메뉴 건너뛰기




Volumn 77, Issue 8, 2003, Pages 4836-4847

Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE INHIBITOR;

EID: 20244387096     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.8.4836-4847.2003     Document Type: Article
Times cited : (207)

References (31)
  • 1
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y., and Y. Hochberg. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing, J. R. Stat. Soc. Ser. B 57:289-300.
    • (1995) J. R. Stat. Soc. Ser. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 2
    • 0031849665 scopus 로고    scopus 로고
    • In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor
    • Carrillo, A., K. D. Stewart, H. L. Sham, D. W. Norbeck, W. E. Kohlbrenner, J. M. Leonard, D. J. Kempf, and A. Molla. 1998. In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor. J. Virol. 72:7532-7541.
    • (1998) J. Virol. , vol.72 , pp. 7532-7541
    • Carrillo, A.1    Stewart, K.D.2    Sham, H.L.3    Norbeck, D.W.4    Kohlbrenner, W.E.5    Leonard, J.M.6    Kempf, D.J.7    Molla, A.8
  • 3
    • 0027943157 scopus 로고
    • Crystal structure at 1.9-Å resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases
    • Chen, Z., Y. Li, E. Chen, D. L. Hall, P. L. Darke, C. Culberson, J. A. Shafer, and L. C. Kuo. 1994. Crystal structure at 1.9-Å resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J. Biol. Chem. 269:26344-26348.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26344-26348
    • Chen, Z.1    Li, Y.2    Chen, E.3    Hall, D.L.4    Darke, P.L.5    Culberson, C.6    Shafer, J.A.7    Kuo, L.C.8
  • 6
    • 0034867418 scopus 로고    scopus 로고
    • Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations
    • Devereux, H. L., V. C. Emery, M. A. Johnson, and C. Loveday. 2001. Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations. J. Med. Virol. 65:218-224.
    • (2001) J. Med. Virol. , vol.65 , pp. 218-224
    • Devereux, H.L.1    Emery, V.C.2    Johnson, M.A.3    Loveday, C.4
  • 7
    • 0028295169 scopus 로고
    • Correlated mutations and residue contacts in proteins
    • Gobel, U., C. Sander, R. Schneider, and A. Valencia. 1994. Correlated mutations and residue contacts in proteins. Proteins 18:309-317.
    • (1994) Proteins , vol.18 , pp. 309-317
    • Gobel, U.1    Sander, C.2    Schneider, R.3    Valencia, A.4
  • 8
    • 0035887670 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 reverse-transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population
    • Gonzales, M. J., R. N. Machekano, and R. W. Shafer. 2001. Human immunodeficiency virus type 1 reverse-transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J. Infect. Dis. 184:998-1006.
    • (2001) J. Infect. Dis. , vol.184 , pp. 998-1006
    • Gonzales, M.J.1    Machekano, R.N.2    Shafer, R.W.3
  • 9
    • 0029151345 scopus 로고
    • Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure
    • Gulnik, S. V., L. I. Suvorov, B. Liu, B. Yu, B. Anderson, H. Mitsuya, and J. W. Erickson. 1995. Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry 34: 9282-9287.
    • (1995) Biochemistry , vol.34 , pp. 9282-9287
    • Gulnik, S.V.1    Suvorov, L.I.2    Liu, B.3    Yu, B.4    Anderson, B.5    Mitsuya, H.6    Erickson, J.W.7
  • 10
    • 0033921617 scopus 로고    scopus 로고
    • Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: A survey of over 6000 samples
    • Hertogs, K., S. Bloor, S. D. Kemp, C. Van den Eynde, T. M. Alcorn, R. Pauwels, M. Van Houtte, S. Staszewski, V. Miller, and B. A. Larder. 2000. Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples. AIDS 14:1203-1210.
