Combinatorial Library Design from Reagent Pharmacophore Fingerprints

Methods in Molecular Biology

Volumn 685, Issue , 2011, Pages 135-152

  Chen, Hongming ^a   Engkvist, Ola ^a   Blomberg, Niklas ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

combinatorial library design; genetic algorithm; multi objective optimisation; pharmacophore fingerprint; ProSAR; Shannon entropy; topological pharmacophore

Indexed keywords

AMINE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG DEVELOPMENT; METHODOLOGY; MOLECULAR LIBRARY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DISCOVERY; INDICATORS AND REAGENTS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

MLCS; MLOWN;

EID: 79952197171     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-60761-931-4_7     Document Type: Chapter

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