Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase

Journal of the American Chemical Society

Volumn 133, Issue 7, 2011, Pages 2292-2302

  Zocher, Georg ^a,b   Richter, Martin E A ^c   Mueller, Uwe ^b   Hertweck, Christian ^c,d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b HAHN MEITNER INSTITUT   (Germany)

^c HANS KNÖLL INSTITUTE   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANCYMIDOL; CHEMO-AND REGIOSELECTIVITIES; COMPUTATIONAL DOCKINGS; CONFORMATIONAL STATE; CYTOCHROME P450; ELECTRON TRANSFER; ENZYMATIC REACTION; HETEROCYCLES; HETEROCYCLIZATIONS; HOMOCHIRAL; METHYL GROUP; MONOOXYGENASES; REGIO-SELECTIVE; SITE DIRECTED MUTAGENESIS; STEREOSPECIFIC; STRUCTURAL DATA; SWITCH FUNCTION;

ALDEHYDES; CARBOXYLIC ACIDS; CYCLIZATION; FUNCTIONAL GROUPS; HYDROXYLATION; OXYGEN; OXYGENATION; OXYGENATORS; REGIOSELECTIVITY;

CHEMICAL ANALYSIS;

ALDEHYDE; ANCYMIDOL; CARBOXYLIC ACID; CHEMICAL COMPOUND; CYTOCHROME P450 151A; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; CYTOCHROME P450 OXYGENASE; DEOXYAUREOTHIN; ENZYME VARIANT; HYDROXYL GROUP; METHYL GROUP; MUTANT PROTEIN; PROTEIN AURH; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYCLIZATION; ELECTRON TRANSPORT; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HETEROCYCLIZATION; HYDROXYLATION; MOLECULAR DOCKING; OXYGENATION; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY;

CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 79951823575     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja110146z     Document Type: Article

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