메뉴 건너뛰기




Volumn 63, Issue 5, 2004, Pages 383-394

Humanized animal models for autoimmune diseases

Author keywords

Autoimmune disease; Celiac disease; Insulin dependent diabetes mellitus; MHC class II; Multiple sclerosis; Rheumatoid arthritis; T cell receptor; Transgenic mice

Indexed keywords

ANTIGEN; AUTOANTIGEN; GLIADIN; GLUTAMATE DECARBOXYLASE; GLUTEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEOLIPID PROTEIN; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

EID: 2442604214     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0001-2815.2004.00243.x     Document Type: Review
Times cited : (35)

References (76)
  • 3
    • 0034141684 scopus 로고    scopus 로고
    • The third function of the thymus
    • Seddon B, Mason D. The third function of the thymus. Immunol Today 2000: 21: 95.
    • (2000) Immunol Today , vol.21 , pp. 95
    • Seddon, B.1    Mason, D.2
  • 4
    • 0023500817 scopus 로고
    • The shared epitope hypothesis - An approach to understanding the molecular genetics of rheumatoid arthritis susceptibility
    • Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis - an approach to understanding the molecular genetics of rheumatoid arthritis susceptibility. Arthritis Rheum 1987: 30: 1205.
    • (1987) Arthritis Rheum , vol.30 , pp. 1205
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 5
    • 0028952168 scopus 로고
    • Peptide binding specificity of HLA-DR4 molecules: Correlation with rheumatoid arthritis association
    • Hammer JF, Gallazzi E, Bono RW et al. Peptide binding specificity of HLA-DR4 molecules: Correlation with rheumatoid arthritis association. J Exp Med 1995: 1: 1847.
    • (1995) J Exp Med , vol.1 , pp. 1847
    • Hammer, J.F.1    Gallazzi, E.2    Bono, R.W.3
  • 6
    • 0027937713 scopus 로고
    • Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
    • Hammer J, Bono E, Gallazzi F, Belunis C, Nagy Z, Sinigaglia F. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J Exp Med 1994: 180: 2353.
    • (1994) J Exp Med , vol.180 , pp. 2353
    • Hammer, J.1    Bono, E.2    Gallazzi, F.3    Belunis, C.4    Nagy, Z.5    Sinigaglia, F.6
  • 7
    • 0023906188 scopus 로고
    • Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR beta chain: A means for graft rejection and immunosuppression
    • Fujinami RS, Nelson JA, Walker L, Oldstone MB. Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR beta chain: a means for graft rejection and immunosuppression. J Virol 1988: 62: 100.
    • (1988) J Virol , vol.62 , pp. 100
    • Fujinami, R.S.1    Nelson, J.A.2    Walker, L.3    Oldstone, M.B.4
  • 8
    • 0023930041 scopus 로고
    • The Epstein-Barr virus glycoprotein gp110, a molecular link between HLA DR4, HLA DR1, and rheumatoid arthritis
    • Roudier J, Rhodes G, Petersen J, Vaughan JH, Carson DA. The Epstein-Barr virus glycoprotein gp110, a molecular link between HLA DR4, HLA DR1, and rheumatoid arthritis. Scand J Immunol 1988: 27: 367.
    • (1988) Scand J Immunol , vol.27 , pp. 367
    • Roudier, J.1    Rhodes, G.2    Petersen, J.3    Vaughan, J.H.4    Carson, D.A.5
  • 11
    • 0018830639 scopus 로고
    • Immunisation against heterologous type II collagen induces arthritis in mice
    • Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature 1980: 283: 666.
    • (1980) Nature , vol.283 , pp. 666
    • Courtenay, J.S.1    Dallman, M.J.2    Dayan, A.D.3    Martin, A.4    Mosedale, B.5
  • 12
    • 0023572289 scopus 로고
    • Experimental arthropathy induced in rhesus monkeys (Macaca mulatta) by intradermal immunization with native bovine type II collagen
    • Rubin AS, Healy CT, Martin LN, Baskin GB, Roberts ED. Experimental arthropathy induced in rhesus monkeys (Macaca mulatta) by intradermal immunization with native bovine type II collagen. Lab Invest 1987: 57: 524.
    • (1987) Lab Invest , vol.57 , pp. 524
    • Rubin, A.S.1    Healy, C.T.2    Martin, L.N.3    Baskin, G.B.4    Roberts, E.D.5
  • 13
    • 0017657009 scopus 로고
    • Autoimmunity to type II collagen an experimental model of arthritis
    • Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 1977: 146: 857.
