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Volumn 10, Issue 9, 2008, Pages 538-542

Role of CHK2 in cancer development

Author keywords

ATM; ATR; Checkpoints; Chemotherapy; CHK2; DNA damage

Indexed keywords

CHECKPOINT KINASE 2; ENZYME INHIBITOR; PROTEIN SERINE THREONINE KINASE;

EID: 56149125558     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-008-0248-5     Document Type: Article
Times cited : (31)

References (39)
  • 1
    • 0035209666 scopus 로고    scopus 로고
    • Detecting, signalling and repairing dna double-strand breaks
    • Review
    • Jackson SP (2001) Detecting, signalling and repairing DNA double-strand breaks. Biochem Soc Trans 29:655-661. Review
    • (2001) Biochem Soc Trans , vol.29 , pp. 655-661
    • Jackson, S.P.1
  • 2
    • 33845627082 scopus 로고    scopus 로고
    • Cellular responses to dna damage: One signal, multiple choices
    • Review
    • Su TT (2006) Cellular responses to DNA damage: one signal, multiple choices. Annu Rev Genet 40:187-208. Review
    • (2006) Annu Rev Genet , vol.40 , pp. 187-208
    • Su, T.T.1
  • 3
    • 33750630463 scopus 로고    scopus 로고
    • Dna repair inhibitors in cancer treatment
    • Review
    • Sánchez-Pérez I (2006) DNA repair inhibitors in cancer treatment. Clin Transl Oncol 8:642-646. Review
    • (2006) Clin Transl Oncol , vol.8 , pp. 642-646
    • Sánchez-Pérez, I.1
  • 4
    • 29244437908 scopus 로고    scopus 로고
    • The role of double-strand break repair-insights from human genetics
    • O'Driscoll M, Jeggo PA (2006) The role of double-strand break repair-insights from human genetics. Nat Rev Genet 7:45-54
    • (2006) Nat Rev Genet , vol.7 , pp. 45-54
    • O'Driscoll, M.1    Jeggo, P.A.2
  • 5
    • 33745001764 scopus 로고    scopus 로고
    • Cdc25: Mechanisms of checkpoint inhibition and recovery
    • Karlsson-Rosenthal C, Millar JB (2006) Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell Biol 16:285-292
    • (2006) Trends Cell Biol , vol.16 , pp. 285-292
    • Karlsson-Rosenthal, C.1    Millar, J.B.2
  • 6
    • 0034624718 scopus 로고    scopus 로고
    • Hcds1-mediated phosphorylation of brca1 regulates the dna damage response
    • Lee JS, Collins KM, Brown AL et al (2000) hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404: 201-204
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.S.1    Collins, K.M.2    Brown, A.L.3
  • 7
    • 0346095320 scopus 로고    scopus 로고
    • Chk2 phosphorylation of brca1 regulates dna double-strand break repair
    • Zhang J, Willers H, Feng Z et al (2004) Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol 24:708-718
    • (2004) Mol Cell Biol , vol.24 , pp. 708-718
    • Zhang, J.1    Willers, H.2    Feng, Z.3
  • 8
    • 32944459979 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated and checkpoint kinase 2 regulate brca1 to promote the fidelity of dna end-joining
    • Wang HC, Chou WC, Shieh SY, Shen CY (2006) Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res 66:1391-1400
    • (2006) Cancer Res , vol.66 , pp. 1391-1400
    • Wang, H.C.1    Chou, W.C.2    Shieh, S.Y.3    Shen, C.Y.4
  • 9
    • 32944477537 scopus 로고    scopus 로고
    • Checkpoint kinase 2-mediated phosphorylation of brca1 regulates the fidelity of nonhomologous endjoining
    • Zhuang J, Zhang J, Willers H et al (2006) Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous endjoining. Cancer Res 66:1401-1408
    • (2006) Cancer Res , vol.66 , pp. 1401-1408
    • Zhuang, J.1    Zhang, J.2    Willers, H.3
  • 10
