Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis. A model for compartment-specific androgen action in the skeleton

Bone

Volumn 43, Issue 3, 2008, Pages 440-451

  Wiren, Kristine M ^a,b   Semirale, Anthony A ^a,b   Zhang, Xiao Wei ^a,b   Woo, Adrian ^c   Tommasini, Steven M ^c   Price, Christopher ^c   Schaffler, Mitchell B ^c   Jepsen, Karl J ^c  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Androgen receptor; Biomechanics; Bone histomorphometry; Dual energy X ray absorptiometry; Osteocyte

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ANDROGEN; ANDROGEN RECEPTOR; BIOCHEMICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; ESTRADIOL; OSTEOCALCIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY COMPOSITION; BONE DEVELOPMENT; BONE FRAGILITY; BONE MARROW; BONE MASS; BONE MATRIX; BONE MATURATION; BONE STRENGTH; BONE TURNOVER; CONTROLLED STUDY; CORTICAL BONE; ESTRADIOL BLOOD LEVEL; FEMALE; GENE OVEREXPRESSION; GENE TARGETING; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HORMONE ACTION; MALE; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; OSTEOLYSIS; PHENOTYPE; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETON; TESTOSTERONE BLOOD LEVEL; TRABECULAR BONE; TRANSGENE; TRANSGENIC MOUSE;

ANDROGENS; ANIMALS; BONE AND BONES; CLONING, MOLECULAR; COLLAGEN; FEMALE; MALE; MICE; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOGENESIS; PLASMIDS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION;

EID: 49149119954     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.04.026     Document Type: Article

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