Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

Antiviral Research

Volumn 58, Issue 3, 2003, Pages 235-242

  Shuman, Cynthia F ^a   Markgren, Per Olof ^a,c   Hämäläinen, Markku ^b   Danielson, U Helena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b BIACORE AB   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Biosensors; Drug resistance; HIV protease; Interaction kinetics; Protease inhibitors

Indexed keywords

AMPRENAVIR; INDINAVIR; NELFINAVIR; RITONAVIR; SAQUINAVIR; VIRUS ENZYME;

ARTICLE; DISSOCIATION; DRUG PROTEIN BINDING; ENZYME IMMOBILIZATION; ENZYMIC BIOSENSOR; HUMAN IMMUNODEFICIENCY VIRUS 1; KINETICS; PRIORITY JOURNAL; REDUCTION; SUBSTITUTION REACTION; VIRUS RESISTANCE; WILD TYPE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0038058949     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(03)00002-0     Document Type: Article

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