Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues

Journal of the American Chemical Society

Volumn 132, Issue 30, 2010, Pages 10407-10413

  Werneburg, Martina ^a   Busch, Benjamin ^a   He, Jing ^a   Richter, Martin E A ^a   Xiang, Longkuan ^b   Moore, Bradley S ^b   Roth, Martin ^a   Dahse, Hans Martin ^a   Hertweck, Christian ^a,c  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-FUNGAL; ANTI-PROLIFERATIVE; ANTI-TUMOR ACTIVITIES; ANTIPROLIFERATIVE ACTIVITIES; ASSEMBLY LINE; COMBINATORIAL BIOSYNTHESIS; CYTOTOXIC; INTEGRATED APPROACH; MUTASYNTHESIS; PATHOGENIC FUNGI; POLYKETIDE SYNTHASES; POLYKETIDES; RING FORMATION; SHIKIMATES; TETRA-HYDROFURAN;

BIOCHEMISTRY; BIOTECHNOLOGY; FUNGI;

ORGANIC SOLVENTS;

ANTIFUNGAL AGENT; ANTIMITOTIC AGENT; AUREOTHIN DERIVATIVE; POLYKETIDE SYNTHASE; PYRONE DERIVATIVE; SHIKIMIC ACID DERIVATIVE; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; ASPERGILLUS TERREUS; BIOSYNTHESIS; BIOTRANSFORMATION; CANDIDA ALBICANS; CANDIDA GLABRATA; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; FUNGUS; GLOMERELLA CINGULATA; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MOUSE; NONHUMAN; OXYGENATION; PENICILLIUM; PENICILLIUM NOTATUM; PHARMACEUTICAL ENGINEERING; PLASTICITY; PROTEIN ASSEMBLY; SPOROBOLOMYCES SALMONICOLOR; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIFUNGAL AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMONES; FUNGI; HUMANS; MYCOSES; NEOPLASMS; STREPTOMYCES;

EID: 77955027108     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja102751h     Document Type: Article

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