Translesion synthesis polymerases in the prevention and promotion of carcinogenesis

Journal of Nucleic Acids

Volumn 2010, Issue , 2010, Pages

  Stallons, L Jay ^a   McGregor, W Glenn ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; DNA POLYMERASE IOTA; DNA POLYMERASE KAPPA; DNA POLYMERASE REV1; DNA POLYMERASE ZETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CARCINOGENESIS; CELL TRANSFORMATION; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INDUCED MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSLESION DNA SYNTHESIS;

MAMMALIA; MUS;

EID: 79551615628     PISSN: 20900201     EISSN: 2090021X     Source Type: Journal    
DOI: 10.4061/2010/643857     Document Type: Review

References (97)

1. Hanahan D., Weinberg R. A., The hallmarks of cancer. Cell 2000 100 1 57 70 2-s2.0-0034614637 (Pubitemid 30046295)
2. Baynton K., Bresson-Roy A., Fuchs R. P. P., Analysis of damage tolerance pathways in Saccharomyces cerevisiae: a requirement for Rev3 DNA polymerase in translesion synthesis. Molecular and Cellular Biology 1998 18 2 960 966 2-s2.0-0031907155 (Pubitemid 28063430)
3. Adar S., Izhar L., Hendel A., Geacintov N., Livneh Z., Repair of gaps opposite lesions by homologous recombination in mammalian cells. Nucleic Acids Research 2009 37 17 5737 5748 10.1093/nar/gkp632 2-s2.0-73049102332
4. Vasquez K. M., Marburger K., Intody Z., Wilson J. H., Manipulating the mammalian genome by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America 2001 98 15 8403 8410 10.1073/pnas.111009698 2-s2.0-0035902445 (Pubitemid 32678042)
5. Shulman M. J., Collins C., Connor A., Read L. R., Baker M. D., Interchromosomal recombination is suppressed in mammalian somatic cells. EMBO Journal 1995 14 16 4102 4107 2-s2.0-0029160045
6. Ohmori H., Friedberg E. C., Fuchs R. P.P., Goodman M. F., Hanaoka F., Hinkle D., Kunkel T. A., Lawrence C. W., Livneh Z., Nohmi T., Prakash L., Prakash S., Todo T., Walker G. C., Wang Z., Woodgate R., woodgate@helix.nih.gov The Y-family of DNA polymerases. Molecular Cell 2001 8 1 7 8 2-s2.0-0025766848 10.1016/S1097-2765(01)00278-7 (Pubitemid 32772900)
7. Gibbs P. E. M., McGregor W. G., Maher V. M., Nisson P., Lawrence C. W., A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ Proceedings of the National Academy of Sciences of the United States of America 1998 95 12 6876 6880 10.1073/pnas.95.12.6876 2-s2.0-0032499748 (Pubitemid 28278074)
8. Lin W., Wu X., Wang Z., A full-length cDNA of hREV3 is predicted to encode DNA polymerase ζ for damage-induced mutagenesis in humans. Mutation Research 1999 433 2 89 98 10.1016/S0921-8777(98)00065-2 2-s2.0-0032994152 (Pubitemid 29101630)
9. McCulloch S. D., Kunkel T. A., The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Research 2008 18 1 148 161 10.1038/cr.2008.4 2-s2.0-38049125552
10. Reynaud C.-A., Delbos F., Faili A., Gueranger Q., Aoufouchi S., Weill J.-C., Competitive repair pathways in immunoglobulin gene hypermutation. Philosophical Transactions of the Royal Society B 2009 364 1517 613 619 10.1098/rstb.2008.0206 2-s2.0-60049087517
11. Diaz M., Lawrence C., An update on the role of translesion synthesis DNA polymerases in Ig hypermutation. Trends in Immunology 2005 26 4 215 220 10.1016/j.it.2005.02.008 2-s2.0-20044379457 (Pubitemid 41556859)
12. Motegi A., Liaw H.-J., Lee K.-Y., Roest H. P., Maas A., Wu X., Moinova H., Markowitz S. D., Ding H., Hoeijmakers J. H. J., Myung K., Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proceedings of the National Academy of Sciences of the United States of America 2008 105 34 12411 12416 10.1073/pnas.0805685105 2-s2.0-50449092205
