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Volumn 92, Issue 3, 2011, Pages 209-220

Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells

Author keywords

Antimicrobial peptides; Defensins; Inflammation; LL 37; Ocular surface; Toll like receptors

Indexed keywords

BETA DEFENSIN; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; POLYPEPTIDE ANTIBIOTIC AGENT; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST;

EID: 79952106615     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.12.005     Document Type: Article
Times cited : (83)

References (76)
  • 1
    • 18644378725 scopus 로고    scopus 로고
    • Human neutrophil defensins induce lung epithelial cell proliferation in vitro
    • Aarbiou J., Ertmann M., van Wetering S., et al. Human neutrophil defensins induce lung epithelial cell proliferation in vitro. J. Leukoc. Biol. 2002, 72:167-174.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 167-174
    • Aarbiou, J.1    Ertmann, M.2    van Wetering, S.3
  • 2
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 3
    • 0033566011 scopus 로고    scopus 로고
    • Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action
    • Befus A.D., Mowat C., Gilchrist M., Hu J., Solomon S., Bateman A. Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action. J. Immunol. 1999, 163:947-953.
    • (1999) J. Immunol. , vol.163 , pp. 947-953
    • Befus, A.D.1    Mowat, C.2    Gilchrist, M.3    Hu, J.4    Solomon, S.5    Bateman, A.6
  • 4
    • 0036451206 scopus 로고    scopus 로고
    • TLR4 as the mammalian endotoxin sensor
    • Beutler B. TLR4 as the mammalian endotoxin sensor. Curr. Top. Microbiol. Immunol. 2002, 270:109-120.
    • (2002) Curr. Top. Microbiol. Immunol. , vol.270 , pp. 109-120
    • Beutler, B.1
  • 5
    • 33644681806 scopus 로고    scopus 로고
    • LBP and CD14 secreted in tears by the lacrimal glands modulate the LPS response of corneal epithelial cells
    • Blais D.R., Vascotto S.G., Griffith M., Altosaar I. LBP and CD14 secreted in tears by the lacrimal glands modulate the LPS response of corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 2005, 46:4235-4244.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 4235-4244
    • Blais, D.R.1    Vascotto, S.G.2    Griffith, M.3    Altosaar, I.4
  • 6
    • 24944480858 scopus 로고    scopus 로고
    • Expression of Toll-like receptors in healthy and allergic conjunctiva
    • Bonini S., Micera A., Iovieno A., et al. Expression of Toll-like receptors in healthy and allergic conjunctiva. Ophthalmol 2005, 112:1528-1534.
    • (2005) Ophthalmol , vol.112 , pp. 1528-1534
    • Bonini, S.1    Micera, A.2    Iovieno, A.3
  • 8
    • 0034201213 scopus 로고    scopus 로고
    • Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells
    • Chaly Y.V., Paleolog E.M., Kolesnikova T.S., Tikhonov I.I., Petratchenko E.V., Voitenok N.N. Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells. Eur. Cytokine Netw. 2000, 11:257-266.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 257-266
    • Chaly, Y.V.1    Paleolog, E.M.2    Kolesnikova, T.S.3    Tikhonov, I.I.4    Petratchenko, E.V.5    Voitenok, N.N.6
  • 9
    • 0030038197 scopus 로고    scopus 로고
    • Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils
    • Chertov O., Michiel D.F., Xu L., Wang J.M., Tani K., Murphy W.J., Longo D.L., Taub D.D., Oppenheim J.J. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J. Biol. Chem. 1996, 271:2935-2940.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2935-2940
    • Chertov, O.1    Michiel, D.F.2    Xu, L.3    Wang, J.M.4    Tani, K.5    Murphy, W.J.6    Longo, D.L.7    Taub, D.D.8    Oppenheim, J.J.9
  • 10
    • 17444420662 scopus 로고    scopus 로고
    • Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses
    • Cook E.B., Stahl J.L., Esnault S., Barney N.P., Graziano F.M. Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Ann. Allergy Asthma Immunol. 2005, 94:486-497.
