메뉴 건너뛰기




Volumn 57, Issue 4, 2010, Pages 467-477

Homocysteine and vitamin therapy in stroke prevention and treatment: A review

Author keywords

Folic acid; Homocysteine; Stroke; Vitamin therapy

Indexed keywords


EID: 79551584071     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2010_2432     Document Type: Review
Times cited : (64)

References (132)
  • 2
    • 0347951237 scopus 로고    scopus 로고
    • Hyperhomocysteinemia activates nuclear factor-κB in endothelial cells via oxidative stress
    • Au-Yeung KKW, Woo CWH, Sung FL, Yip JCW, Siow YL (2004) Hyperhomocysteinemia activates nuclear factor-κB in endothelial cells via oxidative stress. Circ Res 94: 28-36.
    • (2004) Circ Res , vol.94 , pp. 28-36
    • Au-Yeung, K.K.W.1    Woo, C.W.H.2    Sung, F.L.3    Yip, J.C.W.4    Siow, Y.L.5
  • 4
    • 0036141841 scopus 로고    scopus 로고
    • Xanthine oxidase - derived reactive oxygen species convert fow-induced arteriolar dilation to constriction in hyperhomocysteinemia: Possible role of peroxynitrite
    • Bagi Z, Ungvari Z, Koller A (2002) Xanthine oxidase - derived reactive oxygen species convert fow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite. Arterioscl Throm Vas 22: 28-33.
    • (2002) Arterioscl Throm Vas , vol.22 , pp. 28-33
    • Bagi, Z.1    Ungvari, Z.2    Koller, A.3
  • 5
    • 0034627915 scopus 로고    scopus 로고
    • Liquid chromatographic assessment of total and protein-bound homocysteine in human plasma
    • Bald E, Kaniowska E, Chwatko G, Glowacki R (2000) Liquid chromatographic assessment of total and protein-bound homocysteine in human plasma. Talanta 50: 1233-1243.
    • (2000) Talanta , vol.50 , pp. 1233-1243
    • Bald, E.1    Kaniowska, E.2    Chwatko, G.3    Glowacki, R.4
  • 6
    • 33847624075 scopus 로고    scopus 로고
    • Targeting of metallothionein by l-homocysteine: A novel mechanism for disruption of zinc and redox homeostasis
    • Barbato JC, Catanescu O, Murray K, DiBello PM, Jacobsen DW (2007) Targeting of metallothionein by l-homocysteine: a novel mechanism for disruption of zinc and redox homeostasis. Arterioscl Throm Vas 27: 49-54.
    • (2007) Arterioscl Throm Vas , vol.27 , pp. 49-54
    • Barbato, J.C.1    Catanescu, O.2    Murray, K.3    Dibello, P.M.4    Jacobsen, D.W.5
  • 7
    • 0037032665 scopus 로고    scopus 로고
    • Assay of total homocysteine and other thiols by capillary electrophoresis and laser-induced fuorescence detection. II. Pre-analytical and analytical conditions
    • Bayle C, Issac C, Salvayre R, Couderc F, Causse E (2002) Assay of total homocysteine and other thiols by capillary electrophoresis and laser-induced fuorescence detection. II. Pre-analytical and analytical conditions. J Chromatogr A 979: 255-260.
    • (2002) J Chromatogr A , vol.979 , pp. 255-260
    • Bayle, C.1    Issac, C.2    Salvayre, R.3    Couderc, F.4    Causse, E.5
  • 11
    • 34347335713 scopus 로고    scopus 로고
    • Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease
    • Boldyrev AA, Johnson P (2007) Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease. J Alzheimers Dis 11: 219-228.
    • (2007) J Alzheimers Dis , vol.11 , pp. 219-228
    • Boldyrev, A.A.1    Johnson, P.2
  • 13
    • 25644439809 scopus 로고    scopus 로고
    • Homocysteine and folate metabolism in depression
    • Bottiglieri T (2005) Homocysteine and folate metabolism in depression. Prog Neuro-Psychoph 29: 1103-1112.
    • (2005) Prog Neuro-Psychoph , vol.29 , pp. 1103-1112
    • Bottiglieri, T.1
  • 15
    • 0022309434 scopus 로고
