Th17 cytokines and arthritis

Seminars in Immunopathology

Volumn 32, Issue 1, 2010, Pages 43-53

  Lubberts, Erik ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Autoimmunity; IL 17A; IL 17F; IL 22; Inflammation; T cells

Indexed keywords

CYTOKINE; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 22;

ARTHRITIS; ARTHROPATHY; CARTILAGE CELL; CONTROLLED STUDY; HUMAN; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SPONDYLOARTHROPATHY; SYSTEMIC LUPUS ERYTHEMATOSUS; TH17 CELL;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; HUMANS; INTERLEUKIN-17; INTERLEUKINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 77949655330     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-009-0189-9     Document Type: Review

References (101)

1. T Aarvak M Chabaud E Kallberg P Miossec JB Natvig 1999 Change in the Th1/Th2 phenotype of memory T-cell clones from rheumatoid arthritis synovium Scand J Immunol 50 1 9 10.1046/j.1365-3083.1999.00581.x 10404044 1:CAS:528:DyaK1MXksFamsLo%3D (Pubitemid 29298019)
2. S Abdollahi-Roodsaz LA Joosten MI Koenders I Devesa MF Roelofs TR Radstake M Heuvelmans-Jacobs S Akira MJ Nicklin F Ribeiro-Dias WB van den Berg 2008 Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis J Clin Invest 118 205 216 10.1172/JCI32639 18060042 1:CAS:528:DC%2BD1cXksFOltQ%3D%3D
3. WH Abdulahad CA Stegeman PC Limburg CG Kallenberg 2008 Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission Arthritis Rheum 58 2196 2205 10.1002/art.23557 18576340
4. WP Arend JM Dayer 1995 Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis Arthritis Rheum 38 151 160 10.1002/art.1780380202 7848304 1:STN:280:DyaK2M7ltFSnsA%3D%3D
5. SZ Ben-Sasson J Hu-Li J Quiel S Cauchetaux M Ratner I Shapira CA Dinarello WE Paul 2009 IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation Proc Natl Acad Sci USA 106 7119 7124 10.1073/pnas.0902745106 19359475
6. MP Bombara DL Webb P Conrad CW Marlor T Sarr GE Ranges TM Aune JM Greve ML Blue 1993 Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines J Leukoc Biol 54 399 406 7693840 1:CAS:528:DyaK2cXhs1Wmsrk%3D
7. FM Brennan IB McInnes 2008 Evidence that cytokines play a role in rheumatoid arthritis J Clin Invest 118 3537 3545 10.1172/JCI36389 18982160 1:CAS:528:DC%2BD1cXhtlGltLrJ
8. KA Bush KM Farmer JS Walker BW Kirkham 2002 Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein Arthritis Rheum 46 802 805 10.1002/art.10173 11920418 1:CAS:528:DC%2BD38XisFOmtLs%3D (Pubitemid 34214263)
9. KA Bush JS Walker CS Lee BW Kirkham 2001 Cytokine expression and synovial pathology in the initiation and spontaneous resolution phases of adjuvant arthritis: interleukin-17 expression is upregulated in early disease Clin Exp Immunol 123 487 495 10.1046/j.1365-2249.2001.01469.x 11298138 1:CAS:528:DC%2BD3MXjtFyjt7w%3D (Pubitemid 32289970)
10. M Chabaud JM Durand N Buchs F Fossiez G Page L Frappart P Miossec 1999 Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium Arthritis Rheum 42 963 970 10.1002/1529-0131(199905)42: 5<963::AID-ANR15>3.0.CO;2-E 10323452 1:CAS:528:DyaK1MXjtlKjurs%3D (Pubitemid 29215007)
11. Y Chung SH Chang GJ Martinez XO Yang R Nurieva HS Kang L Ma SS Watowich AM Jetten Q Tian C Dong 2009 Critical regulation of early Th17 cell differentiation by interleukin-1 signaling Immunity 30 576 587 10.1016/j.immuni.2009.02.007 19362022 1:CAS:528:DC%2BD1MXls1Sqsr0%3D