    • (2005) Ann. Allergy Asthma Immunol. , vol.94 , pp. 486-497
    • Cook, E.B.1    Stahl, J.L.2    Esnault, S.3    Barney, N.P.4    Graziano, F.M.5
  • 11
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold S.S., Kaisho T., Hemmi H., Akira S., Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004, 303:1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 13
    • 0033024366 scopus 로고    scopus 로고
    • Keratocyte and fibroblast phenotypes in the repairing cornea
    • Fini M.E. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog. Retin. Eye Res. 1999, 18:529-551.
    • (1999) Prog. Retin. Eye Res. , vol.18 , pp. 529-551
    • Fini, M.E.1
  • 15
    • 77954216239 scopus 로고    scopus 로고
    • Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells
    • Garreis F., Schlorf T., Worlitzsch D., Steven P., Bräuer L., Jäger K., Paulsen F.P. Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells. Histochem. Cell Biol. 2010, 134:59-73.
    • (2010) Histochem. Cell Biol. , vol.134 , pp. 59-73
    • Garreis, F.1    Schlorf, T.2    Worlitzsch, D.3    Steven, P.4    Bräuer, L.5    Jäger, K.6    Paulsen, F.P.7
  • 16
    • 70350660970 scopus 로고    scopus 로고
    • Hydrocortisone suppression of the expression of VEGF may relate to toll-like receptor (TLR) 2 and 4
    • Gao T., Lin Z., Jin X. Hydrocortisone suppression of the expression of VEGF may relate to toll-like receptor (TLR) 2 and 4. Curr. Eye Res. 2009, 34:777-784.
    • (2009) Curr. Eye Res. , vol.34 , pp. 777-784
    • Gao, T.1    Lin, Z.2    Jin, X.3
  • 17
    • 21344435975 scopus 로고    scopus 로고
    • Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity
    • Gordon Y.J., Huang L.C., Romanowski E.G., et al. Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr. Eye Res. 2005, 30:385-394.
    • (2005) Curr. Eye Res. , vol.30 , pp. 385-394
    • Gordon, Y.J.1    Huang, L.C.2    Romanowski, E.G.3
  • 18
    • 77954480383 scopus 로고    scopus 로고
    • Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling
    • Guan Y., Ranoa D.R., Jiang S., Mutha S.K., Li X., Baudry J., Tapping R.I. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. J. Immunol. 2010, 184:5094-5103.
    • (2010) J. Immunol. , vol.184 , pp. 5094-5103
    • Guan, Y.1    Ranoa, D.R.2    Jiang, S.3    Mutha, S.K.4    Li, X.5    Baudry, J.6    Tapping, R.I.7
  • 21
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi F., Smith K.D., Ozinsky A., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001, 410:1099-1103.
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1    Smith, K.D.2    Ozinsky, A.3
  • 22
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
    • Heil F., Hemmi H., Hochrein H., et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 2004, 303:1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3
  • 23
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H., Takeuchi O., Kawai T., et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000, 408:740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 24
    • 0346366980 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2
    • Hertz C.J., Wu Q., Porter E.M., Zhang Y.J., Weismüller K.H., Godowski P.J., Ganz T., Randell S.H., Modlin R.L. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J. Immunol. 2003, 171:6820-6826.
    • (2003) J. Immunol. , vol.171 , pp. 6820-6826
    • Hertz, C.J.1    Wu, Q.2    Porter, E.M.3    Zhang, Y.J.4    Weismüller, K.H.5    Godowski, P.J.6    Ganz, T.7    Randell, S.H.8    Modlin, R.L.9
  • 26
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdörfer B., Giese T., Endres S., Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002, 168:4531-4537.
