-
1
-
-
0022495870
-
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
-
Adachi, A., H. E. Gendelman, S. Koenig, T. Folks, R. Willey, A. Rabson, and M. A. Martin. 1986. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59:284-291.
-
(1986)
J. Virol.
, vol.59
, pp. 284-291
-
-
Adachi, A.1
Gendelman, H.E.2
Koenig, S.3
Folks, T.4
Willey, R.5
Rabson, A.6
Martin, M.A.7
-
2
-
-
0344746430
-
Inhibitors of HIV-1 protease
-
P. Veerapandian (d.), Marcel Dekker, Inc., New York, N.Y.
-
Appell, K. 1997. Inhibitors of HIV-1 protease, p. 1-39. In P. Veerapandian (d.), Structure-based drug design. Marcel Dekker, Inc., New York, N.Y.
-
(1997)
Structure-based Drug Design
, pp. 1-39
-
-
Appell, K.1
-
3
-
-
0030979361
-
Antiretroviral therapy for HIV infection in 1947
-
Carpenter, C. C. J., M. A. Fischl, S. M. Hammer, M. S. Hirsch, D. M. Jacobsen, D. A. Katzenstein, J. S. G. Montaner, D. D. Richman, M. S. Saag, R. T. Schooley, M. A. Thompson, S. Vella, P. G. Yeni, and P. A. Volberding. 1997. Antiretroviral therapy for HIV infection in 1947. JAMA 277:1962-1969.
-
(1997)
JAMA
, vol.277
, pp. 1962-1969
-
-
Carpenter, C.C.J.1
Fischl, M.A.2
Hammer, S.M.3
Hirsch, M.S.4
Jacobsen, D.M.5
Katzenstein, D.A.6
Montaner, J.S.G.7
Richman, D.D.8
Saag, M.S.9
Schooley, R.T.10
Thompson, M.A.11
Vella, S.12
Yeni, P.G.13
Volberding, P.A.14
-
4
-
-
0029131607
-
Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials
-
Chen, Z., H. B. Schock, D. Hall, E. Chen, and L. C. Kuo. 1995. Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials. J. Biol. Chem. 270:21433-21436.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21433-21436
-
-
Chen, Z.1
Schock, H.B.2
Hall, D.3
Chen, E.4
Kuo, L.C.5
-
5
-
-
2442723342
-
Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine
-
Collier, A. C., R. W. Coombs, D. A. Schoenfeld, R. L. Bassett, J. Timpone, A. Baruch, M. Jones, K. Facey, C. Whitacre, V. J. McAuliffe, H. M. Friedman, T. C. Merigan, R. C. Reichman, C. Hooper, and L. Corey. 1996. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. N. Engl. J. Med. 334:1011-1017.
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 1011-1017
-
-
Collier, A.C.1
Coombs, R.W.2
Schoenfeld, D.A.3
Bassett, R.L.4
Timpone, J.5
Baruch, A.6
Jones, M.7
Facey, K.8
Whitacre, C.9
McAuliffe, V.J.10
Friedman, H.M.11
Merigan, T.C.12
Reichman, R.C.13
Hooper, C.14
Corey, L.15
-
6
-
-
0342323915
-
A randomized phase II dose range-finding study of the HIV protease inhibitor VIRACEPT® as monotherapy in HIV positive patients
-
abstr. Tu.B.2129. Vancouver, Canada
-
Conant, M., M. Markowitz, A. Hurley, D. Ho, J. Peterkin, and S. Chapman. 1996 A randomized phase II dose range-finding study of the HIV protease inhibitor VIRACEPT® as monotherapy in HIV positive patients, abstr. Tu.B.2129. In Abstracts of the XI International Conference on AIDS. Vancouver, Canada.
-
(1996)
Abstracts of the XI International Conference on AIDS
-
-
Conant, M.1
Markowitz, M.2
Hurley, A.3
Ho, D.4
Peterkin, J.5
Chapman, S.6
-
7
-
-
0028943992
-
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
-
Condra, J. H., W. A. Schleif, O. M. Blahy, L. J. Gabryelski, D. J. Graham, J. C. Quintero, A. Rhodes, H. L. Robbins, E. Roth, and M. Shivaprakash. 1995. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 374:569-571.
