HLA molecules, bacteria and autoimmunity

Journal of Medical Microbiology

Volumn 49, Issue 4, 2000, Pages 305-311

  Ebringer, A ^b   Wilson, C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MIDDLESEX HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; HLA B27 ANTIGEN; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN;

ANKYLOSING SPONDYLITIS; AUTOIMMUNITY; BACTERIAL INFECTION; CAMPYLOBACTER; CHLAMYDIA; GASTROINTESTINAL INFECTION; HLA SYSTEM; KLEBSIELLA PNEUMONIAE; PRIORITY JOURNAL; PROTEUS MIRABILIS; REACTIVE ARTHRITIS; REVIEW; RHEUMATOID ARTHRITIS; SALMONELLA; UROGENITAL TRACT INFECTION; YERSINIA;

EID: 0012964271     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-49-4-305     Document Type: Review

References (77)

1. 1. Zabriskie JB, Hsu KC, Seegal BC. Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance. Clin Exp Immunol 1970; 7: 147-159.
2. 2. Cunningham MW, Swerlick RA. Polyspecificity of anti-Streptococcal murine monoclonal antibodies and their implications in autoimmunity. J Exp Med 1986; 164: 998-1012.
3. 3. Fenderson PG, Fischetti VA, Cunningham MW. Topomyosin shares immunologic epitopes with Group A Streptococcal M proteins. J Immunol 1989; 142; 2475-2481.
4. 4. Cunningham MW, McCormack JM, Talaber LR et al. Human monoclonal antibodies reactive with antigens of the Group A Streptococcus and human heart. J Immunol 1988; 141: 2760-2766.
5. 5. Cunningham MW, McCormack JM, Fenderson PG, Hom K, Beachey EH, Dale JB. Human and murine antibodies cross-reactive with Streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein. J Immunol 1989; 143: 2677-2683.
6. 6. Cunningham MW, Antone SM, Gulizia JM, McManus BM, Fischetti VA, Gauntt CJ. Cytotoxic and viral neutralising antibodies crossreact with Streptococcal M protein, entero-viruses, and human cardiac myosin. Proc Natl Acad Sci USA 1992; 89: 1320-1324.
7. 7. Brewerton DA, Caffrey MFP, Hart FD, James DCO, Nichols A, Sturrock RD. Ankylosing spondylitis and HLA-A27. Lancet 1973; 1: 904-907.
8. 8. Khan MA. Genetics of HLA-B27. Br J Rheumatol 1988; 27 Suppl 2: 6-11.
9. 9. Skoskieiwicz MJ, Colvin RB, Schneeberger EE, Russell PS. Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon. J Exp Med 1985; 162: 1645-1664.
10. 10. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. Structure of human class I histocompatibility antigen, HLA-A2. Nature 1987; 329: 506-512.
11. 11. Benjamin R, Parham P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today 1990; 11: 137-142.
12. 12. Ebringer A, Cowling P, Ngwa Suh et al. Crossreactivity between Klebsiella aerogenes species and HLA-B27 lymphocyte antigens as an aetiological factor in ankylosing spondylitis. In: Dausset J, Svejgaard A (eds) HLA and disease. Paris, INSERM. 1976: 27.
13. 13. Theofilopoulos AN. The basis of autoimmunity: Part 1. Mechanisms of aberrant self-recognition. Immunol Today 1995; 16: 90-98.
14. 14. Moudgil KD, Sercarz EE. Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity. J Exp Med 1993; 178: 2131-2138.
15. 15. Lin R-H, Mamula MJ, Hardin JA, Janeway CA. Induction of autoreactive B cells allows priming of autoreactive T cells. J Exp Med 1991; 173: 1433-1439.
16. 16. Granfors K, Toivanen A. IgA-anti-Yersinia antibodies in Yersinia triggered reactive arthritis. Ann Rheum Dis 1986; 45: 561-565.
17. 17. Gaston JS, Life PF, Granfors K et al. Synovial T lymphocyte recognition of organisms that trigger reactive arthritis. Clin Exp Immunol 1989; 76: 348-353.
18. 18. Hermann E, Mayet WJ, Lohse AW, Grevenstein J, Meyer Zum Büschenfelde K-H, Fleischer B. Proliferative response of synovial fluid and peripheral blood mononuclear cells to arthritogenic and non-arthritogenic microbial antigens and to the 65-kDa mycobacterial heat-shock protein. Med Microbiol Immunol 1990; 179: 215-224.
