메뉴 건너뛰기




Volumn 25, Issue 1, 2010, Pages 3-16

P-Glycoprotein- and cytochrome P-450-mediated herbal drug interactions

Author keywords

Cytochrome P 450 3A; In vitro; In vivo; Inhibitors; P Glycoprotein

Indexed keywords

ALKALOID DERIVATIVE; ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CITRUS FRUIT EXTRACT; CURCUMA LONGA EXTRACT; CURCUMIN; CYTOCHROME P450 3A; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; GARLIC EXTRACT; GINSENG EXTRACT; GLYCOPROTEIN P; GRAPEFRUIT EXTRACT; HERBACEOUS AGENT; HORMONE DERIVATIVE; HYPERICUM PERFORATUM EXTRACT; IMMUNOSUPPRESSIVE AGENT; LOCAL ANESTHETIC AGENT; MACROLIDE; PEPTIDE DERIVATIVE; POMEGRANATE EXTRACT; PROTEINASE INHIBITOR; PYRROLE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; UNINDEXED DRUG;

EID: 79951497709     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.2010.006     Document Type: Review
Times cited : (24)

References (84)
  • 1
    • 0035478779 scopus 로고    scopus 로고
    • Predicting the impact of physiological and biochemical processes on oral drug bioavailability
    • DOI 10.1016/S0169-409X(01)00179-X, PII S0169409X0100179X
    • Agoram B, Woltosz WS, Bolger MB. Predicting the impact of physiological and biochemical processes on oral drug bioavailab (Pubitemid 32905355)
    • (2001) Advanced Drug Delivery Reviews , vol.50 , Issue.SUPPL. 1
    • Agoram, B.1    Woltosz, W.S.2    Bolger, M.B.3
  • 2
    • 0035054725 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption; combined role of cytochrome P450 3A and p-glycoprotein
    • Zhang Y, Benet LZ. The gut as a barrier to drug absorption; combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet 2001;40:159 - 63.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 159-163
    • Zhang, Y.1    Benet, L.Z.2
  • 6
    • 0031944723 scopus 로고    scopus 로고
    • Overlapping substrate specificities of cytochrome P450 3A and P- glycoprotein for a novel cysteine protease inhibitor
    • Zhang Y, Guo X, Lin ET, Benet LZ. Overlapping substrate specifi cities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. Drug Metab Dispos 1998;26:360 - 6. (Pubitemid 28201247)
    • (1998) Drug Metabolism and Disposition , vol.26 , Issue.4 , pp. 360-366
    • Zhang, Y.1    Guo, X.2    Lin, E.T.3    Benet, L.Z.4
  • 7
    • 0035478419 scopus 로고    scopus 로고
    • The drug efflux-metabolism alliance: Biochemical aspects
    • DOI 10.1016/S0169-409X(01)00178-8, PII S0169409X01001788
    • Benet LZ, Cummins CL. The drug effl ux-metabolism alliance: biochemical aspects. Adv Drug Del Rev 2001;50:S3 - 11. (Pubitemid 32905352)
    • (2001) Advanced Drug Delivery Reviews , vol.50 , Issue.SUPPL. 1
    • Benet, L.Z.1    Cummins, C.L.2
  • 10
    • 0029782485 scopus 로고    scopus 로고
    • Carrier-mediated intestinal transport of drugs
    • DOI 10.1023/A:1016086003070
    • Tsuji A, Tamai I. Carrier-mediated intestinal transport of drugs. Pharm Res 1996;13:963 - 77. (Pubitemid 26258994)
    • (1996) Pharmaceutical Research , vol.13 , Issue.7 , pp. 963-977
    • Tsuji, A.1    Tamai, I.2
  • 11
    • 0346728729 scopus 로고    scopus 로고
    • The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
    • DOI 10.1016/j.ejps.2003.07.003
    • Chan LM, Lowes S, Hirst BH. The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci 2004;21:25 - 51. (Pubitemid 38050202)
    • (2004) European Journal of Pharmaceutical Sciences , vol.21 , Issue.1 , pp. 25-51
    • Chan, L.M.S.1    Lowes, S.2    Hirst, B.H.3
  • 13
    • 0031156390 scopus 로고    scopus 로고
    • How does P-glycoprotein recognize its substrates ?
