Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: Identification of novel inhibitors of matrix metalloproteinases

Journal of Medicinal Chemistry

Volumn 41, Issue 13, 1998, Pages 2194-2200

  Szardenings, Anna Katrin ^a   Harris, David ^a   Lam, Stuart ^a   Shi, Lihong ^a   Tien, David ^a   Wang, Yongwen ^a   Patel, Dinesh V ^a   Navre, Marc ^a   Campbell, David A ^a,b  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; ENZYME INHIBITOR; GELATINASE B; MATRIX METALLOPROTEINASE; PIPERAZINEDIONE; STROMELYSIN;

ARTICLE; CRYSTAL STRUCTURE; DNA LIBRARY; DRUG DESIGN; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; EXTRACELLULAR MATRIX; HYDROGEN BOND; HYDROLYSIS; NONHUMAN;

COLLAGENASES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032543517     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980133j     Document Type: Article

References (22)

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19. Numbering is based upon the order of addition as defined in Scheme 1.
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22. Assays were performed in the presence of cysteine to minimize any potential dimerization of mercaptan-DKPs.