-
(1995)
Nature
, vol.374
, pp. 569-571
-
-
Condra, J.H.1
Schleif, W.A.2
Blahy, O.M.3
Gabryelski, L.J.4
Graham, D.J.5
Quintero, J.C.6
Rhodes, A.7
Robbins, H.L.8
Roth, E.9
Shivaprakash, M.10
-
8
-
-
10344263394
-
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor
-
Condra, J. H., D. J. Holder, W. A. Schleif, O. M. Blahy, R. M. Danovich, L. J. Gabryelski, D. J. Graham, D. Laird, J. C. Quintero, A. Rhodes, H. L. Robbins, E. Roth, M. Shivaprakash, T. Yang, J. A. Chodakewitz, P. J. Deutsch, Randi Y. Leavitt, F. E. Massari, J. W. Mellors, K. E. Squires, R. T. Steigbigel, H. Teppler, and E. A. Emini. 1996. Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J. Virol. 70:8270-8276.
-
(1996)
J. Virol.
, vol.70
, pp. 8270-8276
-
-
Condra, J.H.1
Holder, D.J.2
Schleif, W.A.3
Blahy, O.M.4
Danovich, R.M.5
Gabryelski, L.J.6
Graham, D.J.7
Laird, D.8
Quintero, J.C.9
Rhodes, A.10
Robbins, H.L.11
Roth, E.12
Shivaprakash, M.13
Yang, T.14
Chodakewitz, J.A.15
Deutsch, P.J.16
Leavitt, R.Y.17
Massari, F.E.18
Mellors, J.W.19
Squires, K.E.20
Steigbigel, R.T.21
Teppler, H.22
Emini, E.A.23
more..
-
9
-
-
0345176617
-
Treatment with saquinavir (Invirase™) should leave the majority of patients the option to use other HIV proteinase inhibitors
-
Whistler, Canada
-
Craig, J. C., I. B. Duncan, S. Gilbert, H. Jacobsen, R. Jupp, A. Moffatt, E. Race, N. A. Roberts, J. S. Mills, J. Mous, J. Sheldon, P. W. Tomlinson, and L. N. Whittaker. 1996. Treatment with saquinavir (Invirase™) should leave the majority of patients the option to use other HIV proteinase inhibitors, p. 32. In Abstracts of the Fifth International Workshop on HIV Drug Resistance, Whistler, Canada.
-
(1996)
Abstracts of the Fifth International Workshop on HIV Drug Resistance
, pp. 32
-
-
Craig, J.C.1
Duncan, I.B.2
Gilbert, S.3
Jacobsen, H.4
Jupp, R.5
Moffatt, A.6
Race, E.7
Roberts, N.A.8
Mills, J.S.9
Mous, J.10
Sheldon, J.11
Tomlinson, P.W.12
Whittaker, L.N.13
-
10
-
-
0028846165
-
A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease
-
Danner, S. A., A. Carr, J. M. Leonard, L. M. Lehman, F. Gudiol, J. Gonzales, A. Raventos, R. Rubio, E. Bouza, V. Pintado, A. G. Aguado, J. Garcia De Lomas, R. Delgado, J. C. C. Borleffs, A. Hsu, J. M. Valdes, C. A. B. Boucher, and D. A. Cooper. 1995. A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. N. Engl. J. Med. 333:1528-1533.
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 1528-1533
-
-
Danner, S.A.1
Carr, A.2
Leonard, J.M.3
Lehman, L.M.4
Gudiol, F.5
Gonzales, J.6
Raventos, A.7
Rubio, R.8
Bouza, E.9
Pintado, V.10
Aguado, A.G.11
De Garcia Lomas, J.12
Delgado, R.13
Borleffs, J.C.C.14
Hsu, A.15
Valdes, J.M.16
Boucher, C.A.B.17
Cooper, D.A.18
-
12
-
-
0345569340
-
A randomized phase II study of VIRACEPT®, a novel HIV protease inhibitor, used in combination with stavudine vs. stavudine alone
-
abstr. Mo.B.413. Vancouver, Canada
-
Gathe, J., Jr., B. Burkhardt, P. Hawley, M. Conant, J. Peterkin, and S. Chapman. 1996. A randomized phase II study of VIRACEPT®, a novel HIV protease inhibitor, used in combination with stavudine vs. stavudine alone, abstr. Mo.B.413. In Abstracts of the XI International Conference on AIDS, Vancouver, Canada.
