메뉴 건너뛰기




Volumn 2, Issue 11, 2010, Pages 2622-2644

Tetanus toxin c-fragment: The courier and the cure?

Author keywords

Gene therapy; Motor neuron disease; Neurodegenerative disease; Retrograde transport; Tetanus toxin c fragment; Therapeutic molecules

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; BETA N ACETYLHEXOSAMINIDASE A; BRAIN DERIVED NEUROTROPHIC FACTOR; CARDIOTROPHIN 1; COPPER ZINC SUPEROXIDE DISMUTASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUCOSE OXIDASE; GREEN FLUORESCENT PROTEIN; HORSERADISH PEROXIDASE; NEUROTOXIN; SOMATOMEDIN C; SURVIVAL MOTOR NEURON PROTEIN 1; SYNAPTOBREVIN; TETANUS TOXIN; TETANUS TOXIN C FRAGMENT; UNCLASSIFIED DRUG;

EID: 79952119217     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2112622     Document Type: Review
Times cited : (46)

References (122)
  • 2
    • 0035693963 scopus 로고    scopus 로고
    • Delivery of neurotrophic factors to the central nervous system: Pharmacokinetic considerations
    • Thorne, R.G.; Frey, W.H., 2nd. Delivery of neurotrophic factors to the central nervous system: Pharmacokinetic considerations. Clin. Pharm. 2001, 40, 907-946.
    • (2001) Clin. Pharm , vol.40 , pp. 907-946
    • Thorne, R.G.1    Frey II, W.H.2
  • 3
    • 33749383278 scopus 로고    scopus 로고
    • A look to future directions in gene therapy research for monogenic diseases
    • Porteus, M.H.; Connelly, J.P.; Pruett, S.M. A look to future directions in gene therapy research for monogenic diseases. PLoS Genet 2006, 2, e133.
    • (2006) PLoS Genet , vol.e133 , pp. 2
    • Porteus, M.H.1    Connelly, J.P.2    Pruett, S.M.3
  • 4
    • 0344034703 scopus 로고    scopus 로고
    • Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons
    • Lalli, G.; Gschmeissner, S.; Schiavo, G. Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons. J. Cell Sci. 2003, 116, 4639-4650.
    • (2003) J. Cell Sci , vol.116 , pp. 4639-4650
    • Lalli, G.1    Gschmeissner, S.2    Schiavo, G.3
  • 7
    • 0036850282 scopus 로고    scopus 로고
    • Botulinum and tetanus neurotoxins: Structure, function and therapeutic utility
    • Turton, K.; Chaddock, J.A.; Acharya, K.R. Botulinum and tetanus neurotoxins: Structure, function and therapeutic utility. Trends Biochem. Sci. 2002, 27, 552-558.
    • (2002) Trends Biochem. Sci , vol.27 , pp. 552-558
    • Turton, K.1    Chaddock, J.A.2    Acharya, K.R.3
  • 8
    • 0016738156 scopus 로고
    • Tetanus toxin: Direct evidence for retrograde intraaxonal transport
    • Price, D.L.; Griffin, J.; Young, A.; Peck, K.; Stocks, A. Tetanus toxin: Direct evidence for retrograde intraaxonal transport. Science 1975, 188, 945-947.
    • (1975) Science , vol.188 , pp. 945-947
    • Price, D.L.1    Griffin, J.2    Young, A.3    Peck, K.4    Stocks, A.5
  • 9
    • 0026497466 scopus 로고
    • Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
    • Schiavo, G.; Benfenati, F.; Poulain, B.; Rossetto, O.; Polverino de Laureto, P.; DasGupta, B.R.; Montecucco, C. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature 1992, 359, 832-835.
    • (1992) Nature , vol.359 , pp. 832-835
    • Schiavo, G.1    Benfenati, F.2    Poulain, B.3    Rossetto, O.4    de Laureto, P.P.5    Dasgupta, B.R.6    Montecucco, C.7
  • 11
    • 0020368289 scopus 로고
    • Tetanus toxin fragment forms channels in lipid vesicles at low pH
    • Boquet, P.; Duflot, E. Tetanus toxin fragment forms channels in lipid vesicles at low pH. Proc. Natl. Acad. Sci. USA 1982, 79, 7614-7618.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 7614-7618
    • Boquet, P.1    Duflot, E.2
  • 12
    • 0019394903 scopus 로고
    • Papain-derived fragment IIc of tetanus toxin: Its binding to isolated synaptic membranes and retrograde axonal transport
    • Bizzini, B.; Grob, P.; Akert, K. Papain-derived fragment IIc of tetanus toxin: Its binding to isolated synaptic membranes and retrograde axonal transport. Brain Res. 1981, 210, 291-299.
    • (1981) Brain Res , vol.210 , pp. 291-299
    • Bizzini, B.1    Grob, P.2    Akert, K.3
  • 13
    • 0024450326 scopus 로고
    • Transsynaptic transfer of retrogradely transported tetanus protein-peroxidase conjugates
    • Fishman, P.S.; Savitt, J.M. Transsynaptic transfer of retrogradely transported tetanus protein-peroxidase conjugates. Exp. Neurol. 1989, 106, 197-203.
