Is REST a regulator of pluripotency?

Nature

Volumn 457, Issue 7233, 2009, Pages

  Buckley, Noel J ^a   Johnson, Rory ^b   Sun, Yuh Man ^a   Stanton, Lawrence W ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; NEUROGENIN 1; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN REST; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; CELL RENEWAL; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; EMBRYONIC STEM CELL; GENE CONTROL; GENE DELETION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NOTE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; EMBRYONIC STEM CELLS; GENE KNOCKDOWN TECHNIQUES; MICE; MICRORNAS; PLURIPOTENT STEM CELLS; POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS;

EID: 61349137510     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07784     Document Type: Note

References (11)

1. Singh, S. K., Kagalwala, M. N., Parker-Thornburg, J., Adams, H. & Majumder, S. REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 453, 223-227 (2008).
2. Loh, Y. H. et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genet. 38, 431-440 (2006).
3. Chen, Z. F., Paquette, A. J. & Anderson, D. J. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nature Genet. 20, 136-142 (1998).
4. Johnson, R. et al. REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol. 6, e256 (2008).
5. Otto, S. J. et al. A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J. Neurosci. 27, 6729-6739 (2007).
6. Johnson, D., Mortazavi, A., Myers, R. & Wold, B. Genome-wide mapping of in vivo protein-DNA interactions. Science 316, 1497-1502 (2007).
7. Morin, R. et al. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res. 18, 610-621 (2008).
8. Zuccato, C. et al. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature Genet. 35, 76-83 (2003).
9. Johnson, R. et al. A microRNA-based gene dysregulation pathway in Huntington's disease. Neurobiol. Dis. 29, 438-445 (2008).
10. Ying, Q. L. & Smith, A. G. Defined conditions for neural commitment and differentiation. Methods Enzymol. 365, 327-341 (2003).
11. Wei, C. L. et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 124, 207-219 (2006).