-
(1996)
Abstracts of the XI International Conference on AIDS
-
-
Gathe J., Jr.1
Burkhardt, B.2
Hawley, P.3
Conant, M.4
Peterkin, J.5
Chapman, S.6
-
13
-
-
0442268112
-
A controlled trial of two nucleoside analogues plus indinavir in persona with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
-
Hammer, S. M., K. E. Squires, M. D. Hughes, J. M. Grimes, L. M. Demeter, J. S. Currier, J. J. Eron, J. E. Feinberg, H. H. Balfour, L. R. Deyton, J. A. Chodakewitz, and M. A. Fischl. 1997. A controlled trial of two nucleoside analogues plus indinavir in persona with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N. Engl. J. Med. 337:725-733.
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 725-733
-
-
Hammer, S.M.1
Squires, K.E.2
Hughes, M.D.3
Grimes, J.M.4
Demeter, L.M.5
Currier, J.S.6
Eron, J.J.7
Feinberg, J.E.8
Balfour, H.H.9
Deyton, L.R.10
Chodakewitz, J.A.11
Fischl, M.A.12
-
14
-
-
0345629011
-
Experience with a ritonavir/saquinavir based regimen for the treatment ot HIV-infection in subjects developing increased viral loads while receiving nelfinavir
-
abstr. 1-204. Toronto, Canada. American Society for Microbiology, Washington, D.C.
-
Henry K., E. Kane, H. Melroe, J. Simpson, A. Patick, and D. Winslow. 1997. Experience with a ritonavir/saquinavir based regimen for the treatment ot HIV-infection in subjects developing increased viral loads while receiving nelfinavir, abstr. 1-204. In Program and Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada. American Society for Microbiology, Washington, D.C.
-
(1997)
Program and Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Henry, K.1
Kane, E.2
Melroe, H.3
Simpson, J.4
Patick, A.5
Winslow, D.6
-
15
-
-
0003244062
-
The safety of Viracept® (nelfinavir mesylate, NVR) in pivotal phase II/III double-blind randomized controlled trials as monotherapy and in combination with either d4T or AZT/3TC
-
abstr. 240 Washington, D.C.
-
Henry, K., A. Lamarca, R. Myers, and S. Chapman for the Viracept Collaborative Study Group and Agouron Pharmaceuticals. 1997. The safety of Viracept® (nelfinavir mesylate, NVR) in pivotal phase II/III double-blind randomized controlled trials as monotherapy and in combination with either d4T or AZT/3TC, abstr. 240. In Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections, Washington, D.C.
-
(1997)
Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections
-
-
Henry, K.1
Lamarca, A.2
Myers, R.3
Chapman, S.4
-
16
-
-
0344746427
-
Phenotypic resistance testing (PR-RT-Antivirogram™) of clinical HIV-1 isolates confirms the unique and different resistance pathway of nelfinavir
-
latebreaker abstr. 906. Hamburg, Germany
-
Hertogs, K., A. Patick, P. Schel, A. Van Cauwenberge, M. Markowitz, U. Kuritzkes, B. Anderson, and R. Pauwels. 1997. Phenotypic resistance testing (PR-RT-Antivirogram™) of clinical HIV-1 isolates confirms the unique and different resistance pathway of nelfinavir, latebreaker abstr. 906. In Abstracts of the 6th European Conference on Clinical Aspects and Treatment of HIV Infection, Hamburg, Germany.
-
(1997)
Abstracts of the 6th European Conference on Clinical Aspects and Treatment of HIV Infection
-
-
Hertogs, K.1
Patick, A.2
Schel, P.3
Van Cauwenberge, A.4
Markowitz, M.5
Kuritzkes, U.6
Anderson, B.7
Pauwels, R.8
-
17
-
-
0028014288
-
Characterization of human immunodenciency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
-
Ho, D. D., T. Tovoshima, H. Mo, D. J. Kempf, D. Norbeck, C.-M. Chen, N. E. Wideburg, S. K. Burt, J. W. Erickson, and M. K. Singh. 1994. Characterization of human immunodenciency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor. J. Virol. 68:2016-2020.
-
(1994)
J. Virol.
, vol.68
, pp. 2016-2020
-
-
Ho, D.D.1
Tovoshima, T.2
Mo, H.3
Kempf, D.J.4
Norbeck, D.5
Chen, C.-M.6
Wideburg, N.E.7
Burt, S.K.8
Erickson, J.W.9
Singh, M.K.10
-
18
-
-
0030789573
-
Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir
-
Ives, K. J., H. Jacobsen, S. A. Galpin, M. M. Garaev, L. Dorrell, J. Mous, K. Bragman and J. N. Weber. 1997. Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir. J. Antimicrob. Chemother. 39:771-779.
