    • (1999) Nat Genet , vol.23 , pp. 425-428
    • Warrick, J.M.1    Chan, H.Y.2    Gray-Board, G.L.3    Chai, Y.4    Paulson, H.L.5    Bonini, N.M.6
  • 67
    • 29444455075 scopus 로고    scopus 로고
    • Drosophila as a model for human neurodegenerative disease
    • DOI 10.1146/annurev.genet.39.110304.095804
    • J. Bilen, and N.M. Bonini Drosophila as a model for human neurodegenerative disease Annu Rev Genet 39 2005 153 171 (Pubitemid 43011111)
    • (2005) Annual Review of Genetics , vol.39 , pp. 153-171
    • Bilen, J.1    Bonini, N.M.2
  • 68
    • 15944419824 scopus 로고    scopus 로고
    • Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism
    • DOI 10.1016/j.molcel.2005.02.030
    • J.M. Warrick, L.M. Morabito, J. Bilen, B. Gordesky-Gold, L.Z. Faust, and H.L. Paulson Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism Mol Cell 18 2005 37 48 (Pubitemid 40444646)
    • (2005) Molecular Cell , vol.18 , Issue.1 , pp. 37-48
    • Warrick, J.M.1    Morabito, L.M.2    Bilen, J.3    Gordesky-Gold, B.4    Faust, L.Z.5    Paulson, H.L.6    Bonini, N.M.7
  • 69
    • 35949001344 scopus 로고    scopus 로고
    • Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
    • DOI 10.1371/journal.pgen.0030177
    • J. Bilen, and N.M. Bonini Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila PLoS Genet 3 2007 1950 1964 (Pubitemid 350072059)
    • (2007) PLoS Genetics , vol.3 , Issue.10 , pp. 1950-1964
    • Bilen, J.1    Bonini, N.M.2
  • 70
    • 0036962392 scopus 로고    scopus 로고
    • A drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation
    • T.F. Satterfield, S.M. Jackson, and L.J. Pallanck A Drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation Genetics 162 2002 1687 1702 (Pubitemid 36114656)
    • (2002) Genetics , vol.162 , Issue.4 , pp. 1687-1702
    • Satterfield, T.F.1    Jackson, S.M.2    Pallanck, L.J.3
  • 72
    • 37749039120 scopus 로고    scopus 로고
    • DAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1
    • I. Al-Ramahi, A.M. Prez, J. Lim, M. Zhang, R. Sorensen, and M. de Haro dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1 PLoS Genet 3 2007 e234
    • (2007) PLoS Genet , vol.3 , pp. 234
    • Al-Ramahi, I.1    Prez, A.M.2    Lim, J.3    Zhang, M.4    Sorensen, R.5    De Haro, M.6
  • 74
    • 0014310582 scopus 로고
    • Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait
    • W.R. Kennedy, M. Alter, and J.H. Sung Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait Neurology 18 1968 671 680
    • (1968) Neurology , vol.18 , pp. 671-680
    • Kennedy, W.R.1    Alter, M.2    Sung, J.H.3
  • 75
    • 0025800526 scopus 로고
    • Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
    • A.R. La Spada, E.M. Wilson, D.B. Lubahn, A.E. Harding, and K.H. Fischbeck Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy Nature 352 1991 77 79 (Pubitemid 21896702)
    • (1991) Nature , vol.352 , Issue.6330 , pp. 77-79
    • La Spada, A.R.1    Wilson, E.M.2    Lubahn, D.B.3    Harding, A.E.4    Fischbeck, K.H.5
  • 76
    • 0036850456 scopus 로고    scopus 로고
    • Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila
    • H.Y.E. Chan, J.M. Warrick, I. Andriola, D. Merry, and N.M. Bonini Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila Hum Mol Genet 11 2002 2895 2904
    • (2002) Hum Mol Genet , vol.11 , pp. 2895-2904
    • Chan, H.Y.E.1    Warrick, J.M.2    Andriola, I.3    Merry, D.4    Bonini, N.M.5
  • 77
    • 77957011660 scopus 로고    scopus 로고
    • Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
    • N.B. Nedelsky, M. Pennuto, R.B. Smith, I. Palazzolo, J. Moore, and Z. Nie Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy Neuron 67 2010 936 952
    • (2010) Neuron , vol.67 , pp. 936-952
    • Nedelsky, N.B.1    Pennuto, M.2    Smith, R.B.3    Palazzolo, I.4    Moore, J.5    Nie, Z.6
  • 79
    • 54049142949 scopus 로고    scopus 로고
    • A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1
    • M.R. Watson, R.D. Lagow, K. Xu, B. Zhang, and N.M. Bonini A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1 J Biol Chem 283 2008 24972 24981
    • (2008) J Biol Chem , vol.283 , pp. 24972-24981
    • Watson, M.R.1    Lagow, R.D.2    Xu, K.3    Zhang, B.4    Bonini, N.M.5
  • 80
    • 37849053294 scopus 로고    scopus 로고
    • HVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction
    • A. Chai, J. Withers, Y.H. Koh, K. Parry, H. Bao, and B. Zhang hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction Hum Mol Genet 17 2008 266 280
    • (2008) Hum Mol Genet , vol.17 , pp. 266-280
    • Chai, A.1    Withers, J.2    Koh, Y.H.3    Parry, K.4    Bao, H.5    Zhang, B.6
  • 81
    • 48449098142 scopus 로고    scopus 로고
    • A Drosophila model of ALS: Human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
    • A. Ratnaparkhi, G.M. Lawless, F.E. Schweizer, P. Golshani, and G.R. Jackson A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism PLoS ONE 3 2008 e2334
    • (2008) PLoS ONE , vol.3 , pp. 2334
    • Ratnaparkhi, A.1    Lawless, G.M.2    Schweizer, F.E.3    Golshani, P.4    Jackson, G.R.5
  • 85
    • 67349271683 scopus 로고    scopus 로고
    • Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
    • F. Feiguin, V.K. Godena, G. Romano, A. D'Ambrogio, R. Klima, and F.E. Baralle Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior FEBS Lett 583 2009 1586 1592
    • (2009) FEBS Lett , vol.583 , pp. 1586-1592
    • Feiguin, F.1    Godena, V.K.2    Romano, G.3    D'Ambrogio, A.4    Klima, R.5    Baralle, F.E.6
  • 87
    • 77956155218 scopus 로고    scopus 로고
    • Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
    • A.C. Elden, H.-J. Kim, M.P. Hart, A.S. Chen-Plotkin, B.S. Johnson, and X. Fang Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS Nature 466 2010 1069 1075
    • (2010) Nature , vol.466 , pp. 1069-1075
    • Elden, A.C.1    Kim, H.-J.2    Hart, M.P.3    Chen-Plotkin, A.S.4    Johnson, B.S.5    Fang, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.