12. F Ciccia M Bombardieri A Principato A Giardina C Tripodo R Porcasi S Peralta V Franco E Giardina A Craxi C Pitzalis G Triolo 2009 Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis Arthritis Rheum 60 955 965 10.1002/art.24389 19333939 1:CAS:528:DC%2BD1MXltFenu7o%3D
13. G Codolo A Amedei AC Steere E Papinutto A Cappon A Polenghi M Benagiano SR Paccani V Sambri G Del Prete CT Baldari G Zanotti C Montecucco MM D'Elios M de Bernard 2008 Borrelia burgdorferi NapA-driven Th17 cell inflammation in Lyme arthritis Arthritis Rheum 58 3609 3617 10.1002/art.23972 18975343 1:CAS:528:DC%2BD1cXhsV2hs7fJ
14. EM Colin PS Asmawidjaja JP Van Hamburg AMC Mus M van Driel JMW Hazes JPTM van Leeuwen E Lubberts 2010 1, 25-Dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis Arthritis Rheum 62 132 142 10.1002/art.25043 20039421 1:STN:280:DC%2BC3c%2FitVGgug%3D%3D
15. Cornelissen F, Mus AMC, Asmawidjaja PS, van Hamburg JP, Tocker J, Luberts E (2009) Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ T cells. Arthritis Res Ther 11(6):R194
16. NA Daha FA Kurreeman RB Marques G Stoeken-Rijsbergen W Verduijn TW Huizinga RE Toes 2009 Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis Arthritis Rheum 60 1255 1260 10.1002/art.24503 19404967
17. IM de Kleer LR Wedderburn LS Taams A Patel H Varsani M Klein W de Jager G Pugayung F Giannoni G Rijkers S Albani W Kuis B Prakken 2004 CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis J Immunol 172 6435 6443 15128835
18. RJ Dolhain AN van der Heiden NT ter Haar FC Breedveld AM Miltenburg 1996 Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis Arthritis Rheum 39 1961 1969 10.1002/art.1780391204 8961900 1:STN:280:DyaK2s7itFagtg%3D%3D (Pubitemid 27009063)
19. PD Doodes Y Cao KM Hamel Y Wang B Farkas Y Iwakura A Finnegan 2008 Development of proteoglycan-induced arthritis is independent of IL-17 J Immunol 181 329 337 18566398 1:CAS:528:DC%2BD1cXnsVGjtb4%3D
20. T Duhen R Geiger D Jarrossay A Lanzavecchia F Sallusto 2009 Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells Nat Immunol 10 857 863 10.1038/ni.1767 19578369 1:CAS:528: DC%2BD1MXotVClsbw%3D
21. GS Firestein 2003 Evolving concepts of rheumatoid arthritis Nature 423 356 361 10.1038/nature01661 12748655 1:CAS:528:DC%2BD3sXjs1ynu7c%3D (Pubitemid 40852711)
22. M Fujimoto S Serada M Mihara Y Uchiyama H Yoshida N Koike Y Ohsugi T Nishikawa B Ripley A Kimura T Kishimoto T Naka 2008 Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses Arthritis Rheum 58 3710 3719 10.1002/art.24126 19035481 1:CAS:528:DC%2BD1MXmt1ymsQ%3D%3D
23. L Geboes L Dumoutier H Kelchtermans E Schurgers T Mitera JC Renauld P Matthys 2009 Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice Arthritis Rheum 60 390 395 10.1002/art.24220 19180498 1:CAS:528:DC%2BD1MXjt1Cgtbo%3D
24. D Herber TP Brown S Liang DA Young M Collins K Dunussi-Joannopoulos 2007 IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression J Immunol 178 3822 3830 17339481 1:CAS:528:DC%2BD2sXisVGjtrY%3D
25. K Hirota H Yoshitomi M Hashimoto S Maeda S Teradaira N Sugimoto T Yamaguchi T Nomura H Ito T Nakamura N Sakaguchi S Sakaguchi 2007 Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model J Exp Med 204 2803 2812 10.1084/jem.20071397 18025126 1:CAS:528:DC%2BD2sXhsVSgs7zK (Pubitemid 350179551)
26. R Horai A Nakajima K Habiro M Kotani S Nakae T Matsuki A Nambu S Saijo H Kotaki K Sudo A Okahara H Tanioka T Ikuse N Ishii PL Schwartzberg R Abe Y Iwakura 2004 TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice J Clin Invest 114 1603 1611 15578092 1:CAS:528:DC%2BD2cXhtVKhur3O
