-
1
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
DOI 10.1038/nature03097
-
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004;432:316-23. (Pubitemid 39551659)
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
2
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
DOI 10.1016/S1535-6108(03)00110-7, PII S1535610803001107
-
Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003;3:421-9. (Pubitemid 38340288)
-
(2003)
Cancer Cell
, vol.3
, Issue.5
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
3
-
-
36448973875
-
CHK2 kinase: Cancer susceptibility and cancer therapy - Two sides of the same coin?
-
Antoni L, Sodha N, Collins I, Garrett MD. CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?Nat Rev Cancer 2007;7:925-36.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 925-936
-
-
Antoni, L.1
Sodha, N.2
Collins, I.3
Garrett, M.D.4
-
4
-
-
3242884449
-
The Chk2 protein kinase
-
DOI 10.1016/j.dnarep.2004.03.033, PII S1568786404001053
-
Ahn J, Urist M, Prives C. The Chk2 protein kinase. DNA Repair (Amst) 2004;3:1039-47. (Pubitemid 38997946)
-
(2004)
DNA Repair
, vol.3
, Issue.8-9
, pp. 1039-1047
-
-
Ahn, J.1
Urist, M.2
Prives, C.3
-
5
-
-
0033552873
-
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
-
DOI 10.1016/S0960-9822(99)80041-4
-
Blasina A, de Weyer IV, Laus MC, et al. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol 1999;9:1-10. (Pubitemid 29045789)
-
(1999)
Current Biology
, vol.9
, Issue.1
, pp. 1-10
-
-
Blasina, A.1
De Weyer, I.V.2
Laus, M.C.3
Luyten, W.H.M.L.4
Parker, A.E.5
McGowan, C.H.6
-
6
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
DOI 10.1038/35071124
-
Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. The ATMChk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001;410:842-7. (Pubitemid 32303786)
-
(2001)
Nature
, vol.410
, Issue.6830
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
7
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai H, Naka K, Okada Y, et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 2002; 21:5195-205.
-
(2002)
EMBO J
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
Naka, K.2
Okada, Y.3
-
8
-
-
0038054343
-
The Chk2 tumor suppressor is not required for p53 responses in human cancer cells
-
DOI 10.1074/jbc.M213159200
-
Jallepalli PV, Lengauer C, Vogelstein B, Bunz F. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J Biol Chem 2003;278:20475-9. (Pubitemid 36806343)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.23
, pp. 20475-20479
-
-
Jallepalli, P.V.1
Lengauer, C.2
Vogelsteint, B.3
Bunz, F.4
-
9
-
-
50349103243
-
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
-
Jin J, Ang XL, Ye X, Livingstone M, Harper JW. Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase. J Biol Chem 2008;283:19322-8.
-
(2008)
J Biol Chem
, vol.283
, pp. 19322-19328
-
-
Jin, J.1
Ang, X.L.2
Ye, X.3
Livingstone, M.4
Harper, J.W.5
-
10
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 2000;14:278-88.