    • Udeta K, Taguchi H, Morishima M. How does P-glycoprotein recognize its substrates ? Sem Cancer Biol 1997;8:151 - 15.
    • (1997) Sem Cancer Biol , vol.8 , pp. 151-215
    • Udeta, K.1    Taguchi, H.2    Morishima, M.3
  • 15
    • 0042167430 scopus 로고    scopus 로고
    • P-glycoprotein inhibitors and their screening: A perspective from bioavailability enhancement
    • DOI 10.1016/S1043-6618(03)00158-0
    • Varma MV, Ashokraj Y, Dey CS, Panchagula R. P-Glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement. Pharmacol Res 2003;48:347 - 59. (Pubitemid 36945333)
    • (2003) Pharmacological Research , vol.48 , Issue.4 , pp. 347-359
    • Varma, M.V.S.1    Ashokraj, Y.2    Dey, C.S.3    Panchagnula, R.4
  • 16
    • 0031156390 scopus 로고    scopus 로고
    • How does P-glycoprotein recognize its substrates?
    • DOI 10.1006/scbi.1997.0066
    • Udeta K, Taguchi H, Morishima M. How does P-glycoprotein recognize its substrates ? Sem Cancer Biol 1997;8:151 - 9. (Pubitemid 28041012)
    • (1997) Seminars in Cancer Biology , vol.8 , Issue.3 , pp. 151-159
    • Ueda, K.1    Taguchi, Y.2    Morishima, M.3
  • 18
    • 0036732050 scopus 로고    scopus 로고
    • Inhibitory effect of fruit extracts on p-glycoprotein related efflux carriers: An in vitro screening
    • Deferme S, Van Gelder J, Augustijns P. Inhibitory effect of fruit extracts on p-glycoprotein related effl ux carriers: an in vitro screening. J Pharm Pharmacol 2002;54:1213 - 9.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 1213-1219
    • Deferme, S.1    Van Gelder, J.2    Augustijns, P.3
  • 19
    • 0037687304 scopus 로고    scopus 로고
    • Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein: Direct evidence for the substrate-induced fit mechanism for drug binding
    • DOI 10.1074/jbc.C300073200
    • Loo TW, Bartlett C, Clarke DM. Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate induced mechanism for drug binding. J Biol Chem 2003;274:13603 - 6. (Pubitemid 36799891)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 13603-13606
    • Loo, T.W.1    Bartlett, M.C.2    Clarke, D.M.3
  • 22
    • 0037457793 scopus 로고    scopus 로고
    • Drug-drug interaction mediated by inhibition and induction of P-glycoprotein
    • DOI 10.1016/S0169-409X(02)00171-0, PII S0169409X02001710
    • Lin JH. Drug-drug interactions mediated by inhibition and induction of P-glycoprotein. Adv Drug Del Rev 2003;55:53 - 81. (Pubitemid 36082882)
    • (2003) Advanced Drug Delivery Reviews , vol.55 , Issue.1 , pp. 53-81
    • Lin, J.H.1
  • 23
    • 0346728708 scopus 로고    scopus 로고
    • Intestinal membrane transport of drugs and nutrients: Genomics of membrane transporters using expression microarrays
    • DOI 10.1016/S0928-0987(03)00169-6
    • Anderle P, Huang Y, Sadee W. Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays. Eur J Pharm Sci 2004;21:17 - 24. (Pubitemid 38050201)
    • (2004) European Journal of Pharmaceutical Sciences , vol.21 , Issue.1 , pp. 17-24
    • Anderle, P.1    Huang, Y.2    Sadee, W.3
  • 25
    • 0036453655 scopus 로고    scopus 로고
    • An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E D-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein effl ux and enterocyte-based metabolism in excised rat intestine
    • Johnson BM, Charman WN, Porter CJ. An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E D-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein effl ux and enterocyte-based metabolism in excised rat intestine. AAPS PharmSci 2002;4:1 - 11.