19. 19. Probst P, Hermann E, Meyer Zum Büschenfelde K-H, Fleischer B. Identification of the Yersinia enterocolitica urease beta subunit as a target for human synovial T lymphocytes in reactive arthritis. Infect Immun 1993; 61: 4507-4509.
20. 20. Mertz AKH, Daser A, Skurnik M et al. The evolutionarily conserved ribosomal protein L23 and the cationic urease subunit of Yersinia enterocolitica O:3 belong to the immunodominant antigens in Yersinia triggered reactive arthritis: implications for autoimmunity. Mol Med 1994; 1: 1-5.
21. 21. Mertz AK, Batsford SR, Curschellas E, Kist MJ, Gondolf KB. Cationic Yersinia antigen induced chronic allergic arthritis in rats. A model for reactive arthritis in humans. J Clin Invest 1991; 88: 632-642.
22. 22. Maki-Ikola O, Leirisalo-Repo M, Kantele A, Toivanen P, Granfors K. Salmonella-specific antibodies in reactive arthritis. J Infect Dis 1991; 164: 1141-1148.
23. 23. Granfors K, Jalkanen S, Lindberg AA et al. Salmonella lipopolysaccharide in synovial cells from patients with reactive arthritis. Lancet 1990; 335: 685-688.
24. 24. Inman RD, Chiu B, Johnston MEA, Vas S, Falk J. HLA class 1-related impairment in IL-2 production and lymphocyte response to microbial antigens in reactive arthritis. J Immunol 1989; 142: 4256-60.
25. 25. Granfors K, Jalkanen S, Toivanen P, Koski J, Lindberg AA. Bacterial lipopolysaccharide in synovial fluid cells in Shigella triggered reactive arthritis. J Rheumatol 1992; 19: 500.
26. 26. Sieper J, Braun J, Wu P, Hauer R, Laitko S. The possible role of Shigella in sporadic enteric reactive arthritis. Br J Rheumatol 1993; 32: 582-585.
27. 27. Welsh J, Avakian H, Cowling P et al. Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera. Br J Exp Pathol 1980; 61: 85-91.
28. 28. Avakian H, Welsh J, Ebringer A, Entwistle CC. Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera. Br J Exp Pathol 1980; 61: 92-96.
29. 29. Van Bohemen CG, Grumet FC, Zanen HC. Identification of HLA-B27M1 and -M2 cross-reactive antigens in Klebsiella, Shigella and Yersinia. Immunology 1984; 52: 607-610.
30. 30. Kono DH, Ogasawara M, Effros RB, Parks MS, Waldord RL, Yu DT. Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria. Clin Exp Immunol 1985; 61: 503-508.
31. 31. Ogasawara M, Kono DH, Yu DTY. Mimicry of human histocompatibility HLA-B27 antigens by Klebsiella pneumoniae. Infect Immun 1986; 51: 901-908.
32. 32. Schwimmbeck PL, Yu DTY, Oldstone MBA. Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. Molecular mimicry with Klebsiella pneumoniae as a potential mechanism of autoimmune disease. J Exp Med 1987; 166: 173-181.
33. 33. Husby G, Tsuchiya N, Schwimmbeck PL et al. Cross-reactive epitope with Klebsiella pneumoniae nitrogenase in articular tissue of HLA-B27+ patients with ankylosing spondylitis. Arthritis Rheum 1989; 32: 437-445.
34. 34. Ahmadi K, Wilson C, Tiwana H, Ebringer A, Shanmuganathan S, Binder A. Antibodies to Klebsiella pneumoniae nitrogenase reductase in patients with ankylosing spondylitis. Ann Rheum Dis 1998; 57: 441.
35. 35. Fielder M, Pirt SJ, Tarpey I et al. Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae. FEBS Lett 1995; 369: 243-248.
36. 36. Ebringer R, Cooke D, Cawdell DR, Cowling P, Ebringer A. Ankylosing spondylitis: Klebsiella and HLA-B27. Rheumatol Rehabil 1977; 16: 190-196.
37. 37. Ebringer R, Cawdell DR, Cowling P et al. Sequential studies in ankylosing spondylitis: Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis 1978; 37: 146-151.
