메뉴 건너뛰기




Volumn 3, Issue 1, 2011, Pages 47-58

REST: Transcriptional and epigenetic regulator

Author keywords

chromatin; chromatin immunoprecipitation; CNS development and disease; epigenome; histone deacetylases; Huntington's disease; next generation sequencing; REST NRSF; transcriptome

Indexed keywords

MICRORNA; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 79951930596     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.10.76     Document Type: Review
Times cited : (27)

References (103)
  • 1
    • 3042747512 scopus 로고    scopus 로고
    • In search of 'stemness'
    • Cai J, Weiss ML, Rao MS: In search of 'stemness'. Exp. Hematol. 32(7), 585-598 (2004).
    • (2004) Exp. Hematol. , vol.32 , Issue.7 , pp. 585-598
    • Cai, J.1    Weiss, M.L.2    Rao, M.S.3
  • 2
    • 33947301272 scopus 로고    scopus 로고
    • Epigenetic signatures of stem-cell identity
    • DOI 10.1038/nrg2046, PII NRG2046
    • Spivakov M, Fisher AG: Epigenetic signatures of stem-cell identity. Nat. Rev. Genet. 8(4), 263-271 (2007). (Pubitemid 46439288)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 263-271
    • Spivakov, M.1    Fisher, A.G.2
  • 3
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A: Perceptions of epigenetics. Nature 447(7143), 396-408 (2007).
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-408
    • Bird, A.1
  • 4
    • 33847032960 scopus 로고    scopus 로고
    • The Mammalian Epigenome
    • DOI 10.1016/j.cell.2007.01.033, PII S0092867407001286
    • Bernstein BE, Meissner A, Lander ES: The mammalian epigenome. Cell 128(4), 669-681 (2007). (Pubitemid 46273573)
    • (2007) Cell , vol.128 , Issue.4 , pp. 669-681
    • Bernstein, B.E.1    Meissner, A.2    Lander, E.S.3
  • 5
    • 57049151436 scopus 로고    scopus 로고
    • Epigenetic principles and mechanisms underlying nervous system functions in health and disease
    • Mehler MF: Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog. Neurobiol. 86(4), 305-341 (2008).
    • (2008) Prog. Neurobiol. , vol.86 , Issue.4 , pp. 305-341
    • Mehler, M.F.1
  • 6
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin Modifications and Their Function
    • DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
    • Kouzarides T: Chromatin modifications and their function. Cell 128(4), 693-705 (2007). (Pubitemid 46273577)
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 7
    • 34547881887 scopus 로고    scopus 로고
    • Xist function: bridging chromatin and stem cells
    • DOI 10.1016/j.tig.2007.07.004, PII S0168952507002338
    • Wutz A: Xist function: bridging chromatin and stem cells. Trends Genet. 23(9), 457-464 (2007). (Pubitemid 47259575)
    • (2007) Trends in Genetics , vol.23 , Issue.9 , pp. 457-464
    • Wutz, A.1
  • 8
    • 77949874234 scopus 로고    scopus 로고
    • Histone variants - Ancient wrap artists of the epigenome
    • Talbert PB, Henikoff S: Histone variants - ancient wrap artists of the epigenome. Nat. Rev. Mol. Cell. Biol. 11(4), 264-275 (2010).
    • (2010) Nat. Rev. Mol. Cell. Biol. , vol.11 , Issue.4 , pp. 264-275
    • Talbert, P.B.1    Henikoff, S.2
  • 10
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner A, Mikkelsen TS, Gu H et al.: Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454(7205), 766-770 (2008).
    • (2008) Nature , vol.454 , Issue.7205 , pp. 766-770
    • Meissner, A.1    Mikkelsen, T.S.2    Gu, H.3
  • 12
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X et al.: A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125(2), 315-326 (2006).
    • (2006) Cell , vol.125 , Issue.2 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 13
    • 33646872978 scopus 로고    scopus 로고
    • Chromatin signatures of pluripotent cell lines
    • Azuara V, Perry P, Sauer S et al.: Chromatin signatures of pluripotent cell lines. Nat. Cell Biol. 29 (2006).