    • The role of S-adenosylhomocysteine in the biological utilization of S-adenosyl-methionine
    • Cantoni GL (1985) The role of S-adenosylhomocysteine in the biological utilization of S-adenosyl-methionine. Prog Clin Biol Res 198: 47-65.
    • (1985) Prog Clin Biol Res , vol.198 , pp. 47-65
    • Cantoni, G.L.1
  • 16
    • 35349014633 scopus 로고    scopus 로고
    • Homocysteine induces VCAM-1 gene expression through NF-κB and NAD(P)H oxidase activation: Protective role of Mediterranean diet polyphenolic antioxidants
    • Carluccio MA, Ancora MA, Massaro M, Carluccio M, Scoditti E, Distante A, Storelli C, De Caterina R (2007) Homocysteine induces VCAM-1 gene expression through NF-κB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants. Am J Physiol-Heart C 293: H2344-H2354.
    • (2007) Am J Physiol-Heart C , vol.293
    • Carluccio, M.A.1    Ancora, M.A.2    Massaro, M.3    Carluccio, M.4    Scoditti, E.5    Distante, A.6    Storelli, C.7    De Caterina, R.8
  • 18
    • 18744373039 scopus 로고    scopus 로고
    • Enzymatic assay of homocysteine on microtiter plates or a TECAN analyzer using crude lysate containing recombinant methionine γ-lyase
    • Chan E-C, Chang P-Y, Wu T-L, Wu JT (2005) Enzymatic assay of homocysteine on microtiter plates or a TECAN analyzer using crude lysate containing recombinant methionine γ-lyase. Ann Clin Lab Sci 35: 155-160.
    • (2005) Ann Clin Lab Sci , vol.35 , pp. 155-160
    • Chan, E.-C.1    Chang, P.-Y.2    Wu, T.-L.3    Wu, J.T.4
  • 19
    • 42549135938 scopus 로고    scopus 로고
    • Homocysteine inhibits arterial endothelia cell growth through transcriptional down-regulation of fibroblast growth factor-2 involving G protein and DNA methylation
    • Chang P-Y, Lu S-C, Lee C-M, Chen Y-J, Dugan TA, Huang W-H, Chang S-F, Liao WSL, Chen C-H, Lee Y-T (2008) Homocysteine inhibits arterial endothelia cell growth through transcriptional down-regulation of fibroblast growth factor-2 involving G protein and DNA methylation. Circ Res 102: 933-941.
    • (2008) Circ Res , vol.102 , pp. 933-941
    • Chang, P.-Y.1    Lu, S.-C.2    Lee, C.-M.3    Chen, Y.-J.4    Dugan, T.A.5    Huang, W.-H.6    Chang, S.-F.7    Liao, W.S.L.8    Chen, C.-H.9    Lee, Y.-T.10
  • 20
    • 38149119817 scopus 로고    scopus 로고
    • Selective phosphorescence chemosensor for homocysteine based on an iridium (III) complex
    • Chen H, Zhao Q, Wu Y, Li F, Yang H, Yi T, Huang C (2007) Selective phosphorescence chemosensor for homocysteine based on an iridium (III) complex. Inorg Chem 46: 11075-11081.
    • (2007) Inorg Chem , vol.46 , pp. 11075-11081
    • Chen, H.1    Zhao, Q.2    Wu, Y.3    Li, F.4    Yang, H.5    Yi, T.6    Huang, C.7
  • 21
    • 67650561176 scopus 로고    scopus 로고
    • The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neu-rotoxin model of Parkinson disease
    • Chigurupati S, Wei Z, Belal C, Vandermey M, Kyriazis GA, Arumugam TV, Chan S (2009) The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neu-rotoxin model of Parkinson disease. J Biol Chem 284: 18323-18333.
    • (2009) J Biol Chem , vol.284 , pp. 18323-18333
    • Chigurupati, S.1    Wei, Z.2    Belal, C.3    Vandermey, M.4    Kyriazis, G.A.5    Arumugam, T.V.6    Chan, S.7
  • 22
    • 13244287981 scopus 로고    scopus 로고
    • The determination of homocysteine-thiolactone in human plasma
    • Chwatko G, Jakubowski H (2005) The determination of homocysteine-thiolactone in human plasma. Anal Biochem 337: 271-277.
    • (2005) Anal Biochem , vol.337 , pp. 271-277