    • (2002) AAPS PharmSci , vol.4 , pp. 1-11
    • Johnson, B.M.1    Charman, W.N.2    Porter, C.J.3
  • 26
    • 0032885452 scopus 로고    scopus 로고
    • Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein
    • DOI 10.1021/js980378j
    • Doppenschmitt S, Spahn-Langguth H, Regardh CG, Langguth P. Role of P-glycoprotein-mediated secretion in absorptive drug permeability: an approach using passive membrane permeability and affi nity to P glycoprotein. J Pharm Sci 1999;88:1067 - 72. (Pubitemid 29480601)
    • (1999) Journal of Pharmaceutical Sciences , vol.88 , Issue.10 , pp. 1067-1072
    • Doppenschmitt, S.1    Spahn-Langguth, H.2    Regardh, C.G.3    Langguth, P.4
  • 27
    • 1442301563 scopus 로고    scopus 로고
    • How significant is the role of P-glycoprotein in drug absorption and brain uptake?
    • DOI 10.1358/dot.2004.40.1.799434
    • Lin JH. How signifi cant is the role of P-glycoprotein in drug absorption and brain uptake ? Drugs Today 2004;40:5 - 22. (Pubitemid 38270551)
    • (2004) Drugs of Today , vol.40 , Issue.1 , pp. 5-22
    • Lin, J.H.1
  • 28
    • 9044245300 scopus 로고
    • Inhibition of the intestinal digoxin absorption and exorption by quinidine
    • Su SF, Huang JD. Inhibition of the intestinal digoxin absorption and exorption by quinidine. Drug Metab Dispos 1995;24: 142 - 7.
    • (1995) Drug Metab Dispos , vol.24 , pp. 142-147
    • Su, S.F.1    Huang, J.D.2
  • 29
    • 0032848316 scopus 로고    scopus 로고
    • P-glycoprotein system as a determinant of drug interactions: The case of digoxin-verapamil
    • DOI 10.1006/phrs.1999.0535
    • Verschraagen M, Koks CH, Schellens JH, Beijnen JH. P-Glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil. Pharmacol Res 1999;40:301 - 6. (Pubitemid 29472055)
    • (1999) Pharmacological Research , vol.40 , Issue.4 , pp. 301-306
    • Verschraagen, M.1    Koks, C.H.W.2    Schellens, J.H.M.3    Beijnen, J.H.4
  • 30
    • 0031861258 scopus 로고    scopus 로고
    • Effects of ketoconazole on digoxin absorption and disposition in rat
    • DOI 10.1159/000028214
    • Salphati L, Benet LZ. Effect of ketoconazole on digoxin absorption and disposition in rat. Pharmacology 1998;56:308 - 13. (Pubitemid 28246381)
    • (1998) Pharmacology , vol.56 , Issue.6 , pp. 308-313
    • Salphati, L.1    Benet, L.Z.2
  • 31
    • 0032823160 scopus 로고    scopus 로고
    • Intestinal secretion of intravenous talinolol is inhibited by luminal R- verapamil
    • DOI 10.1016/S0009-9236(99)70031-7
    • Gramatte T, Oertel R. Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil. Clin Pharmacol Ther 1999;66:239 - 45. (Pubitemid 29451755)
    • (1999) Clinical Pharmacology and Therapeutics , vol.66 , Issue.3 , pp. 239-245
    • Gramatte, T.1    Oertel, R.2
  • 32
    • 0034525426 scopus 로고    scopus 로고
    • Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus
    • DOI 10.1067/mcp.2000.112363
    • Khaliq Y, Gallicano K, Venance S, Kravcik S, Cameron DW. Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and CSF from patients infected with HIV. Clin Pharmacol Ther 2000;68:637 - 46. (Pubitemid 32059990)
    • (2000) Clinical Pharmacology and Therapeutics , vol.68 , Issue.6 , pp. 637-646
    • Khaliq, Y.1    Gallicano, K.2    Venance, S.3    Kravcik, S.4    Cameron, D.W.5
  • 34
    • 0343488673 scopus 로고    scopus 로고
    • Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption
    • DOI 10.1016/S0169-409X(97)00497-3, PII S0169409X97004973
    • Hunter J, Hirst BH. Intestinal secretion of drugs. The role of P-glycoprotein and related drug effl ux systems in limiting oral drug absorption. Adv Drug Del Rev 1997;25:129 - 57. (Pubitemid 27288486)
    • (1997) Advanced Drug Delivery Reviews , vol.25 , Issue.2-3 , pp. 129-157
    • Hunter, J.1    Hirst, B.H.2
  • 36
    • 85009616563 scopus 로고    scopus 로고
    • Human cytochromes P450 and their role in metabolism- based drug-drug interactions
    • Rodrigues AD, editor. New York: Marcel Dekker
    • Clarke SJ. Human cytochromes P450 and their role in metabolism- based drug-drug interactions. In: Rodrigues AD, editor. Drug-drug interactions. New York: Marcel Dekker, 2002:55 - 88.
