Rodent preclinical models for developing novel antiarthritic molecules: Comparative biology and preferred methods for evaluating efficacy

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Bolon, Brad ^a,b   Stolina, Marina ^a   King, Caroline ^a,c   Middleton, Scot ^a   Gasser, Jill ^a,d   Zack, Debra ^a   Feige, Ulrich ^a,e  

^a AMGEN INC   (United States)

^b GEMpath Inc   (United States)

^c Willamette Orthopaedic Group   (United States)

^d Hamilton Bonaduz AG   (Switzerland)

^e EUROCBI GmbH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; COLLAGEN; COLLAGEN TYPE 2; CORTICOSTEROID; CYCLOSPORIN A; CYTOKINE RECEPTOR ANTAGONIST; DISEASE MODIFYING ANTIRHEUMATIC DRUG; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; OSTEOCLAST DIFFERENTIATION FACTOR; PROSTAGLANDIN SYNTHASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR INHIBITOR; TUMOR NECROSIS FACTOR RECEPTOR;

ARTHRITIS; BACTERIAL CELL WALL; BONE DENSITY; BONE INJURY; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE MODEL; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG RESPONSE; GENETIC ENGINEERING; HORMONAL REGULATION; HUMAN; HUMORAL IMMUNITY; IMMUNE MEDIATED INJURY; MICROFLORA; NONHUMAN; PATHOLOGICAL ANATOMY; PAW EDEMA; REVIEW; RHEUMATOID ARTHRITIS; RODENT; SCREENING TEST; SIGNAL TRANSDUCTION; STREPTOCOCCUS PYOGENES; TREATMENT OUTCOME; ANIMAL; COMPARATIVE STUDY; DRUG SCREENING; METHODOLOGY;

RATTUS; RODENTIA;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HUMANS; RODENTIA; TREATMENT OUTCOME;

EID: 79952212677     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/569068     Document Type: Review

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