27. HC Hsu P Yang J Wang Q Wu R Myers J Chen J Yi T Guentert A Tousson AL Stanus TV Le RG Lorenz H Xu JK Kolls RH Carter DD Chaplin RW Williams JD Mountz 2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice Nat Immunol 9 166 175 10.1038/ni1552 18157131 1:CAS:528:DC%2BD1cXovV2mtQ%3D%3D
28. SG Hymowitz EH Filvaroff JP Yin J Lee L Cai P Risser M Maruoka W Mao J Foster RF Kelley G Pan AL Gurney AM de Vos MA Starovasnik 2001 IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding EMBO J 20 5332 5341 10.1093/emboj/20.19.5332 11574464 1:CAS:528:DC%2BD38XjtVSrug%3D%3D (Pubitemid 32959452)
29. H Ikeuchi T Kuroiwa N Hiramatsu Y Kaneko K Hiromura K Ueki Y Nojima 2005 Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine Arthritis Rheum 52 1037 1046 10.1002/art.20965 15818686 1:CAS:528:DC%2BD2MXktFCksbc%3D (Pubitemid 40530109)
30. C Infarte-Durante HF Horton MC Byrne T Kamradt 2000 Microbial lipopeptides induce the production of IL-17 in T cells J Immunol 165 6107 6115
31. H Ishigame S Kakuta T Nagai M Kadoki A Nambu Y Komiyama N Fujikado Y Tanahashi A Akitsu H Kotaki K Sudo S Nakae C Sasakawa Y Iwakura 2009 Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses Immunity 30 108 119 10.1016/j.immuni.2008.11.009 19144317 1:CAS:528:DC%2BD1MXhtlCnsb4%3D
32. II Ivanov BS McKenzie L Zhou CE Tadokoro A Lepelley JJ Lafaille DJ Cua DR Littman 2006 The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 1121 1133 10.1016/j.cell.2006.07.035 16990136 1:CAS:528:DC%2BD28XhtVCnsrrE (Pubitemid 44380299)
33. Y Iwakura S Nakae S Saijo H Ishigame 2008 The roles of IL-17A in inflammatory immune responses and host defense against pathogens Immunol Rev 226 57 79 10.1111/j.1600-065X.2008.00699.x 19161416 1:CAS:528:DC%2BD1MXhsFGls77P
34. C Jandus G Bioley JP Rivals J Dudler D Speiser P Romero 2008 Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides Arthritis Rheum 58 2307 2317 10.1002/art.23655 18668556
35. E Jang SH Cho H Park DJ Paik JM Kim J Youn 2009 A positive feedback loop of IL-21 signaling provoked by homeostatic CD4∈+∈CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice J Immunol 182 4649 4656 10.4049/jimmunol.0804350 19342640 1:CAS:528: DC%2BD1MXjvFOjtLs%3D
36. HK Kang M Liu SK Datta 2007 Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells J Immunol 178 7849 7858 17548623 1:CAS:528:DC%2BD2sXmtVKnsrk%3D
37. BW Kirkham MN Lassere JP Edmonds KM Juhasz PA Bird CS Lee R Shnier IJ Portek 2006 Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort) Arthritis Rheum 54 1122 1131 10.1002/art.21749 16572447 1:CAS:528:DC%2BD28XksVyht7c%3D (Pubitemid 43672925)
38. HJ Koenen RL Smeets PM Vink E van Rijssen AM Boots I Joosten 2008 Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells Blood 112 2340 2352 10.1182/blood-2008-01-133967 18617638 1:CAS:528: DC%2BD1cXhtFCrurbF
39. T Korn E Bettelli W Gao A Awasthi A Jager TB Strom M Oukka VK Kuchroo 2007 IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells Nature 448 484 487 10.1038/nature05970 17581588 1:CAS:528: DC%2BD2sXotFajurw%3D (Pubitemid 47123515)
40. T Korn E Bettelli M Oukka VK Kuchroo 2009 IL-17 and Th17 Cells Annu Rev Immunol 27 485 517 10.1146/annurev.immunol.021908.132710 19132915 1:CAS:528:DC%2BD1MXlsFSltrY%3D
41. S Kotake N Udagawa N Takahashi K Matsuzaki K Itoh S Ishiyama S Saito K Inoue N Kamatani MT Gillespie TJ Martin T Suda 1999 IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis J Clin Invest 103 1345 1352 10.1172/JCI5703 10225978 1:CAS:528:DyaK1MXivFans7c%3D