    • (2006) Nat. Cell Biol. , vol.29
    • Azuara, V.1    Perry, P.2    Sauer, S.3
  • 14
    • 0028934541 scopus 로고
    • REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
    • Chong JA, Tapia-Ramirez J, Kim S et al.: REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80, 949-957 (1995).
    • (1995) Cell , vol.80 , pp. 949-957
    • Chong, J.A.1    Tapia-Ramirez, J.2    Kim, S.3
  • 15
    • 0028968802 scopus 로고
    • The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
    • Schoenherr CJ, Anderson DJ: The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267(5202), 1360-1363 (1995).
    • (1995) Science , vol.267 , Issue.5202 , pp. 1360-1363
    • Schoenherr, C.J.1    Anderson, D.J.2
  • 16
    • 0028823394 scopus 로고
    • Silencing is golden: Negative regulation in the control of neuronal gene transcription
    • Schoenherr CJ, Anderson DJ: Silencing is golden: negative regulation in the control of neuronal gene transcription. Curr. Opin. Neurobiol. 5(5), 566-571 (1995).
    • (1995) Curr. Opin. Neurobiol. , vol.5 , Issue.5 , pp. 566-571
    • Schoenherr, C.J.1    Anderson, D.J.2
  • 19
    • 19344378337 scopus 로고    scopus 로고
    • REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis
    • DOI 10.1016/j.cell.2005.03.013, PII S0092867405002850
    • Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G: REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121(4), 645-657 (2005). (Pubitemid 40720016)
    • (2005) Cell , vol.121 , Issue.4 , pp. 645-657
    • Ballas, N.1    Grunseich, C.2    Lu, D.D.3    Speh, J.C.4    Mandel, G.5
  • 20
    • 25844518743 scopus 로고    scopus 로고
    • The many faces of REST oversee epigenetic programming of neuronal genes
    • DOI 10.1016/j.conb.2005.08.015, PII S095943880500139X, Neuronal and Glial Cell Biology/New Technologies
    • Ballas N, Mandel G: The many faces of REST oversee epigenetic programming of neuronal genes. Curr. Opin. Neurobiol. 15(5), 500-506 (2005). (Pubitemid 41394393)
    • (2005) Current Opinion in Neurobiology , vol.15 , Issue.5 , pp. 500-506
    • Ballas, N.1    Mandel, G.2
  • 21
    • 34250767817 scopus 로고    scopus 로고
    • Chromatin crosstalk in development and disease: Lessons from REST
    • DOI 10.1038/nrg2100, PII NRG2100
    • Ooi L, Wood IC: Chromatin crosstalk in development and disease: lessons from REST. Nat. Rev. Genet. 8(7), 544-554 (2007). (Pubitemid 46955208)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.7 , pp. 544-554
    • Ooi, L.1    Wood, I.C.2
  • 22
    • 0031694917 scopus 로고    scopus 로고
    • NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis
    • DOI 10.1038/2431
    • Chen ZF, Paquette AJ, Anderson DJ: NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat. Genet. 20(2), 136-142 (1998). (Pubitemid 28455445)
    • (1998) Nature Genetics , vol.20 , Issue.2 , pp. 136-142
    • Chen, Z.-F.1    Paquette, A.J.2    Anderson, D.J.3
  • 23
    • 77952888250 scopus 로고    scopus 로고
    • The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease
    • Buckley NJ, Johnson R, Zuccato C, Bithell A, Cattaneo E: The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiol. Dis. 39(1), 28-39 (2010).
    • (2010) Neurobiol. Dis. , vol.39 , Issue.1 , pp. 28-39
    • Buckley, N.J.1    Johnson, R.2    Zuccato, C.3    Bithell, A.4    Cattaneo, E.5
  • 24
    • 70350142444 scopus 로고    scopus 로고
    • Gene dysregulation in Huntington's disease: REST, microRNAs and beyond
    • Johnson R, Buckley NJ: Gene dysregulation in Huntington's disease: REST, microRNAs and beyond. Neuromolecular Med. 11(3), 183-199 (2009).
