A full-length cDNA of hREV3 is predicted to encode DNA polymerase ζ for damage-induced mutagenesis in humans

Mutation Research - DNA Repair

Volumn 433, Issue 2, 1999, Pages 89-98

  Lin, Wensheng ^a   Wu, Xiaohua ^a   Wang, Zhigang ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

DNA damage; DNA polymerase; Mutagenesis; REV3

Indexed keywords

COMPLEMENTARY DNA; DNA POLYMERASE; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DNA DAMAGE; GENE; HUMAN; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; YEAST;

AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYTIC DOMAIN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; SEQUENCE HOMOLOGY, AMINO ACID;

SACCHAROMYCES CEREVISIAE;

EID: 0032994152     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(98)00065-2     Document Type: Article

References (26)

1. E.C. Friedberg, G.C. Walker, W. Siede, DNA Repair and Mutagenesis, American Society of Microbiology Press, Washington, DC, 1995.
2. Lawrence C.W., Hinkle D.C. DNA polymerase ζ and the control of DNA damage induced mutagenesis in eukaryotes. Cancer Surv. 28:1996;21-31.
3. Lawrence C. The RAD6 DNA repair pathway in Saccharomyces cerevisiae: what does it do, and how does it do it? BioEssays. 16:1994;253-258.
4. Lawrence C.W., Das G., Christensen R.B. REV7, a new gene concerned with UV mutagenesis in yeast. Mol. Gen. Genet. 200:1985;80-85.
5. Reynolds P., Weber S., Prakash L. RAD6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates. Proc. Natl. Acad. Sci. USA. 82:1985;168-172.
6. Morrison A., Christensen R.B., Alley J., Beck A.K., Bernstine E.G., Lemontt J.F., Lawrence C.W. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase. J. Bacteriol. 171:1989;5659-5667.
7. Jones J.S., Weber S., Prakash L. The Saccharomyces cerevisiae RAD18 gene encodes a protein that contains potential zinc finger domains for nucleic acid binding and a putative nucleotide binding sequence. Nucleic Acids Res. 16:1988;7119-7131.
8. Chanet R., Magana-Schwencke N., Fabre F. Potential DNA-binding domains in the RAD18 gene product of Saccharomyces cerevisiae. Gene. 74:1988;543-547.
9. Jentsch S., McGrath J.P., Varshavsky A. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature. 329:1987;131-134.
10. Bailly V., Lamb J., Sung P., Prakash S., Prakash L. Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. Genes Dev. 8:1994;811-820.
11. Bailly V., Prakash S., Prakash L. Domains required for dimerization of yeast Rad6 ubiquitin-conjugating enzyme and Rad18 DNA binding protein. Mol. Cell. Biol. 17:1997;4536-4543.
12. Bailly V., Lauder S., Prakash S., Prakash L. Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J. Biol. Chem. 272:1997;23360-23365.
13. Nelson J.R., Lawrence C.W., Hinkle D.C. Deoxycytidyl transferase activity of yeast REV1 protein. Nature. 382:1996;729-731.
14. Nelson J.R., Lawrence C.W., Hinkle D.C. Thymine-thymine dimer bypass by yeast DNA polymerase ζ Science. 272:1996;1646-1649.
15. Koken M.H.M., Smit E.M.E., Jaspers-Dekker I., Oostra B.A., Hagemeijer A., Bootsma D., Hoeijmakers J.H.J. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q32. Genomics. 12:1992;447-453.
16. Koken M.H.M., Reynolds P., Jaspers-Dekker I., Prakash L., Prakash S., Bootsma D., Hoeijmakers J.H.J. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Proc. Natl. Acad. Sci. USA. 88:1991;8865-8869.
17. Xiao W., Lechler T., Chow B.L., Fontanie T., Agustus M., Carter K.C., Wei Y.F. Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase ζ Carcinogenesis. 19:1998;945-949.
18. Gibbs P.E., McGregor W.G., Maher V.M., Nisson P., Lawrence C.W. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ Proc. Natl. Acad. Sci. USA. 95:1998;6876-6880.
19. Kajiwara K., Nagawawa H., Shimizu-Nishikawa S., Ookuri T., Kimura M., Sugaya E. Molecular characterization of seizure-related genes isolated by differential screening. Biochem. Biophys. Res. Commun. 219:1996;795-799.
20. J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1989.
21. Chevier D., Vezina C., Bastille J., Linard C., Sonenberg N., Boileau G. Higher order structures of the 5′-proximal region decrease the efficiency of translation of the porcine pro-opiomelanocortin mRNA. J. Biol. Chem. 263:1988;902-910.
22. Kozak M. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc. Natl. Acad. Sci. USA. 83:1986;2850-2854.
23. Pelletier J., Sonenberg N. Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell. 40:1985;515-526.
24. Wong S.W., Wahl A.F., Yuan P.M., Arai N., Pearson B.E., Arai K., Korn D., Hunkapiller M.W., Wang T.S. Human DNA polymerase α gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases. EMBO J. 7:1988;37-47.
25. Braithwaite D.K., Ito J. Compilation, alignment, and phylogenetic relationships of DNA polymerases. Nucleic Acids Res. 21:1993;787-802.
26. Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:1987;8125-8148.