    • (2002) J. Immunol. , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdörfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 27
    • 33745837838 scopus 로고    scopus 로고
    • Human corneal epithelial cells responds to ocular-pathogenic, but not to nonpathogenic-flagellin
    • Hozono Y., Ueta M., Hamuro J., et al. Human corneal epithelial cells responds to ocular-pathogenic, but not to nonpathogenic-flagellin. Biochem. Biophys. Res. Commun. 2006, 347:238-247.
    • (2006) Biochem. Biophys. Res. Commun. , vol.347 , pp. 238-247
    • Hozono, Y.1    Ueta, M.2    Hamuro, J.3
  • 29
    • 35748985576 scopus 로고    scopus 로고
    • Cathelicidin-deficient (Cnlp -/-) mice show increased susceptibility to Pseudomonas aeruginosa keratitis
    • Huang L.C., Reins R.Y., Gallo R.L., McDermott A.M. Cathelicidin-deficient (Cnlp -/-) mice show increased susceptibility to Pseudomonas aeruginosa keratitis. Invest. Ophthalmol. Vis. Sci. 2007, 48:4498-4508.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 4498-4508
    • Huang, L.C.1    Reins, R.Y.2    Gallo, R.L.3    McDermott, A.M.4
  • 30
    • 35848930094 scopus 로고    scopus 로고
    • In vitro activity of human beta-defensin 2 against Pseudomonas aeruginosa in the presence of tear fluid
    • Huang L.C., Redfern R.L., Narayanan S., Reins R.Y., McDermott A.M. In vitro activity of human beta-defensin 2 against Pseudomonas aeruginosa in the presence of tear fluid. Antimicrob. Agents Chemother. 2007, 51:3853-3860.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 3853-3860
    • Huang, L.C.1    Redfern, R.L.2    Narayanan, S.3    Reins, R.Y.4    McDermott, A.M.5
  • 32
    • 33747065242 scopus 로고    scopus 로고
    • Preserving the cornea: corneal storage media
    • Jeng B.H. Preserving the cornea: corneal storage media. Curr. Opin. Ophthalmol. 2006, 17:332-337.
    • (2006) Curr. Opin. Ophthalmol. , vol.17 , pp. 332-337
    • Jeng, B.H.1
  • 33
    • 34547652548 scopus 로고    scopus 로고
    • Expression of Toll-like receptors in healthy and herpes simplex virus-infected cornea
    • Jin X., Qin Q., Chen W., et al. Expression of Toll-like receptors in healthy and herpes simplex virus-infected cornea. Cornea 2007, 26:847-852.
    • (2007) Cornea , vol.26 , pp. 847-852
    • Jin, X.1    Qin, Q.2    Chen, W.3
  • 34
    • 41949139585 scopus 로고    scopus 로고
    • Expression of toll-like receptors in the Fusarium solani infected cornea
    • Jin X., Qin Q., Lin Z., Chen W., Qu J. Expression of toll-like receptors in the Fusarium solani infected cornea. Curr. Eye Res. 2008, 33:319-324.
    • (2008) Curr. Eye Res. , vol.33 , pp. 319-324
    • Jin, X.1    Qin, Q.2    Lin, Z.3    Chen, W.4    Qu, J.5
  • 35
    • 73449089086 scopus 로고    scopus 로고
    • Glucocorticoids inhibit the innate immune system of human corneal fibroblast through their suppression of toll-like receptors
    • Jin X., Qin Q., Tu L., Qu J. Glucocorticoids inhibit the innate immune system of human corneal fibroblast through their suppression of toll-like receptors. Mol. Vis. 2009, 15:2435-2441.
    • (2009) Mol. Vis. , vol.15 , pp. 2435-2441
    • Jin, X.1    Qin, Q.2    Tu, L.3    Qu, J.4
  • 36
    • 0036890119 scopus 로고    scopus 로고
    • Expression of functional Toll-like receptor 2 on human epidermal keratinocytes
    • Kawai K., Shimura H., Minagawa M., Ito A., Tomiyama K., Ito M. Expression of functional Toll-like receptor 2 on human epidermal keratinocytes. J. Dermatol. Sci. 2002, 30:185-194.