    • (2009) Neuromolecular Med. , vol.11 , Issue.3 , pp. 183-199
    • Johnson, R.1    Buckley, N.J.2
  • 25
    • 24044505984 scopus 로고    scopus 로고
    • Transcriptional regulation: Cancer, neurons and the REST
    • DOI 10.1016/j.cub.2005.08.032, PII S0960982205009516
    • Coulson JM: Transcriptional regulation: cancer, neurons and the REST. Curr. Biol. 15(17), R665-R668 (2005). (Pubitemid 41219582)
    • (2005) Current Biology , vol.15 , Issue.17
    • Coulson, J.M.1
  • 26
    • 0026659651 scopus 로고
    • Silencing the type II sodium channel gene: A model for neural-specific gene regulation
    • Kraner SD, Chong JA, Tsay HJ, Mandel G: Silencing the type II sodium channel gene: a model for neural-specific gene regulation. Neuron 9(1), 37-44 (1992).
    • (1992) Neuron , vol.9 , Issue.1 , pp. 37-44
    • Kraner, S.D.1    Chong, J.A.2    Tsay, H.J.3    Mandel, G.4
  • 27
    • 0026651523 scopus 로고
    • A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells
    • Mori N, Schoenherr C, Vandenbergh DJ, Anderson DJ: A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells. Neuron 9(1), 45-54 (1992).
    • (1992) Neuron , vol.9 , Issue.1 , pp. 45-54
    • Mori, N.1    Schoenherr, C.2    Vandenbergh, D.J.3    Anderson, D.J.4
  • 29
    • 0033306577 scopus 로고    scopus 로고
    • Transcriptional repression by REST: Recruitment of Sin3A and histone deacetylase to neuronal genes
    • DOI 10.1038/13165
    • Huang Y, Myers SJ, Dingledine R: Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nat. Neurosci. 2(10), 867-872 (1999). (Pubitemid 30602598)
    • (1999) Nature Neuroscience , vol.2 , Issue.10 , pp. 867-872
    • Huang, Y.1    Myers, S.J.2    Dingledine, R.3
  • 31
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • DOI 10.1016/j.cell.2004.12.012, PII S0092867404011997
    • Shi Y, Lan F, Matson C, Mulligan P et al.: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119(7), 941-953 (2004). (Pubitemid 40037608)
    • (2004) Cell , vol.119 , Issue.7 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3    Mulligan, P.4    Whetstine, J.R.5    Cole, P.A.6    Casero, R.A.7    Shi, Y.8
  • 32
    • 2942631126 scopus 로고    scopus 로고
    • Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes
    • DOI 10.1016/j.molcel.2004.05.026, PII S109727650400303X
    • Roopra A, Qazi R, Schoenike B, Daley TJ, Morrison JF: Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes. Mol. Cell 14(6), 727-738 (2004). (Pubitemid 38780847)
    • (2004) Molecular Cell , vol.14 , Issue.6 , pp. 727-738
    • Roopra, A.1    Qazi, R.2    Schoenike, B.3    Daley, T.J.4    Morrison, J.F.5
  • 34
    • 33846029877 scopus 로고    scopus 로고
    • BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression
    • DOI 10.1074/jbc.M605370200
    • Ooi L, Belyaev ND, Miyake K, Wood IC, Buckley NJ: BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. J. Biol. Chem. 281(51), 38974-38980 (2006). (Pubitemid 46041857)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.51 , pp. 38974-38980
    • Ooi, L.1    Belyaev, N.D.2    Miyake, K.3    Wood, I.C.4    Buckley, N.J.5
  • 38
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl- CpG-binding protein 2
    • DOI 10.1038/13810
    • Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY: Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23(2), 185-188 (1999). (Pubitemid 29455390)
    • (1999) Nature Genetics , vol.23 , Issue.2 , pp. 185-188
