Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA

Biochemistry

Volumn 50, Issue 5, 2011, Pages 618-627

  Grogan, Breeana C ^a   Parker, Jared B ^a   Guminski, Amy F ^a   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5-FLUOROURACIL; 5-FLUOROURACIL (5-FU); ANTI-CANCER AGENTS; B CELLS; BASE PAIRS; CELL LINES; CONTROL-CELL; CULTURE MEDIA; DNA FRAGMENTATION; DNA GLYCOSYLASE; DNA LESIONS; DNA REPAIR; DT40 CELL; GENOMIC DNA; HUMAN CELL LINES; HUMAN CELLS; HUMAN ENZYMES; IN-VITRO; KINETIC ANALYSIS; MOUSE CELL LINES; NUCLEAR EXTRACTS; NUCLEOTIDE POOLS; THYMIDYLATE SYNTHASE; URACIL DERIVATIVES; URACIL-DNA GLYCOSYLASE;

ANIMAL CELL CULTURE; ANIMALS; CATALYSTS; CELL DEATH; DNA; LAKES; NUCLEIC ACIDS; TOXICITY; YEAST;

CELL CULTURE;

ADENOSINE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA GLYCOSYLTRANSFERASE; FLOXURIDINE; FLUOROURACIL; GUANINE; RALTITREXED; THYMIDINE TRIPHOSPHATE; THYMIDYLATE SYNTHASE INHIBITOR; URACIL;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BASE PAIRING; CANCER CELL CULTURE; CATALYST; CELL LEVEL; CELL STRAIN HT29; CHICKEN; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA DAMAGE; DNA REPAIR; DRUG METABOLISM; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CHICKENS; DEOXYURACIL NUCLEOTIDES; DNA; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; ENZYME INHIBITORS; FLUOROURACIL; HELA CELLS; HUMANS; KINETICS; MICE; THYMIDYLATE SYNTHASE; THYMINE NUCLEOTIDES; URACIL;

SACCHAROMYCETALES;

EID: 79952097177     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi102046h     Document Type: Article

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