-
(2000)
Genes Dev
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
11
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites
-
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289-300. (Pubitemid 30106484)
-
(2000)
Genes and Development
, vol.14
, Issue.3
, pp. 289-300
-
-
Shieh, S.-Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
12
-
-
0037162506
-
1 arrest but is required for a latent p53-mediated apoptotic response
-
DOI 10.1073/pnas.152053599
-
Jack MT, Woo RA, Hirao A, et al. Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. Proc Natl Acad Sci USA 2002;99:9825-9. (Pubitemid 34831132)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.15
, pp. 9825-9829
-
-
Jack, M.T.1
Woo, R.A.2
Hirao, A.3
Cheung, A.4
Mak, T.W.5
Lee, P.W.K.6
-
13
-
-
0038392762
-
Questioning the role of checkpoint kinase 2 in the p53 DNA damage response
-
DOI 10.1074/jbc.M213185200
-
Ahn J, Urist M, Prives C. Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J Biol Chem 2003;278:20480-9. (Pubitemid 36806344)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.23
, pp. 20480-20489
-
-
Ahn, J.1
Urist, M.2
Prives, C.3
-
14
-
-
0034624718
-
HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
-
DOI 10.1038/35004614
-
Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 2000;404:201-4. (Pubitemid 30154490)
-
(2000)
Nature
, vol.404
, Issue.6774
, pp. 201-204
-
-
Lee, J.-S.1
Collins, K.M.2
Brown, A.L.3
Lee, C.-H.4
Chung, J.H.5
-
15
-
-
0346095320
-
Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair
-
DOI 10.1128/MCB.24.2.708-718.2004
-
Zhang J, Willers H, Feng Z, et al. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol 2004;24:708-18. (Pubitemid 38057922)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.2
, pp. 708-718
-
-
Zhang, J.1
Willers, H.2
Feng, Z.3
Ghosh, J.C.4
Kim, S.5
Weaver, D.T.6
Chung, J.H.7
Powell, S.N.8
Xia, F.9
-
16
-
-
32944477537
-
Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining
-
DOI 10.1158/0008-5472.CAN-05-3278
-
Zhuang J, Zhang J, Willers H, et al. Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res 2006;66:1401-8. (Pubitemid 43259920)
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1401-1408
-
-
Zhuang, J.1
Zhang, J.2
Willers, H.3
Wang, H.4
Chung, J.H.5
Van, G.D.C.6
Hallahan, D.E.7
Powell, S.N.8
Xia, F.9
-
17
-
-
0032574733
-
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
-
DOI 10.1073/pnas.95.9.5287
-
Chen PL, Chen CF, Chen Y, et al. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci USA 1998;95:5287-92. (Pubitemid 28208590)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.9
, pp. 5287-5292
-
-
Chen, P.-L.1
Chen, C.-F.2
Chen, Y.3
Xiao, J.4
Sharp, Z.D.5
Lee, W.-H.6
-
18
-
-
0031472370
-
Association of BRCA1 with Rad51 in mitotic and meiotic cells
-
DOI 10.1016/S0092-8674(00)81847-4
-
Scully R, Chen J, Plug A, et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997;88:265-75. (Pubitemid 28015875)
-
(1997)
Cell
, vol.88
, Issue.2
, pp. 265-275
-
-
Scully, R.1
Chen, J.2
Plug, A.3
Xiao, Y.4
Weaver, D.5
Feunteun, J.6
Ashley, T.7
Livingston, D.M.8
-
19
-
-
0035902551
-
Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
-
DOI 10.1073/pnas.151253498
-
Xia F, Taghian DG, DeFrank JS, et al. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Proc Natl Acad Sci USA 2001;98:8644-9. (Pubitemid 32678081)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.15
, pp. 8644-8649
-
-
Xia, F.1
Taghian, D.G.2
DeFrank, J.S.3
Zeng, Z.-C.4
Willers, H.5
Iliakis, G.6
Powell, S.N.7
-
20
-
-
17944370512
-
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1
-
DOI 10.1038/sj.onc.1204625
-
Wang Q, Zhang H, Guerrette S, et al. Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. Oncogene 2001;20:4640-9. (Pubitemid 32762436)
-
(2001)
Oncogene
, vol.20
, Issue.34
, pp. 4640-4649
-
-
Wang, Q.1
Zhang, H.2
Guerrette, S.3
Chen, J.4
Mazurek, A.5
Wilson, T.6
Slupianek, A.7
Skorski, T.8
Fishel, R.9
Greene, M.I.10
-
21
-
-
0037226473
-