    • (1977) J Exp Med , vol.146 , pp. 857
    • Trentham, D.E.1    Townes, A.S.2    Kang, A.H.3
  • 14
    • 0032522994 scopus 로고    scopus 로고
    • Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes
    • Zhang Y, Guerassimov A, Leroux JY et al. Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes. J Clin Invest 1998: 101: 1678.
    • (1998) J Clin Invest , vol.101 , pp. 1678
    • Zhang, Y.1    Guerassimov, A.2    Leroux, J.Y.3
  • 15
    • 0031692112 scopus 로고    scopus 로고
    • Induction of arthritis in BALB/c mice by cartilage link protein: Involvement of distinct regions recognized by T and B lymphocytes
    • Zhang Y, Guerassimov A, Leroux JY et al. Induction of arthritis in BALB/c mice by cartilage link protein: involvement of distinct regions recognized by T and B lymphocytes. Am J Pathol 1998: 153: 1283.
    • (1998) Am J Pathol , vol.153 , pp. 1283
    • Zhang, Y.1    Guerassimov, A.2    Leroux, J.Y.3
  • 16
    • 0037089664 scopus 로고    scopus 로고
    • Arthritogenic monoclonal antibodies from K/ BxN mice
    • Maccioni M, Zeder-Lutz G, Huang H et al. Arthritogenic monoclonal antibodies from K/ BxN mice. J Exp Med 2002: 195: 1071.
    • (2002) J Exp Med , vol.195 , pp. 1071
    • Maccioni, M.1    Zeder-Lutz, G.2    Huang, H.3
  • 18
    • 0033607499 scopus 로고    scopus 로고
    • Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme
    • Matsumoto I, Staub A, Benoist C, Mathis D. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 1999: 286: 1732.
    • (1999) Science , vol.286 , pp. 1732
    • Matsumoto, I.1    Staub, A.2    Benoist, C.3    Mathis, D.4
  • 19
    • 0033118675 scopus 로고    scopus 로고
    • From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
    • Korganow AS, Ji H, Mangialaio S et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999: 10: 451.
    • (1999) Immunity , vol.10 , pp. 451
    • Korganow, A.S.1    Ji, H.2    Mangialaio, S.3
  • 20
    • 0036230130 scopus 로고    scopus 로고
    • How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
    • Matsumoto I, Maccioni M, Lee DM et al. How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immun 2002: 3: 360.
    • (2002) Nat Immun , vol.3 , pp. 360
    • Matsumoto, I.1    Maccioni, M.2    Lee, D.M.3
  • 21
    • 0030903740 scopus 로고    scopus 로고
    • An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen
    • Rosloniec EF, Brand DD, Myers LK et al. An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen. J Exp Med 1997: 185: 1113.
    • (1997) J Exp Med , vol.185 , pp. 1113
    • Rosloniec, E.F.1    Brand, D.D.2    Myers, L.K.3
  • 22
    • 0032560526 scopus 로고    scopus 로고
    • Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 Tg mice
    • Andersson EC, Hansen BE, Jacobsen H et al. Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 Tg mice. Proc Natl Acad Sci USA 1998: 95: 7574.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7574
    • Andersson, E.C.1    Hansen, B.E.2    Jacobsen, H.3
  • 23
    • 0029932708 scopus 로고    scopus 로고
    • Specificity of an HLA-DRB1*0401 restricted T cell response to type II collagen
    • Fugger L, Rothbard J, McDevitt GS. Specificity of an HLA-DRB1*0401 restricted T cell response to type II collagen. Eur J Immund 1996: 26: 928.
    • (1996) Eur J Immund , vol.26 , pp. 928
    • Fugger, L.1    Rothbard, J.2    McDevitt, G.S.3
  • 24
    • 0036134844 scopus 로고    scopus 로고
    • HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen
    • Rosloniec EF, Whittington KB, Zaller DM, Rang AH. HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen. J Immunol 2002: 168: 253.
    • (2002) J Immunol , vol.168 , pp. 253
    • Rosloniec, E.F.1    Whittington, K.B.2    Zaller, D.M.3    Rang, A.H.4
  • 25
    • 0030701632 scopus 로고    scopus 로고
    • X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II
    • Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. Immunity 1997: 7: 473.