13. Motegi A., Sood R., Moinova H., Markowitz S. D., Liu P. P., Myung K., Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. Journal of Cell Biology 2006 175 5 703 708 10.1083/jcb.200606145 2-s2.0-33845310025 (Pubitemid 44878502)
14. Unk I., Hajdú I., Fátyol K., Hurwitz J., Yoon J.-H., Prakash L., Prakash S., Haracska L., Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Proceedings of the National Academy of Sciences of the United States of America 2008 105 10 3768 3773 10.1073/pnas.0800563105 2-s2.0-41649083002 (Pubitemid 351723473)
15. Unk I., Hajdú I., Fátyol K., Szakál B., Blastyák A., Bermudez V., Hurwitz J., Prakash L., Prakash S., Haracska L., Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. Proceedings of the National Academy of Sciences of the United States of America 2006 103 48 18107 18112 10.1073/pnas.0608595103 2-s2.0-33845309117 (Pubitemid 44871620)
16. Watson N. B., Mukhopadhyay S., McGregor W. G., Translesion DNA replication proteins as molecular targets for cancer prevention. Cancer Letters 2006 241 1 13 22 10.1016/j.canlet.2005.10.013
17. Larimer F. W., Perry J. R., Hardigree A. A., The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis. Journal of Bacteriology 1989 171 1 230 237 2-s2.0-0024526246
18. Nelson J. R., Lawrence C. W., Hinkle D. C., Deoxycytidyl transferase activity of yeast REV1 protein. Nature 1996 382 6593 729 731 10.1038/382729a0 2-s2.0-0029787108 (Pubitemid 26282181)
19. Diaz M., Velez J., Singh M., Cerny J., Flajnik M. F., Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation. International Immunology 1999 11 5 825 833 10.1093/intimm/11.5.825 2-s2.0-0032911308 (Pubitemid 29237773)
20. Gibbs P. E. M., Wang X.-D., Li Z., McManus T. P., McGregor W. G., Lawrence C. W., Maher V. M., The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. Proceedings of the National Academy of Sciences of the United States of America 2000 97 8 4186 4191 10.1073/pnas.97.8.4186 2-s2.0-0034636106 (Pubitemid 30226108)
21. Clark D. R., Zacharias W., Panaitescu L., McGregor W. G., Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene. Nucleic Acids Research 2003 31 17 4981 4988 10.1093/nar/gkg725 2-s2.0-0344875492 (Pubitemid 37441864)
22. Mukhopadyay S., Clark D. R., Watson N. B., Zacharias W., McGregor W. G., REV1 accumulates in DNA damage-induced nuclear foci in human cells and is implicated in mutagenesis by benzo[a]pyrenediolepoxide. Nucleic Acids Research 2004 32 19 5820 5826 10.1093/nar/gkh903 2-s2.0-10244232940 (Pubitemid 39619164)
23. Lawrence C. W., Gibbs P. E. M., Murante R. S., Wang X.-D., Li Z., McManus T. P., McGregor W. G., Nelson J. R., Hinkle D. C., Maher V. M., Roles of DNA polymerase ζ and Rev1 protein in eukaryotic mutagenesis and translesion replication. 65 Proceedings of the Cold Spring Harbor Symposia on Quantitative Biology 2000 61 69 2-s2.0-0034437638 (Pubitemid 32611928)
24. Ross A.-L., Simpson L. J., Sale J. E., Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1. Nucleic Acids Research 2005 33 4 1280 1289 10.1093/nar/gki279 2-s2.0-14844362615 (Pubitemid 41439921)
25. Jansen J. G., Tsaalbi-Shtylik A., Langerak P., Callja F., Meijers C. M., Jacobs H., de Wind N., The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis. Nucleic Acids Research 2005 33 1 356 365 10.1093/nar/gki189 2-s2.0-13744257910 (Pubitemid 40276957)
26. Tsaalbi-Shtylik A., Verspuy J. W. A., Jansen J. G., Rebel H., Carle L. M., Van Der Valk M. A., Jonkers J., De Gruijl F. R., De Wind N., Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia. Proceedings of the National Academy of Sciences of the United States of America 2009 106 51 21836 21841 10.1073/pnas.0909507106 2-s2.0-76049128453