    • (2002) J. Dermatol. Sci. , vol.30 , pp. 185-194
    • Kawai, K.1    Shimura, H.2    Minagawa, M.3    Ito, A.4    Tomiyama, K.5    Ito, M.6
  • 37
    • 11144305015 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts
    • Kumagai N., Fukuda K., Fujitsu Y., Lu Y., Chikamoto N., Nishida T. Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts. Invest. Ophthalmol. Vis. Sci. 2005, 46:114-120.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 114-120
    • Kumagai, N.1    Fukuda, K.2    Fujitsu, Y.3    Lu, Y.4    Chikamoto, N.5    Nishida, T.6
  • 38
    • 32244445123 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells
    • Kumar A., Zhang J., Yu F.S. Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Microbes Infect. 2006, 8:380-389.
    • (2006) Microbes Infect. , vol.8 , pp. 380-389
    • Kumar, A.1    Zhang, J.2    Yu, F.S.3
  • 39
    • 35748965018 scopus 로고    scopus 로고
    • Modulation of corneal epithelial innate immune response to pseudomonas infection by flagellin pretreatment
    • Kumar A., Yin J., Zhang J., Yu F.S. Modulation of corneal epithelial innate immune response to pseudomonas infection by flagellin pretreatment. Invest. Ophthalmol. Vis. Sci. 2007, 48:4664-4670.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 4664-4670
    • Kumar, A.1    Yin, J.2    Zhang, J.3    Yu, F.S.4
  • 40
    • 37749037714 scopus 로고    scopus 로고
    • Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis
    • Kumar A., Hazlett L.D., Yu F.S. Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis. Infect. Immun. 2008, 76:89-96.
    • (2008) Infect. Immun. , vol.76 , pp. 89-96
    • Kumar, A.1    Hazlett, L.D.2    Yu, F.S.3
  • 41
    • 34250179508 scopus 로고    scopus 로고
    • Expression of toll-like receptors in human limbal and conjunctival epithelial cells
    • Li J., Shen J., Beuerman R.W. Expression of toll-like receptors in human limbal and conjunctival epithelial cells. Mol. Vis. 2007, 13:813-822.
    • (2007) Mol. Vis. , vol.13 , pp. 813-822
    • Li, J.1    Shen, J.2    Beuerman, R.W.3
  • 42
    • 33749127871 scopus 로고    scopus 로고
    • Defensins HNP1 and HBD2 stimulation of wound-associated responses in human conjunctival fibroblasts
    • Li J., Raghunath M., Tan D., et al. Defensins HNP1 and HBD2 stimulation of wound-associated responses in human conjunctival fibroblasts. Invest. Ophthalmol. Vis. Sci. 2006, 47:3811-3819.
    • (2006) Invest. Ophthalmol. Vis. Sci. , vol.47 , pp. 3811-3819
    • Li, J.1    Raghunath, M.2    Tan, D.3
  • 43
    • 59449100129 scopus 로고    scopus 로고
    • Stimulation of specific cytokines in human conjunctival epithelial cells by defensins HNP1, HBD2, and HBD3
    • Li J., Zhu H.Y., Beuerman R.W. Stimulation of specific cytokines in human conjunctival epithelial cells by defensins HNP1, HBD2, and HBD3. Invest. Ophthalmol. Vis. Sci. 2009, 50:644-653.
    • (2009) Invest. Ophthalmol. Vis. Sci. , vol.50 , pp. 644-653
    • Li, J.1    Zhu, H.Y.2    Beuerman, R.W.3
  • 44
    • 42049086745 scopus 로고    scopus 로고
    • Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2
    • Li Q., Kumar A., Gui J.F., Yu F.S. Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2. Microb. Pathog. 2008, 44:426-434.
