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Volumn 96, Issue 3, 2011, Pages 600-609

Extrinsic mechanisms involved in age-related defective bone formation

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; ESTROGEN RECEPTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 79952296675     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2113     Document Type: Review
Times cited : (58)

References (125)
  • 1
    • 27944480412 scopus 로고    scopus 로고
    • Pathophysiology of age-related bone loss and osteoporosis
    • Khosla S, Riggs BL 2005 Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am 34:1015-1030, xi
    • (2005) Endocrinol Metab Clin North Am , vol.34
    • Khosla, S.1    Riggs, B.L.2
  • 2
    • 0037172407 scopus 로고    scopus 로고
    • Pathogenesis of bone fragility in women and men
    • DOI 10.1016/S0140-6736(02)08706-8
    • Seeman E 2002 Pathogenesis of bone fragility in women and men. Lancet 359:1841-1850 (Pubitemid 34607063)
    • (2002) Lancet , vol.359 , Issue.9320 , pp. 1841-1850
    • Seeman, E.1
  • 4
    • 49149097805 scopus 로고    scopus 로고
    • Estrogen and bone: Insights from estrogen-resistant, aromatase-deficient, and normal men
    • Khosla S 2008 Estrogen and bone: insights from estrogen-resistant, aromatase-deficient, and normal men. Bone 43:414-417
    • (2008) Bone , vol.43 , pp. 414-417
    • Khosla, S.1
  • 6
    • 41649095977 scopus 로고    scopus 로고
    • Clinical practice. Osteoporosis in men
    • Ebeling PR 2008 Clinical practice. Osteoporosis in men. N Engl J Med 358:1474-1482
    • (2008) N Engl J Med , vol.358 , pp. 1474-1482
    • Ebeling, P.R.1
  • 9
    • 33845202518 scopus 로고    scopus 로고
    • Bone fragility: Failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women
    • DOI 10.1359/jbmr.060904
    • Szulc P, Seeman E, Duboeuf F, Sornay-Rendu E, Delmas PD 2006 Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res 21:1856-1863 (Pubitemid 44851561)
    • (2006) Journal of Bone and Mineral Research , vol.21 , Issue.12 , pp. 1856-1863
    • Szulc, P.1    Seeman, E.2    Duboeuf, F.3    Sornay-Rendu, E.4    Delmas, P.D.5
  • 10
    • 77950928665 scopus 로고    scopus 로고
    • Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck
    • Chen H, Zhou X, Shoumura S, Emura S, Bunai Y 2010 Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck. Osteoporos Int 21:627-636
    • (2010) Osteoporos Int , vol.21 , pp. 627-636
    • Chen, H.1    Zhou, X.2    Shoumura, S.3    Emura, S.4    Bunai, Y.5
  • 12
    • 0036223690 scopus 로고    scopus 로고
    • Mechanisms of bone loss and gain in untreated and treated osteoporosis
    • DOI 10.1385/ENDO:17:1:21
    • Compston J 2002 Mechanisms of bone loss and gain in untreated and treated osteoporosis. Endocrine 17:21-27 (Pubitemid 34311420)
    • (2002) Endocrine , vol.17 , Issue.1 , pp. 21-27
    • Compston, J.1
  • 13
    • 0022815786 scopus 로고
    • Normal and pathological remodeling of human trabecular bone: Three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease
    • Eriksen EF 1986 Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev 7:379-408
    • (1986) Endocr Rev , vol.7 , pp. 379-408
    • Eriksen, E.F.1
  • 14
    • 0027310430 scopus 로고
    • Age- and sex-related changes in iliac cortical bone mass and remodeling
    • DOI 10.1016/8756-3282(93)90092-O
    • Brockstedt H, Kassem M, Eriksen EF, Mosekilde L, Melsen F 1993 Age- and sex-related changes in iliac cortical bone mass and remodeling. Bone 14:681-691 (Pubitemid 23198832)
    • (1993) Bone , vol.14 , Issue.4 , pp. 681-691
    • Brockstedt, H.1    Kassem, M.2    Eriksen, E.F.3    Mosekilde, L.4    Melsen, F.5
  • 15
    • 0026012957 scopus 로고
    • Bone remodeling in type I osteoporosis
    • Parfitt AM 1991 Bone remodeling in type I osteoporosis. J Bone Miner Res 6:95-97
    • (1991) J Bone Miner Res , vol.6 , pp. 95-97
    • Parfitt, A.M.1
  • 16
    • 0028919301 scopus 로고
    • Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis
    • Parfitt AM, Villanueva AR, Foldes J, Rao DS 1995 Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res 10:466-473
    • (1995) J Bone Miner Res , vol.10 , pp. 466-473
    • Parfitt, A.M.1    Villanueva, A.R.2    Foldes, J.3    Rao, D.S.4
  • 17
    • 0026053148 scopus 로고
    • Decreased DNA synthesis by cultured osteoblastic cells in eugonadal osteoporotic men with defective bone formation
    • Marie PJ, de Vernejoul MC, Connes D, Hott M 1991 Decreased DNA synthesis by cultured osteoblastic cells in eugonadal osteoporotic men with defective bone formation. J Clin Invest 88:1167-1172