    • 33846619711 scopus 로고    scopus 로고
    • Chk2 mediates stabilization of the foxm1 transcription factor to stimulate expression of dna repair genes
    • Tan Y, Raychaudhuri P, Costa RH (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol 27:1007-1016
    • (2007) Mol Cell Biol , vol.27 , pp. 1007-1016
    • Tan, Y.1    Raychaudhuri, P.2    Costa, R.H.3
  • 11
    • 0033601346 scopus 로고    scopus 로고
    • Heterozygous germ line hchk2 mutations in li-fraumeni syndrome
    • Bell DW, Varley JM, Szydlo TE et al (1999) Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286:2528-2531
    • (1999) Science , vol.286 , pp. 2528-2531
    • Bell, D.W.1    Varley, J.M.2    Szydlo, T.E.3
  • 12
    • 0023715595 scopus 로고
    • A cancer family syndrome in twenty-four kindreds
    • Li FP, Fraumeni JF Jr., Mulvihill JJ et al (1988) A cancer family syndrome in twenty-four kindreds. Cancer Res 48:5358-5362
    • (1988) Cancer Res , vol.48 , pp. 5358-5362
    • Li, F.P.1    Fraumeni Jr., J.F.2    Mulvihill, J.J.3
  • 13
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin D, Li FP, Strong LC et al (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233-1238
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 14
    • 18544389716 scopus 로고    scopus 로고
    • Low-penetrance susceptibility to breast cancer due to chek2(*)1100delc in noncarriers of brca1 or brca2 mutations
    • CHEK2-Breast Cancer Consortium
    • Meijers-Heijboer H, van den Ouweland A, Klijn J et al; CHEK2-Breast Cancer Consortium (2002) Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet 31:55-59
    • (2002) Nat Genet , vol.31 , pp. 55-59
    • Meijers-Heijboer, H.1    Van Den Ouweland, A.2    Klijn, J.3
  • 15
    • 0242442016 scopus 로고    scopus 로고
    • Germline alterations in msr1 gene and prostate cancer risk
    • Seppälä EH, Ikonen T, Autio V et al (2003) Germline alterations in MSR1 gene and prostate cancer risk. Clin Cancer Res 9:5252-5256
    • (2003) Clin Cancer Res , vol.9 , pp. 5252-5256
    • Seppälä, E.H.1    Ikonen, T.2    Autio, V.3
  • 16
    • 8844220451 scopus 로고    scopus 로고
    • Chek2 is a multiorgan cancer susceptibility gene
    • Cybulski C, Górski B, Huzarski T et al (2004) CHEK2 is a multiorgan cancer susceptibility gene. Am J Hum Genet 75:1131-1135
    • (2004) Am J Hum Genet , vol.75 , pp. 1131-1135
    • Cybulski, C.1    Górski, B.2    Huzarski, T.3
  • 17
    • 33748454829 scopus 로고    scopus 로고
    • Chek2 variants predispose to be nign, borderline and low-grade invasive ovarian tumors
    • Szymanska-Pasternak J, Szymanska A, Medrek K et al (2006) CHEK2 variants predispose to be nign, borderline and low-grade invasive ovarian tumors. Gynecol Oncol 102:429-431
    • (2006) Gynecol Oncol , vol.102 , pp. 429-431
    • Szymanska-Pasternak, J.1    Szymanska, A.2    Medrek, K.3
  • 18
    • 33746830882 scopus 로고    scopus 로고
    • Chek2 i157t associates with familial and sporadic colorectal cancer
    • Kilpivaara O, Alhopuro P, Vahteristo P et al (2006) CHEK2 I157T associates with familial and sporadic colorectal cancer. J Med Genet 43:e34
    • (2006) J Med Genet , vol.43
    • Kilpivaara, O.1    Alhopuro, P.2    Vahteristo, P.3
  • 19
    • 0942279575 scopus 로고    scopus 로고
    • Excess risk for contralateral breast cancer in chek2*1100delc germline mutation carriers
    • Broeks A, de Witte L, Nooijen A et al (2004) Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers. Breast Cancer Res Treat 83:91-93
    • (2004) Breast Cancer Res Treat , vol.83 , pp. 91-93
