HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases

Advances in Immunology

Volumn 97, Issue , 2008, Pages 65-147

  Mangalam, Ashutosh K ^a   Rajagopalan, Govindarajan ^a   Taneja, Veena ^a   David, Chella S ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABRA 14 VACCINE; ANTIBODY; AUTOANTIGEN; BACTERIAL ANTIGEN; EPITOPE; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DQ8 ANTIGEN; HLA DR ANTIGEN; HLA DR2 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; HOUSE DUST ALLERGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PLASMID DNA; PROTEOLIPID PROTEIN; RAGWEED ANTIGEN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; THYROID PEROXIDASE; THYROTROPIN RECEPTOR;

ALLELE; ALLERGIC ENCEPHALOMYELITIS; ANTIGEN EXPRESSION; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; CD4+ T LYMPHOCYTE; CELIAC DISEASE; DERMATITIS HERPETIFORMIS; GENE EXPRESSION; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GRAVES DISEASE; HAPLOTYPE; HLA SYSTEM; HOUSE DUST ALLERGY; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOPATHOGENESIS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; LUNG DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALARIA; MULTIPLE SCLEROSIS; MYASTHENIA GRAVIS; MYCOBACTERIUM TUBERCULOSIS; MYOCARDITIS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RELAPSING POLYCHONDRITIS; RESPIRATORY TRACT DISEASE; REVIEW; RHEUMATOID ARTHRITIS; STAPHYLOCOCCUS; THYMUS; TOXIC SHOCK SYNDROME; TRANSGENIC MOUSE; TUBERCULOSIS; UVEITIS; VACCINE PRODUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; HLA-D ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; IMMUNE SYSTEM DISEASES; MICE; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL;

EID: 44049083751     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(08)00002-3     Document Type: Review

References (235)

1. Abraham R.S., Kudva Y.C., Wilson S.B., Strominger J.L., and David C.S. Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice. Diabetes 49 (2000) 548-554
2. Abraham R.S., Wen L., Marietta E.V., and David C.S. Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model. J. Immunol. 166 (2001) 1370-1379
3. Alsalameh S., Mollenhauer J., Scheuplein F., Stoss H., Kalden J.R., Burkhardt H., and Burmester G.R. Preferential cellular and humoral immune reactivities to native and denatured collagen types IX and XI in a patient with fatal relapsing polychondritis. J. Rheumatol. 20 (1993) 1419-1424
4. Alvarado-de la Barrera C., Zuniga-Ramos J., Ruiz-Morales J.A., Estanol B., Granados J., and Llorente L. HLA class II genotypes in Mexican Mestizos with familial and nonfamilial multiple sclerosis. Neurology 55 (2000) 1897-1900
5. Amirzargar A., Mytilineos J., Yousefipour A., Farjadian S., Scherer S., Opelz G., and Ghaderi A. HLA class II (DRB1, DQA1 and DQB1) associated genetic susceptibility in Iranian multiple sclerosis (MS) patients. Eur. J. Immunogenet. 25 (1998) 297-301
6. Amor S., Groome N., Linington C., Morris M.M., Dornmair K., Gardinier M.V., Matthieu J.M., and Baker D. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J. Immunol. 153 (1994) 4349-4356
7. Andersson E.C., Hansen B.E., Jacobsen H., Madsen L.S., Andersen C.B., Engberg J., Rothbard J.B., McDevitt G.S., Malmstrom V., Holmdahl R., Svejgaard A., and Fugger L. Definition of MHC and T cell receptor contacts in the HLA-DR4 restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc. Natl. Acad. Sci. USA 95 (1998) 7574-7579
8. Ando D.G., Clayton J., Kono D., Urban J.L., and Sercarz E.E. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol. 124 (1989) 132-143
9. Bachmaier K., Neu N., Yeung R.S., Mak T.W., Liu P., and Penninger J.M. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation 99 (1999) 1885-1891
10. Bachmaier K., Krawczyk C., Kozieradzki I., Kong Y.Y., Sasaki T., Oliveira-dos-Santos A., Mariathasan S., Bouchard D., Wakeham A., Itie A., Le J., Ohashi P.S., et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403 (2000) 211-216
11. Banga J.P. In: Wiersinga W.M., Drexhage H.A., and Weetman A.P. (Eds). The Thyroid and Autoimmunity (2007), Georg Thieme Verlag, Stuttgart
12. Barcellos L.F., Oksenberg J.R., Begovich A.B., Martin E.R., Schmidt S., Vittinghoff E., Goodin D.S., Pelletier D., Lincoln R.R., Bucher P., Swerdlin A., Pericak-Vance M.A., et al. HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am. J. Hum. Genet. 72 (2003) 710-716
13. Bell J., Rassenti L., Smoot S., Smith K., Newby C., Hohlfeld R., Toyka K., McDevitt H., and Steinman L. HLA-DQ beta-chain polymorphism linked to myasthenia gravis. Lancet 1 (1986) 1058-1060
14. Bertrams J., and Kuwert E. HL-A antigen frequencies in multiple sclerosis. Significant increase of HL-A3, HL-A10 and W5, and decrease of HL-A12. Eur. Neurol. 7 (1972) 74-78
15. Black K.E., Murray J.A., and David C.S. HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice. J. Immunol. 169 (2002) 5595-5600
16. Boles J.W., Pitt M.L., LeClaire R.D., Gibbs P.H., Ulrich R.G., and Bavari S. Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule. Vaccine 21 (2003) 2791-2796
17. Bradley D.S., Nabozny G.H., Cheng S., Zhou P., Griffiths M.M., Luthra H.S., and David C.S. HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis. J. Clin. Invest. 100 (1997) 2227-2234
18. Bradley D.S., Das P., Griffiths M.M., Luthra H.S., and David C.S. HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: a model for human relapsing polychondritis. J. Immunol. 161 (1998) 5046-5053
19. Brocke S., Gijbels K., Allegretta M., Ferber I., Piercy C., Blankenstein T., Martin R., Utz U., Karin N., Mitchell D., Veromaa T., Waisman A., et al. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379 (1996) 343-346
20. Brogan P.A., Shah V., Bagga A., Klein N., and Dillon M.J. T cell Vbeta repertoires in childhood vasculitides. Clin. Exp. Immunol. 131 (2003) 517-527
21. Brunner C., Lassmann H., Waehneldt T.V., Matthieu J.M., and Linington C. Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats. J. Neurochem. 52 (1989) 296-304