    • (1989) Exp. Neurol , vol.106 , pp. 197-203
    • Fishman, P.S.1    Savitt, J.M.2
  • 14
    • 0027265079 scopus 로고
    • Characterization of the receptor-binding domain of tetanus toxin
    • Halpern, J.L.; Loftus, A. Characterization of the receptor-binding domain of tetanus toxin. J. Biol. Chem. 1993, 268, 11188-11192.
    • (1993) J. Biol. Chem , vol.268 , pp. 11188-11192
    • Halpern, J.L.1    Loftus, A.2
  • 15
    • 0034177056 scopus 로고    scopus 로고
    • C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor
    • Herreros, J.; Lalli, G.; Schiavo, G. C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor. Biochem. J. 2000, 347, 199-204.
    • (2000) Biochem. J , vol.347 , pp. 199-204
    • Herreros, J.1    Lalli, G.2    Schiavo, G.3
  • 16
    • 53949113331 scopus 로고    scopus 로고
    • Action in the axon: Generation and transport of signaling endosomes
    • Cosker, K.E.; Courchesne, S.L.; Segal, R.A. Action in the axon: Generation and transport of signaling endosomes. Curr. Opin. Neurobiol. 2008, 18, 270-275.
    • (2008) Curr. Opin. Neurobiol , vol.18 , pp. 270-275
    • Cosker, K.E.1    Courchesne, S.L.2    Segal, R.A.3
  • 17
    • 0017596090 scopus 로고
    • An antigenic polypeptide fragment isolated from tetanus toxin: Chemical characterization, binding to gangliosides and retrograde axonal transport in various neuron systems
    • Bizzini, B.; Stoeckel, K.; Schwab, M. An antigenic polypeptide fragment isolated from tetanus toxin: chemical characterization, binding to gangliosides and retrograde axonal transport in various neuron systems. J. Neurochem. 1977, 28, 529-542.
    • (1977) J. Neurochem , vol.28 , pp. 529-542
    • Bizzini, B.1    Stoeckel, K.2    Schwab, M.3
  • 18
    • 46849085158 scopus 로고    scopus 로고
    • Molecular basis for tetanus toxin coreceptor interactions
    • Chen, C.; Baldwin, M.R.; Barbieri, J.T. Molecular basis for tetanus toxin coreceptor interactions. Biochemistry 2008, 47, 7179-7186.
    • (2008) Biochemistry , vol.47 , pp. 7179-7186
    • Chen, C.1    Baldwin, M.R.2    Barbieri, J.T.3
  • 19
    • 0017743495 scopus 로고
    • Gangliosides in nervous tissue cultures and binding of 125I-labelled tetanus toxin, a neuronal marker
    • Dimpfel, W.; Huang, R.T.; Habermann, E. Gangliosides in nervous tissue cultures and binding of 125I-labelled tetanus toxin, a neuronal marker. J. Neurochem. 1977, 29, 329-334.
    • (1977) J. Neurochem , vol.29 , pp. 329-334
    • Dimpfel, W.1    Huang, R.T.2    Habermann, E.3
  • 20
    • 0035168442 scopus 로고    scopus 로고
    • Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons
    • Herreros, J.; Ng, T.; Schiavo, G. Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons. Mol. Biol. Cell 2001, 12, 2947-2960.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2947-2960
    • Herreros, J.1    Ng, T.2    Schiavo, G.3
  • 21
    • 0019450641 scopus 로고
    • High affinity binding of tetanus toxin to mammalian brain membranes
    • Rogers, T.B.; Snyder, S.H. High affinity binding of tetanus toxin to mammalian brain membranes. J. Biol. Chem. 1981, 256, 2402-2407.
    • (1981) J. Biol. Chem , vol.256 , pp. 2402-2407
    • Rogers, T.B.1    Snyder, S.H.2
  • 22
    • 0023905930 scopus 로고
    • Complex ganglioside expression and tetanus toxin binding by PC12 pheochromocytoma cells
    • Walton, K.M.; Sandberg, K.; Rogers, T.B.; Schnaar, R.L. Complex ganglioside expression and tetanus toxin binding by PC12 pheochromocytoma cells. J. Biol. Chem. 1988, 263, 2055-2063.
    • (1988) J. Biol. Chem , vol.263 , pp. 2055-2063
    • Walton, K.M.1    Sandberg, K.2    Rogers, T.B.3    Schnaar, R.L.4
  • 23
    • 33746618384 scopus 로고    scopus 로고
    • Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1
    • Deinhardt, K.; Berninghausen, O.; Willison, H.J.; Hopkins, C.R.; Schiavo, G. Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J. Cell Biol. 2006, 174, 459-471.