    • (1991) J Clin Invest , vol.88 , pp. 1167-1172
    • Marie, P.J.1    De Vernejoul, M.C.2    Connes, D.3    Hott, M.4
  • 18
    • 0028104188 scopus 로고
    • Human osteoblastic cells: A potential tool to assess the etiology of pathologic bone formation
    • Marie PJ 1994 Human osteoblastic cells: a potential tool to assess the etiology of pathologic bone formation. J Bone Miner Res 9:1847-1850
    • (1994) J Bone Miner Res , vol.9 , pp. 1847-1850
    • Marie, P.J.1
  • 19
    • 0035553054 scopus 로고    scopus 로고
    • The molecular genetics of bone formation: Implications for therapeutic interventions in bone disorders
    • Marie PJ 2001 The molecular genetics of bone formation: implications for therapeutic interventions in bone disorders. Am J Pharmacogenomics 1:175-187
    • (2001) Am J Pharmacogenomics , vol.1 , pp. 175-187
    • Marie, P.J.1
  • 20
    • 0024147344 scopus 로고
    • Marrow stromal stem cells
    • Owen M 1988 Marrow stromal stem cells. J Cell Sci Suppl 10:63-76 (Pubitemid 19096575)
    • (1988) Journal of Cell Science , Issue.SSUPL. 10 , pp. 63-76
    • Owen, M.1
  • 21
    • 0035236997 scopus 로고    scopus 로고
    • Regulation of Osteoblast Formation and Function
    • DOI 10.1023/A:1010011209064
    • Aubin JE 2001 Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2:81-94 (Pubitemid 33643895)
    • (2001) Reviews in Endocrine and Metabolic Disorders , vol.2 , Issue.1 , pp. 81-94
    • Aubin, J.E.1
  • 22
    • 0034988303 scopus 로고    scopus 로고
    • Bone marrow stromal stem cells: Nature, biology, and potential applications
    • Bianco P, Riminucci M, Gronthos S, Robey PG 2001 Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180-192 (Pubitemid 32524539)
    • (2001) Stem Cells , vol.19 , Issue.3 , pp. 180-192
    • Bianco, P.1    Riminucci, M.2    Gronthos, S.3    Robey, P.G.4
  • 27
    • 42749092987 scopus 로고    scopus 로고
    • Transcription factors controlling osteoblastogenesis
    • Marie PJ 2008 Transcription factors controlling osteoblastogenesis. Arch Biochem Biophys 473:98-105
    • (2008) Arch Biochem Biophys , vol.473 , pp. 98-105
    • Marie, P.J.1
  • 28
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • DOI 10.1210/er.21.2.115
    • Manolagas SC 2000 Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115-137 (Pubitemid 32275592)
    • (2000) Endocrine Reviews , vol.21 , Issue.2 , pp. 115-137
    • Manolagas, S.C.1
  • 31
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • DOI 10.1210/er.23.3.279
    • Riggs BL, Khosla S, Melton 3rd LJ 2002 Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23:279-302 (Pubitemid 34651948)
    • (2002) Endocrine Reviews , vol.23 , Issue.3 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 32
    • 0032093690 scopus 로고    scopus 로고
    • Cytokines, estrogen, and postmenopausal osteoporosis - The second decade
    • Pacifici R 1998 Cytokines, estrogen, and postmenopausal osteoporosis - the second decade. Endocrinology 139:2659-2661
    • (1998) Endocrinology , vol.139 , pp. 2659-2661
    • Pacifici, R.1
  • 33
    • 33744777162 scopus 로고    scopus 로고
    • Direct and indirect estrogen actions on osteoblasts and osteoclasts
    • DOI 10.1196/annals.1346.019
    • Zallone A 2006 Direct and indirect estrogen actions on osteoblasts and osteoclasts. Ann NY Acad Sci 1068:173-179 (Pubitemid 43824147)
    • (2006) Annals of the New York Academy of Sciences , vol.1068 , Issue.1 , pp. 173-179
    • Zallone, A.1
  • 34
    • 0024327978 scopus 로고
    • Osteocalcin and deoxyribonucleic acid synthesis in vitro and histomorphometric indices of bone formation in postmenopausal osteoporosis
    • Marie PJ, Sabbagh A, de Vernejoul MC, Lomri A 1989 Osteocalcin and deoxyribonucleic acid synthesis in vitro and histomorphometric indices of bone formation in postmenopausal osteoporosis. J Clin Endocrinol Metab 69:272-279
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 272-279
    • Marie, P.J.1    Sabbagh, A.2    De Vernejoul, M.C.3    Lomri, A.4
  • 37
    • 0029978894 scopus 로고    scopus 로고
    • Androgens as anabolic agents for bone
    • DOI 10.1016/1043-2760(96)00024-0
    • Orwoll ES 1996 Androgens as anabolic agents for bone. Trends Endocrinol Metab 7:77-84 (Pubitemid 26144497)
    • (1996) Trends in Endocrinology and Metabolism , vol.7 , Issue.3 , pp. 77-84
    • Orwoll, E.S.1
  • 38
    • 49149119954 scopus 로고    scopus 로고
    • Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: A model for compartment-specific androgen action in the skeleton
    • Wiren KM, Semirale AA, Zhang XW, Woo A, Tommasini SM, Price C, Schaffler MB, Jepsen KJ 2008 Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton. Bone 43:440-451
    • (2008) Bone , vol.43 , pp. 440-451
    • Wiren, K.M.1    Semirale, A.A.2    Zhang, X.W.3    Woo, A.4    Tommasini, S.M.5    Price, C.6    Schaffler, M.B.7    Jepsen, K.J.8
  • 39
    • 0032934097 scopus 로고    scopus 로고
    • Effects of growth hormone and testosterone on cortical bone formation and bone density in aged orchiectomized rats
    • DOI 10.1016/S8756-3282(99)00018-6, PII S8756328299000186
    • Prakasam G, Yeh JK, Chen MM, Castro-Magana M, Liang CT, Aloia JF 1999 Effects of growth hormone and testosterone on cortical bone formation and bone density in aged orchiectomized rats. Bone 24:491-497 (Pubitemid 29234138)
    • (1999) Bone , vol.24 , Issue.5 , pp. 491-497
    • Prakasam, G.1    Yeh, J.K.2    Chen, M.-M.3    Castro-Magana, M.4    Liang, C.T.5    Aloia, J.F.6
  • 40
    • 0033305457 scopus 로고    scopus 로고
    • The actions and interactions of sex steroids and growth factors/cytokines on the skeleton
    • Spelsberg TC, Subramaniam M, Riggs BL, Khosla S 1999 The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol Endocrinol 13:819-828 (Pubitemid 30645300)
    • (1999) Molecular Endocrinology , vol.13 , Issue.6 , pp. 819-828
    • Spelsberg, T.C.1    Subramaniam, M.2    Riggs, B.L.3    Khosla, S.4
  • 41
    • 33846900615 scopus 로고    scopus 로고
    • Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor
    • DOI 10.1128/MCB.01550-06
    • Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC 2007 Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol 27:1516-1530 (Pubitemid 46239831)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.4 , pp. 1516-1530
    • Kousteni, S.1    Almeida, M.2    Han, L.3    Bellido, T.4    Jilka, R.L.5    Manolagas, S.C.6
  • 42
    • 0025002791 scopus 로고
    • Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): Positive correlation with the presence of the GH-induced IGF-binding protein BP-3
    • Ernst M, Rodan GA 1990 Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3. Endocrinology 127:807-814 (Pubitemid 20248126)
    • (1990) Endocrinology , vol.127 , Issue.2 , pp. 807-814
    • Ernst, M.1    Rodan, G.A.2
  • 47
    • 75149129597 scopus 로고    scopus 로고
    • From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis
    • Manolagas SC 2010 From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31:266-300
    • (2010) Endocr Rev , vol.31 , pp. 266-300
    • Manolagas, S.C.1
  • 48
    • 46749150471 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness
    • Ryall JG, Schertzer JD, Lynch GS 2008 Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology 9:213-228
    • (2008) Biogerontology , vol.9 , pp. 213-228
    • Ryall, J.G.1    Schertzer, J.D.2    Lynch, G.S.3
  • 49
    • 0034025405 scopus 로고    scopus 로고
    • Role of growth factors in osteoblast alterations induced by skeletal unloading in rats
    • Marie PJ, Zerath E 2000 Role of growth factors in osteoblast alterations induced by skeletal unloading in rats. Growth Factors 18:1-10 (Pubitemid 30303651)
    • (2000) Growth Factors , vol.18 , Issue.1 , pp. 1-10
    • Marie, P.J.1    Zerath, E.2
  • 51
    • 33845987983 scopus 로고    scopus 로고
    • Skeletal unloading induces osteoblast apoptosis and targets α5β1-PI3K-Bcl-2 signaling in rat bone
    • DOI 10.1016/j.yexcr.2006.10.021, PII S0014482706004460
    • Dufour C, Holy X, Marie PJ 2007 Skeletal unloading induces osteoblast apoptosis and targets α5β1-PI3K-Bcl-2 signaling in rat bone. Exp Cell Res 313:394-403 (Pubitemid 46048823)
    • (2007) Experimental Cell Research , vol.313 , Issue.2 , pp. 394-403
    • Dufour, C.1    Holy, X.2    Marie, P.J.3
  • 52
    • 34249776946 scopus 로고    scopus 로고
    • Mechanical loading down-regulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis
    • DOI 10.1210/en.2006-1704
    • David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A 2007 Mechanical loading downregulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 148:2553-2562 (Pubitemid 47007541)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2553-2562
    • David, V.1    Martin, A.2    Lafage-Proust, M.-H.3    Malaval, L.4    Peyroche, S.5    Jones, D.B.6    Vico, L.7    Guignandon, A.8
  • 53
    • 58149084456 scopus 로고    scopus 로고
    • Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity
    • Luu YK, Capilla E, Rosen CJ, Gilsanz V, Pessin JE, Judex S, Rubin CT 2009 Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. J Bone Miner Res 24:50-61
    • (2009) J Bone Miner Res , vol.24 , pp. 50-61
    • Luu, Y.K.1    Capilla, E.2    Rosen, C.J.3    Gilsanz, V.4    Pessin, J.E.5    Judex, S.6    Rubin, C.T.7
  • 54
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • Bonewald LF, Johnson ML 2008 Osteocytes, mechanosensing and Wnt signaling. Bone 42:606-615
    • (2008) Bone , vol.42 , pp. 606-615
    • Bonewald, L.F.1    Johnson, M.L.2
  • 55
    • 33344455592 scopus 로고    scopus 로고
    • Molecular pathways mediating mechanical signaling in bone
    • DOI 10.1016/j.gene.2005.10.028, PII S0378111905006013
    • Rubin J, Rubin C, Jacobs CR 2006 Molecular pathways mediating mechanical signaling in bone. Gene 367:1-16 (Pubitemid 43286736)
    • (2006) Gene , vol.367 , Issue.1-2 , pp. 1-16
    • Rubin, J.1    Rubin, C.2    Jacobs, C.R.3
  • 57
    • 0029120033 scopus 로고
    • Systemic administration of transforming growth factor-β 2 prevents the impaired bone formation and osteopenia induced by unloading in rats
    • Machwate M, Zerath E, Holy X, Hott M, Godet D, Lomri A, Marie PJ 1995 Systemic administration of transforming growth factor-β 2 prevents the impaired bone formation and osteopenia induced by unloading in rats. J Clin Invest 96:1245-1253
    • (1995) J Clin Invest , vol.96 , pp. 1245-1253
    • Machwate, M.1    Zerath, E.2    Holy, X.3    Hott, M.4    Godet, D.5    Lomri, A.6    Marie, P.J.7
  • 58
    • 0033568593 scopus 로고    scopus 로고
    • Skeletal unloading induces biphasic changes in insulin-like growth factor-I mRNA levels and osteoblast activity
    • DOI 10.1006/excr.1999.4539
    • Drissi H, Lomri A, Lasmoles F, Holy X, Zerath E, Marie PJ 1999 Skeletal unloading induces biphasic changes in insulin-like growth factor-I mRNA levels and osteoblast activity. Exp Cell Res 251:275-284 (Pubitemid 29431865)
    • (1999) Experimental Cell Research , vol.251 , Issue.2 , pp. 275-284
    • Drissi, H.1    Lomri, A.2    Lasmoles, F.3    Holy, X.4    Zerath, E.5    Marie, P.J.6
  • 59
    • 57649237947 scopus 로고    scopus 로고
    • β-Catenin levels influence rapid mechanical responses in osteoblasts
    • Case N, Ma M, Sen B, Xie Z, Gross TS, Rubin J 2008 β-Catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem 283:29196-29205
    • (2008) J Biol Chem , vol.283 , pp. 29196-29205
    • Case, N.1    Ma, M.2    Sen, B.3    Xie, Z.4    Gross, T.S.5    Rubin, J.6
  • 62
    • 71749108831 scopus 로고    scopus 로고
    • Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node
    • Sen B, Styner M, Xie Z, Case N, Rubin CT, Rubin J 2009 Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node. J Biol Chem 284:34607-34617
    • (2009) J Biol Chem , vol.284 , pp. 34607-34617
    • Sen, B.1    Styner, M.2    Xie, Z.3    Case, N.4    Rubin, C.T.5    Rubin, J.6
  • 63
    • 57349115394 scopus 로고    scopus 로고
    • Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable β-catenin signal
    • Sen B, Xie Z, Case N, Ma M, Rubin C, Rubin J 2008 Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable β-catenin signal. Endocrinology 149:6065-6075
    • (2008) Endocrinology , vol.149 , pp. 6065-6075
    • Sen, B.1    Xie, Z.2    Case, N.3    Ma, M.4    Rubin, C.5    Rubin, J.6
  • 65
    • 33646902229 scopus 로고    scopus 로고
    • Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear
    • DOI 10.1074/jbc.M509205200
    • Lau KH, Kapur S, Kesavan C, Baylink DJ 2006 Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear. J Biol Chem 281:9576-9588 (Pubitemid 43864676)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.14 , pp. 9576-9588
    • Lau, K.-H.W.1    Kapur, S.2    Kesavan, C.3    Baylink, D.J.4
  • 67
    • 61449231683 scopus 로고    scopus 로고
    • Effects of age and gender on WNT gene expression in human bone marrow stromal cells
    • Shen L, Zhou S, Glowacki J 2009 Effects of age and gender on WNT gene expression in human bone marrow stromal cells. J Cell Biochem 106:337-343
    • (2009) J Cell Biochem , vol.106 , pp. 337-343
    • Shen, L.1    Zhou, S.2    Glowacki, J.3
  • 70
    • 77950567146 scopus 로고    scopus 로고
    • Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor α-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of β-catenin signaling
    • Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, Price JS 2010 Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor α-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of β-catenin signaling. J Biol Chem 285:8743-8758
    • (2010) J Biol Chem , vol.285 , pp. 8743-8758
    • Sunters, A.1    Armstrong, V.J.2    Zaman, G.3    Kypta, R.M.4    Kawano, Y.5    Lanyon, L.E.6    Price, J.S.7
  • 72
    • 70349247916 scopus 로고    scopus 로고
    • Dairy and bone health
    • Heaney RP 2009 Dairy and bone health. J Am Coll Nutr 28 (Suppl 1):82S-90S
    • (2009) J Am Coll Nutr , vol.28 , Issue.SUPPL. 1
    • Heaney, R.P.1
  • 73
    • 33644847724 scopus 로고    scopus 로고
    • Dietary protein: An essential nutrient for bone health
    • Bonjour JP 2005 Dietary protein: an essential nutrient for bone health. J Am Coll Nutr 24:526S-536S
    • (2005) J Am Coll Nutr , vol.24
    • Bonjour, J.P.1
  • 74
    • 0034889433 scopus 로고    scopus 로고
    • Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications
    • DOI 10.1210/er.22.4.477
    • Lips P 2001 Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477-501 (Pubitemid 32762324)
    • (2001) Endocrine Reviews , vol.22 , Issue.4 , pp. 477-501
    • Lips, P.1
  • 75
    • 34147164190 scopus 로고    scopus 로고
    • Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: Evidence from a comparative metaanalysis of randomized controlled trials
    • DOI 10.1210/jc.2006-1404
    • Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P 2007 Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92:1415-1423 (Pubitemid 46556419)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.4 , pp. 1415-1423
    • Boonen, S.1    Lips, P.2    Bouillon, R.3    Bischoff-Ferrari, H.A.4    Vanderschueren, D.5    Haentjens, P.6
  • 76
    • 0030763532 scopus 로고    scopus 로고
    • Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older
    • DOI 10.1056/NEJM199709043371003
    • Dawson-Hughes B, Harris SS, Krall EA, Dallal GE 1997 Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337:670-676 (Pubitemid 27375473)
    • (1997) New England Journal of Medicine , vol.337 , Issue.10 , pp. 670-676
    • Dawson-Hughes, B.1    Harris, S.S.2    Krall, E.A.3    Dallal, G.E.4
  • 78
    • 50949096185 scopus 로고    scopus 로고
    • The direct role of vitamin D on bone homeostasis
    • St-Arnaud R 2008 The direct role of vitamin D on bone homeostasis. Arch Biochem Biophys 473:225-230
    • (2008) Arch Biochem Biophys , vol.473 , pp. 225-230
    • St-Arnaud, R.1
  • 79
    • 3242887187 scopus 로고    scopus 로고
    • Osteoblast differentiation and control by vitamin D and vitamin D metabolites
    • DOI 10.2174/1381612043383818
    • van Driel M, Pols HA, van Leeuwen JP 2004 Osteoblast differentiation and control by vitamin D and vitamin D metabolites. Curr Pharm Des 10:2535-2555 (Pubitemid 39004077)
    • (2004) Current Pharmaceutical Design , vol.10 , Issue.21 , pp. 2535-2555
    • Van Driel, M.1    Pols, H.A.P.2    Van Leeuwen, J.P.T.M.3
  • 80
    • 21644452584 scopus 로고    scopus 로고
    • Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro
    • DOI 10.1002/jcb.20313
    • Sooy K, Sabbagh Y, Demay MB 2005 Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. J Cell Biochem 94:81-87 (Pubitemid 41420326)
    • (2005) Journal of Cellular Biochemistry , vol.94 , Issue.1 , pp. 81-87
    • Sooy, K.1    Sabbagh, Y.2    Demay, M.B.3
  • 81
    • 17144428054 scopus 로고    scopus 로고
    • 3and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes: Mediation by Src, phosphatidylinositol 3-, and JNK kinases
    • DOI 10.1074/jbc.M410720200
    • Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC 2005 Nongenotropic, anti-apoptotic signaling of 1α,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem 280:14130-14137 (Pubitemid 40517315)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.14 , pp. 14130-14137
    • Vertino, A.M.1    Bula, C.M.2    Chen, J.-R.3    Almeida, M.4    Han, L.5    Bellido, T.6    Kousteni, S.7    Norman, A.W.8    Manolagas, S.C.9
  • 82
    • 33747813275 scopus 로고    scopus 로고
    • 3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription
    • DOI 10.1210/me.2006-0102
    • Fretz JA, Zella LA, Kim S, Shevde NK, Pike JW 2006 1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription. Mol Endocrinol 20:2215-2230 (Pubitemid 44286715)
    • (2006) Molecular Endocrinology , vol.20 , Issue.9 , pp. 2215-2230
    • Fretz, J.A.1    Zella, L.A.2    Kim, S.3    Shevde, N.K.4    Pike, J.W.5
  • 83
    • 34247471689 scopus 로고    scopus 로고
    • VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells
    • DOI 10.1002/jcb.21151
    • Cianferotti L, Demay MB 2007 VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells. J Cell Biochem 101:80-88 (Pubitemid 46652574)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.1 , pp. 80-88
    • Cianferotti, L.1    Demay, M.B.2
  • 84
    • 56049095981 scopus 로고    scopus 로고
    • The skeleton as an intracrine organ for vitamin D metabolism
    • Anderson PH, Atkins GJ 2008 The skeleton as an intracrine organ for vitamin D metabolism. Mol Aspects Med 29:397-406
    • (2008) Mol Aspects Med , vol.29 , pp. 397-406
    • Anderson, P.H.1    Atkins, G.J.2
  • 85
    • 73649121302 scopus 로고    scopus 로고
    • Vitamin D metabolism and action in human bone marrow stromal cells
    • Zhou S, LeBoff MS, Glowacki J 2010 Vitamin D metabolism and action in human bone marrow stromal cells. Endocrinology 151:14-22
    • (2010) Endocrinology , vol.151 , pp. 14-22
    • Zhou, S.1    LeBoff, M.S.2    Glowacki, J.3
  • 86
    • 0036905314 scopus 로고    scopus 로고
    • 3: Implications in cell growth and differentiation
    • DOI 10.1210/er.2001-0044
    • Gurlek A, Pittelkow MR, Kumar R 2002 Modulation of growth factor/cytokine synthesis and signaling by 1α,25-dihydroxyvitamin D(3): implications in cell growth and differentiation. Endocr Rev 23:763-786 (Pubitemid 35454588)
    • (2002) Endocrine Reviews , vol.23 , Issue.6 , pp. 763-786
    • Gurlek, A.1    Pittelkow, M.R.2    Kumar, R.3
  • 87
    • 0035158202 scopus 로고    scopus 로고
    • 3 reduces impairment of human osteoblast functions during cellular aging in culture
    • DOI 10.1002/1097-4652(200002)186:2<298::AID-JCP1030>3.0.CO;2-H
    • Kveiborg M, Rattan SI, Clark BF, Eriksen EF, Kassem M 2001 Treatment with 1,25-dihydroxyvitamin D3 reduces impairment of human osteoblast functions during cellular aging in culture. J Cell Physiol 186:298-306 (Pubitemid 32042159)
    • (2001) Journal of Cellular Physiology , vol.186 , Issue.2 , pp. 298-306
    • Kveiborg, M.1    Rattan, S.I.S.2    Clark, B.F.C.3    Eriksen, E.F.4    Kassem, M.5
  • 89
    • 12344287223 scopus 로고    scopus 로고
    • Intrinsic bone tissue properties in adult rat vertebrae: Modulation by dietary protein
    • DOI 10.1016/j.bone.2004.09.013, PII S8756328204003862
    • Hengsberger S, Ammann P, Legros B, Rizzoli R, Zysset P 2005 Intrinsic bone tissue properties in adult rat vertebrae: modulation by dietary protein. Bone 36:134-141 (Pubitemid 40136588)
    • (2005) Bone , vol.36 , Issue.1 , pp. 134-141
    • Hengsberger, S.1    Ammann, P.2    Legros, B.3    Rizzoli, R.4    Zysset, P.5
  • 91
    • 0034021553 scopus 로고    scopus 로고
    • Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency
    • Ammann P, Bourrin S, Bonjour JP, Meyer JM, Rizzoli R 2000 Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency. J Bone Miner Res 15:683-690 (Pubitemid 30174022)
    • (2000) Journal of Bone and Mineral Research , vol.15 , Issue.4 , pp. 683-690
    • Ammann, P.1    Bourrin, S.2    Bonjour, J.-P.3    Meyer, J.-M.4    Rizzoli, R.5
  • 93
    • 77952557041 scopus 로고    scopus 로고
    • The GH/IGF1 axis and signaling pathways in the muscle and bone: Mechanisms underlying age-related skeletal muscle wasting and osteoporosis
    • Perrini S, Laviola L, Carreira MC, Cignarelli A, Natalicchio A, Giorgino F 2010 The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis. J Endocrinol 205:201-210
    • (2010) J Endocrinol , vol.205 , pp. 201-210
    • Perrini, S.1    Laviola, L.2    Carreira, M.C.3    Cignarelli, A.4    Natalicchio, A.5    Giorgino, F.6
  • 94
    • 0033120965 scopus 로고    scopus 로고
    • Age-related changes in insulin-like growth factor I and II in human femoral cortical bone: Lack of correlation with bone mass
    • DOI 10.1016/S8756-3282(98)00186-0, PII S8756328298001860
    • Seck T, Bretz A, Krempien R, Krempien B, Ziegler R, Pfeilschifter J 1999 Age-related changes in insulin-like growth factor I and II in human femoral cortical bone: lack of correlation with bone mass. Bone 24:387-393 (Pubitemid 29134977)
    • (1999) Bone , vol.24 , Issue.4 , pp. 387-393
    • Seck, T.1    Bretz, A.2    Krempien, R.3    Krempien, B.4    Ziegler, R.5    Pfeilschifter, J.6
  • 95
    • 0033378714 scopus 로고    scopus 로고
    • Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGF binding protein [BP]-3, and IGFBP-5) in age-related (type II) femoral neck osteoporosis