27. 2 -dG DNA adducts in yeast cells. Nucleic Acids Research 2006 34 2 417 425 10.1093/nar/gkj446 2-s2.0-32644435469 (Pubitemid 43240231)
28. Dumstorf C. A., Mukhopadhyay S., Krishnan E., Haribabu B., McGregor W. G., REV1 is implicated in the development of carcinogen-induced lung cancer. Molecular Cancer Research 2009 7 2 247 254 10.1158/1541-7786.MCR-08-0399 2-s2.0-61349138821
29. Sakiyama T., Kohno T., Mimaki S., Ohta T., Yanagitani N., Sobue T., Kunitoh H., Saito R., Shimizu K., Hirama C., Kimura J., Maeno G., Hirose H., Eguchi T., Saito D., Ohki M., Yokota J., Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk. International Journal of Cancer 2005 114 5 730 737 10.1002/ijc.20790 2-s2.0-20044381852 (Pubitemid 40344434)
30. Young R. P., Hopkins R. J., Hay B. A., Epton M. J., Mills G. D., Black P. N., Gardner H. D., Sullivan R., Gamble G. D., A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Postgraduate Medical Journal 2009 85 1008 515 524 10.1136/pgmj.2008.077107 2-s2.0-70349682910
31. He X., Ye F., Zhang J., Cheng Q., Shen J., Chen H., REV1 genetic variants associated with the risk of cervical carcinoma. European Journal of Epidemiology 2008 23 6 403 409 10.1007/s10654-008-9251-5 2-s2.0-44449153036
32. Kraemer K. H., Slor H., Xeroderma pigmentosum. Clinics in Dermatology 1985 3 1 33 69 2-s2.0-0021895936
33. Cleaver J. E., Xeroderma pigmentosumml: variants with normal DNA repair and normal sensitivity to ultraviolet light. Journal of Investigative Dermatology 1972 58 3 124 128 2-s2.0-0015310373
34. Tung B. S., McGregor W. G., Wang Y.-C., Maher V. M., McCormick J. J., Comparison of the rate of excision of major UV photoproducts in the strands of the human HPRT gene of normal and xeroderma pigmentosum variant cells. Mutation Research 1996 362 1 65 74 10.1016/0921-8777(95)00034-8 2-s2.0-0030027286 (Pubitemid 26016512)
35. Lehmann A. R., Kirk Bell S., Arlett C. F., Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV irradiation. Proceedings of the National Academy of Sciences of the United States of America 1975 72 1 219 223 2-s2.0-0000242262
36. Boyer J. C., Kaufmann W. K., Brylawski B. P., Cordeiro-Stone M., Defective postreplication repair in xeroderma pigmentosum variant fibroblasts. Cancer Research 1990 50 9 2593 2598 2-s2.0-0025271413 (Pubitemid 20150188)
37. Maher V. M., Ouellette L. M., Curren R. D., Mccormick J. J., Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells. Nature 1976 261 5561 593 595 10.1038/261593a0 2-s2.0-0017309743
38. Masutani C., Kusumoto R., Yamada A., Dohmae N., Yokol M., Yuasa M., Araki M., Iwai S., Takio K., Hanaoka F., The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η Nature 1999 399 6737 700 704 10.1038/21447 2-s2.0-0033578040 (Pubitemid 29289067)
39. Johnson R. E., Kondratick C. M., Prakash S., Prakash L., hRAD30 mutations in the variant form of xeroderma pigmentosum. Science 1999 285 5425 263 265 10.1126/science.285.5425.263 2-s2.0-0033538470 (Pubitemid 29330001)
40. Masutani C., Araki M., Yamada A., Kusumoto R., Nogimori T., Maekawa T., Iwai S., Hanaoka F., Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO Journal 1999 18 12 3491 3501 10.1093/emboj/18.12.3491 2-s2.0-0033564917 (Pubitemid 29276594)
41. Watanabe K., Tateishi S., Kawasuji M., Tsurimoto T., Inoue H., Yamaizumi M., Rad18 guides pol η to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO Journal 2004 23 19 3886 3896 10.1038/sj.emboj.7600383 2-s2.0-6344288785 (Pubitemid 39389719)
