In search of "stemness"

Experimental Hematology

Volumn 32, Issue 7, 2004, Pages 585-598

  Cai, Jingli ^a   Weiss, Mark L ^a,c   Rao, Mahendra S ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER;

APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CELL POPULATION; CELL PROTECTION; DNA REPAIR; HUMAN; MEDICAL LITERATURE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SENESCENCE; STEM CELL;

ANIMALS; BIOLOGICAL MARKERS; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; HUMANS; NERVOUS SYSTEM; STEM CELLS;

EID: 3042747512     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2004.03.013     Document Type: Review

References (118)

1. Lin H., Schagat T. Neuroblasts: a model for the asymmetric division of stem cells. Trends Genet. 13:1997;33-39
2. Morrison S.J., Shah N.M., Anderson D.J. Regulatory mechanisms in stem cell biology. Cell. 88:1997;287-298
3. Burns C.E., Zon L.I. Portrait of a stem cell. Dev Cell. 3:2002;612-613
4. Murphy M., Bartlett P.F. Molecular regulation of neural crest development. Mol Neurobiol. 7:1993;111-135
5. Stanton J.A., Macgregor A.B., Green D.P. Gene expression in the mouse preimplantation embryo. Reproduction. 125:2003;457-468
6. Gage F.H. Mammalian neural stem cells. Science. 287:2000;1433-1438
7. Hillyer C.D., Wells S.J. Alternative sources of hematopoietic stem cells for bone marrow transplantation and rescue. J Hematother. 2:1993;491-499
8. Palis J., Yoder M.C. Yolk-sac hematopoiesis: the first blood cells of mouse and man. Exp Hematol. 29:2001;927-936
9. Broxmeyer H.E., Douglas G.W., Hangoc G., et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A. 86:1989;3828-3832
10. Gale R.P. Fetal liver transplants. Bone Marrow Transplant. 9:(Suppl 1):1992;118-120
11. Becker A.J., McCulloch E.A., Till J.E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 197:1963;452-454
12. Siminovitch L., McCulloch E.A., Till J.E. The distribution of colony-forming cells among spleen colonies. J Cell Comp Physiol. 62:1963;327-336
13. Pevny L., Rao M.S. The stem-cell menagerie. Trends Neurosci. 26:2003;351-359
14. Joshi C., Enver T. Molecular complexities of stem cells. Curr Opin Hematol. 10:2003;220-228
15. Ivanova N.B., Dimos J.T., Schaniel C., Hackney J.A., Moore K.A., Lemischka I.R. A stem cell molecular signature. Science. 298:2002;601-604
16. Ramalho-Santos M., Yoon S., Matsuzaki Y., Mulligan R.C., Melton D.A. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science. 298:2002;597-600
17. Fortunel N.O., Otu H.H., Ng H.H., et al. Comment on "'Stemness': transcriptional profiling of embryonic and adult stem cells" and "A stem cell molecular signature." Science. 302:2003;393. author reply 393
18. Ginis I., Luo Y., Miura T., et al. Differences between human and mouse embryonic stem cells. Dev Biol. 269:2004;360-380
19. Sato N., Sanjuan I.M., Heke M., Uchida M., Naef F., Brivanlou A.H. Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev Biol. 260:2003;404-413
20. Cai J., Wu Y., Mirua T., et al. Properties of a fetal multipotent neural stem cell (NEP cell). Dev Biol. 251:2002;221-240
21. Heimfeld S., Weissman I.L. Characterization of several classes of mouse hematopoietic progenitor cells. Curr Top Microbiol Immunol. 177:1992;95-105
22. Deryugina E.I., Muller-Sieburg C.E. Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development? Crit Rev Immunol. 13:1993;115-150
23. Gupta P., Oegema T.R. Jr., Brazil J.J., Dudek A.Z., Slungaard A., Verfaillie C.M. Structurally specific heparan sulfates support primitive human hematopoiesis by formation of a multimolecular stem cell niche. Blood. 92:1998;4641-4651
24. Kim M., Turnquist H., Jackson J., et al. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res. 8:2002;22-28
25. Bhattacharya S., Jackson J.D., Das A.V., et al. Direct identification and enrichment of retinal stem cells/progenitors by Hoechst dye efflux assay. Invest Ophthalmol Vis Sci. 44:2003;2764-2773
26. Migishima F., Oikawa A., Kondo S., et al. Full reconstitution of hematopoietic system by murine umbilical cord blood. Transplantation. 75:2003;1820-1826