    • Amir, R.E.1    Van Den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 39
    • 34249900454 scopus 로고    scopus 로고
    • The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
    • DOI 10.1038/nature05823, PII NATURE05823
    • Tahiliani M, Mei P, Fang R et al.: The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature 447(7144), 601-605 (2007). (Pubitemid 46868038)
    • (2007) Nature , vol.447 , Issue.7144 , pp. 601-605
    • Tahiliani, M.1    Mei, P.2    Fang, R.3    Leonor, T.4    Rutenberg, M.5    Shimizu, F.6    Li, J.7    Rao, A.8    Shi, Y.9
  • 40
    • 33846936237 scopus 로고    scopus 로고
    • RE1 silencing transcription factor maintains a repressive chromatin environment in embryonic hippocampal neural stem cells
    • DOI 10.1634/stemcells.2006-0207
    • Greenway DJ, Street M, Jeffries A, Buckley NJ: RE1 silencing transcription factor maintains a repressive chromatin environment in embryonic hippocampal neural stem cells. Stem Cells 25(2), 354-363 (2007). (Pubitemid 46232789)
    • (2007) Stem Cells , vol.25 , Issue.2 , pp. 354-363
    • Greenway, D.J.1    Street, M.2    Jeffries, A.3    Buckley, N.J.4
  • 41
    • 0032519868 scopus 로고    scopus 로고
    • Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene
    • Palm K, Belluardo N, Metsis M, Timmusk T: Neuronal expression of zinc finger transcription factor REST/NRSF/ XBR gene. J. Neurosci. 18(4), 1280-1296 (1998). (Pubitemid 28082414)
    • (1998) Journal of Neuroscience , vol.18 , Issue.4 , pp. 1280-1296
    • Palm, K.1    Belluardo, N.2    Metsis, M.3    Timmusk, T.4
  • 43
    • 66449114042 scopus 로고    scopus 로고
    • Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level
    • Bruce AW, Lopez-Contreras AJ, Flicek P et al.: Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Res. 19(6), 994-1005 (2009).
    • (2009) Genome Res. , vol.19 , Issue.6 , pp. 994-1005
    • Bruce, A.W.1    Lopez-Contreras, A.J.2    Flicek, P.3
  • 44
    • 34250159524 scopus 로고    scopus 로고
    • Genome-wide mapping of in vivo protein-DNA interactions
    • DOI 10.1126/science.1141319
    • Johnson DS, Mortazavi A, Myers RM, Wold B: Genome-wide mapping of in vivo protein-DNA interactions. Science 316(5830), 1497-1502 (2007). (Pubitemid 46906620)
    • (2007) Science , vol.316 , Issue.5830 , pp. 1497-1502
    • Johnson, D.S.1    Mortazavi, A.2    Myers, R.M.3    Wold, B.4
  • 45
    • 54949103985 scopus 로고    scopus 로고
    • REST regulates distinct transcriptional networks in embryonic and neural stem cells
    • Johnson R, Teh CH, Kunarso G et al.: REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol. 6(10), e256 (2008).
    • (2008) PLoS Biol. , vol.6 , Issue.10
    • Johnson, R.1    Teh, C.H.2    Kunarso, G.3
  • 47
    • 33749389932 scopus 로고    scopus 로고
    • Comparative genomics modeling of the NRSF/REST repressor network: From single conserved sites to genome-wide repertoire
    • DOI 10.1101/gr.4997306
    • Mortazavi A, Leeper Thompson EC, Garcia ST, Myers RM, Wold B: Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Genome Res. 16(10), 1208-1221 (2006). (Pubitemid 44506954)
    • (2006) Genome Research , vol.16 , Issue.10 , pp. 1208-1221
    • Mortazavi, A.1    Thompson, E.C.L.2    Garcia, S.T.3    Myers, R.M.4    Wold, B.5
  • 49
    • 33750432857 scopus 로고    scopus 로고
    • Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression
    • Wu J, Xie X: Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol. 7(9), R85 (2006).