    • (2002) Drug-drug Interactions , pp. 55-88
    • Clarke, S.J.1
  • 37
    • 0037204549 scopus 로고    scopus 로고
    • Pharmacore modeling of cytochromes P450
    • de Groot MJ, Ekins S. Pharmacore modeling of cytochromes P450. Adv Drug Del Rev 2002;54:367 - 83.
    • (2002) Adv Drug Del Rev , vol.54 , pp. 367-383
    • De, Groot.M.J.1    Ekins, S.2
  • 38
    • 0037131879 scopus 로고    scopus 로고
    • Genetic contribution to variable human CYP3A-mediated metabolism
    • DOI 10.1016/S0169-409X(02)00066-2, PII S0169409X02000662
    • Lamba JK, Lin YS, Schuetz EG, Thummel KE. Genetic contributions to variable human CYP3A-mediated metabolism. Adv Drug Del Rev 2002;54:1271 - 94. (Pubitemid 35284253)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.10 , pp. 1271-1294
    • Lamba, J.K.1    Lin, Y.S.2    Schuetz, E.G.3    Thummel, K.E.4
  • 39
    • 0031765907 scopus 로고    scopus 로고
    • Role of p glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
    • Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 1998;87:1322 - 30.
    • (1998) J Pharm Sci , vol.87 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.3    Benet, L.Z.4
  • 40
    • 0030059953 scopus 로고    scopus 로고
    • Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
    • Schuetz EG, Beck WT, Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P450 3A coordinately upregulate these proteins in human colon carcinoma cells. Mol Pharmacol 1996;49:311 - 8. (Pubitemid 26066117)
    • (1996) Molecular Pharmacology , vol.49 , Issue.2 , pp. 311-318
    • Schuetz, E.G.1    Beck, W.T.2    Schuetz, J.D.3
  • 41
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • Guengerich FP, Martin MV, Beaune PH, Kremers P, Wolff T, Waxman DJ. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J Biol Chem 1986;261:5051 - 60. (Pubitemid 17204301)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.11 , pp. 5051-5060
    • Guengerich, F.P.1    Martin, M.V.2    Beaune, P.H.3
  • 42
    • 0030022629 scopus 로고    scopus 로고
    • An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials
    • Parkinson A. An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials. Toxicol Pathol 1996;24:48 - 57.
    • (1996) Toxicol Pathol , vol.24 , pp. 48-57
    • Parkinson, A.1
  • 44
    • 0031966729 scopus 로고    scopus 로고
    • Drug interactions with grapefruit juice: Extent, probable mechanism and clinical relevance
    • DOI 10.2165/00002018-199818040-00002
    • Fuhr U. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. Drug Saf 1998;18:251 - 72. (Pubitemid 28177290)
    • (1998) Drug Safety , vol.18 , Issue.4 , pp. 251-272
    • Fuhr, U.1
  • 45
    • 0034060357 scopus 로고    scopus 로고
    • Inhibitory effect of natural furanocoumarins on human microsomal cytochrome P450 3A activity
    • DOI 10.1254/jjp.82.122
    • Guo LQ, Taniguchi M, Xiao YQ, Baba K, Ohta T, Yamazoe Y. Inhibitory effect of natural furanocoumarins on human microsomal cytochrome P450 3A activity. Jpn J Pharmacol 2000; 82:122 - 9. (Pubitemid 30153593)
    • (2000) Japanese Journal of Pharmacology , vol.82 , Issue.2 , pp. 122-129
    • Guo, L.-Q.1    Taniguchi, M.2    Xiao, Y.-Q.3    Baba, K.4    Ohta, T.5    Yamazoe, Y.6
  • 46
    • 0033917295 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression
    • Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 2000;294:88 - 95. (Pubitemid 30434674)
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.294 , Issue.1 , pp. 88-95
    • Obach, R.S.1
  • 47
    • 5444251235 scopus 로고    scopus 로고
    • In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: Changes in Pgp and CYP3A4 activity
    • Patel J, Buddha B, Dey S, Pal D, Mitra AK. In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in Pgp and CYP3A4 activity. Am J Ther 2004;11:262 - 77.