27. - murine side population cells are highly enriched for primitive stem cells. Exp Hematol. 31:2003;244-250
28. Zhou S., Schuetz J.D., Bunting K.D., et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med. 7:2001;1028-1034
29. Scharenberg C.W., Harkey M.A., Torok-Storb B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood. 99:2002;507-512
30. Jones R.J., Barber J.P., Vala M.S., et al. Assessment of aldehyde dehydrogenase in viable cells. Blood. 85:1995;2742-2746
31. Kastan M.B., Schlaffer E., Russo J.E., Colvin O.M., Civin C.I., Hilton J. Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells. Blood. 75:1990;1947-1950
32. Storms R.W., Trujillo A.P., Springer J.B., et al. Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity. Proc Natl Acad Sci U S A. 96:1999;9118-9123
33. Cai J., Cheng A., Luo Y., et al. Membrane properties of rat embryonic multipotent neural stem cells. J Neurochem. 88:2004;212-226
34. Rozental R., Morales M., Mehler M.F., et al. Changes in the properties of gap junctions during neuronal differentiation of hippocampal progenitor cells. J Neurosci. 18:1998;1753-1762
35. Alexander D.B., Goldberg G.S. Transfer of biologically important molecules between cells through gap junction channels. Curr Med Chem. 10:2003;2045-2058
36. Levin M. Isolation and community: a review of the role of gap-junctional communication in embryonic patterning. J Membr Biol. 185:2002;177-192
37. Ploemacher R.E., Mayen A.E., De Koning A.E., Krenacs T., Rosendaal M. Hematopoiesis: Gap junction intercellular communication is likely to be involved in regulation of stroma-dependent proliferation of hemopoietic stem cells. Hematol. 5:2000;133-147
38. + haematopoietic progenitor cells is mediated by connexin 43-type gap junctions. Br J Haematol. 111:2000;416-425
39. Bannerman P., Nichols W., Puhalla S., Oliver T., Berman M., Pleasure D. Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction function. J Neurosci Res. 61:2000;605-615
40. Zhang M., Thorgeirsson S.S. Modulation of connexins during differentiation of oval cells into hepatocytes. Exp Cell Res. 213:1994;37-42
41. Oyamada Y., Komatsu K., Kimura H., Mori M., Oyamada M. Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro. Exp Cell Res. 229:1996;318-326
42. Reya T., Duncan A.W., Ailles L., et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 423:2003;409-414
43. Zechner D., Fujita Y., Hulsken J., et al. β-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol. 258:2003;406-418
44. Song X., Xie T. Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila. Development. 130:2003;3259-3268
45. Lobo M.V., Alonso F.J., Redondo C., et al. Cellular characterization of epidermal growth factor-expanded free-floating neurospheres. J Histochem Cytochem. 51:2003;89-103
46. Zhang J., Niu C., Ye L., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 425:2003;836-841
47. Chenn A., Walsh C.A. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science. 297:2002;365-369
48. Stockinger A., Eger A., Wolf J., Beug H., Foisner R. E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity. J Cell Biol. 154:2001;1185-1196
49. Anastasiadis P.Z., Reynolds A.B. Regulation of Rho GTPases by p120-catenin. Curr Opin Cell Biol. 13:2001;604-610
50. Charrasse S., Meriane M., Comunale F., Blangy A., Gauthier-Rouviere C. N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts. J Cell Biol. 158:2002;953-965
51. Wheelock M.J., Johnson K.R. Cadherin-mediated cellular signaling. Curr Opin Cell Biol. 15:2003;509-514
52. Olson M.F., Ashworth A., Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science. 269:1995;1270-1272
53. Moore K.A., Sethi R., Doanes A.M., et al. Rac1 is required for cell proliferation and G2/M progression. Biochem J. 326:(Pt 1):1997;17-20
54. Nagasawa T., Tachibana K., Kishimoto T. A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection. Semin Immunol. 10:1998;179-185
55. Zou Y.R., Kottmann A.H., Kuroda M., Taniuchi I., Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 393:1998;595-599