    • Broeks, A.1    De Witte, L.2    Nooijen, A.3
  • 20
    • 46149124528 scopus 로고    scopus 로고
    • Chk2 suppresses the oncogenic potential of dna replication-associated dna damage
    • Stracker TH, Couto SS, Cordon-Cardo C et al (2008) Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31:21-32
    • (2008) Mol Cell , vol.31 , pp. 21-32
    • Stracker, T.H.1    Couto, S.S.2    Cordon-Cardo, C.3
  • 21
    • 0347626108 scopus 로고    scopus 로고
    • The chek2*1100delc variant acts as a breast cancer risk modifier in non-brca1/brca2 multiple-case families
    • Oldenburg RA, Kroeze-Jansema K, Kraan J et al (2003) The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families. Cancer Res 63:8153-8157
    • (2003) Cancer Res , vol.63 , pp. 8153-8157
    • Oldenburg, R.A.1    Kroeze-Jansema, K.2    Kraan, J.3
  • 22
    • 34247552376 scopus 로고    scopus 로고
    • Mutation analysis of the chk2 gene in breast carcinoma and other cancers
    • Ingvarsson S, Sigbjornsdottir BI, Huiping C et al (2002) Mutation analysis of the CHK2 gene in breast carcinoma and other cancers. Breast Cancer Res 4:R4
    • (2002) Breast Cancer Res , vol.4
    • Ingvarsson, S.1    Sigbjornsdottir, B.I.2    Huiping, C.3
  • 24
    • 33845780616 scopus 로고    scopus 로고
    • Genetic and epigenetic analysis of chek2 in sporadic breast, colon, and ovarian cancers
    • Williams LH, Choong D, Johnson SA, Campbell IG (2006) Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers. Clin Cancer Res 12:6967-6972
    • (2006) Clin Cancer Res , vol.12 , pp. 6967-6972
    • Williams, L.H.1    Choong, D.2    Johnson, S.A.3    Campbell, I.G.4
  • 25
    • 56749177163 scopus 로고    scopus 로고
    • Alterations of chk1 and chk2 expression in colon cancer
    • [Epub ahead of print
    • Stawinska M, Cygankiewicz A, Trzcinski R et al (2008) Alterations of Chk1 and Chk2 expression in colon cancer. Int J Colorectal Dis [Epub ahead of print
    • (2008) Int J Colorectal Dis
    • Stawinska, M.1    Cygankiewicz, A.2    Trzcinski, R.3
  • 26
    • 0034616329 scopus 로고    scopus 로고
    • Caffeine abolishes the mammalian g(2)/m dna damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
    • Zhou BB, Chaturvedi P, Spring K et al (2000) Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia- mutated kinase activity. J Biol Chem 275: 10342-10348
    • (2000) J Biol Chem , vol.275 , pp. 10342-10348
    • Zhou, B.B.1    Chaturvedi, P.2    Spring, K.3
  • 27
    • 0034053130 scopus 로고    scopus 로고
    • The chk1 protein kinase and the cdc25c regulatory pathways are targets of the anticancer agent ucn-01
    • Graves PR, Yu L, Schwarz JK et al (2000) The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem 275:5600-5605
    • (2000) J Biol Chem , vol.275 , pp. 5600-5605
    • Graves, P.R.1    Yu, L.2    Schwarz, J.K.3
  • 28
    • 0034655281 scopus 로고    scopus 로고
    • The radiosensitizing agent 7-hydroxystaurosporine (ucn-01) inhibits the dna damage checkpoint kinase hchk1
    • Busby EC, Leistritz DF, Abraham RT et al (2000) The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res 60:2108-2112
    • (2000) Cancer Res , vol.60 , pp. 2108-2112
    • Busby, E.C.1    Leistritz, D.F.2    Abraham, R.T.3
  • 29
    • 0029895439 scopus 로고    scopus 로고
    • Ucn-01: A potent abrogator of g2 checkpoint function in cancer cells with disrupted p53
    • Wang Q, Fan S, Eastman A et al (1996) UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J Natl Cancer Inst 88:956-965