42. Guo C., Kosarek-Stancel J. N., Tang T.-S., Friedberg E. C., Y-family DNA polymerases in mammalian cells. Cellular and Molecular Life Sciences 2009 66 14 2363 2381 10.1007/s00018-009-0024-4 2-s2.0-67650429924
43. Waters L. S., Minesinger B. K., Wiltrout M. E., D'Souza S., Woodruff R. V., Walker G. C., Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiology and Molecular Biology Reviews 2009 73 1 134 154 10.1128/MMBR.00034-08 2-s2.0-63849131910
44. Lin Q., Clark A. B., McCulloch S. D., Yuan T., Bronson R. T., Kunkel T. A., Kucherlapati R., Increased susceptibility to UV-induced skin carcinogenesis in polymerase η -deficient mice. Cancer Research 2006 66 1 87 94 10.1158/0008-5472.CAN-05-1862 2-s2.0-31544443220 (Pubitemid 43166013)
45. Kuwamoto K., Miyauchi-Hashimoto H., Isei T., Horio T., Xeroderma pigmentosum variant associated with multiple cancers. Photodermatology Photoimmunology and Photomedicine 1999 15 3-4 127 132 2-s2.0-0033027854 (Pubitemid 29277065)
46. Kraemer K. H., Lee M. M., Scotto J., DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum. Carcinogenesis 1984 5 4 511 514 2-s2.0-0021282448 (Pubitemid 14126719)
47. Flanagan A. M., Rafferty G., O'Neill A., Rynne L., Kelly J., McCann J., Carty M. P., The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin. International Journal of Molecular Medicine 2007 19 4 589 596 2-s2.0-34247897059
48. McDonald J. P., Rapić-Otrin V., Epstein J. A., Broughton B. C., Wang X., Lehmann A. R., Wolgemuth D. J., Woodgate R., Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase. Genomics 1999 60 1 20 30 10.1006/geno.1999.5906 2-s2.0-0344631781 (Pubitemid 29422810)
49. Nair D. T., Johnson R. E., Prakash S., Prakash L., Aggarwal A. K., Replication by human DNA polymerase- ι occurs by Hoogsteen base-pairing. Nature 2004 430 6997 377 380 10.1038/nature02692 2-s2.0-3142674288 (Pubitemid 38937748)
50. Wang J., DNA polymerases: hoogsteen base-pairing in DNA replication? Nature 2005 437 7057 E6 E7 10.1038/nature04199 2-s2.0-25144479978 (Pubitemid 41613462)
51. Lee G.-H., Nishimori H., Sasaki Y., Matsushita H., Kitagawa T., Tokino T., Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2. Oncogene 2003 22 15 2374 2382 10.1038/sj.onc.1206387 2-s2.0-0038670767 (Pubitemid 36566792)
52. Wang M., Devereux T. R., Vikis H. G., McCulloch S. D., Holliday W., Anna C., Wang Y., Bebenek K., Kunkel T. A., Guan K., You M., Pol ι is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Research 2004 64 6 1924 1931 10.1158/0008-5472.CAN-03-3080 2-s2.0-12144287580 (Pubitemid 38339435)
53. Lee G.-H., Matsushita H., Genetic linkage between Pol ι deficiency and increased susceptibility to lung tumors in mice. Cancer Science 2005 96 5 256 259 10.1111/j.1349-7006.2005.00042.x 2-s2.0-21244487080 (Pubitemid 40895072)
54. Obata M., Nishimori H., Ogawa K., Lee G.-H., Identification of the Par2 (Pulmonary adenoma resistance) locus on mouse chromosome 18, a major genetic determinant for lung carcinogen resistance in BALB/cByJ mice. Oncogene 1996 13 8 1599 1604 2-s2.0-0029969176 (Pubitemid 26377490)
55. Bebenek K., Tissier A., Frank E. G., McDonald J. P., Prasad R., Wilson S. H., Woodgate R., Kunkel T. A., 5′ -deoxyribose phosphate lyase activity of human DNA polymerase ι in vitro. Science 2001 291 5511 2156 2159 10.1126/science.1058386 2-s2.0-0035896008 (Pubitemid 32224447)
56. Fernando R. C., Nair J., Barbin A., Miller J. A., Bartsch H., Detection of 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine by immunoaffinity/32P-postlabelling in liver and lung DNA of mice treated with ethyl carbamate (urethane) or its metabolites. Carcinogenesis 1996 17 8 1711 1718 2-s2.0-0029665085 (Pubitemid 26280397)
