Expression and activity of β-defensins and LL-37 in the developing human lung

Journal of Immunology

Volumn 174, Issue 3, 2005, Pages 1608-1615

  Starner, Timothy D ^a   Agerberth, Birgitta ^b   Gudmundsson, Gudmundur H ^c   McCray Jr , Paul B ^a  

^a UNIVERSITY OF IOWA   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF ICELAND   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; INTERLEUKIN 1BETA; UNCLASSIFIED DRUG;

ADOLESCENT; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CHILD; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GESTATIONAL AGE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFECTION SENSITIVITY; INNATE IMMUNITY; LUNG DEVELOPMENT; LUNG INFECTION; LUNG PARENCHYMA; NEWBORN; NEWBORN INFECTION; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION;

EID: 12444337486     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.3.1608     Document Type: Article

References (57)

1. Langrish, C. L., J. C. Buddle, A. J. Thrasher, and D. Goldblatt. 2002. Neonatal dendritic cells are intrinsically biased against Th-1 immune responses. Clin. Exp. Immunol. 128:118.
2. Lawton, A. R. 1986. Ontogeny of B cells and pathogenesis of humoral immunodeficiencies. Clin. Immunol. Immunopathol. 40:5.
3. Suen, Y., S. M. Lee, J. Qian, C. van de Ven, and M. S. Cairo. 1998. Dysregulation of lymphokine production in the neonate and its impact on neonatal cell mediated immunity. Vaccine 16:1369.
4. Levy, O., S. Martin, E. Eichenwald, T. Ganz, E. Valore, S. F. Carroll, K. Lee, D. Goldmann, and G. M. Thorne. 1999. Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability- increasing protein. Pediatrics 104:1327.
5. Salzman, N. H., R. A. Polin, M. C. Harris, E. Ruchelli, A. Hebra, S. Zirin-Butler, A. Jawad, E. Martin Porter, and C. L. Bevins. 1998. Enteric defensin expression in necrotizing enterocolitis. Pediatr. Res. 44:20.
6. Mallow, E. B., A. Harris, N. Salzman, J. P. Russell, R. J. DeBerardinis, E. Ruchelli, and C. L. Bevins. 1996. Human enteric defensins: gene structure and developmental expression. J. Biol. Chem. 271:4038.
7. Singh, P. K., H. P. Jia, K. Wiles, J. Hesselberth, L. Liu, B. A. Conway, E. P. Greenberg, E. V. Valore, M. J. Welsh, T. Ganz, et al. 1998. Production of β-defensins by human airway epithelia. Proc. Natl. Acad. Sci. USA 95:14961.
8. Harder, J., J. Bartels, E. Christophers, and J. M. Schroder. 2001. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276:5707.
9. Bals, R., X. Wang, M. Zasloff, and J. M. Wilson. 1998. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc. Natl. Acad. Sci. USA 95:9541.
10. Agerberth, B., J. Grunewald, E. Castanos-Velez, B. Olsson, H. Jornvall, H. Wigzell, A. Eklund, and G. H. Gudmundsson. 1999. Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. Am. J. Respir. Crit. Care Med. 160:283.
11. Yoshio, H., M. Tollin, G. H. Gudmundsson, H. Lagercrantz, H. Jornvall, G. Marchini, and B. Agerberth. 2003. Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense. Pediatr. Res. 53:211.
12. Marchini, G., S. Lindow, H. Brismar, B. Stabi, V. Berggren, A. K. Ulfgren, S. Lonne-Rahm, B. Agerberth, and G. H. Gudmundsson. 2002. The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa. Br. J. Dermatol. 147:1127.
13. Schaller-Bals, S., A. Schulze, and R. Bals. 2002. Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am. J. Respir. Crit. Care Med. 165:992.
14. Valore, E. V., C. H. Park, A. J. Quayle, K. R. Wiles, P. B. McCray, Jr., and T. Ganz. 1998. Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101:1633.
15. Saiman, L., S. Tabibi, T. D. Starner, P. San Gabriel, P. L. Winokur, H. P. Jia, P. B. McCray, Jr., and B. F. Tack. 2001. Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis. Antimicrob. Agents Chemother. 45:2838.
16. Starner, T. D., C. K. Barker, H. P. Jia, Y. Kang, and P. B. McCray, Jr. 2003. CCL20 is an inducible product of human airway epithelia with innate immune properties. Am. J. Respir. Cell Mol. Biol. 29:627.