    • (2008) Microb. Pathog. , vol.44 , pp. 426-434
    • Li, Q.1    Kumar, A.2    Gui, J.F.3    Yu, F.S.4
  • 45
    • 34347323982 scopus 로고    scopus 로고
    • Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa
    • Maltseva I.A., Fleiszig S.M., Evans D.J., Kerr S., Sidhu S.S., McNamara N.A., Basbaum C. Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa. Exp. Eye Res. 2007, 85:142-153.
    • (2007) Exp. Eye Res. , vol.85 , pp. 142-153
    • Maltseva, I.A.1    Fleiszig, S.M.2    Evans, D.J.3    Kerr, S.4    Sidhu, S.S.5    McNamara, N.A.6    Basbaum, C.7
  • 47
    • 0037406799 scopus 로고    scopus 로고
    • Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells
    • McDermott A.M., Redfern R.L., Zhang B., Pei Y., Huang L., Proske R.J. Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 2003, 44:1859-1865.
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 1859-1865
    • McDermott, A.M.1    Redfern, R.L.2    Zhang, B.3    Pei, Y.4    Huang, L.5    Proske, R.J.6
  • 48
    • 0034924159 scopus 로고    scopus 로고
    • Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea
    • McDermott A.M., Redfern R.L., Zhang B. Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea. Curr. Eye Res. 2001, 22:64-67.
    • (2001) Curr. Eye Res. , vol.22 , pp. 64-67
    • McDermott, A.M.1    Redfern, R.L.2    Zhang, B.3
  • 49
    • 0032731116 scopus 로고    scopus 로고
    • Ocular surface epithelia express mRNA for human beta defensin-2
    • McNamara N.A., Van R., Tuchin O.S., Fleiszig S.M. Ocular surface epithelia express mRNA for human beta defensin-2. Exp. Eye Res. 1999, 69:483-490.
    • (1999) Exp. Eye Res. , vol.69 , pp. 483-490
    • McNamara, N.A.1    Van, R.2    Tuchin, O.S.3    Fleiszig, S.M.4
  • 50
    • 1342282224 scopus 로고    scopus 로고
    • Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense
    • Murakami M., Lopez-Garcia B., Braff M., Dorschner R.A., Gallo R.L. Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. J. Immunol. 2004, 172:3070-3077.
    • (2004) J. Immunol. , vol.172 , pp. 3070-3077
    • Murakami, M.1    Lopez-Garcia, B.2    Braff, M.3    Dorschner, R.A.4    Gallo, R.L.5
  • 52
    • 0041861226 scopus 로고    scopus 로고
    • Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease
    • Narayanan S., Miller W.L., McDermott A.M. Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease. Invest. Ophthalmol. Vis. Sci. 2003, 44:3795-3801.
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 3795-3801
    • Narayanan, S.1    Miller, W.L.2    McDermott, A.M.3
  • 53
    • 0035058454 scopus 로고    scopus 로고
    • Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells
    • Niyonsaba F., Someya A., Hirata M., et al. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Eur. J. Immunol. 2001, 31:1066-1075.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1066-1075
    • Niyonsaba, F.1    Someya, A.2    Hirata, M.3
  • 54
    • 33748805216 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase (ALDH) 3A1 expression by the human keratocyte and its repair phenotypes
    • Pei Y., Reins R.Y., McDermott A.M. Aldehyde dehydrogenase (ALDH) 3A1 expression by the human keratocyte and its repair phenotypes. Exp. Eye Res. 2006, 83:1063-1073.
    • (2006) Exp. Eye Res. , vol.83 , pp. 1063-1073
    • Pei, Y.1    Reins, R.Y.2    McDermott, A.M.3
  • 55
    • 77952769522 scopus 로고    scopus 로고
    • Toll-like receptors in ocular surface disease
    • Redfern R.L., McDermott A.M. Toll-like receptors in ocular surface disease. Exp. Eye Res. 2010, 90:679-687.
