A role for threonine 302 in the mechanism-based inactivation of P450 2B4 by 2-ethynylnaphthalene

Archives of Biochemistry and Biophysics

Volumn 331, Issue 2, 1996, Pages 170-176

  Roberts, Elizabeth S ^a   Pernecky, Steven J ^a   Alworth, William L ^b   Hollenberg, Paul F ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Tulane University   (United States)

^c MSRB III ^*  (United States)

Author keywords

2 ethynylnaphthalene; inactivation; mechanism based; P450 2B4; phenobarbital; site directed mutagenesis

Indexed keywords

2 ETHYNYLNAPHTHALENE; CYTOCHROME P450; ENZYME INHIBITOR; MICROSOME ENZYME; NAPHTHALENE DERIVATIVE; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THREONINE; TRITIUM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; ENZYME INACTIVATION; LIVER MICROSOME; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; RABBIT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SITE DIRECTED MUTAGENESIS;

ANIMALIA; ESCHERICHIA COLI; ORYCTOLAGUS CUNICULUS; TRITIUM;

EID: 0030586349     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1996.0295     Document Type: Article

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