    • (2006) J. Cell Biol , vol.174 , pp. 459-471
    • Deinhardt, K.1    Berninghausen, O.2    Willison, H.J.3    Hopkins, C.R.4    Schiavo, G.5
  • 24
    • 23644441527 scopus 로고    scopus 로고
    • Internalization of a GFP-tetanus toxin C-terminal fragment fusion protein at mature mouse neuromuscular junctions
    • Roux, S.; Colasante, C.; Saint Cloment, C.; Barbier, J.; Curie, T.; Girard, E.; Molgo, J.; Brulet, P. Internalization of a GFP-tetanus toxin C-terminal fragment fusion protein at mature mouse neuromuscular junctions. Mol. Cell Neurosci. 2005, 30, 572-582.
    • (2005) Mol. Cell Neurosci , vol.30 , pp. 572-582
    • Roux, S.1    Colasante, C.2    Saint, C.C.3    Barbier, J.4    Curie, T.5    Girard, E.6    Molgo, J.7    Brulet, P.8
  • 25
    • 29644438627 scopus 로고    scopus 로고
    • Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized pH regulation
    • Bohnert, S.; Schiavo, G. Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized pH regulation. J. Biol. Chem. 2005, 280, 42336-42344.
    • (2005) J. Biol. Chem , vol.280 , pp. 42336-42344
    • Bohnert, S.1    Schiavo, G.2
  • 28
    • 0022481875 scopus 로고
    • Transsynaptic retrograde transport of fragment C of tetanus toxin demonstrated by immunohistochemical localization
    • Evinger, C.; Erichsen, J.T. Transsynaptic retrograde transport of fragment C of tetanus toxin demonstrated by immunohistochemical localization. Brain Res. 1986, 380, 383-388.
    • (1986) Brain Res , vol.380 , pp. 383-388
    • Evinger, C.1    Erichsen, J.T.2
  • 29
    • 0017393442 scopus 로고
    • Retrograde axonal transport of 125I-tetanus toxin as a tool for tracing fiber connections in the central nervous system; connections of the rostral part of the rat neostriatum
    • Schwab, M.; Agid, Y.; Glowinski, J.; Thoenen, H. Retrograde axonal transport of 125I-tetanus toxin as a tool for tracing fiber connections in the central nervous system; connections of the rostral part of the rat neostriatum. Brain Res. 1977, 126, 211-224.
    • (1977) Brain Res , vol.126 , pp. 211-224
    • Schwab, M.1    Agid, Y.2    Glowinski, J.3    Thoenen, H.4
  • 30
    • 0017225223 scopus 로고
    • Electron microscopic evidence for a transsynaptic migration of tetanus toxin in spinal cord motoneurons: An autoradiographic and morphometric study
    • Schwab, M.E.; Thoenen, H. Electron microscopic evidence for a transsynaptic migration of tetanus toxin in spinal cord motoneurons: An autoradiographic and morphometric study. Brain Res. 1976, 105, 213-227.
    • (1976) Brain Res , vol.105 , pp. 213-227
    • Schwab, M.E.1    Thoenen, H.2
  • 32
    • 0025182473 scopus 로고
    • Enhanced CNS uptake of systemically administered proteins through conjugation with tetanus C-fragment
    • Fishman, P.S.; Savitt, J.M.; Farrand, D.A. Enhanced CNS uptake of systemically administered proteins through conjugation with tetanus C-fragment. J. Neurol. Sci. 1990, 98, 311-325.
    • (1990) J. Neurol. Sci , vol.98 , pp. 311-325
    • Fishman, P.S.1    Savitt, J.M.2    Farrand, D.A.3
  • 33
    • 0025095916 scopus 로고
    • Retrograde axonal transport of an exogenous enzyme covalently linked to B-IIb fragment of tetanus toxin
    • Beaude, P.; Delacour, A.; Bizzini, B.; Domuado, D.; Remy, M.H. Retrograde axonal transport of an exogenous enzyme covalently linked to B-IIb fragment of tetanus toxin. Biochem. J. 1990, 271, 87-91.
    • (1990) Biochem. J , vol.271 , pp. 87-91
    • Beaude, P.1    Delacour, A.2    Bizzini, B.3    Domuado, D.4    Remy, M.H.5
  • 35
    • 0030740254 scopus 로고    scopus 로고
    • Construction of hybrid proteins that migrate retrogradely and transynaptically into the central nervous system
    • Coen, L.; Osta, R.; Maury, M.; Brulet, P. Construction of hybrid proteins that migrate retrogradely and transynaptically into the central nervous system. Proc. Natl. Acad. Sci. USA 1997, 94, 9400-9405.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9400-9405
    • Coen, L.1    Osta, R.2    Maury, M.3    Brulet, P.4
  • 38
    • 0033384884 scopus 로고    scopus 로고
    • A somatic gene transfer approach using recombinant fusion proteins to map muscle-motoneuron projections in Xenopus spinal cord
    • Coen, L.; Kissa, K.; le Mevel, S.; Brulet, P.; Demeneix, B.A. A somatic gene transfer approach using recombinant fusion proteins to map muscle-motoneuron projections in Xenopus spinal cord. Int. J. Dev. Biol. 1999, 43, 823-830.