    • (2010) Exp. Eye Res. , vol.90 , pp. 679-687
    • Redfern, R.L.1    McDermott, A.M.2
  • 56
    • 40749146805 scopus 로고    scopus 로고
    • Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells
    • Rivas-Santiago B., Hernandez-Pando R., Carranza C., Juarez E., Contreras J.L., Aguilar-Leon D., Torres M., Sada E. Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells. Infect. Immun. 2008, 76:935-941.
    • (2008) Infect. Immun. , vol.76 , pp. 935-941
    • Rivas-Santiago, B.1    Hernandez-Pando, R.2    Carranza, C.3    Juarez, E.4    Contreras, J.L.5    Aguilar-Leon, D.6    Torres, M.7    Sada, E.8
  • 57
    • 39149123168 scopus 로고    scopus 로고
    • MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages
    • Rowlett R.M., Chrestensen C.A., Nyce M., et al. MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 294:G452-G459.
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.294
    • Rowlett, R.M.1    Chrestensen, C.A.2    Nyce, M.3
  • 58
    • 0035724878 scopus 로고    scopus 로고
    • Host-defense mechanism of the ocular surfaces
    • Sack R.A., Nunes I., Beaton A., et al. Host-defense mechanism of the ocular surfaces. Biosci. Rep. 2001, 21:463-480.
    • (2001) Biosci. Rep. , vol.21 , pp. 463-480
    • Sack, R.A.1    Nunes, I.2    Beaton, A.3
  • 59
    • 0036785559 scopus 로고    scopus 로고
    • The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses
    • Scott M.G., Davidson D.J., Gold M.R., et al. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J. Immunol. 2002, 169:3883-3891.
    • (2002) J. Immunol. , vol.169 , pp. 3883-3891
    • Scott, M.G.1    Davidson, D.J.2    Gold, M.R.3
  • 60
    • 12444337486 scopus 로고    scopus 로고
    • Expression and activity of beta-defensins and LL-37 in the developing human lung
    • Starner T.D., Agerberth B., Gudmundsson G.H., McCray P.B. Expression and activity of beta-defensins and LL-37 in the developing human lung. J. Immunol. 2005, 174:1608-1615.
    • (2005) J. Immunol. , vol.174 , pp. 1608-1615
    • Starner, T.D.1    Agerberth, B.2    Gudmundsson, G.H.3    McCray, P.B.4
  • 61
    • 12144286763 scopus 로고    scopus 로고
    • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    • Tabeta K., Georgel P., Janssen E., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:3516-3521.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 3516-3521
    • Tabeta, K.1    Georgel, P.2    Janssen, E.3
  • 62
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi O., Sato S., Horiuchi T., et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 2002, 169:10-14.
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3
  • 63
    • 0024797674 scopus 로고
    • Monocyte-chemotactic activity of defensins from human neutrophils
    • Territo M.C., Ganz T., Selsted M.E., Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J. Clin. Invest. 1989, 84:2017-2020.
    • (1989) J. Clin. Invest. , vol.84 , pp. 2017-2020
    • Territo, M.C.1    Ganz, T.2    Selsted, M.E.3    Lehrer, R.4
  • 64
    • 4344627821 scopus 로고    scopus 로고
    • Endogenous ligands of Toll-like receptors
    • Tsan M.F., Gao B. Endogenous ligands of Toll-like receptors. J. Leukoc. Biol. 2004, 76:514-519.
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 514-519
    • Tsan, M.F.1    Gao, B.2
  • 65
    • 68349125871 scopus 로고    scopus 로고
    • Comparison of gene expression profiles of conjunctival cell lines with primary cultured conjunctival epithelial cells and human conjunctival tissue
    • Tong L., Diebold Y., Calonge M., Gao J., Stern M.E., Beuerman R.W. Comparison of gene expression profiles of conjunctival cell lines with primary cultured conjunctival epithelial cells and human conjunctival tissue. Gene Exp. 2009, 14:265-278.