The mismatch repair system is required for S-phase checkpoint activation
-
DOI 10.1038/ng1052
-
Brown KD, Rathi A, Kamath R, et al. The mismatch repair system is required for S-phase checkpoint activation. Nat Genet 2003;33:80-4. (Pubitemid 36068687)
-
(2003)
Nature Genetics
, vol.33
, Issue.1
, pp. 80-84
-
-
Brown, K.D.1
Rathi, A.2
Kamath, R.3
Beardsley, D.I.4
Zhan, Q.5
Mannino, J.L.6
Baskaran, R.7
-
22
-
-
0038752083
-
Chk2 activates E2F-1 in response to DNA damage
-
DOI 10.1038/ncb974
-
Stevens C, Smith L, La Thangue NB. Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol 2003;5:401-9. (Pubitemid 36592262)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.5
, pp. 401-409
-
-
Stevens, C.1
Smith, L.2
La, T.N.B.3
-
23
-
-
0036847998
-
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
-
DOI 10.1038/ncb869
-
Yang S, Kuo C, Bisi JE, Kim MK. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat Cell Biol 2002;4:865-70. (Pubitemid 35331361)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.11
, pp. 865-870
-
-
Yang, S.1
Kuo, C.2
Bisi, J.E.3
Kim, M.K.4
-
24
-
-
77951971957
-
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells
-
Stolz A, Ertych N, Kienitz A, et al. The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat Cell Biol 2010;12:492-9.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 492-499
-
-
Stolz, A.1
Ertych, N.2
Kienitz, A.3
-
25
-
-
67649522162
-
Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis
-
Holland AJ, Cleveland DW. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 2009;10:478-87.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 478-487
-
-
Holland, A.J.1
Cleveland, D.W.2
-
26
-
-
54349102282
-
Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase
-
Kais Z, Parvin JD. Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther 2008;7:1540-3.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1540-1543
-
-
Kais, Z.1
Parvin, J.D.2
-
27
-
-
33750434275
-
The BRCA1/BARD1 Heterodimer Modulates Ran-Dependent Mitotic Spindle Assembly
-
DOI 10.1016/j.cell.2006.08.053, PII S0092867406012815
-
Joukov V, Groen AC, Prokhorova T, et al. The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell 2006;127:539-52. (Pubitemid 44647427)
-
(2006)
Cell
, vol.127
, Issue.3
, pp. 539-552
-
-
Joukov, V.1
Groen, A.C.2
Prokhorova, T.3
Gerson, R.4
White, E.5
Rodriguez, A.6
Walter, J.C.7
Livingston, D.M.8
-
28
-
-
56149125558
-
Role of CHK2 in cancer development
-
Perona R, Moncho-Amor V, Machado-Pinilla R, Belda-Iniesta C, Sanchez Perez I. Role of CHK2 in cancer development. Clin Transl Oncol 2008;10:538-42.
-
(2008)
Clin Transl Oncol
, vol.10
, pp. 538-542
-
-
Perona, R.1
Moncho-Amor, V.2
Machado-Pinilla, R.3
Belda-Iniesta, C.4
Sanchez Perez, I.5
-
30
-
-
0347626108
-
The CHEK2*1100delC Variant Acts as a Breast Cancer Risk Modifier in Non-BRCA1/BRCA2 Multiple-Case Families
-
Oldenburg RA, Kroeze-Jansema K, Kraan J, et al. The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families. Cancer Res 2003;63:8153-7. (Pubitemid 37549462)
-
(2003)
Cancer Research
, vol.63
, Issue.23
, pp. 8153-8157
-
-
Oldenburg, R.A.1
Kroeze-Jansema, K.2
Kraan, J.3
Morreau, H.4
Klijn, J.G.M.5
Hoogerbrugge, N.6
Ligtenberg, M.J.L.7
Van, A.C.J.8
Vasen, H.F.A.9
Meijers, C.10
Meijers-Heijboer, H.11
De, B.T.H.12
Cornelisse, C.J.13
Devilee, P.14
-
31
-
-
33845780616
-
Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers
-
DOI 10.1158/1078-0432.CCR-06-1770
-
Williams LH, Choong D, Johnson SA, Campbell IG. Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers. Clin Cancer Res 2006;12:6967-72. (Pubitemid 44974490)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.23
, pp. 6967-6972
-
-
Williams, L.H.1
Choong, D.2
Johnson, S.A.3
Campbell, I.G.4
-
32
-
-
2942585478
-
CHK2 kinase expression is downregulated due to promoter methylation in non-small cell lung cancer
-
Zhang P, Wang J, Gao W, et al. CHK2 kinase expression is downregulated due to promoter methylation in non-small cell lung cancer. Mol Cancer 2004;3:14.