42. NJ Kotloski DT Nardelli SH Peterson JR Torrealba TF Warner SM Callister RF Schell 2008 Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species Clin Vaccine Immunol 15 1199 1207 10.1128/CVI.00129-08 18579699 1:CAS:528:DC%2BD1cXhtVWrsLbP
43. K Kreymborg R Etzensperger L Dumoutier S Haak A Rebollo T Buch FL Heppner JC Renauld B Becher 2007 IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis J Immunol 179 8098 8104 18056351 1:CAS:528:DC%2BD2sXhtlyitrbN
44. MA Kroenke TJ Carlson AV Andjelkovic BM Segal 2008 IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition J Exp Med 205 1535 1541 10.1084/jem.20080159 18573909 1:CAS:528:DC%2BD1cXosVKktrc%3D
45. K Kurasawa K Hirose H Sano H Endo H Shinkai Y Nawata K Takabayashi I Iwamoto 2000 Increased interleukin-17 production in patients with systemic sclerosis Arthritis Rheum 43 2455 2463 10.1002/1529-0131(200011)43:11<2455:: AID-ANR12>3.0.CO;2-K 11083268 1:CAS:528:DC%2BD3cXosFyntb0%3D
46. Q Lai Kwan Lam O King Hung Ko BJ Zheng L Lu 2008 Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis Proc Natl Acad Sci USA 105 14993 14998 10.1073/pnas.0806044105 18820032
47. RB Landewe M Boers AC Verhoeven R Westhovens MA van de Laar HM Markusse JC van Denderen ML Westedt AJ Peeters BA Dijkmans P Jacobs A Boonen DM van der Heijde S van der Linden 2002 COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention Arthritis Rheum 46 347 356 10.1002/art.10083 11840436 1:CAS:528: DC%2BD38XhvF2ru7s%3D (Pubitemid 34136571)
48. LR Lard H Visser I Speyer IE van der Horst-Bruinsma AH Zwinderman FC Breedveld JM Hazes 2001 Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies Am J Med 111 446 451 10.1016/S0002-9343(01)00872- 5 11690569 1:CAS:528:DC%2BD3MXnvFCqsrk%3D (Pubitemid 33016415)
49. YK Lee H Turner CL Maynard JR Oliver D Chen CO Elson CT Weaver 2008 Late developmental plasticity in the T helper 17 lineage Immunity 30 92 107 10.1016/j.immuni.2008.11.005 1:CAS:528:DC%2BD1MXhtlCnsLk%3D
50. MH Lexberg A Taubner A Forster I Albrecht A Richter T Kamradt A Radbruch HD Chang 2008 Th memory for interleukin-17 expression is stable in vivo Eur J Immunol 38 2654 2664 10.1002/eji.200838541 18825747 1:CAS:528:DC%2BD1cXhtlOjs7bE
51. SC Liang XY Tan DP Luxenberg R Karim K Dunussi-Joannopoulos M Collins LA Fouser 2006 Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides J Exp Med 203 2271 2279 10.1084/jem.20061308 16982811 1:CAS:528:DC%2BD28XhtVGls7fF (Pubitemid 44498362)
52. E Lubberts 2008 IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis? Cytokine 41 84 91 10.1016/j.cyto.2007.09.014 18039580 1:CAS:528:DC%2BD1cXhsl2gt7c%3D
53. E Lubberts LA Joosten B Oppers L van den Bersselaar CJ Coenen-de Roo JK Kolls P Schwarzenberger FA van de Loo WB van den Berg 2001 IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis J Immunol 167 1004 1013 11441109 1:CAS:528:DC%2BD3MXotFWktLk%3D
54. E Lubberts MI Koenders B Oppers-Walgreen L van den Bersselaar CJ Coenen-de Roo LA Joosten WB van den Berg 2004 Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion Arthritis Rheum 50 650 659 10.1002/art.20001 14872510 1:CAS:528: DC%2BD2cXhvFeiu70%3D (Pubitemid 38198849)
55. E Lubberts MI Koenders WB van den Berg 2005 The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models Arthritis Res Ther 7 29 37 10.1186/ar1478 15642151 1:CAS:528: DC%2BD2MXkvV2qsA%3D%3D (Pubitemid 40214525)
56. E Lubberts P Schwarzenberger W Huang JR Schurr JJ Peschon WB van den Berg JK Kolls 2005 Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis J Immunol 175 3360 3368 16116229 1:CAS:528:DC%2BD2MXos1GhtL0%3D