    • (2006) Genome Biol. , vol.7 , Issue.9
    • Wu, J.1    Xie, X.2
  • 50
    • 77954041258 scopus 로고    scopus 로고
    • REST and CoREST modulate neuronal subtype specification, maturation and maintenance
    • Abrajano JJ, Qureshi IA, Gokhan S, Zheng D, Bergman A, Mehler MF: REST and CoREST modulate neuronal subtype specification, maturation and maintenance. PLoS ONE 4(12), e7936 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.12
    • Abrajano, J.J.1    Qureshi, I.A.2    Gokhan, S.3    Zheng, D.4    Bergman, A.5    Mehler, M.F.6
  • 51
    • 70449578270 scopus 로고    scopus 로고
    • Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation
    • Abrajano JJ, Qureshi IA, Gokhan S, Zheng D, Bergman A, Mehler MF: Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation. PLoS ONE 4(11), e7665 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.11
    • Abrajano, J.J.1    Qureshi, I.A.2    Gokhan, S.3    Zheng, D.4    Bergman, A.5    Mehler, M.F.6
  • 52
    • 77950583698 scopus 로고    scopus 로고
    • BMP-induced REST regulates the establishment and maintenance of astrocytic identity
    • Kohyama J, Sanosaka T, Tokunaga A et al.: BMP-induced REST regulates the establishment and maintenance of astrocytic identity. J. Cell Biol. 189(1), 159-170 (2010).
    • (2010) J. Cell Biol. , vol.189 , Issue.1 , pp. 159-170
    • Kohyama, J.1    Sanosaka, T.2    Tokunaga, A.3
  • 55
    • 70449675049 scopus 로고    scopus 로고
    • Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy
    • Fujiwara T, O'Geen H, Keles S et al.: Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol. Cell 36(4), 667-681 (2009).
    • (2009) Mol. Cell , vol.36 , Issue.4 , pp. 667-681
    • Fujiwara, T.1    O'Geen, H.2    Keles, S.3
  • 56
    • 45449101116 scopus 로고    scopus 로고
    • Extrapolating ENCODE data to the whole human genome
    • Costantini M, Di Filippo M, Bernardi G: Extrapolating ENCODE data to the whole human genome. Gene 419(1-2), 66-69 (2008).
    • (2008) Gene , vol.419 , Issue.1-2 , pp. 66-69
    • Costantini, M.1    Di Filippo, M.2    Bernardi, G.3
  • 59
    • 58149103424 scopus 로고    scopus 로고
    • Regulation of neural macroRNAs by the transcriptional repressor REST
    • Johnson R, Teh CH, Jia H et al.: Regulation of neural macroRNAs by the transcriptional repressor REST. RNA 15(1), 85-96 (2009).
    • (2009) RNA , vol.15 , Issue.1 , pp. 85-96
    • Johnson, R.1    Teh, C.H.2    Jia, H.3
  • 61
    • 33747706117 scopus 로고    scopus 로고
    • Non-coding RNAs in the nervous system
    • DOI 10.1113/jphysiol.2006.113191
    • Mehler MF, Mattick JS: Non-coding RNAs in the nervous system. J. Physiol. 575(Pt 2), 333-341 (2006). (Pubitemid 44270162)
    • (2006) Journal of Physiology , vol.575 , Issue.2 , pp. 333-341
    • Mehler, M.F.1    Mattick, J.S.2
  • 62
  • 63
    • 67949083572 scopus 로고    scopus 로고
    • MicroRNA-mediated switching of chromatin-remodeling complexes in neural development
    • Yoo AS, Staahl BT, Chen L, Crabtree GR: MicroRNA-mediated switching of chromatin-remodeling complexes in neural development. Nature 460(7255), 642-646 (2009).
    • (2009) Nature , vol.460 , Issue.7255 , pp. 642-646
    • Yoo, A.S.1    Staahl, B.T.2    Chen, L.3    Crabtree, G.R.4
  • 69
    • 34250749895 scopus 로고    scopus 로고
    • The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes
    • DOI 10.1128/MCB.00269-07
    • Bingham AJ, Ooi L, Kozera L, White E, Wood IC: The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes. Mol. Cell. Biol. 27(11), 4082-4092 (2007). (Pubitemid 47011005)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.11 , pp. 4082-4092
    • Bingham, A.J.1    Ooi, L.2    Kozera, L.3    White, E.4    Wood, I.C.5
  • 70
    • 60849088861 scopus 로고    scopus 로고
    • Profiling RE1/REST-mediated histone modifications in the human genome
    • Zheng D, Zhao K, Mehler MF: Profiling RE1/REST-mediated histone modifications in the human genome. Genome Biol. 10(1), R9 (2009).