    • (1999) Int. J. Dev. Biol , vol.43 , pp. 823-830
    • Coen, L.1    Kissa, K.2    le Mevel, S.3    Brulet, P.4    Demeneix, B.A.5
  • 41
    • 0037162480 scopus 로고    scopus 로고
    • Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice
    • Maskos, U.; Kissa, K.; St Cloment, C.; Brulet, P. Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice. Proc. Natl. Acad. Sci. USA 2002, 99, 10120-10125.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10120-10125
    • Maskos, U.1    Kissa, K.2    Cloment St., C.3    Brulet, P.4
  • 43
    • 33746309375 scopus 로고    scopus 로고
    • C fragment of tetanus toxin hybrid proteins evaluated for muscle-specific transsynaptic mapping of spinal motor circuitry in the newborn mouse
    • Perreault, M.C.; Bernier, A.P.; Renaud, J.S.; Roux, S.; Glover, J.C. C fragment of tetanus toxin hybrid proteins evaluated for muscle-specific transsynaptic mapping of spinal motor circuitry in the newborn mouse. Neuroscience 2006, 141, 803-816.
    • (2006) Neuroscience , vol.141 , pp. 803-816
    • Perreault, M.C.1    Bernier, A.P.2    Renaud, J.S.3    Roux, S.4    Glover, J.C.5
  • 46
    • 72149107896 scopus 로고    scopus 로고
    • Fluorescence imaging of fast retrograde axonal transport in living animals. Mol
    • Schellingerhout, D.; Le Roux, L.G.; Bredow, S.; Gelovani, J.G. Fluorescence imaging of fast retrograde axonal transport in living animals. Mol. Imaging 2009, 8, 319-329.
    • (2009) Imaging , vol.8 , pp. 319-329
    • Schellingerhout, D.1    le Roux, L.G.2    Bredow, S.3    Gelovani, J.G.4
  • 48
    • 0026510667 scopus 로고
    • Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin
    • Dobrenis, K.; Joseph, A.; Rattazzi, M.C. Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin. Proc. Natl Acad. Sci. USA 1992, 89, 2297-2301.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 2297-2301
    • Dobrenis, K.1    Joseph, A.2    Rattazzi, M.C.3
  • 51
    • 0026583465 scopus 로고
    • Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
    • Przedborski, S.; Kostic, V.; Jackson-Lewis, V.; Naini, A.B.; Simonetti, S.; Fahn, S.; Carlson, E.; Epstein, C.J.; Cadet, J.L. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J. Neurosci. 1992, 12, 1658-1667.
    • (1992) J. Neurosci , vol.12 , pp. 1658-1667
    • Przedborski, S.1    Kostic, V.2    Jackson-Lewis, V.3    Naini, A.B.4    Simonetti, S.5    Fahn, S.6    Carlson, E.7    Epstein, C.J.8    Cadet, J.L.9
  • 52
  • 53
  • 54
    • 77955843240 scopus 로고    scopus 로고
    • Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1(G86R)
    • Audet, J.N.; Gowing, G.; Julien, J.P. Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1(G86R). Neurobiol. Dis. 40, 245-250.
    • Neurobiol. Dis , vol.40 , pp. 245-250
    • Audet, J.N.1    Gowing, G.2    Julien, J.P.3
  • 55
    • 0034520591 scopus 로고    scopus 로고
    • Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1
    • Jaarsma, D.; Haasdijk, E.D.; Grashorn, J.A.; Hawkins, R.; van Duijn, W.; Verspaget, H.W.; London, J.; Holstege, J.C. Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1. Neurobiol. Dis. 2000, 7, 623-643.
    • (2000) Neurobiol. Dis , vol.7 , pp. 623-643
    • Jaarsma, D.1    Haasdijk, E.D.2    Grashorn, J.A.3    Hawkins, R.4    van Duijn, W.5    Verspaget, H.W.6    London, J.7    Holstege, J.C.8
  • 56
    • 0036883891 scopus 로고    scopus 로고
    • Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release
    • Sugawara, T.; Lewen, A.; Gasche, Y.; Yu, F.; Chan, P.H. Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release. FASEB J. 2002, 16, 1997-1999.
    • (2002) FASEB J , vol.16 , pp. 1997-1999
    • Sugawara, T.1    Lewen, A.2    Gasche, Y.3    Yu, F.4    Chan, P.H.5
  • 57
    • 0036138386 scopus 로고    scopus 로고
    • Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation
    • Sugawara, T.; Noshita, N.; Lewen, A.; Gasche, Y.; Ferrand-Drake, M.; Fujimura, M.; Morita-Fujimura, Y.; Chan, P.H. Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J. Neurosci. 2002, 22, 209-217.