57. D Luger PB Silver J Tang D Cua Z Chen Y Iwakura EP Bowman NM Sgambellone CC Chan RR Caspi 2008 Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category J Exp Med 205 799 810 10.1084/jem.20071258 18391061 1:CAS:528: DC%2BD1cXkvVyrsro%3D
58. N Martin-Orozco Y Chung SH Chang YH Wang C Dong 2009 Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells Eur J Immunol 39 216 224 10.1002/eji.200838475 19130584 1:CAS:528:DC%2BD1MXhs1Siurc%3D
59. MJ McGeachy KS Bak-Jensen Y Chen CM Tato W Blumenschein T McClanahan DJ Cua 2007 TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology Nat Immunol 8 1390 1397 10.1038/ni1539 17994024 1:CAS:528:DC%2BD2sXhtlajtr7K (Pubitemid 350138974)
60. IB McInnes BP Leung FY Liew 2000 Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells Arthritis Res 2 374 378 10.1186/ar115 11094451 1:CAS:528:DC%2BD3cXmtVejsLo%3D (Pubitemid 32223767)
61. JA Meyers AJ Mangini T Nagai CF Roff D Sehy GA van Seventer JM van Seventer 2006 Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC Cytokine 35 235 246 10.1016/j.cyto.2006.09.001 17052915 1:CAS:528: DC%2BD28Xht1KltrnO
62. P Miossec 2003 Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy Arthritis Rheum 48 594 601 10.1002/art.10816 12632409 1:CAS:528:DC%2BD3sXislKgtLs%3D (Pubitemid 36301993)
63. J Moisan R Grenningloh E Bettelli M Oukka IC Ho 2007 Ets-1 is a negative regulator of Th17 differentiation J Exp Med 204 2825 2835 10.1084/jem.20070994 17967903 1:CAS:528:DC%2BD2sXhsVSgs73N (Pubitemid 350179553)
64. Y Morita M Yamamura M Kawashima S Harada K Tsuji K Shibuya K Maruyama H Makino 1998 Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis Arthritis Rheum 41 1669 1676 10.1002/1529-0131(199809)41:9<1669:: AID-ART19>3.0.CO;2-G 9751101 1:CAS:528:DyaK1cXmsVChuro%3D (Pubitemid 28459927)
65. CA Murphy CL Langrish Y Chen W Blumenschein T McClanahan RA Kastelein JD Sedgwick DJ Cua 2003 Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J Exp Med 198 1951 1957 10.1084/jem.20030896 14662908 1:CAS:528:DC%2BD3sXpvFakur4%3D (Pubitemid 38032126)
66. Mus AMC et al (2010) Arthritis Rheum (in press)
67. S Nakae S Saijo R Horai K Sudo S Mori Y Iwakura 2003 IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist Proc Natl Acad Sci USA 100 5986 5990 10.1073/pnas.1035999100 12721360 1:CAS:528: DC%2BD3sXjvFOlt70%3D (Pubitemid 36576918)
68. CQ Nguyen MH Hu Y Li C Stewart AB Peck 2008 Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjogren's syndrome: findings in humans and mice Arthritis Rheum 58 734 743 10.1002/art.23214 18311793 1:CAS:528:DC%2BD1cXjslWqurc%3D
69. K Nistala H Moncrieffe KR Newton H Varsani P Hunter LR Wedderburn 2008 Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers Arthritis Rheum 58 875 887 10.1002/art.23291 18311821
70. CA Notley JJ Inglis S Alzabin FE McCann KE McNamee RO Williams 2008 Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells J Exp Med 205 2491 2497 10.1084/jem.20072707 18936235 1:CAS:528:DC%2BD1cXhtlWnt7fK
71. R Nurieva XO Yang G Martinez Y Zhang AD Panopoulos L Ma K Schluns Q Tian SS Watowich AM Jetten C Dong 2007 Essential autocrine regulation by IL-21 in the generation of inflammatory T cells Nature 448 480 483 10.1038/nature05969 17581589 1:CAS:528:DC%2BD2sXotFajur8%3D (Pubitemid 47123514)
72. H Ogura M Murakami Y Okuyama M Tsuruoka C Kitabayashi M Kanamoto M Nishihara Y Iwakura T Hirano 2008 Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction Immunity 29 628 636 10.1016/j.immuni.2008.07.018 18848474 1:CAS:528:DC%2BD1cXhtlWntb%2FN