38. 38. Cowling P, Ebringer R, Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis 1980; 39: 545-549.
39. 39. Eastmond CJ, Wilshaw HE, Burgess SE, Shinebaum R, Cooke EM, Wright V. The frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease. Ann Rheum Dis 1980; 39: 118-123.
40. 40. Hunter T, Harding GKM, Kaprove RE, Schroeder M-L. Fecal carriage of various Klebsiella and Enterobacter species in patients with active ankylosing spondylitis. Arthritis Rheum 1981; 24: 106-108.
41. 41. Kuberski TT, Morse HG, Rate RG, Bonnel MD. Increased recovery of Klebsiella from the gastrointestinal tract of Reiter's syndrome and ankylosing spondylitis patients. Br J Rheumatol 1983; 22 Suppl 2: 85-90.
42. 42. Veys EM, van Laere M. Serum IgG, IgM, and IgA levels in ankylosing spondylitis. Ann Rheum Dis 1977; 32: 493-496.
43. 43. Mackiewicz A, Khan MA, Reymolds TL, van der Linden S, Kushner I. Serum IgA, acute phase proteins and glycosylation of alpha 1-acid glycoprotein in ankylosing spondylitis. Ann Rheum Dis 1989; 48: 99-103.
44. 44. Lamm ME. Cellular aspects of immunoglobulin A. Adv Immunol 1976; 22; 223-290.
45. 45. Ebringer A. The relationship between Klebsiella infection and ankylosing spondylitis. In: Rooney PJ (ed) The gut and rheumatic disease. Baillières Clin Rheumatol International Practice and Research 1989; 3: 321-338.
46. 46. Trull AK, Ebringer R, Panayi GS, Colthorpe D, James DCO, Ebringer A. IgA antibodies to Klebsiella pneumoniae in ankylosing spondylitis. Scand J Rheumatol 1983; 12: 249-253.
47. 47. Trull A, Ebringer A, Panayi GS, Ebringer R, James DCO. HLA-B27 and the immune response to enterobacterial antigens in ankylosing spondylitis. Clin Exp Immunol 1984; 55: 74-80.
48. 48. Ebringer A, Ghuloom M, Ptaszynska T et al. Role of microorganisms in the aetiopathogenesis of HLA-B27 diseases. In: Veys E, Mielants H (eds) Spondyloarthropathies - involvement of the gut. Amsterdam, Elsevier, Excerpta Medica. 1987: 235-247.
49. 49. Abuljadayel I, Ebringer A, Cox NL. Antibodies to Klebsiella measured by immunofluorescence. Clin Rheumatol 1989; 8: 25.
50. 50. Shodjai-Moradi F, Ebringer A, Abuljadayel I, IgA antibody response to klebsiella in ankylosing spondylitis measured by immunoblotting. Ann Rheum Dis 1992; 51: 233-237.
51. 51. Maki-Ikola O, Lehtinen K, Granfors K, Vainionpaa R, Toivanen P. Bacterial antibodies in ankylosing spondylitis. Clin Exp Immunol 1991; 84: 472-475.
52. 52. Garcia-Latorre EA, Dominguez-Lopez ML, Jimenez-Zamudio LA et al. Cellular immune response to different antigenic fractions to Klebsiella pneumoniae in ankylosing spondylitis. 9th International Congress on Immunology. San Francisco 1995. Abstract vol 165.
53. 53. Hermann E, Sucké B, Droste U, Meyer zum Büschenfelde K-H. Klebsiella pneumoniae-reactive T cells in blood and synovial fluid of patients with ankylosing spondylitis. Arthritis Rheum 1995, 38: 1277-1282.
54. 54. Blankenberg-Sprenkels SHD, Fielder M, Feltkamp TEW, Tiwana H, Wilson C, Ebringer A. Antibodies to Klebsiella pneumoniae in Dutch patients with ankylosing spondylitis and acute anterior uveitis and to Proteus mirabilis in rheumatoid arthritis. J Rheumatol 1998; 25: 743-747.
55. 55. Fournier AM, Denizet D, Delagrange A. [Lymphography in ankylosing spondylarthritis.] Lymphographie dans la spondylarthrite ankylosante. J Radio Electrol Med Nucl 1969; 50: 773-784.
56. 56. Mielants H, Veys EM, Cuvelier C, de Vos M. Ileocolonoscopic findings in seronegative sondyloarthropathies. Br J Rheumatol 1988; 27 Suppl 2: 95-105.
57. 57. De Vos M, Mielants H, Cuvelier C, Elewaut A, Veys E. Long-term evolution of gut inflammation in patients with spondyloarthropathy. Gastroenterology 1996; 110: 1696-1703.