22. Buckner J.H., Van Landeghen M., Kwok W.W., and Tsarknaridis L. Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis. Arthritis Rheum. 46 (2002) 238-244
23. Bueno C., Criado G., McCormick J.K., and Madrenas J. T cell signalling induced by bacterial superantigens. Chem. Immunol. Allergy 93 (2007) 161-180
24. Caforio A.L., Mahon N.J., Tona F., and McKenna W.J. Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance. Eur. J. Heart Fail. 4 (2002) 411-417
25. Carayanniotis G., and Kong Y.C. Pathogenic thyroglobulin peptides as model antigens: insights on the induction and maintenance of autoimmune thyroiditis. Int. Rev. Immunol. 19 (2000) 557-572
26. Caspi R.R. Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis. Int. Rev. Immunol. 21 (2002) 197-208
27. Caturegli P., Vidalain P.O., Vali M., Aguilera-Galaviz L.A., and Rose N.R. Cloning and characterization of murine thyroglobulin cDNA. Clin. Immunol. Immunopathol. 85 (1997) 221-226
28. Chambers H.F. The changing epidemiology of Staphylococcus aureus?. Emerg. Infect. Dis. 7 (2001) 178-182
29. Chapoval S.P., Neeno T., Krco C.J., Marietta E.V., Harders J., and David C.S. HLA-DQ6 and HLA-DQ8 transgenic mice respond to ragweed allergens and recognize a distinct set of epitopes on short and giant ragweed group 5 antigens. J. Immunol. 161 (1998) 2032-2037
30. Chapoval S.P., Nabozny G.H., Marietta E.V., Raymond E.L., Krco C.J., Andrews A.G., and David C.S. Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice. J. Clin. Invest. 103 (1999) 1707-1717
31. Cheng S., Baisch J., Krco C., Savarirayan S., Hanson J., Hodgson K., Smart M., and David C. Expression and function of HLA-DQ8 (DQA1*0301/DQB1*0302) genes in transgenic mice. Eur. J. Immunogenet. 23 (1996) 15-20
32. Chiu T., and Lee K.P. Auricular chondropathy in aging rats. Vet. Pathol. 21 (1984) 500-504
33. Choi Y., Kappler J.W., and Marrack P. A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus. Nature 350 (1991) 203-207
34. Christadoss P. Immunogenetics of experimental autoimmune myasthenia gravis. Crit. Rev. Immunol. 9 (1989) 247-278
35. Cole B.C., Sawitzke A.D., Ahmed E.A., Atkin C.L., and David C.S. Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma arthritidis superantigen MAM. Infect. Immun. 65 (1997) 4190-4198
36. Conti-Tronconi B.M., McLane K.E., Raftery M.A., Grando S.A., and Protti M.P. The nicotinic acetylcholine receptor: structure and autoimmune pathology. Crit. Rev. Biochem. Mol. Biol. 29 (1994) 69-123
37. Cosgrove D., Gray D., Dierich A., Kaufman J., Lemeur M., Benoist C., and Mathis D. Mice lacking MHC class II molecules. Cell 66 (1991) 1051-1066
38. Courtenay J.S., Dallman M.J., Dayan A.D., Martin A., and Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature 283 (1980) 666-668
39. Cremer M.A., Pitcock J.A., Stuart J.M., Kang A.H., and Townes A.S. Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen. J. Exp. Med. 154 (1981) 535-540
40. Curione M., Barbato M., De Biase L., Viola F., Lo Russo L., and Cardi E. Prevalence of coeliac disease in idiopathic dilated cardiomyopathy. Lancet 354 (1999) 222-223
41. Das P., Drescher K.M., Geluk A., Bradley D.S., Rodriguez M., and David C.S. Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis. Hum. Immunol. 61 (2000) 279-289
42. DaSilva L., Welcher B.C., Ulrich R.G., Aman M.J., David C.S., and Bavari S. Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccines. J. Infect. Dis. 185 (2002) 1754-1760
43. Dinges M.M., Orwin P.M., and Schlievert P.M. Exotoxins of Staphylococcus aureus. Clin. Microbiol. Rev. 13 (2000) 16-34
44. Drachman D.B. Myasthenia gravis. N. Engl. J. Med. 330 (1994) 1797-1810
45. Elliott J.F., Liu J., Yuan Z.N., Bautista-Lopez N., Wallbank S.L., Suzuki K., Rayner D., Nation P., Robertson M.A., Liu G., and Kavanagh K.M. Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice. Proc. Natl. Acad. Sci. USA 100 (2003) 13447-13452
46. Ellmerich S., Mycko M., Takacs K., Waldner H., Wahid F.N., Boyton R.J., King R.H., Smith P.A., Amor S., Herlihy A.H., Hewitt R.E., Jutton M., et al. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J. Immunol. 174 (2005) 1938-1946
47. Encinas J.A., and Kuchroo V.K. Genetics of experimental autoimmune encephalomyelitis. Curr. Dir. Autoimmun. 1 (1999) 247-272
48. Ferucci E.D., Majka D.S., Parrish L.A., Moroldo M.B., Ryan M., Passo M., Thompson S.D., Deane K.D., Rewers M., Arend W.P., Glass D.N., Norris J.M., et al. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum. 52 (2005) 239-246
49. Flynn J.C., Wan Q., Panos J.C., McCormick D.J., Giraldo A.A., David C.S., and Kong Y.C. Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. J. Autoimmun. 18 (2002) 213-220
50. Flynn J.C., Gardas A., Wan Q., Gora M., Alsharabi G., Wei W.Z., Giraldo A.A., David C.S., Kong Y.M., and Banga J.P. Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice. Clin. Exp. Immunol. 137 (2004) 503-512
51. Flynn J.C., McCormick D.J., Brusic V., Wan Q., Panos J.C., Giraldo A.A., David C.S., and Kong Y.C. Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. Cell Immunol. 229 (2004) 79-85
52. Flynn J.C., Gilbert J.A., Meroueh C., Snower D.P., David C.S., Kong Y.C., and Banga J.P. Chronic exposure in vivo to thyrotropin receptor stimulating monoclonal antibodies sustains high thyroxine levels and thyroid hyperplasia in thyroid autoimmunity-prone HLA-DRB1*0301 transgenic mice. Immunology 122 (2007) 261-267
53. Foidart J.M., Abe S., Martin G.R., Zizic T.M., Barnett E.V., Lawley T.J., and Katz S.I. Antibodies to type II collagen in relapsing polychondritis. N. Engl. J. Med. 299 (1978) 1203-1207
54. Forsthuber T.G., Shive C.L., Wienhold W., de Graaf K., Spack E.G., Sublett R., Melms A., Kort J., Racke M.K., and Weissert R. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells. J. Immunol. 167 (2001) 7119-7125