73. G Parsonage A Filer M Bik D Hardie S Lax K Howlett LD Church K Raza SH Wong E Trebilcock D Scheel-Toellner M Salmon JM Lord CD Buckley 2008 Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha Arthritis Res Ther 10 R47 10.1186/ar2406 18433499 1:CAS:528:DC%2BD1cXotlekurg%3D
74. S Radhakrishnan R Cabrera EL Schenk P Nava-Parada MP Bell VP Van Keulen RJ Marler SJ Felts LR Pease 2008 Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo J Immunol 181 3137 3147 18713984 1:CAS:528:DC%2BD1cXhtVSiu7vI
75. TR Radstake L van Bon J Broen A Hussiani R Hesselstrand DM Wuttge Y Deng R Simms E Lubberts R Lafyatis 2009 The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes PloS one 4 e5903 10.1371/journal.pone.0005903 19536281 1:CAS:528:DC%2BD1MXns1WnsLc%3D
76. K Raza F Falciani SJ Curnow EJ Ross CY Lee AN Akbar JM Lord C Gordon CD Buckley M Salmon 2005 Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin Arthritis Res Ther 7 R784 R795 10.1186/ar1733 15987480 1:CAS:528: DC%2BD2MXkt1CjsLk%3D
77. JC Renauld 2003 Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators Nat Rev 3 667 676 1:CAS:528: DC%2BD3sXntV2rs7Y%3D
78. CR Ruprecht M Gattorno F Ferlito A Gregorio A Martini A Lanzavecchia F Sallusto 2005 Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia J Exp Med 201 1793 1803 10.1084/jem.20050085 15939793 1:CAS:528:DC%2BD2MXltFansr4%3D (Pubitemid 41002898)
79. A Sakai Y Sugawara T Kuroishi T Sasano S Sugawara 2008 Identification of IL-18 and Th17 cells in salivary glands of patients with Sjogren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18 J Immunol 181 2898 2906 18684981 1:CAS:528:DC%2BD1cXptlOjsb0%3D
80. AH Sawalha KM Kaufman JA Kelly AJ Adler T Aberle J Kilpatrick EK Wakeland QZ Li AE Wandstrat DR Karp JA James JT Merrill P Lipsky JB Harley 2008 Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus Ann Rheum Dis 67 458 461 10.1136/ard.2007.075424 17720724 1:CAS:528: DC%2BD1cXltlSlu7Y%3D
81. R Singh A Aggarwal R Misra 2007 Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy J Rheumatol 34 2285 2290 17937463 1:CAS:528:DC%2BD2sXhsVeksLrP
82. KE Sullivan LM Piliero T Dharia D Goldman MA Petri 2000 3-polymorphisms of ETS1 are associated with different clinical phenotypes in SLE Hum Mutat 16 49 53 10.1002/1098-1004(200007)16:1<49::AID-HUMU9>3.0.CO;2-Z 10874305 1:CAS:528:DC%2BD3cXlsF2htb4%3D (Pubitemid 30447968)
83. C Sutton C Brereton B Keogh KH Mills EC Lavelle 2006 A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis J Exp Med 203 1685 1691 10.1084/jem.20060285 16818675 1:CAS:528:DC%2BD28XntVCgs78%3D (Pubitemid 44036274)
84. N Takahashi I Vanlaere R de Rycke A Cauwels LA Joosten E Lubberts WB van den Berg C Libert 2008 IL-17 produced by Paneth cells drives TNF-induced shock J Exp Med 205 1755 1761 10.1084/jem.20080588 18663129 1:CAS:528: DC%2BD1cXpsFOjsrk%3D
85. CN Tran SK Lundy PT White JL Endres CD Motyl R Gupta CM Wilke EA Shelden KC Chung AG Urquhart DA Fox 2007 Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells Am J Pathol 171 1588 1598 10.2353/ajpath.2007.070004 17823284 1:CAS:528:DC%2BD2sXhtlKqsLnN (Pubitemid 350158319)
86. S Trifari CD Kaplan EH Tran NK Crellin H Spits 2009 Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells Nature Immunol 10 864 871 10.1038/ni.1770 1:CAS:528:DC%2BD1MXotVClsbc%3D
87. JP van Hamburg MJ de Bruijn CR de Almeida M van Zwam M van Meurs E de Haas L Boon JN Samsom RW Hendriks 2008 Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology Eur J Immunol 38 2573 2586 10.1002/eji.200737840 18792410 1:CAS:528: DC%2BD1cXht1Sntr%2FO