    • Chwatko, G.1    Jakubowski, H.2
  • 23
    • 31344459617 scopus 로고    scopus 로고
    • B-Vitamin Treatment Trialists' Collaboration: Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
    • Clarke R, Armitage J, Lewington S et al (2006) B-Vitamin Treatment Trialists' Collaboration: Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 151: 282-287.
    • (2006) Am Heart J , vol.151 , pp. 282-287
    • Clarke, R.1    Armitage, J.2    Lewington, S.3
  • 24
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine Studies Collaboration: Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Clarke R, Collins R, Lewington S et al. (2002) Homocysteine Studies Collaboration: Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288: 2015-2022.
    • (2002) JAMA , vol.288 , pp. 2015-2022
    • Clarke, R.1    Collins, R.2    Lewington, S.3
  • 25
    • 0037805185 scopus 로고    scopus 로고
    • High-performance liquid chromatographic assay for plasma total homocysteine
    • Dai CW, Zhang GS, Wu XP (2002) High-performance liquid chromatographic assay for plasma total homocysteine. Hunan Yi Ke Da Xue Xue Bao 27: 556-558.
    • (2002) Hunan Yi Ke Da Xue Xue Bao , vol.27 , pp. 556-558
    • Dai, C.W.1    Zhang, G.S.2    Wu, X.P.3
  • 26
    • 0141629314 scopus 로고    scopus 로고
    • Effect of homocysteine on cytokine production by human endothelial cells and monocytes
    • Dalal S, Parkin SM, Homer-Vanniasinkam S, Nicolaou A (2003) Effect of homocysteine on cytokine production by human endothelial cells and monocytes. Ann Clin Biochem 40: 534-541.
    • (2003) Ann Clin Biochem , vol.40 , pp. 534-541
    • Dalal, S.1    Parkin, S.M.2    Homer-Vanniasinkam, S.3    Nicolaou, A.4
  • 27
    • 0037277037 scopus 로고    scopus 로고
    • Quantitative assay of plasma homocysteine thiolactone by gas chromatogra-phy/mass spectrometry
    • Daneshvar P, Yazdanpanah M, Cuthbert C, Cole DE (2003) Quantitative assay of plasma homocysteine thiolactone by gas chromatogra-phy/mass spectrometry. Rapid Commun Mass Sp 17: 358-362.
    • (2003) Rapid Commun Mass Sp , vol.17 , pp. 358-362
    • Daneshvar, P.1    Yazdanpanah, M.2    Cuthbert, C.3    Cole, D.E.4
  • 29
    • 0036890065 scopus 로고    scopus 로고
    • Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease
    • De Bree A, Verschuren WMM, Kromhout D, Kluijtmans LAJ, Blom HJ (2002) Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 54: 599-618.
    • (2002) Pharmacol Rev , vol.54 , pp. 599-618
    • De Bree, A.1    Verschuren, W.M.M.2    Kromhout, D.3    Kluijtmans, L.A.J.4    Blom, H.J.5
  • 30
    • 0033996557 scopus 로고    scopus 로고
    • Evaluation of the Abbott Imx™ fluorescence polarization immunoassay and the Bio-Rad enzyme immunoassay for homocysteine: Comparison with high-performance liquid chromatography
    • Donnelly JG, Pronovost C (2000) Evaluation of the Abbott Imx™ fluorescence polarization immunoassay and the Bio-Rad enzyme immunoassay for homocysteine: comparison with high-performance liquid chromatography. Ann Clin Biochem 37: 194-198.
    • (2000) Ann Clin Biochem , vol.37 , pp. 194-198
    • Donnelly, J.G.1    Pronovost, C.2
  • 31
    • 38949198356 scopus 로고    scopus 로고
    • Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats
    • Edirimanne VER, Woo CWH, Siow YL, Pierce GN, Xie JY (2007) Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats. Can J Physiol Pharm 85: 1236-1247.
    • (2007) Can J Physiol Pharm , vol.85 , pp. 1236-1247
    • Edirimanne, V.E.R.1    Woo, C.W.H.2    Siow, Y.L.3    Pierce, G.N.4    Xie, J.Y.5