    • (1997) Immunity , vol.7 , pp. 473
    • Dessen, A.1    Lawrence, C.M.2    Cupo, S.3    Zaller, D.M.4    Wiley, D.C.5
  • 26
    • 0033729655 scopus 로고    scopus 로고
    • Human autoimmunity genes in mice
    • Fugger L. Human autoimmunity genes in mice. Curr Opin Immunol 2000: 12: 698.
    • (2000) Curr Opin Immunol , vol.12 , pp. 698
    • Fugger, L.1
  • 28
    • 0028227428 scopus 로고
    • Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response
    • Ronnelid J, Lysholm J, Engstrom-Laurent A, Klareskog L, Heyman B. Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response. Arthritis Rheum 1994: 37: 1023.
    • (1994) Arthritis Rheum , vol.37 , pp. 1023
    • Ronnelid, J.1    Lysholm, J.2    Engstrom-Laurent, A.3    Klareskog, L.4    Heyman, B.5
  • 29
    • 0034469085 scopus 로고    scopus 로고
    • Joint-specific and systemic autoreactivity in the development of inflammatory arthritis
    • Fugger L. Joint-specific and systemic autoreactivity in the development of inflammatory arthritis. Arthritis Res 2000: 2: 2.
    • (2000) Arthritis Res , vol.2 , pp. 2
    • Fugger, L.1
  • 30
    • 0037162490 scopus 로고    scopus 로고
    • Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized Tg mice and in rheumatoid arthritis
    • Backlund J, Carlsen S, Hoger T et al. Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized Tg mice and in rheumatoid arthritis. Proc Natl Acad Sci USA 2002: 99: 9960.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9960
    • Backlund, J.1    Carlsen, S.2    Hoger, T.3
  • 31
    • 0036900514 scopus 로고    scopus 로고
    • Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 Tg mice
    • Myers LK, Sakurai Y, Tang B et al. Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 Tg mice. Arthritis Rheum 2002: 46: 3369.
    • (2002) Arthritis Rheum , vol.46 , pp. 3369
    • Myers, L.K.1    Sakurai, Y.2    Tang, B.3
  • 32
    • 0036525460 scopus 로고    scopus 로고
    • The influence of HLA-DR4 (0401) on the immune response to type II collagen and the development of collagen induced arthritis in mice
    • Wang D, Hill JA, Cairns E, Bell DA. The influence of HLA-DR4 (0401) on the immune response to type II collagen and the development of collagen induced arthritis in mice. J Autoimmun 2002: 18: 95.
    • (2002) J Autoimmun , vol.18 , pp. 95
    • Wang, D.1    Hill, J.A.2    Cairns, E.3    Bell, D.A.4
  • 33
    • 0141923666 scopus 로고    scopus 로고
    • HLA-DRB1*0402 (DW10) transgene protects collagen-induced arthritis-susceptible H2A (q) and DRB1*0401 (DW4) Tg mice from arthritis
    • Taneja V, Taneja N, Behrens M et al. HLA-DRB1*0402 (DW10) transgene protects collagen-induced arthritis-susceptible H2A (q) and DRB1*0401 (DW4) Tg mice from arthritis. J Immunol 2003: 171: 4431.
    • (2003) J Immunol , vol.171 , pp. 4431
    • Taneja, V.1    Taneja, N.2    Behrens, M.3
  • 34
    • 0025767289 scopus 로고
    • HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation
    • Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 1991: 38: 1.
    • (1991) Tissue Antigens , vol.38 , pp. 1
    • Olerup, O.1    Hillert, J.2
  • 35
    • 0033600078 scopus 로고    scopus 로고
    • Progress in determining the causes and treatment of multiple sclerosis
    • Noseworthy JH. Progress in determining the causes and treatment of multiple sclerosis. Nature 1999: 399: A40.
    • (1999) Nature , vol.399
    • Noseworthy, J.H.1
  • 36
    • 0025782929 scopus 로고
    • Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides
    • Trotter JL, Hickey WF, van der Veen RC, Sulze L. Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides. J Neuroimmunol 1991: 33: 55.
    • (1991) J Neuroimmunol , vol.33 , pp. 55
    • Trotter, J.L.1    Hickey, W.F.2    Van Der Veen, R.C.3    Sulze, L.4
  • 37
    • 0025138302 scopus 로고
    • T cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta M, Nicklas JA, Sriram S, Albertini RJ. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990: 247: 718.