-
(1997)
J. Antimicrob. Chemother.
, vol.39
, pp. 771-779
-
-
Ives, K.J.1
Jacobsen, H.2
Galpin, S.A.3
Garaev, M.M.4
Dorrell, L.5
Mous, J.6
Bragman, K.7
Weber, J.N.8
-
19
-
-
0028843163
-
Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor RO 31-8959
-
Jacobsen, H., K. Yasargil, D. L. Winslow, J. C. Craig, A. Krohn, I. B. Duncan, and J. Mous. 1995. Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor RO 31-8959. Virology 206:527-34.
-
(1995)
Virology
, vol.206
, pp. 527-534
-
-
Jacobsen, H.1
Yasargil, K.2
Winslow, D.L.3
Craig, J.C.4
Krohn, A.5
Duncan, I.B.6
Mous, J.7
-
20
-
-
0029824426
-
In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: Mutations, kinetics and frequencies
-
Jacobsen, H., M. Hänggi, M. Ott, I. B. Duncan, S. Owen, M. Andreoni, S. Vella and J. Mous. 1996. In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: mutations, kinetics and frequencies. J. Infect. Dis. 173:1379-1387.
-
(1996)
J. Infect. Dis.
, vol.173
, pp. 1379-1387
-
-
Jacobsen, H.1
Hänggi, M.2
Ott, M.3
Duncan, I.B.4
Owen, S.5
Andreoni, M.6
Vella, S.7
Mous, J.8
-
21
-
-
0027270541
-
Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates
-
Japour, A. J., D. L. Mayers, V. A. Johnson, D. R. Kuritzkes, L. A. Beckett, J.-M. Arduino, J. Lane, R. J. Black, P. S. Reichelderfer, R. T. D'Aquila, C. S. Crumpacker, The RV-43 Study Group, and The Aids Clinical Trials Group, Virology Committee Resistance Working Group. 1993. Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. Antimicrob. Agents Chemother. 37:1095-1101.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1095-1101
-
-
Japour, A.J.1
Mayers, D.L.2
Johnson, V.A.3
Kuritzkes, D.R.4
Beckett, L.A.5
Arduino, J.-M.6
Lane, J.7
Black, R.J.8
Reichelderfer, P.S.9
D'Aquila, R.T.10
Crumpacker, C.S.11
-
22
-
-
14444281534
-
Viracept (nelfinavir mesylate, AG1343): A potent, orally bioavailable inhibitor of HIV-1 protease
-
Kaldor, S. W., V. J. Kalish, J. F. Davies II, B. V. Shelly, J. E. Fritz, K. Appelt, J. A. Burgess, K. M. Campanale, N. Y. Chirgadze, D. K. Clawson, B. A. Dressman, S. D. Hatch, D. A. Khalil, M. B. Kosa, P. P. Lubbehusen, M. A. Myesing, A. K. Patick, S. H. Reich, K. S. Su, and J. H. Tatlock. 1997. Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J. Med. Chem. 40:3979-3985.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 3979-3985
-
-
Kaldor, S.W.1
Kalish, V.J.2
Davies J.F. II3
Shelly, B.V.4
Fritz, J.E.5
Appelt, K.6
Burgess, J.A.7
Campanale, K.M.8
Chirgadze, N.Y.9
Clawson, D.K.10
Dressman, B.A.11
Hatch, S.D.12
Khalil, D.A.13
Kosa, M.B.14
Lubbehusen, P.P.15
Myesing, M.A.16
Patick, A.K.17
Reich, S.H.18
Su, K.S.19
Tatlock, J.H.20
more..
-
23
-
-
15844378825
-
Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays
-
Kozal, M. J., N. Shah, N. Shen, R. Yang, R. Fucini, T. C. Merigan, D. D. Richman, D. Morris, E. Hubbell, M. Chee, and T. R. Gingeras. 1996. Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat. Med. 2:753-759.
-
(1996)
Nat. Med.
, vol.2
, pp. 753-759
-
-
Kozal, M.J.1
Shah, N.2
Shen, N.3
Yang, R.4
Fucini, R.5
Merigan, T.C.6
Richman, D.D.7
Morris, D.8
Hubbell, E.9
Chee, M.10
Gingeras, T.R.11
-
24
-
-
0344314223
-
Prevalence of protease inhibitor (PRI) and reverse transcriptase inhibitor (RTI) drug-resistance mutations in a rural Iowa HIV+ population: Implication for treatment
-
abstr. 9. Washington, D.C.