    • (2002) J. Neurosci , vol.22 , pp. 209-217
    • Sugawara, T.1    Noshita, N.2    Lewen, A.3    Gasche, Y.4    Ferrand-Drake, M.5    Fujimura, M.6    Morita-Fujimura, Y.7    Chan, P.H.8
  • 60
    • 0030130574 scopus 로고    scopus 로고
    • The neurobiology of childhood spinal muscular atrophy
    • Crawford, T.O.; Pardo, C.A. The neurobiology of childhood spinal muscular atrophy. Neurobiol. Dis. 1996, 3, 97-110.
    • (1996) Neurobiol. Dis , vol.3 , pp. 97-110
    • Crawford, T.O.1    Pardo, C.A.2
  • 62
    • 29144463310 scopus 로고    scopus 로고
    • Spinal muscular atrophy: A deficiency in a ubiquitous protein; a motor neuron-specific disease
    • Monani, U.R. Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease. Neuron 2005, 48, 885-896.
    • (2005) Neuron , vol.48 , pp. 885-896
    • Monani, U.R.1
  • 64
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan, D.R.; Miller, F.D. Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 2000, 10, 381-391.
    • (2000) Curr. Opin. Neurobiol , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 66
    • 0036646739 scopus 로고    scopus 로고
    • In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice
    • Lesbordes, J.C.; Bordet, T.; Haase, G.; Castelnau-Ptakhine, L.; Rouhani, S.; Gilgenkrantz, H.; Kahn, A. In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice. Hum. Mol. Genet. 2002, 11, 1615-1625.
    • (2002) Hum. Mol. Genet , vol.11 , pp. 1615-1625
    • Lesbordes, J.C.1    Bordet, T.2    Haase, G.3    Castelnau-Ptakhine, L.4    Rouhani, S.5    Gilgenkrantz, H.6    Kahn, A.7
  • 69
    • 12744273097 scopus 로고    scopus 로고
    • Synaptic targeting of retrogradely transported trophic factors in motoneurons: Comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin
    • Rind, H.B.; Butowt, R.; von Bartheld, C.S. Synaptic targeting of retrogradely transported trophic factors in motoneurons: Comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin. J. Neurosci. 2005, 25, 539-549.
    • (2005) J. Neurosci , vol.25 , pp. 539-549
    • Rind, H.B.1    Butowt, R.2    von Bartheld, C.S.3
  • 70
    • 77953417539 scopus 로고    scopus 로고
    • Basic mechanisms of neurodegeneration: A critical update
    • Jellinger, K.A. Basic mechanisms of neurodegeneration: A critical update. J. Cell. Mol. Med. 2010, 14, 457-487.
    • (2010) J. Cell. Mol. Med , vol.14 , pp. 457-487
    • Jellinger, K.A.1
  • 71
    • 0032750753 scopus 로고    scopus 로고
    • Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Vukosavic, S.; Dubois-Dauphin, M.; Romero, N.; Przedborski, S. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 1999, 73, 2460-2468.
    • (1999) J. Neurochem , vol.73 , pp. 2460-2468
    • Vukosavic, S.1    Dubois-Dauphin, M.2    Romero, N.3    Przedborski, S.4
  • 72
    • 58149461546 scopus 로고    scopus 로고
    • Fusion of the tetanus toxin C fragment binding domain and Bcl-xL for protection of peripheral nerve neurons
    • Carlton, E.; Teng, Q.; Federici, T.; Yang, J.; Riley, J.; Boulis, N.M. Fusion of the tetanus toxin C fragment binding domain and Bcl-xL for protection of peripheral nerve neurons. Neurosurgery 2008, 63, 1175-1182, 1182-1174.
    • (2008) Neurosurgery , vol.63
    • Carlton, E.1    Teng, Q.2    Federici, T.3    Yang, J.4    Riley, J.5    Boulis, N.M.6
  • 73
    • 0029435250 scopus 로고
    • Overview of motor neuron disease: Classification and nomenclature
    • Bradley, W.G. Overview of motor neuron disease: classification and nomenclature. Clin. Neurosci. 1995, 3, 323-326.
    • (1995) Clin. Neurosci , vol.3 , pp. 323-326
    • Bradley, W.G.1
  • 74
    • 6844266272 scopus 로고    scopus 로고
    • Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group
    • Lai, E.C.; Felice, K.J.; Festoff, B.W.; Gawel, M.J.; Gelinas, D.F.; Kratz, R.; Murphy, M.F.; Natter, H.M.; Norris, F.H.; Rudnicki, S.A. Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group. Neurology 1997, 49, 1621-1630.
    • (1997) Neurology , vol.49 , pp. 1621-1630
    • Lai, E.C.1    Felice, K.J.2    Festoff, B.W.3    Gawel, M.J.4    Gelinas, D.F.5    Kratz, R.6    Murphy, M.F.7    Natter, H.M.8    Norris, F.H.9    Rudnicki, S.A.10
  • 75
    • 0029952139 scopus 로고    scopus 로고
    • Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis
    • Miller, R.G.; Bryan, W.W.; Dietz, M.A.; Munsat, T.L.; Petajan, J.H.; Smith, S.A.; Goodpasture, J.C. Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis. Neurology 1996, 47, 1329-1331.
