Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene

Journal of Pharmacology and Experimental Therapeutics

Volumn 333, Issue 3, 2010, Pages 663-669

  Lin, Hsia Lien ^a   Zhang, Haoming ^a   Jushchyshyn, Monica ^a   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 TERT BUTYLPHENYLACETYLENE; CYTOCHROME P450 2B1; HEME; PHENOL DERIVATIVE; THREONINE; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; DATA BASE; ENZYME DEGRADATION; ENZYME INACTIVATION; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; TANDEM MASS SPECTROMETRY;

ACETYLENE; AMINO ACID SEQUENCE; CAPILLARY ELECTROCHROMATOGRAPHY; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP2B1; DATABASES, PROTEIN; ESCHERICHIA COLI; HEME; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTRUM ANALYSIS; THREONINE; TRYPSIN;

EID: 77952389208     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.164350     Document Type: Article

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