Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis

Neurology

Volumn 47, Issue 5, 1996, Pages 1329-1331

  Miller, R G ^a,h   Bryan, W W ^b   Dietz, M A ^c   Munsat, T L ^d   Petajan, J H ^e   Smith, S A ^f   Goodpasture, J C ^g  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b University of Texas   (United States)

^c Associates in Neurology   (United States)

^d TUFTS MEDICAL CENTER   (United States)

^e UNIVERSITY OF UTAH   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g ROCHE BIOSCIENCE   (United States)

^h NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; RECOMBINANT CILIARY NEUROTROPHIC FACTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ANOREXIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DOSE RESPONSE; DRUG TOLERABILITY; HERPES LABIALIS; HERPES SIMPLEX VIRUS 1; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SUBCUTANEOUS DRUG ADMINISTRATION; VIRUS REACTIVATION; WEIGHT REDUCTION;

EID: 0029952139     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.47.5.1329     Document Type: Article

References (10)

1. Martinou J-C, Martinou I, Kato AC. Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motor neurons in vitro. Neuron 1992;8:737-744.
2. Oppenheim RW, Prevette D, Qin-Wei Y, et al. Control of embryonic motor neuron survival in vivo by ciliary neurotrophic factor. Science 1991;252:1616-1618.
3. Sendtner M, Schmalbruch H, Stockli KA, et al. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuropathy. Nature 1992; 358:502-504.
4. Ikeda K, Wong V, Holmlund TH, et al. Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Ann Neurol 1995;37:47-54.
5. Miller RG, Bryan WW, Dietz MA, et al. Safety, tolerability and pharmacokinetics of recombinant human ciliary neurotrophic factor (rhCNTF) in patients with amyotrophic lateral sclerosis (ALS) [abstract]. Ann Neurol 1993;34:P241.
6. Brooks BR, Sanjak M, Mitsmoto H, et al. Recombinant human ciliary neurotrophic factor (rhCNTF) in amyotrophic lateral sclerosis (ALS) patients: phase I-II safety, tolerability and pharmacokinetic studies [abstract]. Neurology 1993;43(suppl): A416.
7. Miller RG, Petajan MD, Bryan WW, et al. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. Ann Neurol 1996;39: 256-260.
8. ALS CNTF Treatment Study Group. A double-blind placebocontrolled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rhCNTF) in amyotrophic lateral sclerosis. Neurology 1996;46:1244-1249.
9. Henderson JT, Senuik NA, Richardson PM, et al. Systemic administration of ciliary neurotrophic factor induces cachexia in rodents. J Clin Invest 1994;93:2632-2638.
10. Curtis R, Adryan KM, Zhu Y, et al. Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Nature 1993;365:253-255.