    • (1990) Science , vol.247 , pp. 718
    • Allegretta, M.1    Nicklas, J.A.2    Sriram, S.3    Albertini, R.J.4
  • 38
    • 0035254476 scopus 로고    scopus 로고
    • T cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls
    • Hellings N, Baree M, Verhoeven C et al. T cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls. J Neurosci Res 2001: 63: 290.
    • (2001) J Neurosci Res , vol.63 , pp. 290
    • Hellings, N.1    Baree, M.2    Verhoeven, C.3
  • 39
    • 0027144752 scopus 로고
    • Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
    • Kerlero de Rosbo N, Milo R, Lees MB, Burger D, Bernard CC, Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest 1993: 92: 2602.
    • (1993) J Clin Invest , vol.92 , pp. 2602
    • Kerlero De Rosbo, N.1    Milo, R.2    Lees, M.B.3    Burger, D.4    Bernard, C.C.5    Ben-Nun, A.6
  • 40
    • 0028120895 scopus 로고
    • Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
    • Wucherpfennig KW, Sette A, Southwood S et al. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med 1994: 179: 279.
    • (1994) J Exp Med , vol.179 , pp. 279
    • Wucherpfennig, K.W.1    Sette, A.2    Southwood, S.3
  • 41
    • 0032719206 scopus 로고    scopus 로고
    • A humanized model for multiple sclerosis utilizing HLA-DR2 and a human T cell receptor
    • Madsen LS, Andersson EC, Jansson L et al. A humanized model for multiple sclerosis utilizing HLA-DR2 and a human T cell receptor. Nature Genet 1999: 23: 343.
    • (1999) Nature Genet , vol.23 , pp. 343
    • Madsen, L.S.1    Andersson, E.C.2    Jansson, L.3
  • 42
    • 0034678450 scopus 로고    scopus 로고
    • Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA) -DR2-MBP 85-99 complex
    • Krogsgaard M, Wucherpfennig KW, Canella B et al. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA) -DR2-MBP 85-99 complex. J Exp Med 2000: 191: 1395.
    • (2000) J Exp Med , vol.191 , pp. 1395
    • Krogsgaard, M.1    Wucherpfennig, K.W.2    Canella, B.3
  • 43
    • 0025780265 scopus 로고
    • Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen-Ia complex
    • Aharoni R, Teitelbaum D, Arnon R, Puri J. Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen-Ia complex. Nature 1991: 351: 147.
    • (1991) Nature , vol.351 , pp. 147
    • Aharoni, R.1    Teitelbaum, D.2    Arnon, R.3    Puri, J.4
  • 44
    • 0036793245 scopus 로고    scopus 로고
    • A functional and structural basis for TCR cross-reactivity in multiple sclerosis
    • Lang HL, Jacobsen H, Ikemizu S et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immun 2002: 3: 940.
    • (2002) Nat Immun , vol.3 , pp. 940
    • Lang, H.L.1    Jacobsen, H.2    Ikemizu, S.3
  • 45
    • 0034711376 scopus 로고    scopus 로고
    • Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins
    • Li Y, Li H, Martin R, Mariuzza RA. Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins. J Mol Biol 2000: 304: 177.
    • (2000) J Mol Biol , vol.304 , pp. 177
    • Li, Y.1    Li, H.2    Martin, R.3    Mariuzza, R.A.4
  • 47
    • 0021879526 scopus 로고
    • An experimental model of detrusor instability in the obstructed pig
    • Sibley GN. An experimental model of detrusor instability in the obstructed pig. Br J Urol 1985: 57: 292.
    • (1985) Br J Urol , vol.57 , pp. 292
    • Sibley, G.N.1
  • 48
    • 0037869060 scopus 로고    scopus 로고
    • Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 Tg mice
    • Vandenbark AA, Rich C, Mooney J et al. Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 Tg mice. J Immunol 2003: 171: 127.
    • (2003) J Immunol , vol.171 , pp. 127
    • Vandenbark, A.A.1    Rich, C.2    Mooney, J.3
  • 49
    • 0032402243 scopus 로고    scopus 로고
    • Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis
    • Burrows GG, Bebo BF Jr, Adlard KL, Vandenbark AA, Offner H. Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis. J Immunol 1998: 161: 5987.