    • (2000) AIDS , vol.14 , pp. 1203-1210
    • Hertogs, K.1    Bloor, S.2    Kemp, S.D.3    Van den Eynde, C.4    Alcorn, T.M.5    Pauwels, R.6    Van Houtte, M.7    Staszewski, S.8    Miller, V.9    Larder, B.A.10
  • 11
    • 0028014288 scopus 로고
    • Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
    • Ho, D. D., T. Toyoshima, H. Mo, D. J. Kempf, D. Norbeck, C. M. Chen, N. E. Wideburg, S. K. Burt, J. W. Erickson, and M. K. Singh. 1994. Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor. J. Virol. 68:2016-2020.
    • (1994) J. Virol. , vol.68 , pp. 2016-2020
    • Ho, D.D.1    Toyoshima, T.2    Mo, H.3    Kempf, D.J.4    Norbeck, D.5    Chen, C.M.6    Wideburg, N.E.7    Burt, S.K.8    Erickson, J.W.9    Singh, M.K.10
  • 13
    • 0034909925 scopus 로고    scopus 로고
    • Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
    • Kempf, D. J., J. D. Isaacson, M. S. King, S. C. Brun, Y. Xu, K. Real, B. M. Bernstein, A. J. Japour, E. Sun, and R. A. Rode. 2001. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J. Virol. 75:7462-7469.
    • (2001) J. Virol. , vol.75 , pp. 7462-7469
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3    Brun, S.C.4    Xu, Y.5    Real, K.6    Bernstein, B.M.7    Japour, A.J.8    Sun, E.9    Rode, R.A.10
  • 14
    • 0027297096 scopus 로고
    • Covariation of mutations in the V3 loop of human immunodeficiency virus type 1 envelope protein: An information theoretic analysis
    • Korber, B. T., R. M. Farber, D. H. Wolpert, and A. S. Lapedes. 1993. Covariation of mutations in the V3 loop of human immunodeficiency virus type 1 envelope protein: an information theoretic analysis. Proc. Natl. Acad. Sci. USA 90:7176-7180.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7176-7180
    • Korber, B.T.1    Farber, R.M.2    Wolpert, D.H.3    Lapedes, A.S.4
  • 16
    • 0034721944 scopus 로고    scopus 로고
    • Analysis of covariation in an SH3 domain sequence alignment: Applications in tertiary contact prediction and the design of compensating hydrophobic core substitutions
    • Larson, S. M., A. A. Di Nardo, and A. R. Davidson. 2000. Analysis of covariation in an SH3 domain sequence alignment: applications in tertiary contact prediction and the design of compensating hydrophobic core substitutions. J. Mol. Biol. 303:433-446.
    • (2000) J. Mol. Biol. , vol.303 , pp. 433-446
    • Larson, S.M.1    Di Nardo, A.A.2    Davidson, A.R.3
  • 17
    • 0036174439 scopus 로고    scopus 로고
    • Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: Selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors
    • Maguire, M., D. Shortino, A. Klein, W. Harris, V. Manohitharajah, M. Tisdale, R. Elston, J. Yeo, S. Randall, F. Xu, H. Parker, J. May, and W. Snowden. 2002. Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors. Antimicrob. Agents Chemother. 46:731-738.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 731-738
    • Maguire, M.1    Shortino, D.2    Klein, A.3    Harris, W.4    Manohitharajah, V.5    Tisdale, M.6    Elston, R.7    Yeo, J.8    Randall, S.9    Xu, F.10    Parker, H.11    May, J.12    Snowden, W.13
  • 18
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1
    • Martinez-Picado, J., A. V. Savara, L. Sutton, and R. T. D'Aquila. 1999. Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J. Virol. 73:3744-3752.
    • (1999) J. Virol. , vol.73 , pp. 3744-3752
    • Martinez-Picado, J.1    Savara, A.V.2    Sutton, L.3    D'Aquila, R.T.4
  • 22
    • 0029731556 scopus 로고    scopus 로고
    • Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity
    • Schock, H. B., V. M. Garsky, and L. C. Kuo. 1996. Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity. J. Biol. Chem. 271:31957-31963.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31957-31963
    • Schock, H.B.1    Garsky, V.M.2    Kuo, L.C.3
  • 23
    • 0034483901 scopus 로고    scopus 로고
    • Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance
    • Scott, W. R., and C. A. Schiffer. 2000. Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance. Struct. Fold. Des. 8:1259-1265.