-
(2004)
Mol Cancer
, vol.3
, pp. 14
-
-
Zhang, P.1
Wang, J.2
Gao, W.3
-
33
-
-
18544389716
-
Lowpenetrance susceptibility to breast cancer due to CHEK2(*) 1100delC in noncarriers of BRCA1 or BRCA2 mutations
-
Meijers-Heijboer H, Van Den Ouweland A, Klijn J, et al. Lowpenetrance susceptibility to breast cancer due to CHEK2(*) 1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet 2002;31:55-9.
-
(2002)
Nat Genet
, vol.31
, pp. 55-59
-
-
Meijers-Heijboer, H.1
Van Den Ouweland, A.2
Klijn, J.3
-
34
-
-
0242442016
-
Germ-Line Alterations in MSR1 Gene and Prostate Cancer Risk
-
Seppala EH, Ikonen T, Autio V, et al. Germ-line alterations in MSR1 gene and prostate cancer risk. Clin Cancer Res 2003;9:5252-6. (Pubitemid 37413576)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.14
, pp. 5252-5256
-
-
Seppala, E.H.1
Ikonen, T.2
Autio, V.3
Rokman, A.4
Mononen, N.5
Matikainen, M.P.6
Tammela, T.L.J.7
Schleutker, J.8
-
35
-
-
0037274361
-
Familial breast cancer and the hCHK2 1100delC mutation: Assessing cancer risk
-
DOI 10.1186/bcr582
-
Varley J, Haber DA. Familial breast cancer and the hCHK2 1100delC mutation: assessing cancer risk. Breast Cancer Res 2003;5:123-5. (Pubitemid 36519403)
-
(2003)
Breast Cancer Research
, vol.5
, Issue.3
, pp. 123-125
-
-
Varley, J.1
Haber, D.A.2
-
36
-
-
8844220451
-
CHEK2 is a multiorgan cancer susceptibility gene
-
DOI 10.1086/426403
-
Cybulski C, Gorski B, Huzarski T, et al. CHEK2 is a multiorgan cancer susceptibility gene. Am J Hum Genet 2004;75:1131-5. (Pubitemid 39532081)
-
(2004)
American Journal of Human Genetics
, vol.75
, Issue.6
, pp. 1131-1135
-
-
Cybulski, C.1
Gorski, B.2
Huzarski, T.3
Masojc, B.4
Mierzejewski, M.5
Debniak, T.6
Teodorczyk, U.7
Byrski, T.8
Gronwald, J.9
Matyjasik, J.10
Zlowocka, E.11
Lenner, M.12
Grabowska, E.13
Nej, K.14
Castaneda, J.15
Medrek, K.16
Szymanska, A.17
Szymanska, J.18
Kurzawski, G.19
Suchy, J.20
Oszurek, O.21
Witek, A.22
Narod, S.A.23
Lubinski, J.24
more..