    • (2009) Gene Exp. , vol.14 , pp. 265-278
    • Tong, L.1    Diebold, Y.2    Calonge, M.3    Gao, J.4    Stern, M.E.5    Beuerman, R.W.6
  • 66
    • 4344705045 scopus 로고    scopus 로고
    • Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium
    • Ueta M., Nochi T., Jang M.H., et al. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J. Immunol. 2004, 173:3337-3347.
    • (2004) J. Immunol. , vol.173 , pp. 3337-3347
    • Ueta, M.1    Nochi, T.2    Jang, M.H.3
  • 67
    • 17444368008 scopus 로고    scopus 로고
    • Triggering of TLR3 by polyI: C in human corneal epithelial cells to induce inflammatory cytokines
    • Ueta M., Hamuro J., Kiyono H., Kinoshita S. Triggering of TLR3 by polyI: C in human corneal epithelial cells to induce inflammatory cytokines. Biochem. Biophys. Res. Commun. 2005, 331:285-294.
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , pp. 285-294
    • Ueta, M.1    Hamuro, J.2    Kiyono, H.3    Kinoshita, S.4
  • 70
    • 63149168111 scopus 로고    scopus 로고
    • Beta-defensin-2 promotes resistance against infection with P. aeruginosa
    • Wu M., McClellan S.A., Barrett R.P., Hazlett L.D. Beta-defensin-2 promotes resistance against infection with P. aeruginosa. J. Immunol. 2009, 182:1609-1611.
    • (2009) J. Immunol. , vol.182 , pp. 1609-1611
    • Wu, M.1    McClellan, S.A.2    Barrett, R.P.3    Hazlett, L.D.4
  • 71
    • 76249084929 scopus 로고    scopus 로고
    • Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis
    • Wu M., McClellan S.A., Barrett R.P., Zhang Y., Hazlett L.D. Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. J. Immunol. 2009, 183:8054-8060.
    • (2009) J. Immunol. , vol.183 , pp. 8054-8060
    • Wu, M.1    McClellan, S.A.2    Barrett, R.P.3    Zhang, Y.4    Hazlett, L.D.5
  • 72
    • 34249809399 scopus 로고    scopus 로고
    • Expression profiles and function of Toll-like receptors in human corneal epithelia
    • Wu X., Gao J., Ren M. Expression profiles and function of Toll-like receptors in human corneal epithelia. China Med. J. 2007, 120:893-897.
    • (2007) China Med. J. , vol.120 , pp. 893-897
    • Wu, X.1    Gao, J.2    Ren, M.3
  • 73
    • 33746689785 scopus 로고    scopus 로고
    • The role of Toll-like receptors and related receptors of the innate immune system in asthma
    • Yang I.A., Fong K.M., Holgate S.T., Holloway J.W. The role of Toll-like receptors and related receptors of the innate immune system in asthma. Curr. Opin. Allergy Clin. Immunol. 2006, 6:23-28.
    • (2006) Curr. Opin. Allergy Clin. Immunol. , vol.6 , pp. 23-28
    • Yang, I.A.1    Fong, K.M.2    Holgate, S.T.3    Holloway, J.W.4
  • 75
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415:389-395.
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 76
    • 47349116634 scopus 로고    scopus 로고
    • Aspergillus fumigatus antigens activate immortalized human corneal epithelial cells via toll-like receptors 2 and 4
    • Zhao J., Wu X.Y. Aspergillus fumigatus antigens activate immortalized human corneal epithelial cells via toll-like receptors 2 and 4. Curr. Eye Res. 2008, 33:447-454.
    • (2008) Curr. Eye Res. , vol.33 , pp. 447-454
    • Zhao, J.1    Wu, X.Y.2


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