55. Frustaci A., Cuoco L., Chimenti C., Pieroni M., Fioravanti G., Gentiloni N., Maseri A., and Gasbarrini G. Celiac disease associated with autoimmune myocarditis. Circulation 105 (2002) 2611-2618
56. Fugger L., Michie S.A., Rulifson I., Lock C.B., and McDevitt G.S. Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response. Proc. Natl. Acad. Sci. USA 91 (1994) 6151-6155
57. Fujinami R.S., von Herrath M.G., Christen U., and Whitton J.L. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin. Microbiol. Rev. 19 (2006) 80-94
58. Gebe J.A., Falk B., Unrath K., and Nepom G.T. Autoreactive T cells in a partially humanized murine model of T1D. Ann. N. Y. Acad. Sci. 1103 (2007) 69-76
59. Geluk A., Taneja V., van Meijgaarden K.E., de Vries R.R., David C.S., and Ottenhoff T.H. HLA-DR/DQ transgenic, class II deficient mice as a novel model to select for HSP T cell epitopes with immunotherapeutic or preventative vaccine potential. Biotherapy 10 (1998) 191-196
60. Geluk A., Taneja V., van Meijgaarden K.E., Zanelli E., Abou-Zeid C., Thole J.E., de Vries R.R., David C.S., and Ottenhoff T.H. Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice. Proc. Natl. Acad. Sci. USA 95 (1998) 10797-10802
61. Godkin A., Friede T., Davenport M., Stevanovic S., Willis A., Jewell D., Hill A., and Rammensee H. Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2). Int. Immunol. 9 (1997) 905-911
62. Gold R., Hartung H.P., and Toyka K.V. Animal models for autoimmune demyelinating disorders of the nervous system. Mol. Med. Today 6 (2000) 88-91
63. Gonnerman W., Cathcart E., Hayes K., Angello V., Lazzari A., and Franzblau C. Anticollagen antibody specificity in arthritic nonhuman primates. Arthritis Rheum. 27S (1984) 581
64. Gonzalez A., Nicovani S., Massardo L., Bull P., Rodriguez L., and Jacobelli S. Novel genetic markers of rheumatoid arthritis in Chilean patients, by DR serotyping and restriction fragment length polymorphism analysis. Arthritis Rheum. 35 (1992) 282-289
65. Gonzalez-Gay M.A., Nabozny G.H., Bull M.J., Zanelli E., Douhan III J., Griffiths M.M., Glimcher L.H., Luthra H.S., and David C.S. Protective role of major histocompatibility complex class II Ebd transgene on collagen-induced arthritis. J. Exp. Med. 180 (1994) 1559-1564
66. Gonzalez-Gay M.A., Zanelli E., Krco C.J., Nabozny G.H., Hanson J., Griffiths M.M., Luthra H.S., and David C.S. Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis. Immunogenetics 42 (1995) 35-40
67. Gonzalez-Gay M.A., Zanelli E., Khare S.D., Krco C.J., Zhou P., Inoko H., Griffiths M.M., Luthra H.S., and David C.S. Human leukocyte antigen-DRB1*1502 (DR2Dw12) transgene reduces incidence and severity of arthritis in mice. Hum. Immunol. 50 (1996) 54-60
68. Gould H.J., Takhar P., Harries H.E., Chevretton E., and Sutton B.J. The allergic march from Staphylococcus aureus superantigens to immunoglobulin E. Chem. Immunol. Allergy 93 (2007) 106-136
69. Gregersen P.K., Shen M., Song Q.L., Merryman P., Degar S., Seki T., Maccari J., Goldberg D., Murphy H., Schwenzer J., Wang C.Y., Winchester R.J., et al. Molecular diversity of HLA-DR4 haplotypes. Proc. Natl. Acad. Sci. USA 83 (1986) 2642-2646
70. Haines J.L., Bradford Y., Garcia M.E., Reed A.D., Neumeister E., Pericak-Vance M.A., Rimmler J.B., Menold M.M., Martin E.R., Oksenberg J.R., Barcellos L.F., Lincoln R., et al. Multiple susceptibility loci for multiple sclerosis. Hum. Mol. Genet. 11 (2002) 2251-2256
71. Hansson A.S., Heinegard D., and Holmdahl R. A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1). J. Clin. Invest. 104 (1999) 589-598
72. Hayward S.L., Bautista-Lopez N., Suzuki K., Atrazhev A., Dickie P., and Elliott J.F. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J. Immunol. 176 (2006) 7715-7725
73. He X., Kang A.H., and Stuart J.M. Accumulation of T cells reactive to type II collagen in synovial fluid of patients with rheumatoid arthritis. J. Rheumatol. 27 (2000) 589-593
74. Herman A.E., Tisch R.M., Patel S.D., Parry S.L., Olson J., Noble J.A., Cope A.P., Cox B., Congia M., and McDevitt H.O. Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif. J. Immunol. 163 (1999) 6275-6282
75. Ho S.N., Hunt H.D., Horton R.M., Pullen J.K., and Pease L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77 (1989) 51-59
76. Howell M.D., Winters S.T., Olee T., Powell H.C., Carlo D.J., and Brostoff S.W. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246 (1989) 668-670
77. Infante A.J., Thompson P.A., Krolick K.A., and Wall K.A. Determinant selection in murine experimental autoimmune myasthenia gravis. Effect of the bm12 mutation on T cell recognition of acetylcholine receptor epitopes. J. Immunol. 146 (1991) 2977-2982
78. Ito K., Bian H.J., Molina M., Han J., Magram J., Saar E., Belunis C., Bolin D.R., Arceo R., Campbell R., Falcioni F., Vidovic D., et al. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J. Exp. Med. 183 (1996) 2635-2644
79. Jackow C.M., Cather J.C., Hearne V., Asano A.T., Musser J.M., and Duvic M. Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion. Blood 89 (1997) 32-40
80. Jahromi M.M., and Eisenbarth G.S. Cellular and molecular pathogenesis of type 1A diabetes. Cell. Mol. Life Sci. 64 (2007) 865-872
81. Kaplan M.H., Sun Y.L., Hoey T., and Grusby M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382 (1996) 174-177
82. Karras E., Yang H., Lymberi P., and Christadoss P. Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice. J. Autoimmun. 24 (2005) 291-296
83. Kawamura K., Yamamura T., Yokoyama K., Chui D.H., Fukui Y., Sasazuki T., Inoko H., David C.S., and Tabira T. Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. J. Clin. Invest. 105 (2000) 977-984
84. Kent P.D., Michet Jr. C.J., and Luthra H.S. Relapsing polychondritis. Curr. Opin. Rheumatol. 16 (2004) 56-61
85. Kerlero de Rosbo N., Milo R., Lees M.B., Burger D., Bernard C.C., and Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J. Clin. Invest. 92 (1993) 2602-2608
