Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: Characterization of reactive intermediate adducts to the heme and apoprotein

Chemical Research in Toxicology

Volumn 15, Issue 12, 2002, Pages 1561-1571

  Blobaum, Anna L ^a   Kent, Ute M ^a   Alworth, William L ^b   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Tulane University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE DERIVATIVE; APOPROTEIN; CYTOCHROME P450; CYTOCHROME P450 2E1; HEME;

ALKYLATION; ANIMAL CELL; ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; RABBIT;

ACETYLENE; ALKYLATION; AMINO ACID SUBSTITUTION; ANIMALS; APOPROTEINS; CARBON MONOXIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; HEME; HYDROXYLATION; KINETICS; NADP; RABBITS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY;

ANIMALIA; ESCHERICHIA COLI; ORYCTOLAGUS CUNICULUS;

EID: 0036918608     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx020052x     Document Type: Article

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