    • (1998) J Immunol , vol.161 , pp. 5987
    • Burrows, G.G.1    Bebo Jr., B.F.2    Adlard, K.L.3    Vandenbark, A.A.4    Offner, H.5
  • 50
    • 0034660502 scopus 로고    scopus 로고
    • Regulation of encephalitogenic T cells with recombinant TCR ligands
    • Burrows GG, Adlard KL, Bebo BF Jr et al. Regulation of encephalitogenic T cells with recombinant TCR ligands. J Immunol 2000: 164: 6366.
    • (2000) J Immunol , vol.164 , pp. 6366
    • Burrows, G.G.1    Adlard, K.L.2    Bebo Jr., B.F.3
  • 51
    • 0032522194 scopus 로고    scopus 로고
    • T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects
    • Trotter JL, Pelfrey CM, Trotter AL et al. T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects. J Neuroimmunol 1998: 84: 172.
    • (1998) J Neuroimmunol , vol.84 , pp. 172
    • Trotter, J.L.1    Pelfrey, C.M.2    Trotter, A.L.3
  • 52
    • 0028802217 scopus 로고
    • Analysis of proteolipid protein (PLP)-specific T cells in multiple sclerosis: Identification of PLP 95-116 as an HLA-DR2,w15-associated determinant
    • Ohashi T, Yamamura T, Inobe J, Kondo T, Kunishita T, Tabira T. Analysis of proteolipid protein (PLP)-specific T cells in multiple sclerosis: identification of PLP 95-116 as an HLA-DR2,w15-associated determinant. International Immunol 1995: 7: 1771.
    • (1995) International Immunol , vol.7 , pp. 1771
    • Ohashi, T.1    Yamamura, T.2    Inobe, J.3    Kondo, T.4    Kunishita, T.5    Tabira, T.6
  • 53
    • 0034128717 scopus 로고    scopus 로고
    • HLA-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in Tg mice
    • Kawamura K, Yamamura T, Yokoyama K et al. HLA-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in Tg mice. J Clin Invest 2000: 105: 977.
    • (2000) J Clin Invest , vol.105 , pp. 977
    • Kawamura, K.1    Yamamura, T.2    Yokoyama, K.3
  • 54
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T cell receptor Tg mice develop spontaneous autoimmune optic neuritis
    • Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor Tg mice develop spontaneous autoimmune optic neuritis. J Exp Med 2003: 197: 1073.
    • (2003) J Exp Med , vol.197 , pp. 1073
    • Bettelli, E.1    Pagany, M.2    Weiner, H.L.3    Linington, C.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 55
    • 0037882036 scopus 로고    scopus 로고
    • Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year
    • Steinman L. Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year. J Exp Med 2003: 197: 1065.
    • (2003) J Exp Med , vol.197 , pp. 1065
    • Steinman, L.1
  • 56
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell 1996: 85: 291.
    • (1996) Cell , vol.85 , pp. 291
    • Tisch, R.1    McDevitt, H.2
  • 57
    • 0034812119 scopus 로고    scopus 로고
    • Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models
    • Todd JA, Wicker LS. Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. Immunity 2001: 15: 387.
    • (2001) Immunity , vol.15 , pp. 387
    • Todd, J.A.1    Wicker, L.S.2
  • 58
    • 0033485917 scopus 로고    scopus 로고
    • Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif
    • Herman AE, Tisch RM, Patel SD et al. Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif. J Immunol 1999: 163: 6275.
    • (1999) J Immunol , vol.163 , pp. 6275
    • Herman, A.E.1    Tisch, R.M.2    Patel, S.D.3
  • 59
    • 0033048174 scopus 로고    scopus 로고
    • Major DQ8-restricted T cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 Tg IA (null) NOD mice
    • Liu J, Purdy LE, Rabinovitch S, Jevnikar AM, Elliott JF. Major DQ8-restricted T cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 Tg IA (null) NOD mice. Diabetes 1999: 48: 469.
    • (1999) Diabetes , vol.48 , pp. 469
    • Liu, J.1    Purdy, L.E.2    Rabinovitch, S.3    Jevnikar, A.M.4    Elliott, J.F.5
  • 60
    • 0030759825 scopus 로고    scopus 로고
    • Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 using HLA-DR (a*10101, b*10401) Tg mice
    • Patel SD, Cope AP, Congia M et al. Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 using HLA-DR (a*10101, b*10401) Tg mice. Proc Natl Acad Sci USA 1997: 94: 8082.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8082
    • Patel, S.D.1    Cope, A.P.2    Congia, M.3
  • 61
    • 0344824000 scopus 로고    scopus 로고
    • Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 Tg IAbeta knockout NOD mice
    • Elliott JF, Liu J, Yuan ZN et al. Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 Tg IAbeta knockout NOD mice. Proc Natl Acad Sci USA 2003: 100: 13447.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13447
    • Elliott, J.F.1    Liu, J.2    Yuan, Z.N.3
  • 62
    • 0034598313 scopus 로고    scopus 로고
    • In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes
    • Wen L, Wong FS, Tang J et al. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J Exp Med 2000: 191: 97.