86. Khare M., Rodriguez M., and David C.S. HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclerosis pathogenesis. Int. Immunol. 15 (2003) 535-546
87. Khare M., Mangalam A., Rodriguez M., and David C.S. HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice. J. Neuroimmunol. 169 (2005) 1-12
88. Kim K., Hofling K., Carson S., Chapman N., and Tracy S. In: Cooper J.L.T. (Ed). Myocarditis from Bench to Bedside (2002), Humana Press, Totowa, NJ
89. Klehmet J., Shive C., Guardia-Wolff R., Petersen I., Spack E.G., Boehm B.O., Weissert R., and Forsthuber T.G. T cell epitope spreading to myelin oligodendrocyte glycoprotein in HLA-DR4 transgenic mice during experimental autoimmune encephalomyelitis. Clin. Immunol. 111 (2004) 53-60
90. Kluytmans J., van Belkum A., and Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin. Microbiol. Rev. 10 (1997) 505-520
91. Kong Y.C., Lomo L.C., Motte R.W., Giraldo A.A., Baisch J., Strauss G., Hammerling G.J., and David C.S. HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene. J. Exp. Med. 184 (1996) 1167-1172
92. Kong Y.C., Flynn J.C., Banga J.P., and David C.S. Application of HLA class II transgenic mice to study autoimmune regulation. Thyroid 17 (2007) 995-1003
93. Kotb M., Norrby-Teglund A., McGeer A., El-Sherbini H., Dorak M.T., Khurshid A., Green K., Peeples J., Wade J., Thomson G., Schwartz B., and Low D.E. An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat. Med. 8 (2002) 1398-1404
94. Kouskoff V., Fehling H.J., Lemeur M., Benoist C., and Mathis D. A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice. J. Immunol. Methods 166 (1993) 287-291
95. Kravitz G.R., Dries D.J., Peterson M.L., and Schlievert P.M. Purpura fulminans due to Staphylococcus aureus. Clin. Infect. Dis. 40 (2005) 941-947
96. Kuchroo V.K., Greer J.M., Kaul D., Ishioka G., Franco A., Sette A., Sobel R.A., and Lees M.B. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol. 153 (1994) 3326-3336
97. Kurdi A., Ayesh I., Abdallat A., and Maayta U. Different B lymphocyte alloantigens associated with multiple sclerosis in Arabs and North Europeans. Lancet 1 (1977) 1123-1125
98. Lamoureux J.L., Buckner J.H., David C.S., and Bradley D.S. Mice expressing HLA-DQ6alpha8beta transgenes develop polychondritis spontaneously. Arthritis Res. Ther. 8 (2006) R134
99. Lanchbury J.S., Sakkas L.I., Marsh S.G., Bodmer J.G., Welsh K.I., and Panayi G.S. HLA-DQ beta 3.1 allele is a determinant of susceptibility to DR4-associated rheumatoid arthritis. Hum. Immunol. 26 (1989) 59-71
100. Lang B., Rothenfusser A., Lanchbury J.S., Rauh G., Breedveld F.C., Urlacher A., Albert E.D., Peter H.H., and Melchers I. Susceptibility to relapsing polychondritis is associated with HLA-DR4. Arthritis Rheum. 36 (1993) 660-664
101. Ledford D.K. Indoor allergens. J. Allergy Clin. Immunol. 94 (1994) 327-334
102. Lee K.H., Wucherpfennig K.W., and Wiley D.C. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2 (2001) 501-507
103. Lennon V.A., Lindstrom J.M., and Seybold M.E. Experimental autoimmune myasthenia gravis: cellular and humoral immune responses. Ann. N. Y. Acad. Sci. 274 (1976) 283-299
104. Letko E., Zafirakis P., Baltatzis S., Voudouri A., Livir-Rallatos C., and Foster C.S. Relapsing polychondritis: a clinical review. Semin. Arthritis Rheum. 31 (2002) 384-395
105. Levine B.B., Stember R.H., and Fotino M. Ragweed hay fever: genetic control and linkage to HL-A haplotypes. Science 178 (1972) 1201-1203
106. Li H., Llera A., Malchiodi E.L., and Mariuzza R.A. The structural basis of T cell activation by superantigens. Annu. Rev. Immunol. 17 (1999) 435-466
107. Limas C.J. Autoimmunity in dilated cardiomyopathy and the major histocompatibility complex. Int. J. Cardiol. 54 (1996) 113-116
108. Limas C.J., Limas C., Goldenberg I.F., and Blair R. Possible involvement of the HLA-DQB1 gene in susceptibility and resistance to human dilated cardiomyopathy. Am. Heart J. 129 (1995) 1141-1144
109. Lindstrom J., Shelton D., and Fujii Y. Myasthenia gravis. Adv. Immunol. 42 (1988) 233-284
110. Londei M., Savill C.M., Verhoef A., Brennan F., Leech Z.A., Duance V., Maini R.N., and Feldmann M. Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 86 (1989) 636-640
111. Lozano M.D., Rubocki R.J., Wilson J.E., McManus B.M., and Wisecarver J.L. Human leukocyte antigen class II associations in patients with idiopathic dilated cardiomyopathy. Myocarditis Treatment Trial Investigators. J. Card. Fail. 3 (1997) 97-103
112. Lund T., O'Reilly L., Hutchings P., Kanagawa O., Simpson E., Gravely R., Chandler P., Dyson J., Picard J.K., Edwards A., et al. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain. Nature 345 (1990) 727-729
113. Madsen J.M. Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents. Clin. Lab. Med. 21 (2001) 593-605
114. Madsen L.S., Andersson E.C., Jansson L., krogsgaard M., Andersen C.B., Engberg J., Strominger J.L., Svejgaard A., Hjorth J.P., Holmdahl R., Wucherpfennig K.W., and Fugger L. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat. Genet. 23 (1999) 343-347
115. Mangalam A.K., Khare M., Krco C., Rodriguez M., and David C. Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II-transgenic mice. Eur. J. Immunol. 34 (2004) 280-290
116. Mangalam A.K., Khare M., Krco C.J., Rodriguez M., and David C.S. Delineation of the minimal encephalitogenic epitope of proteolipid protein peptide(91-110) and critical residues required for induction of EAE in HLA-DR3 transgenic mice. J. Neuroimmunol. 161 (2005) 40-48
117. Mangalam A., Rodriguez M., and David C. Role of MHC class II expressing CD4+ T cells in proteolipid protein(91-110)-induced EAE in HLA-DR3 transgenic mice. Eur. J. Immunol. 36 (2006) 3356-3370
118. Mangalam A., Luckey D., Basal E., Behrens M., Rodriguez M., and David C. HLA-DQ6 (DQB1*0601)-restricted T cells Protect against Experimental Autoimmune Encephalomyelitis in HLA-DR3.DQ6 Double-transgenic Mice by Generating Anti-inflammatory IFN-γ. J. Immunol (2008) Article in press.