88. JP van Hamburg AM Mus MJ de Bruijn L de Vogel L Boon F Cornelissen P Asmawidjaja RW Hendriks E Lubberts 2009 GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis Arthritis Rheum 60 750 759 10.1002/art.24329 19248112 1:CAS:528:DC%2BD1MXktVGmsLk%3D
89. H Visser S le Cessie K Vos FC Breedveld JM Hazes 2002 How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis Arthritis Rheum 46 357 365 10.1002/art.10117 11840437 (Pubitemid 34136572)
90. D Wang SA John JL Clements DH Percy KP Barton LA Garrett-Sinha 2005 Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease Int Immunol 17 1179 1191 10.1093/intimm/dxh295 16051621 1:CAS:528:DC%2BD2MXpsValu7s%3D (Pubitemid 41236075)
91. R Webb JT Merrill JA Kelly A Sestak KM Kaufman CD Langefeld J Ziegler RP Kimberly JC Edberg R Ramsey-Goldman M Petri JD Reveille GS Alarcon LM Vila ME Alarcon-Riquelme JA James GS Gilkeson CO Jacob KL Moser PM Gaffney TJ Vyse SK Nath P Lipsky JB Harley AH Sawalha 2009 A polymorphism within IL21R confers risk for systemic lupus erythematosus Arthritis Rheum 60 2402 2407 10.1002/art.24658 19644854 1:CAS:528:DC%2BD1MXhtV2hsLbM
92. G Wei L Wei J Zhu C Zang J Hu-Li Z Yao K Cui Y Kanno TY Roh WT Watford DE Schones W Peng HW Sun WE Paul JJ O'Shea K Zhao 2009 Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells Immunity 30 155 167 10.1016/j.immuni.2008.12.009 19144320 1:CAS:528:DC%2BD1MXhtlCnsbc%3D
93. K Wolk E Witte E Wallace WD Docke S Kunz K Asadullah HD Volk W Sterry R Sabat 2006 IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis Eur J Immunol 36 1309 1323 10.1002/eji.200535503 16619290 1:CAS:528:DC%2BD28Xlt1ekurY%3D
94. CK Wong CY Ho EK Li CW Lam 2000 Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus Lupus 9 589 593 10.1191/096120300678828703 11035433 1:CAS:528:DC%2BD3cXnsFCitbs%3D
95. L Xu A Kitani I Fuss W Strober 2007 Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta J Immunol 178 6725 6729 17513718 1:CAS:528:DC%2BD2sXlsVOnt7w%3D
96. H Yamada Y Nakashima K Okazaki T Mawatari JI Fukushi N Kaibara A Hori Y Iwamoto Y Yoshikai 2008 Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis Ann Rheum Dis 67 1299 1304 10.1136/ard.2007.080341 18063670 1:STN:280:DC%2BD1crhtlWgsg%3D%3D
97. XO Yang SH Chang H Park R Nurieva B Shah L Acero YH Wang KS Schluns RR Broaddus Z Zhu C Dong 2008 Regulation of inflammatory responses by IL-17F J Exp Med 205 1063 1075 10.1084/jem.20071978 18411338 1:CAS:528:DC%2BD1cXlvFWrsrc%3D
98. XO Yang BP Pappu R Nurieva A Akimzhanov HS Kang Y Chung L Ma B Shah AD Panopoulos KS Schluns SS Watowich Q Tian AM Jetten C Dong 2008 T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma Immunity 28 29 39 10.1016/j.immuni.2007.11.016 18164222 1:CAS:528:DC%2BD1cXht1Ontrs%3D
99. L Zhou II Ivanov R Spolski R Min K Shenderov T Egawa DE Levy WJ Leonard DR Littman 2007 IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nature Immunol 8 967 974 10.1038/ni1488 1:CAS:528:DC%2BD2sXptlSkurw%3D (Pubitemid 47300011)
100. M Ziolkowska A Koc G Luszczykiewicz K Ksiezopolska-Pietrzak E Klimczak H Chwalinska-Sadowska W Maslinski 2000 High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism J Immunol 164 2832 2838 10679127 1:CAS:528: DC%2BD3cXhsVKhur0%3D
101. S Zrioual R Ecochard A Tournadre V Lenief MA Cazalis P Miossec 2009 Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes J Immunol 182 3112 3120 10.4049/jimmunol. 0801967 19234208 1:CAS:528:DC%2BD1MXitFKgsro%3D