    • (2009) Genome Biol. , vol.10 , Issue.1
    • Zheng, D.1    Zhao, K.2    Mehler, M.F.3
  • 71
    • 61349137510 scopus 로고    scopus 로고
    • Is REST a regulator of pluripotency?
    • discussion E7
    • Buckley NJ, Johnson R, Sun YM, Stanton LW: Is REST a regulator of pluripotency? Nature 457(7233), E5-E6; discussion E7 (2009).
    • (2009) Nature , vol.457 , Issue.7233
    • Buckley, N.J.1    Johnson, R.2    Sun, Y.M.3    Stanton, L.W.4
  • 73
    • 77956308708 scopus 로고    scopus 로고
    • Can controversies be put to REST?
    • discussion E5
    • Jorgensen HF, Fisher AG: Can controversies be put to REST? Nature 467(7311), E3-E4; discussion E5 (2010).
    • (2010) Nature , vol.467 , Issue.7311
    • Jorgensen, H.F.1    Fisher, A.G.2
  • 74
    • 43449100341 scopus 로고    scopus 로고
    • REST maintains self-renewal and pluripotency of embryonic stem cells
    • DOI 10.1038/nature06863, PII NATURE06863
    • Singh SK, Kagalwala MN, Parker- Thornburg J, Adams H, Majumder S: REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 453(7192), 223-227 (2008). (Pubitemid 351667975)
    • (2008) Nature , vol.453 , Issue.7192 , pp. 223-227
    • Singh, S.K.1    Kagalwala, M.N.2    Parker-Thornburg, J.3    Adams, H.4    Majumder, S.5
  • 75
    • 73349091835 scopus 로고    scopus 로고
    • REST promotes the early differentiation of mouse ESCs but is not required for their maintenance
    • Yamada Y, Aoki H, Kunisada T, Hara A: REST promotes the early differentiation of mouse ESCs but is not required for their maintenance. Cell Stem Cell 6(1), 10-15 (2010).
    • (2010) Cell Stem Cell , vol.6 , Issue.1 , pp. 10-15
    • Yamada, Y.1    Aoki, H.2    Kunisada, T.3    Hara, A.4
  • 76
    • 56349138235 scopus 로고    scopus 로고
    • Rest-mediated regulation of extracellular matrix is crucial for neural development
    • Sun YM, Cooper M, Finch S et al.: Rest-mediated regulation of extracellular matrix is crucial for neural development. PLoS ONE 3(11), e3656 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.11
    • Sun, Y.M.1    Cooper, M.2    Finch, S.3
  • 77
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 72(6), 971-983 (1993).
    • (1993) Cell , vol.72 , Issue.6 , pp. 971-983
  • 80
    • 33745200299 scopus 로고    scopus 로고
    • Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective
    • Qiu Z, Norflus F, Singh B et al.: Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective. J. Biol. Chem. 281(24), 16672-16680 (2006).
    • (2006) J. Biol. Chem. , vol.281 , Issue.24 , pp. 16672-16680
    • Qiu, Z.1    Norflus, F.2    Singh, B.3
  • 84
    • 58149375393 scopus 로고    scopus 로고
    • The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease
    • Packer AN, Xing Y, Harper SQ, Jones L, Davidson BL: The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. J. Neurosci. 28(53), 14341-14346 (2008).
    • (2008) J. Neurosci. , vol.28 , Issue.53 , pp. 14341-14346
    • Packer, A.N.1    Xing, Y.2    Harper, S.Q.3    Jones, L.4    Davidson, B.L.5
  • 87
    • 70450192073 scopus 로고    scopus 로고
    • Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease
    • Bithell A, Johnson R, Buckley NJ: Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease. Biochem. Soc. Trans. 37(Pt 6), 1270-1275 (2009).