17. Karp, P. H., T. O. Moninger, S. P. Weber, T. S. Nesselhauf, J. L. Launspach, J. Zabner, and M. J. Welsh. 2002. An in vitro model of differentiated human airway epithelia: methods for establishing primary cultures. Methods Mol. Biol. 188:115.
18. Proud, D., S. P. Sanders, and S. Wiehler. 2004. Human rhinovirus infection induces airway epithelial cell production of human β-defensin 2 both in vitro and in vivo. J. Immunol. 172:4637.
19. Gudmundsson, G. H., B. Agerberth, J. Odeberg, T. Bergman, B. Olsson, and R. Salcedo. 1996. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur. J. Biochem. 238:325.
20. Starner, T. D., W. E. Swords, M. A. Apicella, and P. B. McCray, Jr. 2002. Susceptibility of nontypeable Haemophilus influenzae to human β-defensins is influenced by lipooligosaccharide acylation. Infect. Immun. 70:5287.
21. Hoban, D. J., D. J. Biedenbach, A. H. Mutnick, and R. N. Jones. 2003. Pathogen of occurrence and susceptibility patterns associated with pneumonia in hospitalized patients in North America: results of the SENTRY Antimicrobial Surveillance Study (2000). Diagn. Microbiol. Infect. Dis. 45:279.
22. Yin, C. C., L. W. Huah, J. T. Lin, A. Goh, H. Ling, and C. O. Moh. 2003. Lower respiratory tract infection in hospitalized children. Respirology 8:83.
23. Schroder, J. M., and J. Harder. 1999. Human β-defensin-2. Int. J. Biochem. Cell Biol. 31:645.
24. Mathews, M., H. P. Jia, J. M. Guthmiller, G. Losh, S. Graham, G. K. Johnson, B. F. Tack, and P. B. McCray, Jr. 1999. Production of β-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect. Immun. 67:2740.
25. O'Neil, D. A., E. M. Porter, D. Elewaut, G. M. Anderson, L. Eckmann, T. Ganz, and M. F. Kagnoff. 1999. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium. J. Immunol. 163:6718.
26. Harder, J., U. Meyer-Hoffert, L. M. Teran, L. Schwichtenberg, J. Bartels, S. Maune, and J. M. Schroder. 2000. Mucoid Pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6, induce human β-defensin-2 in respiratory epithelia. Am. J. Respir. Cell Mol. Biol. 22:714.
27. Tsutsumi-Ishii, Y., and I. Nagaoka. 2003. Modulation of human β-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J. Immunol. 170:4226.
28. Jia, H. P., T. Starner, M. Ackermann, P. Kirby, B. F. Tack, and P. B. McCray. 2001. Abundant human β-defensin-I expression in milk and mammary gland epithelium. J. Pediatr. 138:109.
29. Huttner, K. M., D. J. Brezinski-Caliguri, M. M. Mahoney, and G. Diamond. 1998. Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract. J. Nutr. 128:297S.
30. Meyerholz, D. K., J. M. Gallup, B. M. Grubor, R. B. Evans, B. F. Tack, P. B. McCray, Jr., and M. R. Ackermann. 2004. Developmental expression and distribution of sheep β-defensin-2. Dev. Comp. Immunol. 28:171.
31. Ouellette, A. J., R. M. Greco, M. James, D. Frederick, J. Naftilan, and J. T. Fallon. 1989. Developmental regulation of cryptdin, a corticostatin/ defensin precursor mRNA in mouse small intestinal crypt epithelium. J. Cell Biol. 108:1687.
32. Dorschner, R. A., K. H. Lin, M. Murakami, and R. L. Gallo. 2003. Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response. Pediatr. Res. 53:566.
33. Diamond, G., D. E. Jones, and C. L. Bevins. 1993. Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc. Natl. Acad. Sci. USA 90:4596.
34. McCray, P. B., Jr., and L. Bentley. 1997. Human airway epithelia express a β-defensin. Am. J. Respir. Cell Mol. Biol. 16:343.
35. Sadow, K. B., R. Derr, and S. J. Teach. 1999. Bacterial infections in infants 60 days and younger: epidemiology, resistance, and implications for treatment. Arch. Pediatr. Adolesc. Med. 153:611.
36. Jain, A., I. Roy, M. K. Gupta, M. Kumar, and S. K. Agarwal. 2003. Prevalence of extended-spectrum β-lactamase-producing Gram-negative bacteria in septicaemic neonates in a tertiary care hospital. J. Med. Microbiol. 52:421.
37. Brown, J. C., J. L. Burns, and P. Cummings. 2002. Ampicillin use in infant fever: a systematic review. Arch. Pediatr. Adolesc. Med. 156:27.