    • (2004) Am J Ther , vol.11 , pp. 262-277
    • Patel, J.1    Buddha, B.2    Dey, S.3    Pal, D.4    Mitra, A.K.5
  • 48
    • 0034695608 scopus 로고    scopus 로고
    • Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers
    • PII S0024320599006591
    • Markowitz JS, DeVane CL, Boulton DW, Carson SW, Nahas Z, Risch SC. Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers. Life Sci 2000;66:133 - 9. (Pubitemid 30077858)
    • (2000) Life Sciences , vol.66 , Issue.9 , pp. 133-139
    • Markowitz, J.S.1    DeVane, C.L.2    Boulton, D.W.3    Carson, S.W.4    Nahas, Z.5    Risch, S.C.6
  • 49
    • 0036186534 scopus 로고    scopus 로고
    • St. John's wort extract induces CYP3A and CYP2E1 in the Swiss webster mouse
    • DOI 10.1093/toxsci/66.1.27
    • Bray BJ, Perry NB, Menkes DB, Rosengren RJ. St. John's wort extract induces CYP3A and CYP2E1 in the Swiss Webster mouse. Toxicol Sci 2002;66:27 - 33. (Pubitemid 34202026)
    • (2002) Toxicological Sciences , vol.66 , Issue.1 , pp. 27-33
    • Bray, B.J.1    Perry, N.B.2    Menkes, D.B.3    Rosengren, R.J.4
  • 50
    • 0037119057 scopus 로고    scopus 로고
    • Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity
    • DOI 10.1016/S0024-3205(02)01913-6, PII S0024320502019136
    • Zou L, Harkey MR, Henderson GL. Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci 2002;71:1579 - 89. (Pubitemid 34808718)
    • (2002) Life Sciences , vol.71 , Issue.13 , pp. 1579-1589
    • Zou, L.1    Harkey, M.R.2    Henderson G.L3
  • 51
    • 16644395523 scopus 로고    scopus 로고
    • The grapefruit challenge: The juice inhibits a crucial enzyme, with possibly fatal consequences
    • Karch AM. The grapefruit challenge: the juice inhibits a crucial enzyme, with possibly fatal consequences. Am J Nurs 2004;104:33 - 5.
    • (2004) Am J Nurs , vol.104 , pp. 33-35
    • Karch, A.M.1
  • 53
    • 84921706287 scopus 로고    scopus 로고
    • Pom: The new juice in town
    • July:1 - 4
    • Pom: the new juice in town. Consumer Reports 2005;July:1 - 4.
    • (2005) Consumer Reports
  • 55
    • 74749104214 scopus 로고    scopus 로고
    • Effect of silymarin and pomegranate pretreatment on intestinal transport of buspirone across rat intestine
    • Shravan KY, Ramesh G, Adukondalu D, Vamshi VY, Chinna RP, Shiva KR, et al. Effect of silymarin and pomegranate pretreatment on intestinal transport of buspirone across rat intestine. Acta Pharm Sci 2009;51:289 - 96.
