Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 10, 2007, Pages 4459-4467

  Mayer, Wolfgang J ^a,b   Irschick, Ulrike M ^a   Moser, Patrizia ^c   Wurm, Martin ^a   Huemer, Hartwig P ^a   Romani, Nikolaus ^a   Irschick, Eveline U ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF MUNICH   (Germany)

^c MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD209 ANTIGEN; CD45 ANTIGEN; CELL MARKER; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; GLYCOPROTEIN P 15095; HLA DR ANTIGEN; LANGERIN; T6 ANTIGEN; BIOLOGICAL MARKER; LEUKOCYTE ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CELL DENSITY; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; CORNEA STROMA; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LANGERHANS CELL; MACROPHAGE; MALE; PRIORITY JOURNAL; CELL CULTURE; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; MIDDLE AGED; PHENOTYPE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; BIOLOGICAL MARKERS; CELLS, CULTURED; CORNEA; DENDRITIC CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HLA-DR ANTIGENS; HUMANS; LANGERHANS CELLS; MALE; MIDDLE AGED; PHENOTYPE;

EID: 35748933544     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1184     Document Type: Article

References (43)

1. Hamrah P, Huq SO, Liu Y, Zhang Q, Dana MR. Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leukoc Biol. 2003;74:172-178.
2. Hamrah P, Liu Y, Zhang Q, Dana MR. The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci. 2003;44:581-589.
3. Hamrah P, Zhang Q, Liu Y, Dana MR. Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci. 2002;43:639-646.
4. Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana MR. Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med. 2002;195:259-268.
5. Niederkorn JY. The immune privilege of corneal allografts. Transplantation. 1999;67:1503-1508.
6. Novak N, Siepmann K, Zierhut M, Bieber T. The good, the bad and the ugly - APCs of the eye. Trends Immunol. 2003;24:570-574.
7. Valladeau J, Ravel O, Dezutter-Dambuyant C, et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000;12:71-81.
8. Lutz MB, Steinkasserer A. Handbook of Dendritic Cells. 1st ed. Weinheim, Germany: Wiley-VCH; 2006:1226.
9. Romani N, Holzmann S, Tripp CH, Koch F, Stoitzner P. Langerhans cells - dendritic cells of the epidermis. Apmis. 2003;111:725-740.
10. Pels E, van der Gaag R. HLA-A,B,C, and HLA-DR antigens and dendritic cells in fresh and organ culture preserved corneas. Cornea. 1984;3:231-239.
11. Hamrah P, Dana MR. Corneal antigen-presenting cells. Chem Immunol Allergy. 2007;92:58-70.
12. Valladeau J, Duvert-Frances V, Pin JJ, et al. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur J Immunol. 1999;29:2695-2704.
13. Hunger RE, Sieling PA, Ochoa MT, et al. Langerhans cells utilize CD1a and Langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest. 2004;113:701-708.
14. Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell. 2000;100:587-597.
15. Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell. 2000;100:575-585.
16. Steinman RM. DC-SIGN: a guide to some mysteries of dendritic cells. Cell. 2000;100:491-494.
17. Ebner S, Ehammer Z, Holzmann S, et al. Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Int Immunol. 2004;16:877-887.
18. de Saint-Vis B, Vincent J, Vandenabeele S, et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity. 1998;9:325-336.
19. Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol. 1997;9:10-16.
20. Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Topics Microbiol Immunol. 2006;311:17-58.
21. Huemer HP, Larcher C, Kirchebner W, Klingenschmid J, Gottinger W, Irschick EU. Susceptibility of human retinal pigment epithelial cells to different viruses. Graefe's Arch Clin Exper Ophthalmol. 1996;234:177-185.
22. Dzionek A, Fuchs A, Schmidt P, et al. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 2000;165:6037-6046.
23. Jahnsen FL, Gran E, Haye R, Brandtzaeg P. Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. Am J Respir Cell Mol Biol. 2004;30:31-37.
24. MacDonald KP, Munster DJ, Clark GJ, Dzionek A, Schmitz J, Hart DN. Characterization of human blood dendritic cell subsets. Blood. 2002;100:4512-4520.
25. Streilein JW, Toews GB, Bergstresser PR. Corneal allografts fail to express Ia antigens. Nature. 1979;282:326-327.
26. Dana MR, Qian Y, Hamrah P. Twenty-five-year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection. Cornea. 2000;19:625-643.
27. Niederkorn JY. Immunology and immunomodulation of corneal transplantation. Int Rev Immunol. 2002;21:173-196.
28. Stoitzner P, Holzmann S, McLellan AD, et al. Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207. J Invest Dermatol. 2003;120:266-274.
29. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev. 2002;2:77-84.
30. Rodrigues MM, Rowden G, Hackett J, Bakos I. Langerhans cells in the normal conjunctiva and peripheral cornea of selected species. Invest Ophthalmol Vis Sci. 1981;21:759-765.
31. Seto SK, Chandler JW. Lack of T6 induction on human corneal Langerhans cells in vitro. Invest Ophthalmol Vis Sci. 1990;31:102-106.
32. Yamagami S, Usui T, Amano S, Ebihara N. Bone marrow-derived cells in mouse and human cornea. Cornea. 2005;24:S71-S74.
33. Philipp W, Gottinger W. T6-positive Langerhans cells in diseased corneas. Invest Ophthalmol Vis Sci. 1991;32:2492-2497.
34. - Langerhans cells of the human cornea. Invest Ophthalmol Vis Sci. 1987;28:1719-1722.
35. Yamagami S, Yokoo S, Usui T, Yamagami H, Amano S, Ebihara N. Distinct populations of dendritic cells in the normal human donor corneal epithelium. Invest Ophthalmol Vis Sci. 2005;46:4489-4494.
36. Holzmann S, Tripp CH, Schmuth M, et al. A model system using tape stripping for characterization of Langerhans cell-precursors in vivo. J Invest Dermatol. 2004;122:1165-1174.
37. Granelli-Piperno A, Pritsker A, Pack M, et al. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction. J Immunol. 2005;175:4265-4273.
38. Salaun B, de Saint-Vis B, Clair-Moninot V, et al. Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 2003;33:2619-2629.
39. Ardjomand N, Berghold A, Reich ME. Loss of corneal Langerhans cells during storage in organ culture medium, Optisol and McCarey-Kaufman medium. Eye. 12(pt 1):134-138, 1998.
40. Ardjomand N, Komericki P, Radner H, Aigner R, Reich ME. [Corneal Langerhans cells: behavior during storage in organ culture]. Ophthalmologe. 1997;94:703-706.
41. Simon M, Fellner P, El-Shabrawi Y, Ardjomand N. Influence of donor storage time on corneal allograft survival. Ophthalmology. 2004;111:1534-1538.
42. Krueger GG, Emam M. Biology of Langerhans cells: analysis by experiments to deplete Langerhans cells from human skin. J Invest Dermatol. 1984;82:613-617.
43. Merad M, Manz MG, Karsunky H, et al. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol. 2002;3:1135-1141.