Early smoking is associated with peak bone mass and prevalent fractures in young, healthy men

Journal of Bone and Mineral Research

Volumn 25, Issue 2, 2010, Pages 379-387

  Taes, Youri ^a   Lapauw, Bruno ^a   Vanbillemont, Griet ^a   Bogaert, Veerle ^a   De Bacquer, Dirk ^b   Goemaere, Stefan ^a   Zmierczak, Hans ^a   Kaufman, Jean Marc ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Androgens; Estrogens; Osteoporosis; Peak bone mass; Smoking

Indexed keywords

ESTRADIOL; SEX HORMONE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BELGIUM; BONE DENSITY; BONE MASS; COMPUTER ASSISTED TOMOGRAPHY; CORTICAL BONE; CROSS-SECTIONAL STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FRACTURE; HIP FRACTURE; HUMAN; HUMERUS FRACTURE; IMMUNOASSAY; LEG FRACTURE; MALE; PREDICTION; PREVALENCE; QUESTIONNAIRE; RADIUS; SELF REPORT; SHOULDER FRACTURE; SIBLING; SMOKING; SMOKING HABIT; THICKNESS; TRABECULAR BONE; VOLUMETRY; WRIST FRACTURE; FAMILY; FRACTURES, BONE; METABOLISM; MOTOR ACTIVITY; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; RISK FACTOR;

ABSORPTIOMETRY, PHOTON; ADULT; BONE DENSITY; FAMILY; FRACTURES, BONE; GONADAL STEROID HORMONES; HUMANS; MALE; MOTOR ACTIVITY; QUESTIONNAIRES; RISK FACTORS; SMOKING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77953451102     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.090809     Document Type: Article

References (45)