    • (1996) Neurology , vol.47 , pp. 1329-1331
    • Miller, R.G.1    Bryan, W.W.2    Dietz, M.A.3    Munsat, T.L.4    Petajan, J.H.5    Smith, S.A.6    Goodpasture, J.C.7
  • 76
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar, B.K.; Llado, J.; Sherkat, N.; Rothstein, J.D.; Gage, F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003, 301, 839-842.
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 78
    • 48349133827 scopus 로고    scopus 로고
    • Systemic Insulin-like growth factor-1 reverses hypoalgesia and improves mobility in a mouse model of diabetic peripheral neuropathy
    • Chu, Q.; Moreland, R.; Yew, N.S.; Foley, J.; Ziegler, R.; Scheule, R.K. Systemic Insulin-like growth factor-1 reverses hypoalgesia and improves mobility in a mouse model of diabetic peripheral neuropathy. Mol. Ther. 2008, 16, 1400-1408.
    • (2008) Mol. Ther , vol.16 , pp. 1400-1408
    • Chu, Q.1    Moreland, R.2    Yew, N.S.3    Foley, J.4    Ziegler, R.5    Scheule, R.K.6
  • 79
    • 33644861386 scopus 로고    scopus 로고
    • Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle
    • Payne, A.M.; Zheng, Z.; Messi, M.L.; Milligan, C.E.; Gonzalez, E.; Delbono, O. Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle. J. Physiol. 2006, 570, 283-294.
    • (2006) J. Physiol , vol.570 , pp. 283-294
    • Payne, A.M.1    Zheng, Z.2    Messi, M.L.3    Milligan, C.E.4    Gonzalez, E.5    Delbono, O.6
  • 80
    • 33847644076 scopus 로고    scopus 로고
    • Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice
    • Payne, A.M.; Messi, M.L.; Zheng, Z.; Delbono, O. Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice. Exp. Gerontol. 2007, 42, 309-319.
    • (2007) Exp. Gerontol , vol.42 , pp. 309-319
    • Payne, A.M.1    Messi, M.L.2    Zheng, Z.3    Delbono, O.4
  • 82
    • 34548294685 scopus 로고    scopus 로고
    • The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS
    • Messi, M.L.; Clark, H.M.; Prevette, D.M.; Oppenheim, R.W.; Delbono, O. The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS. Exp. Neurol. 2007, 207, 52-63.
    • (2007) Exp. Neurol , vol.207 , pp. 52-63
    • Messi, M.L.1    Clark, H.M.2    Prevette, D.M.3    Oppenheim, R.W.4    Delbono, O.5
  • 84
    • 0028822549 scopus 로고
    • Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor
    • Li, L.; Wu, W.; Lin, L.F.; Lei, M.; Oppenheim, R.W.; Houenou, L.J. Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 1995, 92, 9771-9775.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9771-9775
    • Li, L.1    Wu, W.2    Lin, L.F.3    Lei, M.4    Oppenheim, R.W.5    Houenou, L.J.6
  • 86
    • 0029950147 scopus 로고    scopus 로고
    • GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice
    • Sagot, Y.; Tan, S.A.; Hammang, J.P.; Aebischer, P.; Kato, A.C. GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice. J. Neurosci. 1996, 16, 2335-2341.
    • (1996) J. Neurosci , vol.16 , pp. 2335-2341
    • Sagot, Y.1    Tan, S.A.2    Hammang, J.P.3    Aebischer, P.4    Kato, A.C.5
  • 87
    • 0028854836 scopus 로고
    • In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons
    • Yan, Q.; Matheson, C.; Lopez, O.T. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 1995, 373, 341-344.
    • (1995) Nature , vol.373 , pp. 341-344
    • Yan, Q.1    Matheson, C.2    Lopez, O.T.3
  • 88
    • 0030725572 scopus 로고    scopus 로고
    • Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
    • Bjorklund, A.; Rosenblad, C.; Winkler, C.; Kirik, D. Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol. Dis. 1997, 4, 186-200.
    • (1997) Neurobiol. Dis , vol.4 , pp. 186-200
    • Bjorklund, A.1    Rosenblad, C.2    Winkler, C.3    Kirik, D.4
  • 92
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • Slevin, J.T.; Gerhardt, G.A.; Smith, C.D.; Gash, D.M.; Kryscio, R.; Young, B. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J. Neurosurg. 2005, 102, 216-222.
    • (2005) J. Neurosurg , vol.102 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Kryscio, R.5    Young, B.6
  • 93
    • 33846428095 scopus 로고    scopus 로고
    • Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS
    • Li, W.; Brakefield, D.; Pan, Y.; Hunter, D.; Myckatyn, T.M.; Parsadanian, A. Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS. Exp. Neurol. 2007, 203, 457-471.