57. Choudhury S., Adhikari S., Cheema A., Roy R., Evidence of complete cellular repair of 1,N6-ethenoadenine, a mutagenic and potential damage for human cancer, revealed by a novel method. Molecular and Cellular Biochemistry 2008 313 1-2 19 28 10.1007/s11010-008-9737-1 2-s2.0-44449101045
58. McDonald J. P., Frank E. G., Plosky B. S., Rogozin I. B., Masutani C., Hanaoka F., Woodgate R., Gearhart P. J., 129-Derived strains of mice are deficient in DNA polymerase ι and have normal immunoglobulin hypermutation. Journal of Experimental Medicine 2003 198 4 635 643 10.1084/jem.20030767 2-s2.0-0042422042 (Pubitemid 37040397)
59. Wang Y., Woodgate R., McManus T. P., Mead S., McCormick J. J., Maher V. M., Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase η DNA polymerase ι causes the very high frequency and unique spectrum of UV-induced mutations. Cancer Research 2007 67 7 3018 3026 10.1158/0008-5472.CAN-06-3073 2-s2.0-34248195087 (Pubitemid 46724838)
60. Dumstorf C. A., Clark A. B., Lin Q., Kissling G. E., Yuan T., Kucherlapati R., McGregor W. G., Kunkel T. A., Participation of mouse DNA polymerase ι in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer. Proceedings of the National Academy of Sciences of the United States of America 2006 103 48 18083 18088 10.1073/pnas.0605247103 2-s2.0-33845287261 (Pubitemid 44871616)
61. Ohkumo T., Kondo Y., Yokoi M., Tsukamoto T., Yamada A., Sugimoto T., Kanao R., Higashi Y., Kondoh H., Tatematsu M., Masutani C., Hanaoka F., UV-B radiation induces epithelial tumors in mice lacking DNA polymerase η and mesenchymal tumors in mice deficient for DNA polymerase ι Molecular and Cellular Biology 2006 26 20 7696 7706 10.1128/MCB.01076-06 2-s2.0-33749602964 (Pubitemid 44547716)
62. Mitchell D. L., Jen J., Cleaver J. E., Relative induction of cyclobutane dimers and cytosine photohydrates in DNA irradiated in vitro and in vivo with ultraviolet-C and ultraviolet-B light. Photochemistry and Photobiology 1991 54 5 741 746 2-s2.0-0026252312
63. Newcomb E. W., Diamond L. E., Sloan S. R., Corominas M., Guerrerro I., Pellicer A., Radiation and chemical activation of ras oncogenes in different mouse strains. Environmental Health Perspectives 1989 81 33 37 2-s2.0-0024383259 (Pubitemid 19156858)
64. Petta T. B., Nakajima S., Zlatanou A., Despras E., Couve-Privat S., Ishchenko A., Sarasin A., Yasui A., Kannouche P., Human DNA polymerase iota protects cells against oxidative stress. EMBO Journal 2008 27 21 2883 2895 10.1038/emboj.2008.210 2-s2.0-55549089967
65. Poltoratsky V., Horton J. K., Prasad R., Beard W. A., Woodgate R., Wilson S. H., Negligible impact of pol ι expression on the alkylation sensitivity of pol β -deficient mouse fibroblast cells. DNA Repair 2008 7 6 830 833 10.1016/j.dnarep.2008.02.013 2-s2.0-43849089895
66. Wang H., Wu W., Wang H. W., Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance. Neuro-Oncology 2010 12 7 679 686 10.1093/neuonc/nop074
67. Zienolddiny S., Campa D., Lind H., Ryberg D., Skaug V., Stangeland L., Phillips D. H., Canzian F., Haugen A., Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis 2006 27 3 560 567 10.1093/carcin/bgi232 2-s2.0-33644870366 (Pubitemid 43372885)
68. Vineis P., Manuguerra M., Kavvoura F. K., Guarrera S., Allione A., Rosa F., Di Gregorio A., Polidoro S., Saletta F., Ioannidis J. P.A., jioannid@cc.uoi.gr Matullo G., A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. Journal of the National Cancer Institute 2009 101 1 24 36 2-s2.0-4444234483 10.1093/jnci/djn437