    • (2009) Acta Pharm Sci , vol.51 , pp. 289-296
    • Shravan, K.Y.1    Ramesh, G.2    Adukondalu, D.3    Vamshi, V.Y.4    Chinna, R.P.5    Shiva, K.R.6
  • 56
    • 0035512382 scopus 로고    scopus 로고
    • Herb-drug interactions: Review and assessment of report reliability
    • Fugh BA, Ernst E. Herb-drug interactions: review and assessment of report reliability. Br J Clin Pharmacol 2001;52:587 - 95.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 587-595
    • Fugh, B.A.1    Ernst, E.2
  • 58
    • 77954346375 scopus 로고    scopus 로고
    • The infl uence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices
    • Berginc K, Trontelj J, Kristl A. The infl uence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices. Drug Metab Pharmacokinet 2010;25:307 - 13.
    • (2010) Drug Metab Pharmacokinet , vol.25 , pp. 307-313
    • Berginc, K.1    Trontelj, J.2    Kristl, A.3
  • 59
    • 78349305570 scopus 로고    scopus 로고
    • Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans
    • Hajda J, Rentsch KM, Gubler C, Steinert H, Steiger B, Fattinger K. Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans. Eur J Pharm Sci 2010;41:729 - 35.
    • (2010) Eur J Pharm Sci , vol.41 , pp. 729-735
    • Hajda, J.1    Rentsch, K.M.2    Gubler, C.3    Steinert, H.4    Steiger, B.5    Fattinger, K.6
  • 60
    • 77952290102 scopus 로고    scopus 로고
    • Inhibition of cytochrome P4503A4 activity by schisandrol a and gomisin a isolated from fructus schisandrae chinensis
    • Wana CK, Tse AK, Yu ZL, Zhu GY, Wang H, Fong DW. Inhibition of cytochrome P4503A4 activity by schisandrol A and gomisin A isolated from Fructus schisandrae chinensis. Phytomedicine 2010;17:702 - 5.
    • (2010) Phytomedicine , vol.17 , pp. 702-705
    • Wana, C.K.1    Tse, A.K.2    Yu, Z.L.3    Zhu, G.Y.4    Wang, H.5    Fong, D.W.6
  • 61
    • 0031914073 scopus 로고    scopus 로고
    • Saquinavir. Clinical pharmacology and efficacy
    • DOI 10.2165/00003088-199834030-00002
    • Vella S, Floridia M. Saquinavir. Clinical pharmacology and effi cacy. Clin Pharmacokinet 1998;34:189 - 201. (Pubitemid 28112398)
    • (1998) Clinical Pharmacokinetics , vol.34 , Issue.3 , pp. 189-201
    • Vella, S.1    Floridia, M.2
  • 62
    • 0031751330 scopus 로고    scopus 로고
    • Ritonavir: Clinical pharmacokinetics and interactions with other anti-HIV agents
    • DOI 10.2165/00003088-199835040-00002
    • Hsu A, Granneman GR, Bertz RJ. Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents. Clin Pharmacokinet 1998;35:275 - 91. (Pubitemid 28491214)
    • (1998) Clinical Pharmacokinetics , vol.35 , Issue.4 , pp. 275-291
    • Hsu, A.1    Granneman, G.R.2    Bertz, R.J.3
  • 63
    • 0032871057 scopus 로고    scopus 로고
    • Transport, metabolism and elimination mechanisms of anti-HIV agents
    • DOI 10.1016/S0169-409X(99)00021-6, PII S0169409X99000216
    • Li X, Chan WK. Transport, metabolism and elimination mechanisms of anti-HIV agents. Adv Drug Deliv Rev 1999;39:81 - 103. (Pubitemid 29430231)
    • (1999) Advanced Drug Delivery Reviews , vol.39 , Issue.1-3 , pp. 81-103
    • Li, X.1    Chan, W.K.2
  • 64
    • 0032987962 scopus 로고    scopus 로고
    • Drug interactions of HIV protease inhibitors
    • DOI 10.2165/00002018-199920020-00005
    • Malaty LI, Kuper JJ. Drug interactions of HIV protease inhibitors. Drug Saf 1999;20:147 - 69. (Pubitemid 29101279)
    • (1999) Drug Safety , vol.20 , Issue.2 , pp. 147-169
    • Malaty, L.I.1    Kuper, J.J.2
  • 65
    • 0032847425 scopus 로고    scopus 로고
    • Oral absorption of the HIV protease inhibitors: A current update
    • DOI 10.1016/S0169-409X(99)00027-7, PII S0169409X99000277
    • Williams GC, Sinko PJ. Oral absorption of the HIV protease inhibitors: a current update. Adv Drug Deliv Rev 1999;39:211 - 38. (Pubitemid 29430237)
    • (1999) Advanced Drug Delivery Reviews , vol.39 , Issue.1-3 , pp. 211-238
    • Williams, G.C.1    Sinko, P.J.2
  • 67
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 1976;455:152 - 62.