-
Kozal, M., N. Leahy, J. Ross, N. Swack, and J. Stapleton. 1997 Prevalence of protease inhibitor (PRI) and reverse transcriptase inhibitor (RTI) drug-resistance mutations in a rural Iowa HIV+ population: implication for treatment, abstr. 9. In Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections, Washington, D.C.
-
(1997)
Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections
-
-
Kozal, M.1
Leahy, N.2
Ross, J.3
Swack, N.4
Stapleton, J.5
-
25
-
-
9044230526
-
In vivo sequence diversity of the protease of human immunodeficiency virus type 1: Presence of protease inhibitor-resistant variants in untreated subjects
-
Lech, W. J., G. Wang, Y. L. Yang, Y. Chee, K. Dorman, D. McCrae, L. C. Lazzeroni, J. W. Erickson, J. S. Sinsheimer, and A. H. Kaplan. 1996. In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J. Virol. 70:2038-2043.
-
(1996)
J. Virol.
, vol.70
, pp. 2038-2043
-
-
Lech, W.J.1
Wang, G.2
Yang, Y.L.3
Chee, Y.4
Dorman, K.5
McCrae, D.6
Lazzeroni, L.C.7
Erickson, J.W.8
Sinsheimer, J.S.9
Kaplan, A.H.10
-
26
-
-
0028854676
-
Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
-
Markowitz, M., H. Mo, D. J. Kempf,. D. W. Norbeck, T. Narayana Bhat, J. W. Erickson, and D. D. Ho. 1995. Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J. Virol. 69:701-706.
-
(1995)
J. Virol.
, vol.69
, pp. 701-706
-
-
Markowitz, M.1
Mo, H.2
Kempf, D.J.3
Norbeck, D.W.4
Narayana Bhat, T.5
Erickson, J.W.6
Ho, D.D.7
-
27
-
-
0028806725
-
A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
-
Markowitz, M., M. Saag, W. G. Powderly, A. M. Hurley, A. Hsu, J. M. Valdes, D. Henry, F. Sattler, A. La Marca, J. M. Leonard, and D. D. Ho. 1995. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N. Engl. J. Med. 333:1534-1539.
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 1534-1539
-
-
Markowitz, M.1
Saag, M.2
Powderly, W.G.3
Hurley, A.M.4
Hsu, A.5
Valdes, J.M.6
Henry, D.7
Sattler, F.8
La Marca, A.9
Leonard, J.M.10
Ho, D.D.11
-
28
-
-
26844441959
-
Triple therapy with nelfinavir in combination with AZT and 3TC in 12 antiretroviral-naïve subjects chronically infected with HIV-1
-
Atlanta, Ga.
-
Markowitz, M., D. Winslow, Y. Cao, A. Hurley, R. O'Donavan, and B. Anderson. 1997. Triple therapy with nelfinavir in combination with AZT and 3TC in 12 antiretroviral-naïve subjects chronically infected with HIV-1. In Abstracts of the 10th International Conference on Antiviral Research, Atlanta, Ga.
-
(1997)
Abstracts of the 10th International Conference on Antiviral Research
-
-
Markowitz, M.1
Winslow, D.2
Cao, Y.3
Hurley, A.4
O'Donavan, R.5
Anderson, B.6
-
29
-
-
3643060051
-
A preliminary evaluation of nelfinavir mesylate, an inhibitor of HIV-1 protease, to treat HIV infection
-
in press
-
Markowitz, M., M. Conant, A. Hurley, R. Schluger, M. Duran, J. Peterkin, S. Chapman, A. Patick, A. Henricks, G. J. Yuen, W. Hoskins, N. Clendennin, and D. D. Ho. A preliminary evaluation of nelfinavir mesylate, an inhibitor of HIV-1 protease, to treat HIV infection. J. Infect. Dis., in press.
-
J. Infect. Dis.
-
-
Markowitz, M.1
Conant, M.2
Hurley, A.3
Schluger, R.4
Duran, M.5
Peterkin, J.6
Chapman, S.7
Patick, A.8
Henricks, A.9
Yuen, G.J.10
Hoskins, W.11
Clendennin, N.12
Ho, D.D.13
-
30
-
-
0030993833
-
Human immunodeficiency virus type 1 protease inhibitors
-
McDonald, C. K., and D. R. Kuritzkes. 1997. Human immunodeficiency virus type 1 protease inhibitors. Arch. Intern. Med. 157:951-959.