119. Marietta E., Black K., Camilleri M., Krause P., Rogers III R.S., David C., Pittelkow M.R., and Murray J.A. A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. J. Clin. Invest. 114 (2004) 1090-1097
120. Marone G., Rossi F.W., Detoraki A., Granata F., Genovese A., and Spadaro G. Role of superallergens in allergic disorders. Chem. Immunol. Allergy 93 (2007) 195-213
121. Marrosu M.G., Muntoni F., Murru M.R., Spinicci G., Pischedda M.P., Goddi F., Cossu P., and Pirastu M. Sardinian multiple sclerosis is associated with HLA-DR4: a serologic and molecular analysis. Neurology 38 (1988) 1749-1753
122. Marrosu M.G., Murru M.R., Costa G., Cucca F., Sotgiu S., Rosati G., and Muntoni F. Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles. Am. J. Hum. Genet. 61 (1997) 454-457
123. McCormick J.K., Yarwood J.M., and Schlievert P.M. Toxic shock syndrome and bacterial superantigens: an update. Annu. Rev. Microbiol. 55 (2001) 77-104
124. McCune W.J., Schiller A.L., Dynesius-Trentham R.A., and Trentham D.E. Type II collagen-induced auricular chondritis. Arthritis Rheum. 25 (1982) 266-273
125. McEwen B.J., and Barsoum N.J. Auricular chondritis in Wistar rats. Lab. Anim. 24 (1990) 280-283
126. Minohara M., Ochi H., Matsushita S., Irie A., Nishimura Y., and Kira J. Differences between T-cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls. Tissue Antigens 57 (2001) 447-456
127. Nabozny G.H., Baisch J.M., Cheng S., Cosgrove D., Griffiths M.M., Luthra H.S., and David C.S. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J. Exp. Med. 183 (1996) 27-37
128. Naeim F., Keesey J.C., Herrmann Jr. C., Lindstrom J., Zeller E., and Walford R.L. Association of HLA-B8, DRw3, and anti-acetylcholine receptor antibodies in myasthenia gravis. Tissue Antigens 12 (1978) 381-386
129. Nashev D., Toshkova K., Salasia S.I., Hassan A.A., Lammler C., and Zschock M. Distribution of virulence genes of Staphylococcus aureus isolated from stable nasal carriers. FEMS Microbiol. Lett. 233 (2004) 45-52
130. Neeno T., Krco C.J., Harders J., Baisch J., Cheng S., and David C.S. HLA-DQ8 transgenic mice lacking endogenous class II molecules respond to house dust allergens: identification of antigenic epitopes. J. Immunol. 156 (1996) 3191-3195
131. Nooh M.M., El-Gengehi N., Kansal R., David C.S., and Kotb M. HLA Transgenic Mice Provide Evidence for a Direct and Dominant Role of HLA Class II Variation in Modulating the Severity of Streptococcal Sepsis. J. Immunol. 178 (2007) 3076-3083
132. O'Brien R.M., Thomas W.R., and Wootton A.M. T cell responses to the purified major allergens from the house dust mite Dermatophagoides pteronyssinus. J. Allergy Clin. Immunol. 89 (1992) 1021-1031
133. Ohashi T., Yamamura T., Inobe J., Kondo T., Kunishita T., and Tabira T. Analysis of proteolipid protein (PLP)-specific T cells in multiple sclerosis: identification of PLP 95-116 as an HLA-DR2,w15-associated determinant. Int. Immunol. 7 (1995) 1771-1778
134. Okada K., Boss J.M., Prentice H., Spies T., Mengler R., Auffray C., Lillie J., Grossberger D., and Strominger J.L. Gene organization of DC and DX subregions of the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 82 (1985) 3410-3414
135. Olinde K.D., and O'Connell J.B. Inflammatory heart disease: pathogenesis, clinical manifestations, and treatment of myocarditis. Annu. Rev. Med. 45 (1994) 481-490
136. Ottenhoff T.H., Elferink D.G., Hermans J., and de Vries R.R. The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes. Hum. Immunol. 13 (1985) 1947-1952
137. Ottenhoff T.H., Ab B.K., Van Embden J.D., Thole J.E., and Kiessling R. HLA class II restriction repertoire of antigen-specific T cells. I. The main restriction determinants for antigen presentation are associated with HLA-D/DR and not with DP and DQ. J. Exp. Med. 168 (1988) 105-116
138. Ottenhoff T.H., Haanen J.B., Geluk A., Mutis T., Ab B.K., Thole J.E., van Schooten W.C., van den Elsen P.J., and de Vries R.R. Regulation of mycobacterial heat-shock protein-reactive T cells by HLA class II molecules: lessons from leprosy. Immunol. Rev. 121 (1991) 171-191
139. Papouchado B.G., Chapoval S.P., Marietta E.V., Weiler C.R., and David C.S. HLA-DQ/human CD4-restricted immune response to cockroach allergens in transgenic mice. Tissue Antigens 55 (2000) 303-311
140. Papouchado B.G., Chapoval S.P., Marietta E.V., Weiler C.R., and David C.S. Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice. J. Immunol. 167 (2001) 4627-4634
141. Patel S.D., Cope A.P., Congia M., Chen T.T., Kim E., Fugger L., Wherrett D., and Sonderstrup-McDevitt G. Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice. Proc. Natl. Acad. Sci. USA 94 (1997) 8082-8087
142. Pennesi G., and Caspi R.R. Genetic control of susceptibility in clinical and experimental uveitis. Int. Rev. Immunol. 21 (2002) 67-88
143. Pennesi G., Mattapallil M.J., Sun S.H., Avichezer D., Silver P.B., Karabekian Z., David C.S., Hargrave P.A., McDowell J.H., Smith W.C., Wiggert B., Donoso L.A., et al. A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J. Clin. Invest. 111 (2003) 1171-1180
144. Penninger J.M., and Bachmaier K. Review of microbial infections and the immune response to cardiac antigens. J. Infect. Dis. 181 Suppl. 3 (2000) S498-S504
145. Perabo F.G., Willert P.L., Wirger A., Schmidt D.H., Wardelmann E., Sitzia M., von Ruecker A., and Mueller S.C. Preclinical evaluation of superantigen (staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer. Int. J. Cancer 115 (2005) 591-598
146. Petersson K., Pettersson H., Skartved N.J., Walse B., and Forsberg G. Staphylococcal enterotoxin H induces V alpha-specific expansion of T cells. J. Immunol. 170 (2003) 4148-4154