-
37
-
-
33748454829
-
CHEK2 variants predispose to benign, borderline and low-grade invasive ovarian tumors
-
DOI 10.1016/j.ygyno.2006.05.040, PII S0090825806004628
-
Szymanska-Pasternak J, Szymanska A, Medrek K, et al. CHEK2 variants predispose to benign, borderline and low-grade invasive ovarian tumors. Gynecol Oncol 2006;102:429-31. (Pubitemid 44353662)
-
(2006)
Gynecologic Oncology
, vol.102
, Issue.3
, pp. 429-431
-
-
Szymanska-Pasternak, J.1
Szymanska, A.2
Medrek, K.3
Imyanitov, E.N.4
Cybulski, C.5
Gorski, B.6
Magnowski, P.7
Dziuba, I.8
Gugala, K.9
Debniak, B.10
Gozdz, S.11
Sokolenko, A.P.12
Krylova, N.Y.13
Lobeiko, O.S.14
Narod, S.A.15
Lubinski, J.16
-
38
-
-
33746830882
-
CHEK2 I157T associates with familial and sporadic colorectal cancer
-
Kilpivaara O, Alhopuro P, Vahteristo P, Aaltonen LA, Nevanlinna H. CHEK2 I157T associates with familial and sporadic colorectal cancer. J Med Genet 2006;43:e34.
-
(2006)
J Med Genet
, vol.43
-
-
Kilpivaara, O.1
Alhopuro, P.2
Vahteristo, P.3
Aaltonen, L.A.4
Nevanlinna, H.5
-
39
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
Bell DW, Varley JM, Szydlo TE, et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 1999;286:2528-31.
-
(1999)
Science
, vol.286
, pp. 2528-2531
-
-
Bell, D.W.1
Varley, J.M.2
Szydlo, T.E.3
-
41
-
-
0035817764
-
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
-
DOI 10.1038/sj.onc.1204811
-
Falck J, Lukas C, Protopopova M, et al. Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Oncogene 2001;20:5503-10. (Pubitemid 32889487)
-
(2001)
Oncogene
, vol.20
, Issue.39
, pp. 5503-5510
-
-
Falck, J.1
Lukas, C.2
Protopopova, M.3
Lukas, J.4
Selivanova, G.5
Bartek, J.6
-
42
-
-
85047695017
-
Concomitant inactivation of p53 and Chk2 in breast cancer
-
DOI 10.1038/sj/onc/1205207
-
Sullivan A, Yuille M, Repellin C, et al. Concomitant inactivation of p53 and Chk2 in breast cancer. Oncogene 2002;21:1316-24. (Pubitemid 34214497)
-
(2002)
Oncogene
, vol.21
, Issue.9
, pp. 1316-1324
-
-
Sullivan, A.1
Yuille, M.2
Repellin, C.3
Reddy, A.4
Reelfs, O.5
Bell, A.6
Dunne, B.7
Gusterson, B.A.8
Osin, P.9
Farrell, P.J.10
Yulug, I.11
Evans, A.12
Ozcelik, T.13
Gasco, M.14
Crook, T.15
-
43
-
-
49849083943
-
Whole chromosome instability and cancer: A complex relationship
-
Ricke RM, van Ree JH, van Deursen JM. Whole chromosome instability and cancer: a complex relationship. Trends Genet 2008;24:457-66.
-
(2008)
Trends Genet
, vol.24
, pp. 457-466
-
-
Ricke, R.M.1
Van Ree, J.H.2
Van Deursen, J.M.3
-
44
-
-
0035823105
-
Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells
-
DOI 10.1016/S0014-5793(01)02756-9, PII S0014579301027569
-
Yu Q, Rose JH, Zhang H, Pommier Y. Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells. FEBS Lett 2001;505:7-12. (Pubitemid 32831020)
-
(2001)
FEBS Letters
, vol.505
, Issue.1
, pp. 7-12
-
-
Yu, Q.1
Rose, J.H.L.2
Zhang, H.3
Pommier, Y.4
-
45
-
-
33846188519
-
Activated checkpoint kinase 2 provides a survival signal for tumor cells
-
DOI 10.1158/0008-5472.CAN-06-3095
-
Ghosh JC, Dohi T, Raskett CM, Kowalik TF, Altieri DC. Activated checkpoint kinase 2 provides a survival signal for tumor cells. Cancer Res 2006;66:11576-9. (Pubitemid 46094165)
-
(2006)
Cancer Research
, vol.66
, Issue.24
, pp. 11576-11579
-
-
Ghosh, J.C.1
Dohi, T.2
Raskett, C.M.3
Kowalik, T.F.4
Altieri, D.C.5