56. Ma Q., Jones D., Borghesani P.R., et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 95:1998;9448-9453
57. Lu M., Grove E.A., Miller R.J. Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci U S A. 99:2002;7090-7095
58. Klein R.S., Rubin J.B., Gibson H.D., et al. SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Development. 128:2001;1971-1981
59. Ratajczak M.Z., Kucia M., Reca R., Majka M., Janowska-Wieczorek A., Ratajczak J. Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells "hide out" in the bone marrow. Leukemia. 18:2004;29-40
60. Krylov D.M., Nasmyth K., Koonin E.V. Evolution of eukaryotic cell cycle regulation: stepwise addition of regulatory kinases and late advent of the CDKs. Curr Biol. 13:2003;173-177
61. Ohnuma S., Harris W.A. Neurogenesis and the cell cycle. Neuron. 40:2003;199-208
62. D'Urso G., Datta S. Cell cycle control, checkpoints, and stem cell biology. Marshak D.R., Gardner R.L., Gottlieb D. Stem Cell Biology. 2001;61-94 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
63. Savatier P., Lapillonne H., Jirmanova L., Vitelli L., Samarut J. Analysis of the cell cycle in mouse embryonic stem cells. Methods Mol Biol. 185:2002;27-33
64. Sommer L., Rao M. Neural stem cells and regulation of cell number. Prog Neurobiol. 66:2002;1-18
65. Yoshikawa K. Cell cycle regulators in neural stem cells and postmitotic neurons. Neurosci Res. 37:2000;1-14
66. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1999;1501-1512
67. Stead E., White J., Faast R., et al. Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene. 21:2002;8320-8333
68. Ohnuma S., Hopper S., Wang K.C., Philpott A., Harris W.A. Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina. Development. 129:2002;2435-2446
69. Jirmanova L., Afanassieff M., Gobert-Gosse S., Markossian S., Savatier P. Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene. 21:2002;5515-5528
70. Burdon T., Smith A., Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 12:2002;432-438
71. Savatier P., Lapillonne H., van Grunsven L.A., Rudkin B.B., Samarut J. Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene. 12:1996;309-322
72. Faast R., White J., Cartwright P., Crocker L., Sarcevic B., Dalton S. Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Oncogene. 23:2004;491-502
73. Luo Y., Cai J., Liu Y., et al. Microarray analysis of selected genes in neural stem and progenitor cells. J Neurochem. 83:2002;1481-1497
74. Lessard J., Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 423:2003;255-260
75. Park I.K., Qian D., Kiel M., et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 423:2003;302-305
76. van der Lugt N.M., Domen J., Linders K., et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8:1994;757-769
77. Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 425:2003;962-967
78. Morrison S.J. Pten-uating neural growth. Nat Med. 8:2002;16-18
79. Li L., Liu F., Ross A.H. PTEN regulation of neural development and CNS stem cells. J Cell Biochem. 88:2003;24-28
80. Suzuki A., de la Pompa J.L., Stambolic V., et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol. 8:1998;1169-1178
81. Di Cristofano A., Pesce B., Cordon-Cardo C., Pandolfi P.P. Pten is essential for embryonic development and tumour suppression. Nat Genet. 19:1998;348-355
82. Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M. PTEN gene alterations in lymphoid neoplasms. Blood. 92:1998;3410-3415
83. Lin H. The tao of stem cells in the germline. Annu Rev Genet. 31:1997;455-491
84. Lu B., Jan L., Jan Y.N. Control of cell divisions in the nervous system: symmetry and asymmetry. Annu Rev Neurosci. 23:2000;531-556
85. Anderson D.J. Stem cells and pattern formation in the nervous system: the possible vs the actual. Neuron. 30:2001;19-35
86. Steidl U., Kronenwett R., Martin S., Haas R. Molecular biology of hematopoietic stem cells. Vitam Horm. 66:2003;1-28
87. Sherley J.L., Stadler P.B., Johnson D.R. Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics. Proc Natl Acad Sci U S A. 92:1995;136-140
