메뉴 건너뛰기




Volumn 116, Issue 8, 2006, Pages 2152-2160

Glucocorticoids suppress bone formation via the osteoclast

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COLONY STIMULATING FACTOR 1; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; RAC PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VAV PROTEIN;

EID: 33746715059     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI28084     Document Type: Article
Times cited : (325)

References (40)
  • 2
    • 0032528180 scopus 로고    scopus 로고
    • Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids
    • Weinstein, R.S., Jilka, R.L., Parfitt, A.M., and Manolagas, S.C. 1998. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. J. Clin. Invest. 102:274-282.
    • (1998) J. Clin. Invest. , vol.102 , pp. 274-282
    • Weinstein, R.S.1    Jilka, R.L.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 3
    • 0035047358 scopus 로고    scopus 로고
    • Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture
    • Pereira, R.M., Delany, A.M., and Canalis, E. 2001. Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. Bone. 28:484-490.
    • (2001) Bone , vol.28 , pp. 484-490
    • Pereira, R.M.1    Delany, A.M.2    Canalis, E.3
  • 4
    • 0036256989 scopus 로고    scopus 로고
    • Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: Correlation with CCAAT-enhancer binding protein expression
    • Pereira, R.C., Delany, A.M., and Canalis, E. 2002. Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone. 30:685-691.
    • (2002) Bone , vol.30 , pp. 685-691
    • Pereira, R.C.1    Delany, A.M.2    Canalis, E.3
  • 5
    • 0033103604 scopus 로고    scopus 로고
    • Osteoprogenitor cell frequency in rat bone marrow stromal populations: Role for heterotypic cell-cell interactions in osteoblast differentiation
    • Aubin, J.E. 1999. Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation. J. Cell. Biochem. 72:396-410.
    • (1999) J. Cell. Biochem. , vol.72 , pp. 396-410
    • Aubin, J.E.1
  • 6
    • 0346250853 scopus 로고    scopus 로고
    • Sustained in vitro expansion of bone progenitors is cell density dependent
    • Purpura, K.A., Aubin, J.E., and Zandstra, P.W. 2004. Sustained in vitro expansion of bone progenitors is cell density dependent. Stem Cells. 22:39-50.
    • (2004) Stem Cells , vol.22 , pp. 39-50
    • Purpura, K.A.1    Aubin, J.E.2    Zandstra, P.W.3
  • 7
    • 0141684971 scopus 로고    scopus 로고
    • The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    • Black, D.M., et al. 2003. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N. Engl. J. Med. 349:1207-1215.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1207-1215
    • Black, D.M.1
  • 8
    • 0141796739 scopus 로고    scopus 로고
    • The effects of parathyroid hormone, alendronate, or both in men with osteoporosis
    • Finkelstein, J.S., et al. 2003. The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N. Engl. J. Med. 349:1216-1226.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1216-1226
    • Finkelstein, J.S.1
  • 9
    • 0033007352 scopus 로고    scopus 로고
    • New developments in the pathogenesis and treatment of steroid-induced osteoporosis
    • Manolagas, S.C., and Weinstein, R.S. 1999. New developments in the pathogenesis and treatment of steroid-induced osteoporosis. J. Bone Miner. Res. 14:1061-1066.
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 1061-1066
    • Manolagas, S.C.1    Weinstein, R.S.2
  • 10
    • 0036802878 scopus 로고    scopus 로고
    • Effect of corticosteroids on human osteoclast formation and activity
    • Hirayama, T., Sabokbar, A., and Athanasou, N.A. 2002. Effect of corticosteroids on human osteoclast formation and activity. J. Endocrinol. 175:155-163.
    • (2002) J. Endocrinol. , vol.175 , pp. 155-163
    • Hirayama, T.1    Sabokbar, A.2    Athanasou, N.A.3
  • 11
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum, S.L. 2000. Bone resorption by osteoclasts. Science. 289:1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 12
    • 0033304809 scopus 로고    scopus 로고
    • Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis
    • Hofbauer, L.C., et al. 1999. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology. 140:4382-4389.
    • (1999) Endocrinology , vol.140 , pp. 4382-4389
    • Hofbauer, L.C.1
  • 13
    • 0031769051 scopus 로고    scopus 로고
    • Dexamethasone promotes expression of membrane-bound macrophage colony-stimulating factor in murine osteoblast-like cells
    • Rubin, J., et al. 1998. Dexamethasone promotes expression of membrane-bound macrophage colony-stimulating factor in murine osteoblast-like cells. Endocrinology. 139:1006-1012.