    • (2000) J Exp Med , vol.191 , pp. 97
    • Wen, L.1    Wong, F.S.2    Tang, J.3
  • 63
    • 0035061420 scopus 로고    scopus 로고
    • The regulatory role of DR4 in a spontaneous diabetes DQ8 Tg model
    • Wen L, Chen NY, Tang J, Sherwin R, Wong FS. The regulatory role of DR4 in a spontaneous diabetes DQ8 Tg model. J Clin Invest 2001: 107: 871.
    • (2001) J Clin Invest , vol.107 , pp. 871
    • Wen, L.1    Chen, N.Y.2    Tang, J.3    Sherwin, R.4    Wong, F.S.5
  • 64
    • 0036688819 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes mellitus
    • Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun 2002: 3: 235.
    • (2002) Genes Immun , vol.3 , pp. 235
    • Pociot, F.1    McDermott, M.F.2
  • 65
    • 0034121187 scopus 로고    scopus 로고
    • Molecular basis of celiac disease
    • Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol 2000: 18: 53.
    • (2000) Annu Rev Immunol , vol.18 , pp. 53
    • Sollid, L.M.1
  • 67
    • 0037111368 scopus 로고    scopus 로고
    • HLA-DQ determines the response to exogenous wheat proteins: A model of gluten sensitivity in Tg knockout mice
    • Black KE, Murray JA, David CS. HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in Tg knockout mice. J Immunol 2002: 169: 5595.
    • (2002) J Immunol , vol.169 , pp. 5595
    • Black, K.E.1    Murray, J.A.2    David, C.S.3
  • 68
    • 0031779478 scopus 로고    scopus 로고
    • Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
    • Molberg O, McAdam SN, Korner R et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998: 4: 713.
    • (1998) Nat Med , vol.4 , pp. 713
    • Molberg, O.1    McAdam, S.N.2    Korner, R.3
  • 69
    • 0034924028 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
    • Hahm KB, Im YH, Parks TW et al. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001: 49: 190.
    • (2001) Gut , vol.49 , pp. 190
    • Hahm, K.B.1    Im, Y.H.2    Parks, T.W.3
  • 70
    • 0034789792 scopus 로고    scopus 로고
    • Antigen-specific immunomodulation via altered peptide ligands
    • Bielekova B, Martin R. Antigen-specific immunomodulation via altered peptide ligands. J Mol Med 2001: 79: 552.
    • (2001) J Mol Med , vol.79 , pp. 552
    • Bielekova, B.1    Martin, R.2
  • 71
    • 0026091380 scopus 로고
    • Mice lacking MHC class II molecules
    • Cosgrove D, Gray D, Dierich A et al. Mice lacking MHC class II molecules. Cell 1991: 66: 1051.
    • (1991) Cell , vol.66 , pp. 1051
    • Cosgrove, D.1    Gray, D.2    Dierich, A.3
  • 72
    • 0026044013 scopus 로고
    • Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice
    • Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 1991: 253: 1417.
    • (1991) Science , vol.253 , pp. 1417
    • Grusby, M.J.1    Johnson, R.S.2    Papaioannou, V.E.3    Glimcher, L.H.4
  • 75
    • 0037255428 scopus 로고    scopus 로고
    • Characterization of HLA DR3/DQ2 Tg mice: A potential humanized animal model for autoimmune disease studies
    • Chen D, Ueda R, Harding F et al. Characterization of HLA DR3/DQ2 Tg mice: a potential humanized animal model for autoimmune disease studies. Eur J Immunol 2003: 33: 172.
    • (2003) Eur J Immunol , vol.33 , pp. 172
    • Chen, D.1    Ueda, R.2    Harding, F.3
  • 76
    • 18544362452 scopus 로고    scopus 로고
    • Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis
    • Jawaheer D, Li W, Graham RR et al. Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet 2002: 71: 585.
    • (2002) Am J Hum Genet , vol.71 , pp. 585
    • Jawaheer, D.1    Li, W.2    Graham, R.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.