    • (2009) Biochem. Soc. Trans. , vol.37 , Issue.PART 6 , pp. 1270-1275
    • Bithell, A.1    Johnson, R.2    Buckley, N.J.3
  • 88
    • 78651318398 scopus 로고    scopus 로고
    • Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease
    • Soldati C, Bithell A, Conforti P, Cattaneo E, Buckley NJ: Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease. J. Neurochem. 116(3), 415-425 (2011).
    • (2011) J. Neurochem. , vol.116 , Issue.3 , pp. 415-425
    • Soldati, C.1    Bithell, A.2    Conforti, P.3    Cattaneo, E.4    Buckley, N.J.5
  • 89
    • 68849083063 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neurodegenerative diseases
    • Zuccato C, Cattaneo E: Brain-derived neurotrophic factor in neurodegenerative diseases. Nat. Rev. Neurol. 5(6), 311-322 (2009).
    • (2009) Nat. Rev. Neurol. , vol.5 , Issue.6 , pp. 311-322
    • Zuccato, C.1    Cattaneo, E.2
  • 94
    • 77957736469 scopus 로고    scopus 로고
    • Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability
    • Mucha M, Ooi L, Linley JE et al.: Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability. J. Neurosci. 30(40), 13235-13245 (2010).
    • (2010) J. Neurosci. , vol.30 , Issue.40 , pp. 13235-13245
    • Mucha, M.1    Ooi, L.2    Linley, J.E.3
  • 95
    • 39749193120 scopus 로고    scopus 로고
    • MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production
    • Abuhatzira L, Makedonski K, Kaufman Y, Razin A, Shemer R: MeCP2 deficiency in the brain decreases BDNF levels by REST/ CoREST-mediated repression and increases TRKB production. Epigenetics 2(4), 214-222 (2007). (Pubitemid 351308296)
    • (2007) Epigenetics , vol.2 , Issue.4 , pp. 214-222
    • Abuhatzira, L.1    Makedonski, K.2    Kaufman, Y.3    Razin, A.4    Shemer, R.5
  • 97
    • 0036812485 scopus 로고    scopus 로고
    • Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus
    • Huang Y, Doherty JJ, Dingledine R: Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. J. Neurosci. 22(19), 8422-8428 (2002). (Pubitemid 35387582)
    • (2002) Journal of Neuroscience , vol.22 , Issue.19 , pp. 8422-8428
    • Huang, Y.1    Doherty, J.J.2    Dingledine, R.3
  • 98
    • 0028239654 scopus 로고
    • Stem cells and transcription factors in the development of the mammalian neural crest
    • Anderson DJ: Stem cells and transcription factors in the development of the mammalian neural crest. FASEB J. 8(10), 707-713 (1994). (Pubitemid 24229764)
    • (1994) FASEB Journal , vol.8 , Issue.10 , pp. 707-713
    • Anderson, D.J.1
  • 99
    • 77955172885 scopus 로고    scopus 로고
    • Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors
    • Adli M, Zhu J, Bernstein BE: Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors. Nat. Methods 7(8), 615-618 (2010).
    • (2010) Nat. Methods , vol.7 , Issue.8 , pp. 615-618
    • Adli, M.1    Zhu, J.2    Bernstein, B.E.3
  • 101
    • 58849107237 scopus 로고    scopus 로고
    • Transcriptome content and dynamics at single-nucleotide resolution
    • Cloonan N, Grimmond SM: Transcriptome content and dynamics at single-nucleotide resolution. Genome Biol. 9(9), 234 (2008).
    • (2008) Genome Biol. , vol.9 , Issue.9 , pp. 234
    • Cloonan, N.1    Grimmond, S.M.2
  • 102
    • 77952887349 scopus 로고    scopus 로고
    • Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: Unraveling the genome to understand the mind
    • Hsieh J, Eisch AJ: Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol. Dis. 39(1), 73-84 (2010).
    • (2010) Neurobiol. Dis. , vol.39 , Issue.1 , pp. 73-84
    • Hsieh, J.1    Eisch, A.J.2
  • 103
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A, Esteller M: Epigenetic modifications and human disease. Nat. Biotechnol. 28(10), 1057-1068 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , Issue.10 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.