    • (1998) Endocrinology , vol.139 , pp. 1006-1012
    • Rubin, J.1
  • 14
    • 0036123845 scopus 로고    scopus 로고
    • Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
    • doi:10.1172/JCI200214538
    • Weinstein, R.S., et al. 2002. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J. Clin. Invest. 109:1041-1048. doi:10.1172/JCI200214538.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1041-1048
    • Weinstein, R.S.1
  • 17
    • 0024554774 scopus 로고
    • Bone histomorphometry in glucocorticoid-induced osteoporosis
    • Dempster, D.W. 1989. Bone histomorphometry in glucocorticoid-induced osteoporosis. J. Bone Miner. Res. 4:137-141.
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 137-141
    • Dempster, D.W.1
  • 18
    • 0142137222 scopus 로고    scopus 로고
    • T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
    • Brewer, J.A., et al. 2003. T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat. Med. 9:1318-1322.
    • (2003) Nat. Med. , vol.9 , pp. 1318-1322
    • Brewer, J.A.1
  • 19
    • 0041731907 scopus 로고    scopus 로고
    • Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin
    • Faccio, R., Novack, D.V., Zallone, A., Ross, F.P., and Teitelbaum, S.L. 2003. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin. J. Cell Biol. 162:499-509.
    • (2003) J. Cell Biol. , vol.162 , pp. 499-509
    • Faccio, R.1    Novack, D.V.2    Zallone, A.3    Ross, F.P.4    Teitelbaum, S.L.5
  • 20
    • 0037094007 scopus 로고    scopus 로고
    • IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex
    • Nakamura, I., et al. 2002. IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex. J. Immunol. 168:5103-5109.
    • (2002) J. Immunol. , vol.168 , pp. 5103-5109
    • Nakamura, I.1
  • 21
    • 0034697358 scopus 로고    scopus 로고
    • Rho-A is critical for osteoclast podosome organization, motility, and bone resorption
    • Chellaiah, M.A., et al. 2000. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J. Biol. Chem. 275:11993-12002.
    • (2000) J. Biol. Chem. , vol.275 , pp. 11993-12002
    • Chellaiah, M.A.1
  • 22
    • 33746710556 scopus 로고    scopus 로고
    • Rac1 and Rac2 GTPases play distinct roles and are essential for full osteoclast differentiation
    • Paper presented. December 11. Atlanta, Georgia, USA
    • Korhonen, M., et al. 2005. Rac1 and Rac2 GTPases play distinct roles and are essential for full osteoclast differentiation. Paper presented at the 47th American Society of Hematology Annual Meeting. December 11. Atlanta, Georgia, USA.
    • (2005) 47th American Society of Hematology Annual Meeting
    • Korhonen, M.1
  • 23
    • 16244368766 scopus 로고    scopus 로고
    • Vav3 regulates osteoclast function and bone mass
    • Faccio, R., et al. 2005. Vav3 regulates osteoclast function and bone mass. Nat. Med. 11:284-290.
    • (2005) Nat. Med. , vol.11 , pp. 284-290
    • Faccio, R.1
  • 24
    • 0025049142 scopus 로고
    • Origin of osteoclasts: Mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells
    • Udagawa, N., et al. 1990. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc. Natl. Acad. Sci. U. S. A. 87:7260-7264.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 7260-7264
    • Udagawa, N.1
  • 25
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey, D.L., et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:165-176.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1
  • 26
    • 13244267455 scopus 로고    scopus 로고
    • Osteoclast-derived activity in the coupling of bone formation to resorption
    • Martin, T.J., and Sims, N.A. 2005. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol. Med. 11:76-81.
    • (2005) Trends Mol. Med. , vol.11 , pp. 76-81
    • Martin, T.J.1    Sims, N.A.2
  • 27
    • 0034676060 scopus 로고    scopus 로고
    • Decreased c-Src expression enhances osteoblast differentiation and bone formation
    • Marzia, M., et al. 2000. Decreased c-Src expression enhances osteoblast differentiation and bone formation. J. Cell Biol. 151:311-320.
    • (2000) J. Cell Biol. , vol.151 , pp. 311-320
    • Marzia, M.1
  • 28
    • 0028173214 scopus 로고
    • c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling
    • Grigoriadis, A.E., et al. 1994. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science. 266:443-448.
    • (1994) Science , vol.266 , pp. 443-448
    • Grigoriadis, A.E.1
  • 29
    • 0036772573 scopus 로고    scopus 로고
    • Anabolic actions of parathyroid hormone during bone growth are dependent on c-fos