147. Pettinelli C.B., and McFarlin D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes. J. Immunol. 127 (1981) 1420-1423
148. Pham-Dinh D., Mattei M.G., Nussbaum J.L., Roussel G., Pontarotti P., Roeckel N., Mather I.H., Artzt K., Lindahl K.F., and Dautigny A. Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region. Proc. Natl. Acad. Sci. USA 90 (1993) 386-391
149. Pham-Dinh D., Jones E.P., Pitiot G., Della Gaspera B., Daubas P., Mallet J., Le Paslier D., Fischer Lindahl K., and Dautigny A. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Immunogenetics 42 (1995) 7990-7994
150. Pimtanothai N., Parra M., Johnson A.H., David C.S., and Katovich Hurley C. Assessing the binding of four Plasmodium falciparum T helper cell epitopes to HLA-DQ and induction of T-cell responses in HLA-DQ transgenic mice. Infect. Immun. 68 (2000) 1366-1373
151. Popa E.R., Stegeman C.A., Kallenberg C.G., and Cohen Tervaert J.W. Staphylococcus aureus and Wegener's granulomatosis. Arthritis Res. 4 (2002) 77-79
152. Poussin M.A., Goluszko E., David C.S., Franco J.U., and Christadoss P. HLA-DQ6 transgenic mice resistance to experimental autoimmune myasthenia gravis is linked to reduced acetylcholine receptor-specific IFN-gamma, IL-2 and IL-10 production. J. Autoimmun. 17 (2001) 175-180
153. Proft T., and Fraser J.D. Bacterial superantigens. Clin. Exp. Immunol. 133 (2003) 299-306
154. Protti M.P., Manfredi A.A., Horton R.M., Bellone M., and Conti-Tronconi B.M. Myasthenia gravis: recognition of a human autoantigen at the molecular level. Immunol. Today 14 (1993) 363-368
155. Quandt J.A., Baig M., Yao K., Kawamura K., Huh J., Ludwin S.K., Bian H.J., Bryant M., Quigley L., Nagy Z.A., McFarland H.F., Muraro P.A., et al. Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice. J. Exp. Med. 200 (2004) 223-234
156. Rajagopalan G., Smart M.K., Marietta E.V., and David C.S. Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the {beta} cells of islets of Langerhans. Int. Immunol. 14 (2002) 1035-1044
157. Rajagopalan G., Kudva Y.C., Chen L., Wen L., and David C.S. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of Langerhans. Int. Immunol. 15 (2003) 169-179
158. Rajagopalan G., Sen M., and David C.S. In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonisits. Infect. Immun. 72 (2004) 6733-6737
159. Rajagopalan G., Singh M., Sen M., Murali N., Nath K.A., and David C.S. Intranasal Exposure to Staphylococcal Enterotoxin B Elicits an Acute Systemic Inflammatory Response. Clin. Diagn. Lab. Immunonol. 12 (2005) 647-656
160. Rajagopalan G., Sen M., Singh M., Murali N., Nath K.A., Iijima K., Kita H., Leontovich A.A., Unnikrishnan G., Patel R., and David C.S. Endogenous superantigens shape response to exogenous superantigens. Shock 25 (2006) 1119-1122
161. Rajagopalan G., Mangalam A.K., Sen M.M., Cheng S., Kudva Y.C., and David C.S. Staphylococcal enterotoxin B-induced activation and concomitant resistance to cell death in CD28-deficient HLA-DQ8 transgenic mice. Autoimmunity 40 (2007) 801-812
162. Raju R., Munn S.R., and David C.S. Cryptic determinants and promiscuous sequences on human acetylcholine receptor: HLA-dependent dichotomy in T-cell function. Hum. Immunol. 58 (1997) 237-247
163. Raju R., Zhan W.Z., Karachunski P., Conti-Fine B., Sieck G.C., and David C. T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic mice. J. Immunol. 160 (1998) 21-29
164. Raju R., Spack E.G., and David C.S. Acetylcholine receptor peptide recognition in HLA DR3-transgenic mice: in vivo responses correlate with MHC-peptide binding. J. Immunol. 167 (2001) 1118-1124
165. Raju R., Marietta E., Vinasco J., Conti-Fine B.M., Infante A.J., and David C.S. Polymorphism at the HLA-DQ locus determines susceptibility to experimental autoimmune myasthenia gravis. Hum. Immunol. 63 (2002) 4169-4174
166. Redondo M.J., and Eisenbarth G.S. Genetic control of autoimmunity in Type I diabetes and associated disorders. Diabetologia 45 (2002) 605-622
167. Rich C., Link J.M., Zamora A., Jacobsen H., Meza-Romero R., Offner H., Jones R., Burrows G.G., Fugger L., and Vandenbark A.A. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur. J. Immunol. 34 (2004) 1251-1261
168. Rose N.R. Viral damage or 'molecular mimicry'-placing the blame in myocarditis. Nat. Med. 6 (2000) 631-632
169. Rosloniec E.F., Brand D.D., Myers L.K., Whittington K.B., Gumanovskaya M., Zaller D.M., Woods A., Altmann D.M., Stuart J.M., and Kang A.H. Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen. J. Exp. Med. 185 (1997) 2573-2578
170. Rosloniec E.F., Brand D.D., Myers L.K., Esaki Y., Whittington K.B., Zaller D.M., Woods A., Stuart J.M., and Kang A.H. An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J. Immunol. 160 (1998) 1113-1122
171. Rosloniec E.F., Whittington K.B., He X., Stuart J.M., and Kang A.H. Collagen-induced arthritis mediated by HLA-DR1 (*0101) and HLA-DR4 (*0401). Am. J. Med. Sci. 327 (2004) 169-179
172. Roy C.J., Warfield K.L., Welcher B.C., Gonzales R.F., Larsen T., Hanson J., David C.S., Krakauer T., and Bavari S. Human Leukocyte Antigen-DQ8 Transgenic Mice: A Model To Examine the Toxicity of Aerosolized Staphylococcal Enterotoxin B. Infect. Immun. 73 (2005) 2452-2460
173. Sattar M.A., al-Saffar M., Guindi R.T., Sugathan T.N., and Behbehani K. Association between HLA-DR antigens and rheumatoid arthritis in Arabs. Ann. Rheum. Dis. 49 (1990) 147-149
174. Scholl P., Diez A., Karr R., Sekaly R., Trowsdale J., and Geha R. Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II molecules. J. Immunol. 144 (1990) 226-230