    • (2000) Struct. Fold. Des. , vol.8 , pp. 1259-1265
    • Scott, W.R.1    Schiffer, C.A.2
  • 24
    • 0033060308 scopus 로고    scopus 로고
    • Identification of biased amino acid substitution patterns in human immunodeficiency virus type 1 isolates from patients treated with protease inhibitors
    • Shafer, R. W., P. Hsu, A. K. Patick, C. Craig, and V. Brendel. 1999. Identification of biased amino acid substitution patterns in human immunodeficiency virus type 1 isolates from patients treated with protease inhibitors. J. Virol. 73:6197-6202.
    • (1999) J. Virol. , vol.73 , pp. 6197-6202
    • Shafer, R.W.1    Hsu, P.2    Patick, A.K.3    Craig, C.4    Brendel, V.5
  • 25
    • 0032947107 scopus 로고    scopus 로고
    • Human immunodeficiency virus reverse transcriptase and protease sequence database
    • Shafer, R. W., D. Stevenson, and B. Chan. 1999. Human immunodeficiency virus reverse transcriptase and protease sequence database. Nucleic Acids Res. 27:348-352.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 348-352
    • Shafer, R.W.1    Stevenson, D.2    Chan, B.3
  • 26
    • 0032103187 scopus 로고    scopus 로고
    • Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients
    • Shafer, R. W., M. A. Winters, S. Palmer, and T. C. Merigan. 1998. Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients. Ann. Intern. Med. 128:906-911.
    • (1998) Ann. Intern. Med. , vol.128 , pp. 906-911
    • Shafer, R.W.1    Winters, M.A.2    Palmer, S.3    Merigan, T.C.4
  • 27
    • 0026344399 scopus 로고
    • The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU
    • Spinelli, S., Q. Z. Liu, P. M. Alzari, P. H. Hirel, and R. J. Poljak. 1991. The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU. Biochimie 73:1391-1396.
    • (1991) Biochimie , vol.73 , pp. 1391-1396
    • Spinelli, S.1    Liu, Q.Z.2    Alzari, P.M.3    Hirel, P.H.4    Poljak, R.J.5
  • 29
    • 0035910029 scopus 로고    scopus 로고
    • Computational study of protein specificity: The molecular basis of HIV-1 protease drug resistance
    • Wang, W., and P. A. Kollman. 2001. Computational study of protein specificity: the molecular basis of HIV-1 protease drug resistance. Proc. Natl. Acad. Sci. USA 98:14937-14942.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14937-14942
    • Wang, W.1    Kollman, P.A.2
  • 30
    • 0027218692 scopus 로고
    • Structure-based inhibitors of HIV-1 protease
    • Wlodawer, A., and J. W. Erickson. 1993. Structure-based inhibitors of HIV-1 protease. Annu. Rev. Biochem. 62:543-585.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 543-585
    • Wlodawer, A.1    Erickson, J.W.2
  • 31
    • 0036145503 scopus 로고    scopus 로고
    • A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site
    • Yoshimura, K., R. Kato, M. F. Kavlick, A. Nguyen, V. Maroun, K. Maeda, K. A. Hussain, A. K. Ghosh, S. V. Gulnik, J. W. Erickson, and H. Mitsuya. 2002. A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site. J. Virol. 76:1349-1358.
    • (2002) J. Virol. , vol.76 , pp. 1349-1358
    • Yoshimura, K.1    Kato, R.2    Kavlick, M.F.3    Nguyen, A.4    Maroun, V.5    Maeda, K.6    Hussain, K.A.7    Ghosh, A.K.8    Gulnik, S.V.9    Erickson, J.W.10    Mitsuya, H.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.