38. Byington, C. L., K. K. Rittichier, K. E. Bassett, H. Castillo, T. S. Glasgow, J. Daly, and A. T. Pavia. 2003. Serious bacterial infections in febrile infants younger than 90 days of age: the importance of ampicillin-resistant pathogens. Pediatrics 111:964.
39. Sinha, A., D. Yokoe, and R. Platt. 2003. Intraparturn antibiotics and neonatal invasive infections caused by organisms other than group B streptococcus. J. Pediatr. 142:492.
40. Dargaville, P. A., M. South, P. Vervaart, and P. N. McDougall. 1999. Validity of markers of dilution in small volume lung lavage. Am. J. Respir. Crit. Care Med. 160:778.
41. Marcy, T. W., W. W. Merrill, J. A. Rankin, and H. Y. Reynolds. 1987. Limitations of using urea to quantify epithelial lining fluid recovered by bronchoalveolar lavage. Am. Rev. Respir. Dis. 135:1276.
42. Rennard, S. I., G. Basset, D. Lecossier, K. M. O'Donnell, P. Pinkston, P. G. Martin, and R. G. Crystal. 1986. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J. Appl. Physiol. 60:532.
43. Travis, S. M., B. A. Conway, J. Zabner, J. J. Smith, N. N. Anderson, P. K. Singh, E. P. Greenberg, and M. J. Welsh. 1999. Activity of abundant antimicrobials of the human airway. Am. J. Respir. Cell Mol. Biol. 20:872.
44. Singh, P., B. Tack, P. McCray, and M. Welsh. 2000. Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am. J. Physiol. 279:L799.
45. Yang, D., O. Chertov, S. N. Bykovskaia, Q. Chen, M. J. Buffo, J. Shogan, M. Anderson, J. M. Schroder, J. M. Wang, O. M. Howard, et al. 1999. β-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525.
46. Wu, Z., D. M. Hoover, D. Yang, C. Boulegue, F. Santamaria, J. J. Oppenheim, J. Lubkowski, and W. Lu. 2003. Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3. Proc. Natl. Acad. Sci. USA 100:8880.
47. Scott, M. G., D. J. Davidson, M. R. Gold, D. Bowdish, and R. E. Hancock. 2002. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J. Immunol. 169:3883.
48. Davidson, D. J., A. J. Currie, G. S. Reid, D. M. Bowdish, K. L. MacDonald, R. C. Ma, R. E. Hancock, and D. P. Speert. 2004. The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. J. Immunol. 172:1146.
49. Jia, H. P., B. C. Schutte, A. Schudy, R. Linzmeier, J. M. Guthmiller, G. K. Johnson, B. F. Tack, J. P. Mitros, A. Rosenthal, T. Ganz, et al. 2001. Discovery of new human β-defensins using a genomics-based approach. Gene 263:211.
50. Turner, J., Y. Cho, N. N. Dinh, A. J. Waring, and R. I. Lehrer. 1998. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agents Chemother. 42:2206.
51. Liu, L., A. A. Roberts, and T. Ganz. 2003. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J. Immunol. 170:575.
52. Stumbles, P. A., J. W. Upham, and P. G. Holt. 2003. Airway dendritic cells: co-ordinators of immunological homeostasis and immunity in the respiratory tract. Apmis 111:741.
53. Krisanaprakornkit, S., J. R. Kimball, A. Weinberg, R. P. Darveau, B. W. Bainbridge, and B. A. Dale. 2000. Inducible expression of human β-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect. Immun. 68:2907.
54. Duits, L. A., P. H. Nibbering, E. van Strijen, J. B. Vos, S. P. Mannesse-Lazeroms, M. A. van Sterkenburg, and P. S. Hiemstra. 2003. Rhinovirus increases human β-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells. FEMS Immunol. Med. Microbiol. 38:59.
55. Krishnan, S., M. Craven, R. C. Welliver, N. Ahmad, and M. Halonen. 2003. Differences in participation of innate and adaptive immunity to respiratory syncytial virus in adults and neonates. J. Infect. Dis. 188:433.
56. Koczulla, R., G. von Degenfeld, C. Kupatt, F. Krotz, S. Zahler, T. Gloe, K. Issbrucker, P. Unterberger, M. Zaiou, C. Lebherz, et al. 2003. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 111:1665.
57. Murphy, C. J., B. A. Foster, M. J. Mannis, M. E. Selsted, and T. W. Reid. 1993. Defensins are mitogenic for epithelial cells and fibroblasts. J. Cell Physiol. 155:408.