-
(1997)
Arch. Intern. Med.
, vol.157
, pp. 951-959
-
-
McDonald, C.K.1
Kuritzkes, D.R.2
-
31
-
-
15444377672
-
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
-
Molla, A., M. Korneyeva, Q. Gao, S. Vasavanonda, P. J. Schipper, H.-M. Mo, M. Markowitz, T. Chernyavskiy, P. Niu, N. Lyons, A. Hsu, G. R. Granneman, D. D. Ho, C. A. B. Boucher, J. M. Leonard, D. W. Norbeck, and D. J. Kempf. 1996. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat. Med. 2:760-766.
-
(1996)
Nat. Med.
, vol.2
, pp. 760-766
-
-
Molla, A.1
Korneyeva, M.2
Gao, Q.3
Vasavanonda, S.4
Schipper, P.J.5
Mo, H.-M.6
Markowitz, M.7
Chernyavskiy, T.8
Niu, P.9
Lyons, N.10
Hsu, A.11
Granneman, G.R.12
Ho, D.D.13
Boucher, C.A.B.14
Leonard, J.M.15
Norbeck, D.W.16
Kempf, D.J.17
-
32
-
-
0003518435
-
-
Los Alamos National Laboratory, Los Alamos, N.Mex.
-
Myers, G., S. Wain-Hobson, L. E. Henderson, B. Korber, K.-T. Jeang, and G. N. Pavlakis. 1993. Human retroviruses and AIDS. Los Alamos National Laboratory, Los Alamos, N.Mex.
-
(1993)
Human Retroviruses and AIDS
-
-
Myers, G.1
Wain-Hobson, S.2
Henderson, L.E.3
Korber, B.4
Jeang, K.-T.5
Pavlakis, G.N.6
-
33
-
-
0029092503
-
In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity of hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease
-
Partaledis, J. A., K. Yamaguchi, M. Tisdale, E. E. Blair, C. Falcione, B. Maschera, R. E. Myers, S. Pazhanisamy, O. Futer, A. B. Cullinan, C. M. Stuver, R. A. Byrn, and D. J. Livingston. 1995. In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity of hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease. J. Virol. 69:5228-5235.
-
(1995)
J. Virol.
, vol.69
, pp. 5228-5235
-
-
Partaledis, J.A.1
Yamaguchi, K.2
Tisdale, M.3
Blair, E.E.4
Falcione, C.5
Maschera, B.6
Myers, R.E.7
Pazhanisamy, S.8
Futer, O.9
Cullinan, A.B.10
Stuver, C.M.11
Byrn, R.A.12
Livingston, D.J.13
-
34
-
-
0028949246
-
Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor
-
Patick, A. K., R. Rose, J. Greytok, C. M. Bechtold, M. A. Hermsmeier, P. T. Chen, J. C. Barrish, R. Zahler, R. J. Colonno, and P.-F. Lin. 1995. Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor. J. Virol. 69:2148-2152.
-
(1995)
J. Virol.
, vol.69
, pp. 2148-2152
-
-
Patick, A.K.1
Rose, R.2
Greytok, J.3
Bechtold, C.M.4
Hermsmeier, M.A.5
Chen, P.T.6
Barrish, J.C.7
Zahler, R.8
Colonno, R.J.9
Lin, P.-F.10
-
35
-
-
13344275873
-
Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease
-
Patick, A. K., H. Mo, M. Markowitz, K. Appelt, B. Wu, L. Musick, V. Kalish, S. Kaldor, S. Reich, D. Ho, and S. Webber. 1996. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob. Agents Chemother. 40:292-297.
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 292-297
-
-
Patick, A.K.1
Mo, H.2
Markowitz, M.3
Appelt, K.4
Wu, B.5
Musick, L.6
Kalish, V.7
Kaldor, S.8
Reich, S.9
Ho, D.10
Webber, S.11
-
36
-
-
0030812875
-
Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vivo
-
Patick, A. K., T. J. Boritzki, and L. A. Bloom. 1997. Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vivo. Antimicrob. Agents Chemother. 41:2159-2164.