    • Boonen S, Mohan S, Dequeker J, Aerssens J, Vanderschueren D, Verbeke G, Broos P, Bouillon R, Baylink DJ 1999 Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGF binding protein [BP]-3, and IGFBP-5) in age-related (type II) femoral neck osteoporosis. J Bone Miner Res 14:2150-2158 (Pubitemid 30026965)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.12 , pp. 2150-2158
    • Boonen, S.1    Mohan, S.2    Dequeker, J.3    Aerssens, J.4    Vanderschueren, D.5    Verbeke, G.6    Broos, P.7    Bouillon, R.8    Baylink, D.J.9
  • 96
    • 0034635778 scopus 로고    scopus 로고
    • Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women
    • DOI 10.1016/S0140-6736(99)05463-X
    • Garnero P, Sornay-Rendu E, Delmas PD 2000 Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. Lancet 355:898-899 (Pubitemid 30137673)
    • (2000) Lancet , vol.355 , Issue.9207 , pp. 898-899
    • Garnero, P.1    Sornay-Rendu, E.2    Delmas, P.D.3
  • 98
    • 0034769201 scopus 로고    scopus 로고
    • Protein intake and bone disorders in the elderly
    • DOI 10.1016/S1297-319X(01)00295-0
    • Rizzoli R, Ammann P, Chevalley T, Bonjour JP 2001 Protein intake and bone disorders in the elderly. Joint Bone Spine 68:383-392 (Pubitemid 32988524)
    • (2001) Joint Bone Spine , vol.68 , Issue.5 , pp. 383-392
    • Rizzoli, R.1    Ammann, P.2    Chevalley, T.3    Bonjour, J.-P.4
  • 99
    • 75949091648 scopus 로고    scopus 로고
    • Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture
    • Chevalley T, Hoffmeyer P, Bonjour JP, Rizzoli R 2010 Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture. Clin Nutr 29:78-83
    • (2010) Clin Nutr , vol.29 , pp. 78-83
    • Chevalley, T.1    Hoffmeyer, P.2    Bonjour, J.P.3    Rizzoli, R.4
  • 101
    • 1642412598 scopus 로고    scopus 로고
    • Inhibitory Effect of Alcohol on Osteogenic Differentiation in Human Bone Marrow-Derived Mesenchymal Stem Cells
    • DOI 10.1097/01.ALC.0000118315.58404.C1
    • Gong Z, Wezeman FH 2004 Inhibitory effect of alcohol on osteogenic differentiation inhumanbone marrow-derived mesenchymal stem cells. Alcohol Clin Exp Res 28:468-479 (Pubitemid 38380750)
    • (2004) Alcoholism: Clinical and Experimental Research , vol.28 , Issue.3 , pp. 468-479
    • Gong, Z.1    Wezeman, F.H.2
  • 103
    • 40849125378 scopus 로고    scopus 로고
    • Effects of low-dose parathyroid hormone on bone mass, turnover, and ectopic osteoinduction in a rat model for chronic alcohol abuse
    • Iwaniec UT, Trevisiol CH, Maddalozzo GF, Rosen CJ, Turner RT 2008 Effects of low-dose parathyroid hormone on bone mass, turnover, and ectopic osteoinduction in a rat model for chronic alcohol abuse. Bone 42:695-701
    • (2008) Bone , vol.42 , pp. 695-701
    • Iwaniec, U.T.1    Trevisiol, C.H.2    Maddalozzo, G.F.3    Rosen, C.J.4    Turner, R.T.5
  • 104
    • 58649095889 scopus 로고    scopus 로고
    • Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts
    • Chen JR, Lazarenko OP, Haley RL, Blackburn ML, Badger TM, Ronis MJ 2009 Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts. J Bone Miner Res 24:221-230
    • (2009) J Bone Miner Res , vol.24 , pp. 221-230
    • Chen, J.R.1    Lazarenko, O.P.2    Haley, R.L.3    Blackburn, M.L.4    Badger, T.M.5    Ronis, M.J.6
  • 105
    • 0034469587 scopus 로고    scopus 로고
    • Bone loss. Epidemiology of bone loss
    • Hunter DJ, Sambrook PN 2000 Bone loss. Epidemiology of bone loss. Arthritis Res 2:441-445
    • (2000) Arthritis Res , vol.2 , pp. 441-445
    • Hunter, D.J.1    Sambrook, P.N.2
  • 108
    • 0035093060 scopus 로고    scopus 로고
    • Cigarette smoke inhibits osteogenic differentiation and proliferation of human osteoprogenitor cells in monolayer and three-dimensional collagen gel culture
    • DOI 10.1067/mlc.2001.113066
    • Liu XD, Zhu YK, Umino T, Spurzem JR, Romberger DJ, Wang H, Reed E, Rennard SI 2001 Cigarette smoke inhibits osteogenic differentiation and proliferation of human osteoprogenitor cells in monolayer and three-dimensional collagen gel culture. J Lab Clin Med 137:208-219 (Pubitemid 32203201)
    • (2001) Journal of Laboratory and Clinical Medicine , vol.137 , Issue.3 , pp. 208-219
    • Liu, X.D.1    Zhu, Y.K.2    Umino, T.3    Spurzem, J.R.4    Romberger, D.J.5    Wang, H.6    Reed, E.7    Rennard, S.I.8
  • 109
    • 68949146637 scopus 로고    scopus 로고
    • Nicotine modulates bone metabolism-associated gene expression in osteoblast cells
    • Rothem DE, Rothem L, Soudry M, Dahan A, Eliakim R 2009 Nicotine modulates bone metabolism-associated gene expression in osteoblast cells. J Bone Miner Metab 27:555-561