175. Schuppan D., and Hahn E.G. Celiac disease and its link to type 1 diabetes mellitus. J. Pediatr. Endocrinol. Metab. 14 Suppl. 1 (2001) 597-605
176. Senger S., Luongo D., Maurano F., Mazzeo M.F., Siciliano R.A., Gianfrani C., David C., Troncone R., Auricchio S., and Rossi M. Intranasal administration of a recombinant alpha-gliadin down-regulates the immune response to wheat gliadin in DQ8 transgenic mice. Immunol. Lett. 88 (2003) 127-134
177. Senger S., Maurano F., Mazzeo M.F., Gaita M., Fierro O., David C.S., Troncone R., Auricchio S., Siciliano R.A., and Rossi M. Identification of immunodominant epitopes of alpha-gliadin in HLA-DQ8 transgenic mice following oral immunization. J. Immunol. 175 (2005) 8087-8095
178. Serjeantson S.W., Gao X., Hawkins B.R., Higgins D.A., and Yu Y.L. Novel HLA-DR2-related haplotypes in Hong Kong Chinese implicate the DQB1*0602 allele in susceptibility to multiple sclerosis. Eur. J. Immunogenet. 19 (1992) 11-19
179. Sharma S.D., Nag B., Su X.M., Green D., Spack E., Clark B.R., and Sriram S. Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes. Proc. Natl. Acad. Sci. USA 88 (1991) 11465-11469
180. Silverstein R. D-galactosamine lethality model: scope and limitations. J. Endotoxin Res. 10 (2004) 147-162
181. Singal D.P., D'Souza M., Reid B., Bensen W.G., Kassam Y.B., and Adachi J.D. HLA-DQ beta-chain polymorphism in HLA-DR4 haplotypes associated with rheumatoid arthritis. Lancet 2 (1987) 1118-1120
182. Sireci G., Dieli F., Caccamo N., Barera A., Carta P., Di Sano C., Meraviglia S., Bonanno C.T., and Salerno A. A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein. Scand. J. Immunol. 58 (2003) 188-194
183. Slavin A.J., Soos J.M., Stuve O., Patarroyo J.C., Weiner H.L., Fontana A., Bikoff E.K., and Zamvil S.S. Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. J. Clin. Invest. 108 (2001) 1133-1139
184. Smith S.C., and Allen P.M. Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis. Proc. Natl. Acad. Sci. USA 89 (1992) 9131-9135
185. Sriskandan S., Unnikrishnan M., Krausz T., Dewchand H., Van Noorden S., Cohen J., and Altmann D.M. Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice. J. Infect. Dis. 184 (2001) 166-173
186. Stastny P. HLA-D and Ia antigens in rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum. 21 (1978) S139-S143
187. Stazi A.V., and Mantovani A. Possible animal models of endocrine, immune and reproductive complications of celiac disease. Minerva Med. 93 (2002) 457-470
188. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85 (1996) 299-302
189. Stewart G.A., and Thompson P.J. The biochemistry of common aeroallergens. Clin. Exp. Allergy 26 (1996) 1020-1044
190. Strauss G., Vignali D.A., Schonrich G., and Hammerling G.J. Negative and positive selection by HLA-DR3(DRw17) molecules in transgenic mice. Immunogenetics 40 (1994) 104-108
191. Stuart J.M., Cremer M.A., Kang A.H., and Townes A.S. Collagen-induced arthritis in rats. Evaluation of early immunologic events. Arthritis Rheum. 22 (1979) 1344-1351
192. Swanborg R.H. Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and autoreactivity. Immunol. Rev. 184 (2001) 129-135
193. Takahashi N. Neonatal toxic shock syndrome-like exanthematous disease (NTED). Pediatr. Int. 45 (2003) 233-237
194. Taneja V., Mehra N.K., Kailash S., Anand C., and Malaviya A.N. Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice. Indian J. Med. Res. 96 (1992) 1054-1064
195. Taneja V., Giphart M.J., Verduijn W., Naipal A., Malaviya A.N., and Mehra N.K. Polymorphism of HLA-DRB, -DQA1, and -DQB1 in rheumatoid arthritis in Asian Indians: association with DRB1*0405 and DRB1*1001. Hum. Immunol. 46 (1996) 35-41
196. Taneja V., Hansen J., Smart M., Griffiths M., Luthra H., and David C.S. Auricular chondritis in NOD.DQ8.Abetao (Ag7-/-) transgenic mice resembles human relapsing polychondritis. Int. Immunol. 9 (1997) 1843-1850
197. Taneja V., Griffiths M.M., Luthra H., and David C.S. Modulation of HLA-DQ-restricted collagen-induced arthritis by HLA-DRB1 polymorphism. Int. Immunol. 10 (1998) 1449-1457
198. Taneja V., Griffiths M., Behrens M., Luthra H.S., and David C.S. Expression of the H2-E molecule mediates protection to collagen-induced arthritis in HLA-DQ8 transgenic mice: role of cytokines. J. Clin. Invest. 112 (2003) 1213-1219
199. Taneja V., Behrens M., Cooper L.T., Yamada S., Kita H., Redfield M.M., Terzic A., and David C. Protective risk DR phenotypes in Asian Indian patients with rheumatoid arthritis. J. Mol. Cell. Cardiol. 42 (2007) 16-23
200. Tarkowski A., Klareskog L., Carlsten H., Herberts P., and Koopman W.J. Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum. 32 (1989) 1087-1092
201. Taylor J.A., Havari E., McInerney M.F., Bronson R., Wucherpfennig K.W., and Lipes M.A. A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J. Immunol. 172 (2004) 2651-2658
202. Terato K., Shimozuru Y., Katayama K., Takemitsu Y., Yamashita I., Miyatsu M., Fujii K., Sagara M., Kobayashi S., Goto M., et al. Specificity of antibodies to type II collagen in rheumatoid arthritis. Arthritis Rheum. 33 (1990) 1493-1500
203. Tiwari J.L., and Terasaki P.I. HLA-DR and disease associations. Prog. Clin. Biol. Res. 58 (1981) 151-163
204. Todd J.A., Acha-Orbea H., Bell J.I., Chao N., Fronek Z., Jacob C.O., McDermott M., Sinha A.A., Timmerman L., Steinman L., et al. A molecular basis for MHC class II--associated autoimmunity. Science 240 (1988) 1003-1009
205. Todd J.A., and Wicker L.S. Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. Immunity 15 (2001) 387-395
206. Tompkins S.M., Padilla J., Dal Canto M.C., Ting J.P., Van Kaer L., and Miller S.D. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J. Immunol. 168 (2002) 4173-4183