-
(1997)
Antimicrob. Agents Chemother.
, vol.41
, pp. 2159-2164
-
-
Patick, A.K.1
Boritzki, T.J.2
Bloom, L.A.3
-
37
-
-
12644277366
-
Genotypic analysis of HIV-1 variants isolated from patients treated with the protease inhibitor nelfinavir, alone or in combination with d4T, AZT and 3TC
-
abstr. 10. Washington, D.C.
-
Patick, A. K., M. Duran, Y. Cao, T. Ho, P. Zhou, M. R. Keller, S. Chapman, R. Anderson, D. Kuritzkes, D. Shugarts, D. Ho, and M. Markowitz. 1997. Genotypic analysis of HIV-1 variants isolated from patients treated with the protease inhibitor nelfinavir, alone or in combination with d4T, AZT and 3TC, abstr. 10. In Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections, Washington, D.C.
-
(1997)
Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections
-
-
Patick, A.K.1
Duran, M.2
Cao, Y.3
Ho, T.4
Zhou, P.5
Keller, M.R.6
Chapman, S.7
Anderson, R.8
Kuritzkes, D.9
Shugarts, D.10
Ho, D.11
Markowitz, M.12
-
38
-
-
0345176605
-
Genotypic and phenotypic analyses of HIV-1 variants isolated from patients treated with nelfinavir and other HIV-1 protease inhibitors
-
abstr. 18. St. Petersburg, Fla.
-
Patick, A. K., D. Kuritzkes, V. A. Johnson, D. Shugarts, M. Bakhtiari, K. E. Potts, A. Farnsworth, R. Anderson, J. L. Koel, J. D. Hazelwood, C. D. Nail, M. Duran, M. Markowitz, D. Ho, and D. Richman. 1997. Genotypic and phenotypic analyses of HIV-1 variants isolated from patients treated with nelfinavir and other HIV-1 protease inhibitors, abstr. 18. In Abstracts of the International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication, St. Petersburg, Fla.
-
(1997)
Abstracts of the International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication
-
-
Patick, A.K.1
Kuritzkes, D.2
Johnson, V.A.3
Shugarts, D.4
Bakhtiari, M.5
Potts, K.E.6
Farnsworth, A.7
Anderson, R.8
Koel, J.L.9
Hazelwood, J.D.10
Nail, C.D.11
Duran, M.12
Markowitz, M.13
Ho, D.14
Richman, D.15
-
39
-
-
0005514294
-
The efficacy of VIRACEPT® (nelfinavir mesylate, NFV) in pivotal phase II/III double-blind randomized controlled trials as monotherapy and in combination with d4T or AZT/3TC
-
abstr. 370. Washington, D.C.
-
Powderly, W., M. Sension, M. Conant, A. Stein, and N. Clendeninn. 1997. The efficacy of VIRACEPT® (nelfinavir mesylate, NFV) in pivotal phase II/III double-blind randomized controlled trials as monotherapy and in combination with d4T or AZT/3TC, abstr. 370. In Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections, Washington, D.C.
-
(1997)
Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections
-
-
Powderly, W.1
Sension, M.2
Conant, M.3
Stein, A.4
Clendeninn, N.5
-
40
-
-
0029869305
-
Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors
-
Rose, R. E., Y.-F. Gong, J. A. Greytok, C. M. Bechtold, B. J. Terry, B. S. Robinson, M. Alam, R. J. Colonno, and P.-F. Lin. 1995. Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors. Proc. Natl. Acad. Sci. USA 93:1648-1653.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1648-1653
-
-
Rose, R.E.1
Gong, Y.-F.2
Greytok, J.A.3
Bechtold, C.M.4
Terry, B.J.5
Robinson, B.S.6
Alam, M.7
Colonno, R.J.8
Lin, P.-F.9
-
41
-
-
0009647873
-
Long term virological and immunological effect of the HIV protease inhibitor, Viracept (nelfinavir mesylate) in combination with zidovudine and lamivudine
-
San Francisco, Calif.
-
Saag, M., M. Gersten, Y. Chang, S. L. Greenberg, G. Yu, and N. J. Clendeninn. 1997. Long term virological and immunological effect of the HIV protease inhibitor, Viracept (nelfinavir mesylate) in combination with zidovudine and lamivudine, abstr. In Abstracts of the Infectious Disease Society of America, San Francisco, Calif.