-
46
-
-
34147177714
-
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2
-
DOI 10.1158/1535-7163.MCT-06-0567
-
Carlessi L, Buscemi G, Larson G, et al. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther 2007;6:935-44. (Pubitemid 46554563)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.3
, pp. 935-944
-
-
Carlessi, L.1
Buscemi, G.2
Larson, G.3
Hong, Z.4
Wu, J.Z.5
Delia, D.6
-
47
-
-
34748854847
-
Identification of a Bis-guanylhydrazone [4,40-Diacetyldiphenylurea- bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase
-
Jobson AG, Cardellina JH 2nd, Scudiero D, et al. Identification of a Bis-guanylhydrazone [4,40-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol 2007;72:876-84.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 876-884
-
-
Jobson, A.G.1
Cardellina II, J.H.2
Scudiero, D.3
-
48
-
-
4444344407
-
G2 checkpoint abrogators as anticancer drugs
-
Kawabe T. G2 checkpoint abrogators as anticancer drugs. Mol Cancer Ther 2004;3:513-9.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 513-519
-
-
Kawabe, T.1
-
49
-
-
33846567414
-
Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo
-
Matthews DJ, Yakes FM, Chen J, et al. Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo. Cell Cycle 2007;6:104-10. (Pubitemid 46173886)
-
(2007)
Cell Cycle
, vol.6
, Issue.1
, pp. 104-110
-
-
Matthews, D.J.1
Yakes, F.M.2
Chen, J.3
Tadano, M.4
Bornheim, L.5
Clary, D.O.6
Tai, A.7
Wagner, J.M.8
Miller, N.9
Kim, Y.D.10
Robertson, S.11
Murray, L.12
Karnitz, L.M.13
-
50
-
-
0029992520
-
2-checkpoint inhibitor
-
Bunch RT, Eastman A. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor. Clin Cancer Res 1996;2:791-7. (Pubitemid 26168931)
-
(1996)
Clinical Cancer Research
, vol.2
, Issue.5
, pp. 791-797
-
-
Bunch, R.T.1
Eastman, A.2
-
51
-
-
33846424957
-
2 checkpoint abrogation
-
DOI 10.1158/0008-5472.CAN-06-2548
-
Vogel C, Hager C, Bastians H. Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation. Cancer Res 2007;67:339-45. (Pubitemid 46142793)
-
(2007)
Cancer Research
, vol.67
, Issue.1
, pp. 339-345
-
-
Vogel, C.1
Hager, C.2
Bastians, H.3
-
52
-
-
77949414415
-
Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors
-
Pires IM, Ward TH, Dive C. Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors. Br J Pharmacol 2010;159:1326-38.
-
(2010)
Br J Pharmacol
, vol.159
, pp. 1326-1338
-
-
Pires, I.M.1
Ward, T.H.2
Dive, C.3
-
53
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
DOI 10.1038/nature03445
-
Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21. (Pubitemid 40559006)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
McCabe, H.2
Lord, C.J.3
Tutt, A.H.J.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
Martin, N.M.B.11
Jackson, S.P.12
Smith, G.C.M.13
Ashworth, A.14
-
54
-
-
33748065304
-
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
-
DOI 10.1158/0008-5472.CAN-06-0140
-
McCabe N, Turner NC, Lord CJ, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADPribose) polymerase inhibition. Cancer Res 2006;66:8109-15. (Pubitemid 44299177)
-
(2006)
Cancer Research
, vol.66
, Issue.16
, pp. 8109-8115
-
-
McCabe, N.1
Turner, N.C.2
Lord, C.J.3
Kluzek, K.4
Bialkowska, A.5
Swift, S.6
Giavara, S.7
O'Connor, M.J.8
Tutt, A.N.9
Zdzienicka, M.Z.10
Smith, G.C.M.11
Ashworth, A.12
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