1. Kanis JA, Johnell O, Oden A, et al. Smoking and fracture risk: a meta-analysis. Osteoporos Int. 2005;16:155-162.
2. Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ. 1997;315:841-846.
3. Szulc P, Garnero P, Claustrat B, Marchand F, Duboeuf F, Delmas PD. Increased bone resorption in moderate smokers with low body weight: the MINOS study. J Clin Endocrinol Metab. 2002; 87:666-674. (Pubitemid 34158235)
4. Lorentzon M, Mellström D, Haug E, Ohlsson C. Smoking is associated with lower bone mineral density and reduced cortical thickness in young men. J Clin Endocrinol Metab. 2007;92:497-503. (Pubitemid 46255286)
5. Orwoll ES, Klein RF. Osteoporosis in men. Endocr Rev. 1995;16:87-116.
6. Vanderschueren D, Venken K, Ophoff J, Bouillon R, Boonen S. Sex steroids and the periosteum: reconsidering the roles of androgens and estrogens in periosteal expansion. J Clin Endocrinol Metab. 2006;91:378-382. (Pubitemid 43236896)
7. Van Pottelbergh I, Goemaere S, Kaufman JM. Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. J Clin Endocrinol Metab. 2003;88:3075-3081. (Pubitemid 36877475)
8. Fink HA, Ewing SK, Ensrud KE, et al. Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men. J Clin Endocrinol Metab. 2006;91:3908-3915.
9. Khosla S, Melton LJ III, Robb RA, et al. Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men. J Bone Miner Res. 2005;20:730-740. (Pubitemid 40571629)
10. Lorentzon M, Swanson C, Andersson N, Mellström D, Ohlsson C. Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young swedish men: the GOOD study. J Bone Miner Res. 2005;20:1334-1341. (Pubitemid 41033517)
11. Napoli N, Faccio R, Shrestha V, Bucchieri S, Rini G, Armamento-Villareal R. Estrogen metabolism modulates bone density in men. Calcif Tissue Int. 2007;80:227-232. (Pubitemid 46675253)
12. Khosla S, Melton LJ III, Atkinson EJ, O'Fallon WM. Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab. 2001;86:3555-3561. (Pubitemid 32755943)
13. Van Pottelbergh I, Goemaere S, Zmierczak H, De Bacquer D, Kaufman JM. Deficient acquisition of bone during maturation underlies idiopathic osteoporosis in men: evidence from a three-generation family study. J Bone Miner Res. 2003;18:303-311. (Pubitemid 36125922)
14. Van Pottelbergh I, Goemaere S, Zmierczak H, Kaufman JM. Perturbed sex steroid status in men with idiopathic osteoporosis and their sons. J Clin Endocrinol Metab. 2004;89:4949-4953. (Pubitemid 39391433)
15. Baron JA, La Vecchia C, Levi F. The antiestrogenic effect of cigarette smoking in women. Am J Obstet Gynecol. 1990;162:502-514. (Pubitemid 20068531)
16. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982;36:936-942. (Pubitemid 13214364)
17. Szulc P, Claustrat B, Munoz F, Marchand F, Delmas PD. Assessment of the role of 17β-oestradiol in bone metabolism in men: does the assay technique matter? The MINOS study. Clin Endocrinol. 2004;61:447-457. (Pubitemid 39388483)
18. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84:3666-3672. (Pubitemid 30645223)
19. Lapauw B, Taes Y, Bogaert V, et al. Serum estradiol is associated with volumetric bone mineral density and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblings. J Bone Miner Res. 2009;l24:1075-1085.
20. Vogel JM, Davis JW, Nomura A, Wasnich RD, Ross PD. The effects of smoking on bone mass and the rates of bone loss among elderly Japanese-American men. J Bone Miner Res. 1997;12:1495-1501. (Pubitemid 27375394)
21. Burger H, de Laet CE, van Daele PL, et al. Risk factors for increased bone loss in an elderly population: the Rotterdam study. Am J Epidemiol. 1998;147:871-879. (Pubitemid 28243460)
22. Olofsson H, Byberg L, Mohsen R, Melhus H, Lithell H, Michaëlsson K. Smoking and the risk of fracture in older men. J Bone Miner Res. 2005;20:1208-1215. (Pubitemid 40863809)
23. Bouillon R, Bex M, Vanderschueren D, Boonen S. Estrogens are essential for male pubertal periosteal bone expansion. J Clin Endocrinol Metab. 2004;89:6025-6029. (Pubitemid 39628410)
24. Barbieri RL, Gochberg J, Ryan KJ. Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. J Clin Invest. 1986;77:1727-1733. (Pubitemid 16062622)
25. Blackburn CW, Peterson CA, Hales HA, et al. Nicotine, but not cotinine, has a direct toxic effect on ovarian function in the immature gonadotropin-stimulated rat. Reprod Toxicol. 1994;8:325-331.
26. Kinney A, Kline J, Kelly A, Reuss ML, Levin B. Smoking, alcohol and caffeine in relation to ovarian age during the reproductive years. Hum Reprod. 2007;22:1175-1185.
27. Jensen J, Christiansen C, Rødbro P. Cigarette smoking, serum estrogens and bone loss during hormone replacement therapy early after menopause. N Engl J Med. 1985;313:973-975. (Pubitemid 15250216)
28. Bjarnason NH, Christiansen C. The influence of thinness and smoking on bone loss and response to hormone replacement therapy in early postmenopausal women. J Clin Endocrinol Metab. 2000;85:590-596. (Pubitemid 32273638)
29. Bjarnason NH, Nielsen TF, Jørgensen HL, Christiansen C. The influence of smoking on bone loss and response to nasal estradiol. Climacteric. 2009;12:59-65.
30. Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL, Fishman J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med. 1986;315:1305-1309. (Pubitemid 17030406)
31. Michnovicz JJ, Hershcopf RJ, Haley NJ, Bradlow HL, Fishman J. Cigarette smoking alters hepatic estrogen metabolism in men: implications for atherosclerosis. Metabolism. 1989;38:537-541. (Pubitemid 19145767)
32. Osawa Y, Tochigi B, Tochigi M, et al. Aromatase inhibitors in cigarette smoke, tobacco leaves and other plants. J Enzyme Inhib. 1990;4:187-200.
33. Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab. 1996;81:1821-1826. (Pubitemid 26152470)
34. Bauman KE, Foshee VA, Koch GG, Haley NJ, Downton MI. Testosterone and cigarette smoking in early adolescence. J Behav Med. 1989;12:425-433.
35. De Laet C, Kanis JA, Odén A, et al. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int. 2005;16:1330-1338. (Pubitemid 41532085)
36. Longcope C, Johnston CC Jr. Androgen and estrogen dynamics in pre- and postmenopausal women: a comparison between smokers and nonsmokers. J Clin Endocrinol Metab. 1988;67:379-383.
37. Need AG, Kemp A, Giles N, Morris HA, Horowitz M, Nordin BE. Relationships between intestinal calcium absorption, serum vitamin D metabolites and smoking in postmenopausal women. Osteoporos Int. 2002;13:83-88. (Pubitemid 34157835)
38. Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H. Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone. Eur J Pharmacol. 1999;383:387-393.
39. Higashi E, Fukami T, Itoh M, et al. Human CYP2A6 is induced by estrogen via estrogen receptor. Drug Metab Dispos. 2007;35:1935-1941. (Pubitemid 47481589)
40. Benowitz NL, Lessov-Schlaggar CN, Swan GE, Jacob P III. Female sex and oral contraceptive use accelerate nicotine metabolism. Clin Pharmacol Ther. 2006;79:480-488.
41. Almeida M, Han L, Martin-Millan M, et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007;282:27285-27297. (Pubitemid 47501960)
42. Yanbaeva DG, Dentener MA, Creutzberg EC, Wesseling G, Wouters EF. Systemic effects of smoking. Chest. 2007;131:1557-1566.
43. Cooper C, Dennison EM, Leufkens HG, Bishop N, van Staa TP. Epidemiology of childhood fractures in Britain: a study using the general practice research database. J Bone Miner Res. 2004;19:1976-1981. (Pubitemid 41103412)
44. Ismail AA, O'Neill TW, Cockerill W, et al. Validity of self-report of fractures: results from a prospective study in men and women across Europe. European Prospective Osteoporosis Study (EPOS) Group. Osteoporos Int. 2000;11:248-254.
45. Khosla S, Amin S, Singh RJ, Atkinson EJ, Melton LJ III, Riggs BL. Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density. Osteoporos Int. 2008;19: 1465-1471.