207. Trentham D.E., Townes A.S., and Kang A.H. Autoimmunity to type II collagen an experimental model of arthritis. J. Exp. Med. 146 (1977) 857-868
208. Trotter J.L., Pelfrey C.M., Trotter A.L., Selvidge J.A., Gushleff K.C., Mohanakumar T., and McFarland H.F. T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects. J. Neuroimmunol. 84 (1998) 172-178
209. Vaidya B., Kendall-Taylor P., and Pearce S.H. The genetics of autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 87 (2002) 5385-5397
210. Vladutiu A.O., and Rose N.R. Autoimmune murine thyroiditis relation to histocompatibility (H-2) type. Science 174 (1971) 1137-1139
211. Wang Y., Afanasyeva M., Hill S.L., and Rose N.R. Characterization of murine autoimmune myocarditis induced by self and foreign cardiac myosin. Autoimmunity 31 (1999) 151-162
212. Weinshenker B.G., Santrach P., Bissonet A.S., McDonnell S.K., Schaid D., Moore S.B., and Rodriguez M. Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study. Neurology 51 (1998) 742-747
213. Welcher B.C., Carra J.H., DaSilva L., Hanson J., David C.S., Aman M.J., and Bavari S. Lethal shock induced by streptococcal pyrogenic exotoxin A in mice transgenic for human leukocyte antigen-DQ8 and human CD4 receptors: implications for development of vaccines and therapeutics. J. Infect. Dis. 186 (2002) 501-510
214. Wen L., Wong F.S., Burkly L., Altieri M., Mamalaki C., Kioussis D., Flavell R.A., and Sherwin R.S. The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. J. Clin. Invest. 102 (1998) 871-880
215. Wen L., Wong F.S., Tang J., Chen N.Y., Altieri M., David C., Flavell R., and Sherwin R. Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. J. Exp. Med. 191 (2000) 947-957
216. Wen L., Chen N.Y., Tang J., Sherwin R., and Wong F.S. Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7. J. Clin. Invest. 107 (2001) 3635-3640
217. Wen L., Wong F.S., Sherwin R., and Mora C. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J. Immunol. 168 (2002) 97-104
218. White J., Herman A., Pullen A.M., Kubo R., Kappler J.W., and Marrack P. The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56 (1989) 27-35
219. Wicker L.S., Todd J.A., and Peterson L.B. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes- associated human MHC class II allele, DRB1*0401. Annu. Rev. Immunol. 13 (1995) 2597-2603
220. Wicker L.S., Chen S.L., Nepom G.T., Elliott J.F., Freed D.C., Bansal A., Zheng S., Herman A., Lernmark A., Zaller D.M., Peterson L.B., Rothbard J.B., et al. Type 1 diabetes genes and pathways shared by humans and NOD mice. J. Clin. Invest. 98 (1996) 29-33
221. Wicker L.S., Clark J., Fraser H.I., Garner V.E.S., Gonzalez-Munoz A., Healy B., Howlett S., Hunter K., Rainbow D., and Rosa R.L. Genetic control of autoimmune diabetes in the NOD mouse. J. Autoimmun. 25 (2005) 179-200
222. Willkens R.F., Nepom G.T., Marks C.R., Nettles J.W., and Nepom B.S. Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope. Arthritis Rheum. 34 (1991) 43-47
223. Wilson K., and Eisenbarth G.S. Immunopathogenesis and Immunotherapy of Type 1 Diabetes doi:10.1146/annurev.me.41.020190.002433. Annu. Rev. Med. 41 (1990) 497-508
224. Wolf J., Lilly F., and Shin S.I. The influence of genetic background on the susceptibility of inbred mice to streptozotocin-induced diabetes. Diabetes 33 (1984) 567-571
225. Woods A., Chen H.Y., Trumbauer M.E., Sirotina A., Cummings R., and Zaller D.M. Human major histocompatibility complex class II-restricted T cell responses in transgenic mice. J. Exp. Med. 180 (1994) 173-181
226. Wooley P.H., Luthra H.S., Stuart J.M., and David C.S. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J. Exp. Med. 154 (1981) 688-700
227. Wucherpfennig K.W. Mechanisms for the induction of autoimmunity by infectious agents. J. Clin. Invest. 108 (2001) 1097-1104
228. Yang C.L., Brinckmann J., Rui H.F., Vehring K.H., Lehmann H., Kekow J., Wolff H.H., Gross W.L., and Muller P.K. Autoantibodies to cartilage collagens in relapsing polychondritis. Arch. Dermatol. Res. 285 (1993) 245-249
229. Yelamos J., Garcia-Lozano J.R., Moreno I., Aguilera I., Gonzalez M.F., Garcia A., Nunez-Roldan A., and Sanchez B. Association of HLA-DR4-Dw15 (DRB1*0405) and DR10 with rheumatoid arthritis in a Spanish population. Arthritis Rheum. 36 (1993) 811-814
230. Yoo T.J., Lee M.K., Min Y.S., Chiang H.J., Wang K., Fujiyoshi T., Watanabe T., Krug M.S., Seyer J., and Cheng K.C. Epitope specificity and T cell receptor usage in type II collagen induced autoimmune ear disease. Cell. Immunol. 157 (1994) 249-262
231. Zamvil S.S., and Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8 (1990) 579-621
232. Zeuner M., Straub R.H., Rauh G., Albert E.D., Scholmerich J., and Lang B. Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J. Rheumatol. 24 (1997) 96-101
233. Zhou P., Anderson G.D., Savarirayan S., Inoko H., and David C.S. Thymic deletion of V beta 11+, V beta 5+ T cells in H-2E negative, HLA-DQ beta+ single transgenic mice. J. Immunol. 146 (1991) 854-859
234. Zhou P., Smart M.K., Cheng S., Savarirayan S., Inoko H., and David C.S. HLA-DQ beta chain can present mouse endogenous provirus MTV-9 product and clonally delete Tcr V beta 5+ and V beta 11+ T cells in transgenic mice. Immunogenetics 35 (1992) 219-223
235. Zorgani A., Essery S.D., Madani O.A., Bentley A.J., James V.S., MacKenzie D.A., Keeling J.W., Rambaud C., Hilton J., Blackwell C.C., Weir D.M., and Busuttil A. Detection of pyrogenic toxins of Staphylococcus aureus in sudden infant death syndrome. FEMS Immunol. Med. Microbiol. 25 (1999) 103-108