    • (2007) Exp. Neurol , vol.203 , pp. 457-471
    • Li, W.1    Brakefield, D.2    Pan, Y.3    Hunter, D.4    Myckatyn, T.M.5    Parsadanian, A.6
  • 94
    • 37549065020 scopus 로고    scopus 로고
    • GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS
    • Suzuki, M.; McHugh, J.; Tork, C.; Shelley, B.; Klein, S.M.; Aebischer, P.; Svendsen, C.N. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS One 2007, 2, e689.
    • (2007) PLoS One , vol.2
    • Suzuki, M.1    McHugh, J.2    Tork, C.3    Shelley, B.4    Klein, S.M.5    Aebischer, P.6    Svendsen, C.N.7
  • 98
    • 43349084139 scopus 로고    scopus 로고
    • Antiapoptotic activity maintenance of Brain Derived Neurotrophic factor and the C fragment of the tetanus toxin genetic fusion protein
    • Ciriza, J.; García-Ojeda, M.; Martín-Burriel, I.; Agulhon, C.; Miana-Mena, F.J.; Munoz, M.J.; Zaragoza, P.; Brulet, P.; Osta, R. Antiapoptotic activity maintenance of Brain Derived Neurotrophic factor and the C fragment of the tetanus toxin genetic fusion protein. CEJB 2008, 3, 105-112.
    • (2008) CEJB , vol.3 , pp. 105-112
    • Ciriza, J.1    García-Ojeda, M.2    Martín-Burriel, I.3    Agulhon, C.4    Miana-Mena, F.J.5    Munoz, M.J.6    Zaragoza, P.7    Brulet, P.8    Osta, R.9
  • 99
    • 33748883190 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals
    • Roux, S.; Saint Cloment, C.; Curie, T.; Girard, E.; Mena, F.J.; Barbier, J.; Osta, R.; Molgo, J.; Brulet, P. Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals. Eur. J. Neurosci. 2006, 24, 1546-1554.
    • (2006) Eur. J. Neurosci , vol.24 , pp. 1546-1554
    • Roux, S.1    Saint, C.C.2    Curie, T.3    Girard, E.4    Mena, F.J.5    Barbier, J.6    Osta, R.7    Molgo, J.8    Brulet, P.9
  • 100
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S.R.; Brunet, A.; Greenberg, M.E. Cellular survival: A play in three Akts. Genes Dev. 1999, 13, 2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 101
    • 0032808154 scopus 로고    scopus 로고
    • Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
    • Kennedy, S.G.; Kandel, E.S.; Cross, T.K.; Hay, N. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol. 1999, 19, 5800-5810.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 5800-5810
    • Kennedy, S.G.1    Kandel, E.S.2    Cross, T.K.3    Hay, N.4
  • 102
    • 0035872218 scopus 로고    scopus 로고
    • HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction
    • Gil, C.; Chaib-Oukadour, I.; Blasi, J.; Aguilera, J. HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction. Biochem. J. 2001, 356, 97-103.
    • (2001) Biochem. J , vol.356 , pp. 97-103
    • Gil, C.1    Chaib-Oukadour, I.2    Blasi, J.3    Aguilera, J.4
  • 103
    • 0343714642 scopus 로고    scopus 로고
    • Activation of signal transduction pathways involving trkA, PLCgamma-1, PKC isoforms and ERK-1/2 by tetanus toxin
    • Gil, C.; Chaib-Oukadour, I.; Pelliccioni, P.; Aguilera, J. Activation of signal transduction pathways involving trkA, PLCgamma-1, PKC isoforms and ERK-1/2 by tetanus toxin. FEBS Lett. 2000, 481, 177-182.
    • (2000) FEBS Lett , vol.481 , pp. 177-182
    • Gil, C.1    Chaib-Oukadour, I.2    Pelliccioni, P.3    Aguilera, J.4
  • 104
    • 4444360288 scopus 로고    scopus 로고
    • The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: Involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
    • Chaib-Oukadour, I.; Gil, C.; Aguilera, J. The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. J. Neurochem. 2004, 90, 1227-1236.
    • (2004) J. Neurochem , vol.90 , pp. 1227-1236
    • Chaib-Oukadour, I.1    Gil, C.2    Aguilera, J.3
  • 105
    • 0037148530 scopus 로고    scopus 로고
    • Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR
    • Lalli, G.; Schiavo, G. Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR. J. Cell. Biol. 2002, 156, 233-239.
    • (2002) J. Cell. Biol , vol.156 , pp. 233-239
    • Lalli, G.1    Schiavo, G.2
  • 107
    • 67650502218 scopus 로고    scopus 로고
    • The carboxyl-terminal domain of the heavy chain of tetanus toxin prevents dopaminergic degeneration and improves motor behavior in rats with striatal MPP(+)-lesions
    • Mendieta, L.; Venegas, B.; Moreno, N.; Patricio, A.; Martinez, I.; Aguilera, J.; Limon, I.D. The carboxyl-terminal domain of the heavy chain of tetanus toxin prevents dopaminergic degeneration and improves motor behavior in rats with striatal MPP(+)-lesions. Neurosci. Res. 2009, 65, 98-106.