69. Luedeke M., Linnert C. M., Hofer M. D., Surowy H. M., Rinckleb A. E., Hoegel J., Kuefer R., Rubin M. A., Vogel W., Maier C., Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes. Cancer Epidemiology Biomarkers and Prevention 2009 18 11 3030 3035 10.1158/1055-9965. EPI-09-0772 2-s2.0-72749125600
70. Petrovics G., Liu A., Shaheduzzaman S., Furasato B., Sun C., Chen Y., Nau M., Ravindranath L., Chen Y., Dobi A., Srikantan V., Sesterhenn I. A., McLeod D. G., Vahey M., Moul J. W., Srivastava S., Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome. Oncogene 2005 24 23 3847 3852 10.1038/sj.onc.1208518 2-s2.0-20444493600 (Pubitemid 40826884)
71. Tomlins S. A., Rhodes D. R., Perner S., Dhanasekaran S. M., Mehra R., Sun X.-W., Varambally S., Cao X., Tchinda J., Kuefer R., Lee C., Montie J. E., Shah R. B., Pienta K. J., Rubin M. A., Chinnaiyan A. M., Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005 310 5748 644 648 10.1126/science.1117679 2-s2.0-27344451557 (Pubitemid 41528150)
72. Bienko M., Green C. M., Crosetto N., Rudolf F., Zapart G., Coull B., Kannouche P., Wider G., Peter M., Lehmann A. R., Hofmann K., Dikic I., Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005 310 5755 1821 1824 10.1126/science.1120615 2-s2.0-29144499065 (Pubitemid 41814383)
73. 2 -BPDE (7,8-dihydroxy- anti -9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene). Biochemistry 2002 41 19 6100 6106 10.1021/bi020049c 2-s2.0-0037076538 (Pubitemid 34498916)
74. 6-dA lesions catalyzed by DNA bypass polymerases. Journal of Biological Chemistry 2002 277 34 30488 30494 2-s2.0-0034847259 10.1074/jbc.M201167200 (Pubitemid 34970740)
75. Zhang Y., Wu X., Guo D., Rechkoblit O., Wang Z., Activities of human DNA polymerase κ in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion. DNA Repair 2002 1 7 559 569 10.1016/S1568-7864(02)00055-1 2-s2.0-0037125136 (Pubitemid 34655713)
76. Guo N., Faller D. V., Vaziri C., Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell Growth and Differentiation 2002 13 2 77 86 2-s2.0-0034307181 (Pubitemid 34205515)
77. Bi X., Slater D. M., Ohmori H., Vaziri C., DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint. The Journal of Biological Chemistry 2005 280 22343 22355 (Pubitemid 40827891)
78. Avkin S., Goldsmith M., Velasco-Miguel S., Geacintov N., Friedberg E. C., Livneh Z., Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase. Journal of Biological Chemistry 2004 279 51 53298 53305 10.1074/jbc.M409155200 2-s2.0-11144237897 (Pubitemid 40051834)
79. Shachar S., Ziv O., Avkin S., Adar S., Wittschieben J., Reiner T., Chaney S., Friedberg E. C., Wang Z., Carell T., Geacintov N., Livneh Z., Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO Journal 2009 28 4 383 393 10.1038/emboj.2008.281 2-s2.0-60549096252
80. Ogi T., Lehmann A. R., The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair. Nature Cell Biology 2006 8 6 640 642 10.1038/ncb1417 2-s2.0-33744789415
81. Ogi T., Limsirichaikul S., Overmeer R. M., Volker M., Takenaka K., Cloney R., Nakazawa Y., Niimi A., Miki Y., Jaspers N. G., Mullenders L. H. F., Yamashita S., Fousteri M. I., Lehmann A. R., Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Molecular Cell 2010 37 5 714 727 10.1016/j.molcel.2010.02.009 2-s2.0-77649242633
82. Schenten D., Gerlach V. L., Guo C., Velasco-Miguel S., Hladik C. L., White C. L., Friedberg E. C., Rajewsky K., Esposito G., DNA polymerase K deficiency does not affect somatic hypermutation in mice. European Journal of Immunology 2002 32 11 3152 3160 10.1002/1521-4141(200211)32:113152::AID- IMMU3152>3.0.CO;2-2 2-s2.0-0036859318 (Pubitemid 35414873)