    • (2009) J Bone Miner Metab , vol.27 , pp. 555-561
    • Rothem, D.E.1    Rothem, L.2    Soudry, M.3    Dahan, A.4    Eliakim, R.5
  • 113
    • 0003160309 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteoporosis: Assessment and treatment
    • Reid IR 1998 Glucocorticoid-induced osteoporosis: assessment and treatment. J Clin Densitom 1:65-73 (Pubitemid 128354261)
    • (1998) Journal of Clinical Densitometry , vol.1 , Issue.1 , pp. 65-73
    • Reid, I.R.1
  • 114
    • 58149134854 scopus 로고    scopus 로고
    • 11β-Hydroxysteroid dehydrogenase: A regulator of glucocorticoid response in osteoporosis
    • Cooper MS 2008 11β-Hydroxysteroid dehydrogenase: a regulator of glucocorticoid response in osteoporosis. J Endocrinol Invest 31(7 Suppl):16-21
    • (2008) J Endocrinol Invest , vol.31 , Issue.7 SUPPL. , pp. 16-21
    • Cooper, M.S.1
  • 115
    • 0018765006 scopus 로고
    • Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration
    • Hahn TJ, Halstead LR, Teitelbaum SL, Hahn BH 1979 Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration. J Clin Invest 64:655-665 (Pubitemid 9235013)
    • (1979) Journal of Clinical Investigation , vol.64 , Issue.2 , pp. 655-665
    • Hahn, T.J.1    Halstead, L.R.2    Teitelbaum, S.L.3    Hahn, B.H.4
  • 116
    • 0033304809 scopus 로고    scopus 로고
    • Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis
    • Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, Khosla S 1999 Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 140:4382-4389 (Pubitemid 30666099)
    • (1999) Endocrinology , vol.140 , Issue.10 , pp. 4382-4389
    • Hofbauer, L.C.1    Gori, F.2    Riggs, B.L.3    Lacey, D.L.4    Dunstan, C.R.5    Spelsberg, T.C.6    Khosla, S.7
  • 117
    • 0020550907 scopus 로고
    • Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosis
    • Dempster DW, Arlot MA, Meunier PJ 1983 Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosis. Calcif Tissue Int 35:410-417 (Pubitemid 13028605)
    • (1983) Calcified Tissue International , vol.35 , Issue.4-5 , pp. 410-417
    • Dempster, D.W.1    Arlot, M.A.2    Meunier, P.J.3
  • 118
    • 0038434107 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid-induced osteoporosis
    • DOI 10.1097/00002281-200307000-00013
    • Canalis E 2003 Mechanisms of glucocorticoid-induced osteoporosis. Curr Opin Rheumatol 15:454-457 (Pubitemid 36774258)
    • (2003) Current Opinion in Rheumatology , vol.15 , Issue.4 , pp. 454-457
    • Canalis, E.1
  • 120
    • 55549113911 scopus 로고    scopus 로고
    • FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/β-catenin signaling-dependent Runx2 expression
    • Hamidouche Z, Haÿ E, Vaudin P, Charbord P, Schüle R, Marie PJ, Fromigué O 2008 FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/β-catenin signaling-dependent Runx2 expression. FASEB J 22:3813-3822
    • (2008) FASEB J , vol.22 , pp. 3813-3822
    • Hamidouche, Z.1    Haÿ, E.2    Vaudin, P.3    Charbord, P.4    Schüle, R.5    Marie, P.J.6    Fromigué, O.7
  • 121
    • 1642546419 scopus 로고    scopus 로고
    • Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength
    • DOI 10.1210/en.2003-0990
    • O'Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS 2004 Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 145:1835-1841 (Pubitemid 38402392)
    • (2004) Endocrinology , vol.145 , Issue.4 , pp. 1835-1841
    • O'Brien, C.A.1    Jia, D.2    Plotkin, L.I.3    Bellido, T.4    Powers, C.C.5    Stewart, S.A.6    Manolagas, S.C.7    Weinstein, R.S.8
  • 124
    • 0034799514 scopus 로고    scopus 로고
    • Glucocorticoid suppression of IGF I transcription in osteoblasts
    • DOI 10.1210/me.15.10.1781
    • Delany AM, Durant D, Canalis E 2001 Glucocorticoid suppression of IGF I transcription in osteoblasts. Mol Endocrinol 15:1781-1789 (Pubitemid 32939308)
    • (2001) Molecular Endocrinology , vol.15 , Issue.10 , pp. 1781-1789
    • Delany, A.M.1    Durant, D.2    Canalis, E.3
  • 125
    • 17744364306 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass
    • DOI 10.1210/en.2004-1050
    • Wang FS, Lin CL, Chen YJ, Wang CJ, Yang KD, Huang YT, Sun YC, Huang HC 2005 Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass. Endocrinology 146:2415-2423 (Pubitemid 40577529)
    • (2005) Endocrinology , vol.146 , Issue.5 , pp. 2415-2423
    • Wang, F.-S.1    Lin, C.-L.2    Chen, Y.-J.3    Wang, C.-J.4    Yang, K.D.5    Huang, Y.-T.6    Sun, Y.-C.7    Huang, H.-C.8


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