-
(1997)
Abstracts of the Infectious Disease Society of America
-
-
Saag, M.1
Gersten, M.2
Chang, Y.3
Greenberg, S.L.4
Yu, G.5
Clendeninn, N.J.6
-
43
-
-
0030012398
-
Resistance-related mutations in the HIV-1 protease gene of patients treated for one year with the protease inhibitor ritonavir
-
ABT-538
-
Schmit, J.-C., L. Ruiz, B. Clotet, A. Raventos, J. Tor, J. Leonard, J. Desmyter, E. DeClercq, and A.-M. Vandamme. 1996. Resistance-related mutations in the HIV-1 protease gene of patients treated for one year with the protease inhibitor ritonavir (ABT-538). AIDS 10:995-999.
-
(1996)
AIDS
, vol.10
, pp. 995-999
-
-
Schmit, J.-C.1
Ruiz, L.2
Clotet, B.3
Raventos, A.4
Tor, J.5
Leonard, J.6
Desmyter, J.7
DeClercq, E.8
Vandamme, A.-M.9
-
44
-
-
0029731556
-
Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials
-
Schock, H. B., V. M. Garsky, and L. C. Kuo. 1996. Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. J. Biol. Chem. 271:31957-31963.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31957-31963
-
-
Schock, H.B.1
Garsky, V.M.2
Kuo, L.C.3
-
45
-
-
0031035963
-
A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor sc-55389a
-
Smidt, M. L., K. E. Potts, S. P. Tucker, L. Blystone, T. R. Steibel, W. C. Stallings, J. J. McDonald, D. Pillay, D. D. Richman, and M. L. Bryant. 1996. A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor sc-55389a. Antimicrob. Agents Chemother. 41:515-522.
-
(1996)
Antimicrob. Agents Chemother.
, vol.41
, pp. 515-522
-
-
Smidt, M.L.1
Potts, K.E.2
Tucker, S.P.3
Blystone, L.4
Steibel, T.R.5
Stallings, W.C.6
McDonald, J.J.7
Pillay, D.8
Richman, D.D.9
Bryant, M.L.10
-
46
-
-
0003277318
-
Virologie responses to a ritonavir/saquinavir containing regimen in patients who have previously failed nelfinavir
-
abstr. 510. Chicago, Ill.
-
Tebas, P., E. Kane, M. Klebert, J. Simpson, W. G. Powderly, and K. Henry. 1998. Virologie responses to a ritonavir/saquinavir containing regimen in patients who have previously failed nelfinavir, abstr. 510. p. 175. In Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections, Chicago, Ill.
-
(1998)
Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections
, pp. 175
-
-
Tebas, P.1
Kane, E.2
Klebert, M.3
Simpson, J.4
Powderly, W.G.5
Henry, K.6
-
47
-
-
0029133978
-
Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors
-
Tisdale, M., R. E. Myers, B. Maschera, N. R. Parry, N. M. Oliver, and E. D. Blair. 1995. Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors. Antimicrob. Agents Chemother. 39:1704-1710.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1704-1710
-
-
Tisdale, M.1
Myers, R.E.2
Maschera, B.3
Parry, N.R.4
Oliver, N.M.5
Blair, E.D.6
-
48
-
-
0029927979
-
+ lymphocyte/plasma RNA changes, and emergence of HIV strains with reduced phenotypic sensitivity
-
+ lymphocyte/plasma RNA changes, and emergence of HIV strains with reduced phenotypic sensitivity. Antiviral Res. 29:91-93.
-
(1996)
Antiviral Res.
, vol.29
, pp. 91-93
-
-
Vella, S.1
Galluzzo, C.2
Giannini, G.3
Pirilo, M.F.4
Duncan, I.5
Jacobsen, H.6
Andreoni, M.7
Sarmati, L.8
Ercoli, L.9
-
49
-
-
0345176602
-
Use of protease inhibitors
-
Williams, I. G. 1996. Use of protease inhibitors. J. HIV Combin. Ther. 1:4-7.
-
(1996)
J. HIV Combin. Ther.
, vol.1
, pp. 4-7
-
-
Williams, I.G.1
-
50
-
-
0027218692
-
Structure-based inhibitors ot HIV-1 protease
-
Wlodawer, A., and J. W. Erickson. 1993. Structure-based inhibitors ot HIV-1 protease. Annu. Rev. Biochem. 62:543-585.
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 543-585
-
-
Wlodawer, A.1
Erickson, J.W.2
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