Mechanism-based inactivation of cytochrome P450 3A4 by 17α-ethynylestradiol: Evidence for heme destruction and covalent binding to protein

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 1, 2002, Pages 160-167

  Lin, Hsia Lien ^a   Kent, Ute M ^a   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRACEPTIVE AGENT; CYTOCHROME P450 3A4; ETHINYLESTRADIOL; HEME; ORAL CONTRACEPTIVE AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; TESTOSTERONE; TRITIUM;

ARTICLE; DRUG PROTEIN BINDING; ENZYME INACTIVATION; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONAL CONTRACEPTION; HUMAN; LIVER METABOLISM; NONHUMAN; ORAL CONTRACEPTION; PRIORITY JOURNAL; STOICHIOMETRY;

APOPROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ESCHERICHIA COLI; ETHINYL ESTRADIOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEME; MIXED FUNCTION OXYGENASES; NADP; OXIDATION-REDUCTION; PROTEIN BINDING; SOLUBILITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0036196318     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.1.160     Document Type: Article

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