    • (2009) Neurosci. Res , vol.65 , pp. 98-106
    • Mendieta, L.1    Venegas, B.2    Moreno, N.3    Patricio, A.4    Martinez, I.5    Aguilera, J.6    Limon, I.D.7
  • 110
    • 0025872046 scopus 로고
    • Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol
    • Stenmark, H.; Moskaug, J.O.; Madshus, I.H.; Sandvig, K.; Olsnes, S. Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol. J. Cell. Biol. 1991, 113, 1025-1032.
    • (1991) J. Cell. Biol , vol.113 , pp. 1025-1032
    • Stenmark, H.1    Moskaug, J.O.2    Madshus, I.H.3    Sandvig, K.4    Olsnes, S.5
  • 111
    • 0033507498 scopus 로고    scopus 로고
    • Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c))
    • Fishman, P.S.; Parks, D.A.; Patwardhan, A.J.; Matthews, C.C. Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c)). Nat. Toxins 1999, 7, 151-156.
    • (1999) Nat. Toxins , vol.7 , pp. 151-156
    • Fishman, P.S.1    Parks, D.A.2    Patwardhan, A.J.3    Matthews, C.C.4
  • 112
    • 0030036897 scopus 로고    scopus 로고
    • Immune response in mice following immunization with DNA encoding fragment C of tetanus toxin
    • Anderson, R.; Gao, X.M.; Papakonstantinopoulou, A.; Roberts, M.; Dougan, G. Immune response in mice following immunization with DNA encoding fragment C of tetanus toxin. Infect. Immun. 1996, 64, 3168-3173.
    • (1996) Infect. Immun , vol.64 , pp. 3168-3173
    • Anderson, R.1    Gao, X.M.2    Papakonstantinopoulou, A.3    Roberts, M.4    Dougan, G.5
  • 113
    • 33744929630 scopus 로고    scopus 로고
    • Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxin
    • Fishman, P.S.; Matthews, C.C.; Parks, D.A.; Box, M.; Fairweather, N.F. Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxin. J. Neurosci. Res. 2006, 83, 1540-1543.
    • (2006) J. Neurosci. Res , vol.83 , pp. 1540-1543
    • Fishman, P.S.1    Matthews, C.C.2    Parks, D.A.3    Box, M.4    Fairweather, N.F.5
  • 116
    • 0016726129 scopus 로고
    • Comparison between the retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neurons
    • Stockel, K.; Schwab, M.; Thoenen, H. Comparison between the retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neurons. Brain Res. 1975, 99, 1-16.
    • (1975) Brain Res , vol.99 , pp. 1-16
    • Stockel, K.1    Schwab, M.2    Thoenen, H.3
  • 117
    • 69049112930 scopus 로고    scopus 로고
    • Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
    • Lai, C.; Xie, C.; Shim, H.; Chandran, J.; Howell, B.W.; Cai, H. Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin. Mol. Brain 2009, 2, 23.
    • (2009) Mol. Brain , vol.2 , pp. 23
    • Lai, C.1    Xie, C.2    Shim, H.3    Chandran, J.4    Howell, B.W.5    Cai, H.6
  • 118
    • 0035839187 scopus 로고    scopus 로고
    • Impaired retrograde axonal transport of adenovirus-mediated E. coli LacZ gene in the mice carrying mutant SOD1 gene
    • Murakami, T.; Nagano, I.; Hayashi, T.; Manabe, Y.; Shoji, M.; Setoguchi, Y.; Abe, K. Impaired retrograde axonal transport of adenovirus-mediated E. coli LacZ gene in the mice carrying mutant SOD1 gene. Neurosci. Lett. 2001, 308, 149-152.
    • (2001) Neurosci. Lett , vol.308 , pp. 149-152
    • Murakami, T.1    Nagano, I.2    Hayashi, T.3    Manabe, Y.4    Shoji, M.5    Setoguchi, Y.6    Abe, K.7
  • 121
    • 34748904149 scopus 로고    scopus 로고
    • Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons
    • Townsend, S.A.; Evrony, G.D.; Gu, F.X.; Schulz, M.P.; Brown, R.H., Jr.; Langer, R. Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. Biomaterials 2007, 28, 5176-5184.
    • (2007) Biomaterials , vol.28 , pp. 5176-5184
    • Townsend, S.A.1    Evrony, G.D.2    Gu, F.X.3    Schulz, M.P.4    Brown Jr., R.H.5    Langer, R.6
  • 122
    • 77952239026 scopus 로고    scopus 로고
    • Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c
    • Oliveira, H.; Fernandez, R.; Pires, L.R.; Martins, M.C.; Simoes, S.; Barbosa, M.A.; Pego, A.P. Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c. J. Control. Release 2010, 143, 350-358.
    • (2010) J. Control. Release , vol.143 , pp. 350-358
    • Oliveira, H.1    Fernandez, R.2    Pires, L.R.3    Martins, M.C.4    Simoes, S.5    Barbosa, M.A.6    Pego, A.P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.