88. Rubin H. The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat Biotechnol. 20:2002;675-681
89. Yaswen P., Stampfer M.R. Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells. Int J Biochem Cell Biol. 34:2002;1382-1394
90. Bree R.T., Stenson-Cox C., Grealy M., Byrnes L., Gorman A.M., Samali A. Cellular longevity: role of apoptosis and replicative senescence. Biogerontology. 3:2002;195-206
91. Rao M.S., Mattson M.P. Stem cells and aging: expanding the possibilities. Mech Ageing Dev. 122:2001;713-734
92. Van Sloun P.P., Jansen J.G., Weeda G., et al. The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage. Nucleic Acids Res. 27:1999;3276-3282
93. Smith L.L., Coller H.A., Roberts J.M. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol. 5:2003;474-479
94. Prost S., Bellamy C.O., Clarke A.R., Wyllie A.H., Harrison D.J. p53-independent DNA repair and cell cycle arrest in embryonic stem cells. FEBS Lett. 425:1998;499-504
95. Gorbunova V., Seluanov A., Pereira-Smith O.M. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J Biol Chem. 277:2002;38540-38549
96. Corbet S.W., Clarke A.R., Gledhill S., Wyllie A.H. p53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells. Oncogene. 18:1999;1537-1544
97. Sabapathy K., Klemm M., Jaenisch R., Wagner E.F. Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO J. 16:1997;6217-6229
98. Ziegler A., Jonason A.S., Leffell D.J., et al. Sunburn and p53 in the onset of skin cancer. Nature. 372:1994;773-776
99. Aladjem M.I., Spike B.T., Rodewald L.W., et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol. 8:1998;145-155
100. Lee J.C., Mayer-Proschel M., Rao M.S. Gliogenesis in the central nervous system. Glia. 30:2000;105-121
101. Campagnoni C.W., Landry C.F., Pribyl T.M., et al. Identification of genes in the oligodendrocyte lineage through the analysis of conditionally immortalized cell lines. Dev Neurosci. 23:2001;452-463
102. Germain M., Shore G.C. Cellular distribution of bcl-2 family proteins. Sci STKE. 10:2003
103. Norgaard G.A., Jensen J.N., Jensen J. FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol. 264:2003;323-338
104. Prior H.M., Walter M.A. SOX genes: architects of development. Mol Med. 2:1996;405-412
105. Pevny L.H., Lovell-Badge R. Sox genes find their feet. Curr Opin Genet Dev. 7:1997;338-344
106. Azuma T., Seki N., Yoshikawa T., Saito T., Masuho Y., Muramatsu M. cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18. J Hum Genet. 45:2000;192-195
107. Cheung M., Abu-Elmagd M., Clevers H., Scotting P.J. Roles of Sox4 in central nervous system development. Brain Res Mol Brain Res. 79:2000;180-191
108. Takash W., Canizares J., Bonneaud N., et al. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. Nucleic Acids Res. 29:2001;4274-4283
109. Katoh M. Expression of human SOX7 in normal tissues and tumors. Int J Mol Med. 9:2002;363-368
110. Saitoh T., Katoh M. Expression of human SOX18 in normal tissues and tumors. Int J Mol Med. 10:2002;339-344
111. Friedrich U., Griese E., Schwab M., Fritz P., Thon K., Klotz U. Telomere length in different tissues of elderly patients. Mech Ageing Dev. 119:2000;89-99
112. Nakamura K., Izumiyama-Shimomura N., Sawabe M., et al. Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol. 119:2002;1014-1019
113. Jiang Y., Vaessen B., Lenvik T., Blackstad M., Reyes M., Verfaillie C.M. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol. 30:2002;896-904
114. Jiang Y., Jahagirdar B.N., Reinhardt R.L., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:2002;41-49
115. Reyes M., Lund T., Lenvik T., Aguiar D., Koodie L., Verfaillie C.M. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 98:2001;2615-2625
116. Tucker R.P. Neural crest cells: a model for invasive behavior. Int J Biochem Cell Biol. 36:2004;173-177
117. Orkin S.H., Morrison S.J. Stem-cell competition. Nature. 418:2002;25-27
118. Brandenberger R, Wei H, Zhang S, et al. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nat Biotechnol. In press.