    • Demiralp, B., Chen, H.L., Koh, A.J., Keller, E.T., and McCauley, L.K. 2002. Anabolic actions of parathyroid hormone during bone growth are dependent on c-fos. Endocrinology. 143:4038-4047.
    • (2002) Endocrinology , vol.143 , pp. 4038-4047
    • Demiralp, B.1    Chen, H.L.2    Koh, A.J.3    Keller, E.T.4    McCauley, L.K.5
  • 30
    • 0028117413 scopus 로고
    • Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2
    • Rickard, D.J., Sullivan, T.A., Shenker, B.J., Leboy, P.S., and Kazhdan, I. 1994. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev. Biol. 161:218-228.
    • (1994) Dev. Biol. , vol.161 , pp. 218-228
    • Rickard, D.J.1    Sullivan, T.A.2    Shenker, B.J.3    Leboy, P.S.4    Kazhdan, I.5
  • 31
    • 15944413442 scopus 로고    scopus 로고
    • Severely suppressed bone turnover: A potential complication of alendronate therapy
    • Odvina, C.V., et al. 2005. Severely suppressed bone turnover: a potential complication of alendronate therapy. J. Clin. Endocrinol. Metab. 90:1294-1301.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 1294-1301
    • Odvina, C.V.1
  • 32
    • 0036736811 scopus 로고    scopus 로고
    • Clinical review 151: The role of parathyroid hormone in the pathogenesis of glucocorticoid-induced osteoporosis: A re-examination of the evidence
    • Rubin, M.R., and Bilezikian, J.P. 2002. Clinical review 151: the role of parathyroid hormone in the pathogenesis of glucocorticoid-induced osteoporosis: a re-examination of the evidence. J. Clin. Endocrinol. Metab. 87:4033-4041.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4033-4041
    • Rubin, M.R.1    Bilezikian, J.P.2
  • 33
    • 0031831666 scopus 로고    scopus 로고
    • The science and therapy of glucocorticoid-induced bone loss
    • Lane, N.E., and Lukert, B. 1998. The science and therapy of glucocorticoid-induced bone loss. Endocrinol. Metab. Clin. North Am. 27:465-483.
    • (1998) Endocrinol. Metab. Clin. North Am. , vol.27 , pp. 465-483
    • Lane, N.E.1    Lukert, B.2
  • 34
    • 1642546362 scopus 로고    scopus 로고
    • The skeletal effects of glucocorticoid excess override those of orchidectomy in mice
    • Weinstein, R.S., et al. 2004. The skeletal effects of glucocorticoid excess override those of orchidectomy in mice. Endocrinology. 145:1980-1987.
    • (2004) Endocrinology , vol.145 , pp. 1980-1987
    • Weinstein, R.S.1
  • 35
    • 14944371405 scopus 로고    scopus 로고
    • IL-1 mediates TNF-induced osteoclastogenesis
    • doi:10.1172/JCI200523394
    • Wei, S., Kitaura, H., Zhou, P., Ross, F.P., and Teitelbaum, S.L. 2005. IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest. 115:282-290. doi:10.1172/JCI200523394.
    • (2005) J. Clin. Invest. , vol.115 , pp. 282-290
    • Wei, S.1    Kitaura, H.2    Zhou, P.3    Ross, F.P.4    Teitelbaum, S.L.5
  • 36
    • 0033621890 scopus 로고    scopus 로고
    • Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
    • McHugh, K.P., et al. 2000. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts. J. Clin. Invest. 105:433-440.
    • (2000) J. Clin. Invest. , vol.105 , pp. 433-440
    • McHugh, K.P.1
  • 37
    • 0037332596 scopus 로고    scopus 로고
    • c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation
    • doi:10.1172/JCI200316924
    • Faccio, R., Zallone, A., Ross, F.P., and Teitelbaum, S.L. 2003. c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation. J. Clin. Invest. 111:749-758. doi:10.1172/JCI200316924.
    • (2003) J. Clin. Invest. , vol.111 , pp. 749-758
    • Faccio, R.1    Zallone, A.2    Ross, F.P.3    Teitelbaum, S.L.4
  • 38
    • 25444437569 scopus 로고    scopus 로고
    • Regulation of actin ring formation by rho GTPases in osteoclasts
    • Chellaiah, M.A. 2005. Regulation of actin ring formation by rho GTPases in osteoclasts. J. Biol. Chem. 280:32930-32943.
    • (2005) J. Biol. Chem. , vol.280 , pp. 32930-32943
    • Chellaiah, M.A.1
  • 39
    • 28844441619 scopus 로고    scopus 로고
    • Fast glucocorticoid actions on brain: Back to the future
    • Dallman, M.F. 2005. Fast glucocorticoid actions on brain: back to the future. Front. Neuroendocrinol. 26:103-108.
    • (2005) Front. Neuroendocrinol. , vol.26 , pp. 103-108
    • Dallman, M.F.1
  • 40
    • 0033177995 scopus 로고    scopus 로고
    • Conditional gene targeting in macrophages and granulocytes using LysMcre mice
    • Clausen, B.E., Burkhardt, C., Reith, W., Renkawitz, R., and Forster, I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 8:265-277.
    • (1999) Transgenic Res. , vol.8 , pp. 265-277
    • Clausen, B.E.1    Burkhardt, C.2    Reith, W.3    Renkawitz, R.4    Forster, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.