Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS

Biochemical and Biophysical Research Communications

Volumn 390, Issue 3, 2009, Pages 947-951

  Li, Jianhong ^a   Chian, Ru Ju ^a   Ay, Ilknur ^a   Kashi, Brenda B ^a   Celia, Samuel A ^a   Tamrazian, Eric ^a   Pepinsky, R Blake ^b   Fishman, Paul S ^c,d   Brown Jr , Robert H ^a   Francis, Jonathan W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BIOGEN   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

GDNF; Intramuscular injection; Intrathecal infusion; Recombinant protein; Spinal cord; Tetanus toxin fragment C

Indexed keywords

CHOLINE ACETYLTRANSFERASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR TETANUS TOXIN C FRAGMENT HYBRID PROTEIN; HYBRID PROTEIN; TETANUS TOXIN; TETANUS TOXIN C FRAGMENT; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; INSECT; LUMBAR SPINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD VENTRAL HORN; STATISTICAL SIGNIFICANCE; WEIGHT REDUCTION;

ANIMALS; BIOLOGICAL AVAILABILITY; DRUG DELIVERY SYSTEMS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED C57BL; MOTOR NEURONS; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; SPINAL CORD; TETANUS TOXIN;

HEXAPODA; MAMMALIA; MUS;

EID: 70449705814     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.083     Document Type: Article

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