58. 58. Tiwana H, Wilson C, Walmsley RS et al. Antibody responses to gut bacteria in ankylosing spondylitis. Rheumatoid arthritis, Crohn's disease and ulcerative colitis. Rheumatol Int 1997; 17: 11-16.
59. 59. Nepom GT, Byers P, Seyfried CE et al. HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using oligonucleotide probes. Arthritis Rheum 1989; 32: 15-21.
60. 60. Watanabe Y, Tokunaga K, Matsuki et al. Putative amino sequence of HLA-DRB chain contributing to rheumatoid arthritis susceptibility. J Exp Med 1989; 169: 2263-2268.
61. 61. Ebringer A, Ptaszynska T, Corbett M et al. Antibodies to Proteus in rheumatoid arthritis. Lancet 1985; 2: 305-307.
62. 62. Ebringer A, Cox NL, Abuljadayel I et al. Klebsiella antibodies in ankylosing spondylitis and Proteus antibodies in rheumatiod arthritis. Br J Rheumatol 1988; 27 Suppl 2: 72-85.
63. 63. Ebringer A, Cunningham P, Ahmadi K, Wrigglesworth J, Hosseini R, Wilson C. Sequence similarity between HLA-DR1 and DR4 subtypes associated with rheumatoid arthritis and proteus/serratia membrane haemolysins. Ann Rheum Dis 1992; 51: 1245-1246.
64. 64. Wilson C, Ebringer A, Ahmadi K et al. Shared amino acid sequences between major histocompatibility complex class II glycoproteins, type XI collagen and Proteus mirabilis in rheumatoid arthritis. Ann Rheum Dix 1995; 54: 216-220.
65. 65. Takeuchi F, Kosuge E, Matsuta K et al. Antibody to a specific HLA-DR Beta 1 sequence in Japanese patients with rheumatoid arthritis. Arthritis Rheum 1990; 33: 1867-1868.
66. 66. Dybwad A, Forre O, Sioud M. Increased serum and synovial fluid antibodies to immunoselected peptides in patients with rheumatoid arthritis. Ann Rheum Dis 1996; 55: 437-441.
67. 67. Tiwana H, Wilson C, Cunningham P, Binder A, Ebringer A. Antibodies to four Gram-negative bacteria in rheumatoid arthritis which share sequences with the rheumatoid arthritis susceptibility motif. Br J Rheumatol 1996; 35: 592-594.
68. 68. Subair H, Tiwana H, Fielder M et al. Elevation in anti-Proteus antibodies in patients with rheumatoid arthritis from Bermuda and England. J Rheumatol 1995; 22: 1825-1828.
69. 69. Rogers P, Hassan J, Bresnihan B, Feighery C, Whelan A. Antibodies to Proteus in rheumatoid arthritis. Br J Rheumatol 1988; 27 Suppl 2: 90-94.
70. 70. Deighton CM, Gray JW, Bint AJ, Walker DJ. Anti-Proteus antibodies in rheumatoid arthritis same sexed siblings. Br J Rheumatol 1992; 31: 241-245.
71. 71. Kjeldsen-Kragh J, Rashid T, Dybwad A et al. Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet. Ann Rheum Dis 1995; 54: 221-224.
72. 72. Senior BW, McBride PDF, Morley KD, Kerr MA. The detection of raised levels of IgM to Proteus mirabilis in sera from patients with rheumatoid arthritis. J Med Microbiol 1995; 43: 176-184.
73. 73. Tani Y, Tiwana H, Hukuda S et al. Antibodies to Klebsiella, Proteus and HLA-B27 peptides in Japanese patients with ankylosing spondylitis and rheumatoid arthritis. J Rheumatol 1997; 24: 109-114.
74. 74. Wilson C, Thakore A, Isenberg D, Ebringer A. Correlation between anti-Proteus antibodies and isolation rates of P. mirabilis in rheumatoid arthritis. Rheumatol Int 1997; 16: 187-189.
75. 75. Wilson C, Senior BW, Tiwana H, Caparros-Wanderley W, Ebringer A. Antibiotic sensitivity and proticine typing of Proteus mirabilis strains associated with rheumatoid arthritis. Rheumatol Int 1998; 17: 203-205.
76. 76. Senior BW. The special affinity of particular types of Proteus mirabilis for the urinary tract. J Med Microbiol 1979; 12: 1-8.
77. 77. Lachmann PJ. Complement - friend or foe? Br J Rheumatol 1987; 26: 409-415.