    • (1996) J Natl Cancer Inst , vol.88 , pp. 956-965
    • Wang, Q.1    Fan, S.2    Eastman, A.3
  • 30
    • 0033555260 scopus 로고    scopus 로고
    • A role for atr in the dna damage-induced phosphorylation of p53
    • Tibbetts RS, Brumbaugh KM, Williams JM et al (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13: 152-157
    • (1999) Genes Dev , vol.13 , pp. 152-157
    • Tibbetts, R.S.1    Brumbaugh, K.M.2    Williams, J.M.3
  • 31
    • 0035829685 scopus 로고    scopus 로고
    • Inhibition of chk1-dependent g2 dna damage checkpoint radiosensitizes p53 mutant human cells
    • Koniaras K, Cuddihy AR, Christopoulos H et al (2001) Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 20:7453-7463
    • (2001) Oncogene , vol.20 , pp. 7453-7463
    • Koniaras, K.1    Cuddihy, A.R.2    Christopoulos, H.3
  • 33
    • 36949012288 scopus 로고    scopus 로고
    • Targeted cancer therapies based on the inhibition of dna strand break repair
    • O'Connor MJ, Martin NM, Smith GC (2007) Targeted cancer therapies based on the inhibition of DNA strand break repair. Oncogene 26:7816-7824
    • (2007) Oncogene , vol.26 , pp. 7816-7824
    • O'Connor, M.J.1    Martin, N.M.2    Smith, G.C.3
  • 34
    • 4444344407 scopus 로고    scopus 로고
    • G2 checkpoint abrogators as anticancer drugs
    • Review
    • Kawabe T (2004) G2 checkpoint abrogators as anticancer drugs. Mol Cancer Ther 3:513-519. Review
    • (2004) Mol Cancer Ther , vol.3 , pp. 513-519
    • Kawabe, T.1
  • 35
    • 20144371717 scopus 로고    scopus 로고
    • Checkpoint kinase inhibitors: Sar and radioprotective properties of a series of 2-arylbenzimidazoles
    • Arienti KL, Brunmark A, Axe FU et al (2005) Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem 48:1873-1885
    • (2005) J Med Chem , vol.48 , pp. 1873-1885
    • Arienti, K.L.1    Brunmark, A.2    Axe, F.U.3
  • 36
    • 34147177714 scopus 로고    scopus 로고
    • Biochemical and cellular characterization of vrx0466617, a novel and selective inhibitor for the checkpoint kinase chk2
    • Carlessi L, Buscemi G, Larson G et al (2007) Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther 6:935-944
    • (2007) Mol Cancer Ther , vol.6 , pp. 935-944
    • Carlessi, L.1    Buscemi, G.2    Larson, G.3
  • 37
    • 33846188519 scopus 로고    scopus 로고
    • Activated checkpoint kinase 2 provides a survival signal for tumor cells
    • Ghosh JC, Dohi T, Raskett CM et al (2006) Activated checkpoint kinase 2 provides a survival signal for tumor cells. Cancer Res 66:11576-11579
    • (2006) Cancer Res , vol.66 , pp. 11576-11579
    • Ghosh, J.C.1    Dohi, T.2    Raskett, C.M.3
  • 38
    • 22244486020 scopus 로고    scopus 로고
    • Dual induction of apoptosis and senescence in cancer cells by chk2 activation: Checkpoint activation as a strategy against cancer
    • Chen CR, Wang W, Rogoff HA et al (2005) Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer. Cancer Res 65:6017-6021
    • (2005) Cancer Res , vol.65 , pp. 6017-6021
    • Chen, C.R.1    Wang, W.2    Rogoff, H.A.3
  • 39
    • 36448973875 scopus 로고    scopus 로고
    • Chk2 kinase: Cancer susceptibility and cancer therapy-two sides of the same coin?
    • Antoni L, Sodha N, Collins I, Garrett MD (2007) CHK2 kinase: cancer susceptibility and cancer therapy-two sides of the same coin? Nat Rev Cancer 7:925-936
    • (2007) Nat Rev Cancer , vol.7 , pp. 925-936
    • Antoni, L.1    Sodha, N.2    Collins, I.3    Garrett, M.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.