    • (1976) Biochim Biophys Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 70
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993; 62:385 - 427. (Pubitemid 23237876)
    • (1993) Annual Review of Biochemistry , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 71
    • 0037229942 scopus 로고    scopus 로고
    • Role of P-glycoprotein in pharmacokinetics: Clinical implications
    • DOI 10.2165/00003088-200342010-00003
    • Lin JH, Yamazaki M. Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet 2003;42:59 - 98. (Pubitemid 36092258)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.1 , pp. 59-98
    • Lin, J.H.1    Yamazaki, M.2
  • 76
    • 0028807793 scopus 로고
    • Effects of fl avonols on P-glycoprotein activity in cultured rat hepatocytes
    • Chieli E, Romiti N, Cervelli F, Tongiani R. Effects of fl avonols on P-glycoprotein activity in cultured rat hepatocytes. Life Sci 1995;57:1741 - 51.
    • (1995) Life Sci , vol.57 , pp. 1741-1751
    • Chieli, E.1    Romiti, N.2    Cervelli, F.3    Tongiani, R.4
  • 78
    • 0031581819 scopus 로고    scopus 로고
    • Effect of quercetin in Hoechst 33342 transport by purified and reconstituted P-glycoprotein
    • DOI 10.1016/S0006-2952(96)00826-X, PII S000629529600826X
    • Shapiro AB, Ling V. Effect of quercetin on Hoechst 33342 transport by purifi ed and reconstituted P-glycoprotein. Biochem Pharmacol 1997;53:587 - 96. (Pubitemid 27149553)
    • (1997) Biochemical Pharmacology , vol.53 , Issue.4 , pp. 587-596
    • Shapiro, A.B.1    Ling, V.2
  • 80
    • 70649091119 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from citrus species in human colon and leukaemia cell lines
    • El-Readi MZ, Hamdan D, Farrag N, El-Shazly A, Wink M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur J Pharm Sci 2010;626:139 - 45.
    • (2010) Eur J Pharm Sci , vol.626 , pp. 139-145
    • El-Readi, M.Z.1    Hamdan, D.2    Farrag, N.3    El-Shazly, A.4    Wink, M.5
  • 81
    • 0035813012 scopus 로고    scopus 로고
    • Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters
    • DOI 10.1016/S0300-483X(01)00454-1, PII S0300483X01004541
    • Leslie EM, Deeley RG, Cole SP. Toxicological relevance of the multidrug resistance protein 1 MRP1 (ABCC1) and related transporters. Toxicology 2001;167:3 - 23. (Pubitemid 32830943)
    • (2001) Toxicology , vol.167 , Issue.1 , pp. 3-23
    • Leslie, E.M.1    Deeley, R.G.2    Cole S.P.C3
  • 82
    • 0035198013 scopus 로고    scopus 로고
    • Strategies to overcome simultaneous P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of drugs
    • DOI 10.1517/14622416.2.4.401
    • Mitra AK, Patel J. Strategies to overcome simultaneous P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of drugs. Pharmacogenomics 2001;2:401 - 15. (Pubitemid 33120900)
    • (2001) Pharmacogenomics , vol.2 , Issue.4 , pp. 401-415
    • Patel, J.1    Mitra, A.K.2
  • 84
    • 0034922290 scopus 로고    scopus 로고
    • Inhibition of substance P-induced cytokine synthesis by St. John's wort extracts
    • Fiebich BL, Holli A, Lieb K. Inhibition of substance P-induced cytokine synthesis by St. John's wort extracts. Pharmacopsychiatry 2001;34:S26 - 8.
    • (2001) Pharmacopsychiatry , vol.34
    • Fiebich, B.L.1    Holli, A.2    Lieb, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.