83. Shimizu T., Shinkai Y., Ogi T., Ohmori H., Azuma T., The absence of DNA polymerase κ does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene. Immunology Letters 2003 86 3 265 270 10.1016/S0165-2478(03)00046-4 2-s2.0-0037403827 (Pubitemid 36428686)
84. Stancel J. N. K., McDaniel L. D., Velasco S., Richardson J., Guo C., Friedberg E. C., Polk mutant mice have a spontaneous mutator phenotype. DNA Repair 2009 8 12 1355 1362 10.1016/j.dnarep.2009.09.003 2-s2.0-70450222118
85. O-Wang J., Kawamura K., Tada Y., Ohmori H., Kimura H., Sakiyama S., Tagawa M., DNA polymerase κ implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer. Cancer Research 2001 61 14 5366 5369 2-s2.0-0035879009 (Pubitemid 32694911)
86. Wang Y., Seimiya M., Kawamura K., Yu L., Ogi T., Takenaga K., Shishikura T., Nakagawara A., Sakiyama S., Tagawa M., O-Wang J., Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53. International Journal of Oncology 2004 25 1 161 165 2-s2.0-10044269443
87. Skaug V., Ryberg D., Kure E. H., Arab M. O., Stangeland L., Myking A. O., Haugen A., p53 Mutations in defined structural and functional domains are related to poor clinical outcome in non-small cell lung cancer patients. Clinical Cancer Research 2000 6 3 1031 1037 2-s2.0-0034100053 (Pubitemid 30159364)
88. Diaz M., Watson N. B., Turkington G., Verkoczy L. K., Klinman N. R., McGregor W. G., Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase ζ Molecular Cancer Research 2003 1 11 836 847 2-s2.0-0141542616 (Pubitemid 37174455)
89. Murakumo Y., Roth T., Ishii H., Rasio D., Numata S.-I., Croce C. M., Fishel R., A human REV7 homolog that interacts with the polymerase ζ catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. Journal of Biological Chemistry 2000 275 6 4391 4397 10.1074/jbc.275.6.4391 2-s2.0-0034635445 (Pubitemid 30094682)
90. Quah S. K., Von Borstel R. C., Hastings P. J., The origin of spontaneous mutation in Saccharomyces cerevisiae. Genetics 1980 96 4 819 839 2-s2.0-0019291994 (Pubitemid 11076044)
91. Van Sloun P. P. H., Varlet I., Sonneveld E., Boei J. J. W. A., Romeijn R. J., Eeken J. C. J., De Wind N., Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage. Molecular and Cellular Biology 2002 22 7 2159 2169 10.1128/MCB.22.7.2159-2169.2002 2-s2.0-0036124453 (Pubitemid 34224623)
92. Wittschieben J. P., Reshmi S. C., Gollin S. M., Wood R. D., Loss of DNA polymerase ζ causes chromosomal instability in mammalian cells. Cancer Research 2006 66 1 134 142 10.1158/0008-5472.CAN-05-2982 2-s2.0-31544434491 (Pubitemid 43166018)
93. Bemark M., Khamlichi A. A., Davies S. L., Neuberger M. S., Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro. Current Biology 2000 10 19 1213 1216 10.1016/S0960-9822(00)00724-7 2-s2.0-0034609744
94. Wittschieben J., Shivji M. K. K., Lalani E., Jacobs M. A., Marini F., Gearhart P. J., Rosewell I., Stamp G., Wood R. D., Disruption of the developmentally regulated Rev31 gene causes embryonic lethality. Current Biology 2000 10 19 1217 1220 10.1016/S0960-9822(00)00725-9 2-s2.0-0034609760
95. Esposito G., Godin I., Klein U., Yaspo M.-L., Cumano A., Rajewsky K., Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality. Current Biology 2000 10 19 1221 1224 10.1016/S0960-9822(00)00726-0 2-s2.0-0034609725
96. Brondello J.-M., Pillaire M. J., Rodriguez C., Gourraud P.-A., Selves J., Cazaux C., Piette J., Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol ζ Oncogene 2008 27 47 6093 6101 2-s2.0-0038052722 10.1038/onc.2008.212
97. Kawamura K., O-Wang J., Bahar R., Koshikawa N., Shishikura T., Nakagawara A., Sakiyama S., Kajiwara K., Kimura M., Tagawa M., The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues. International Journal of Oncology 2001 18 1 97 103 2-s2.0-0035227156