  • 32
    • 0034056466 scopus 로고    scopus 로고
    • Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke
    • Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI (2000) Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 31: 1069-1075.
    • (2000) Stroke , vol.31 , pp. 1069-1075
    • Eikelboom, J.W.1    Hankey, G.J.2    Anand, S.S.3    Lofthouse, E.4    Staples, N.5    Baker, R.I.6
  • 34
    • 0034575668 scopus 로고    scopus 로고
    • Total plasma homocysteine analysis by HPLC with SBD-F precolumn derivatization
    • Cooper C, Packer N, Williams K, eds, Humana Press Inc., Totova, NJ
    • Fermo I, Paroni R (2000) Total plasma homocysteine analysis by HPLC with SBD-F precolumn derivatization. In Amino Acid Analysis Protocols, Series: Methods in Molecular Biology Vol No 159. Cooper C, Packer N, Williams K, eds, pp 237-244. Humana Press Inc., To-tova, NJ.
    • (2000) Amino Acid Analysis Protocols, Series: Methods in Molecular Biology , vol.159 , pp. 237-244
    • Fermo, I.1    Paroni, R.2
  • 35
    • 0031748093 scopus 로고    scopus 로고
    • The metabolism of homocysteine: Pathways and regulation
    • Finkelstein JD (1998) The metabolism of homocysteine: pathways and regulation. Eur J Pediatr 157: S40-Z44.
    • (1998) Eur J Pediatr , vol.157
    • Finkelstein, J.D.1
  • 36
    • 0031886747 scopus 로고    scopus 로고
    • Enzyme conversion immunoassay for determining total homocysteine in plasma or serum
    • Frantzen F, Faaren AL, Alfheim I, Nordhei AK (1998) Enzyme conversion immunoassay for determining total homocysteine in plasma or serum. Clin Chem 44: 311-316.
    • (1998) Clin Chem , vol.44 , pp. 311-316
    • Frantzen, F.1    Faaren, A.L.2    Alfheim, I.3    Nordhei, A.K.4
  • 37
    • 48949084887 scopus 로고    scopus 로고
    • Increased homocysteine-induced release of excitatory amino acids in the striatum of spontaneously hypertensine stroke-prone rats
    • Ganguly PK, Maddaford TG, Edel AL, O K, Smeda JS, Pierce GN (2008) Increased homocysteine-induced release of excitatory amino acids in the striatum of spontaneously hypertensine stroke-prone rats. Brain Res 1226: 192-198.
    • (2008) Brain Res , vol.1226 , pp. 192-198
    • Ganguly, P.K.1    Maddaford, T.G.2    Edel, A.L.O.K.3    Smeda, J.S.4    Pierce, G.N.5
  • 38
    • 70249128338 scopus 로고    scopus 로고
    • Fully automated method for simultaneous determination of total cysteine, cysteinylglycine, glutathione and homocysteine in plasma by HPLC with UV absorbance detection
    • Glowacki R, Bald E (2009) Fully automated method for simultaneous determination of total cysteine, cysteinylglycine, glutathione and homocysteine in plasma by HPLC with UV absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci 877: 3400-3404.
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , pp. 3400-3404
    • Glowacki, R.1    Bald, E.2
  • 40
    • 4644355552 scopus 로고    scopus 로고
    • Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24-h observation period
    • Guttormsen AB, Solheim E, Refsum H (2004) Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24-h observation period. Am J Clin Nutr 79: 76-79.
    • (2004) Am J Clin Nutr , vol.79 , pp. 76-79
    • Guttormsen, A.B.1    Solheim, E.2    Refsum, H.3
  • 41
    • 0032540276 scopus 로고    scopus 로고
    • Tissue plasminogen activator binding to the annexin II tail domain. Direct moduation by homocysteine
    • Hajjar KA, Mauri L, Jacovina AT, Zhong F, Mirza UA, Padovan JC, Chait B (1998) Tissue plasminogen activator binding to the annexin II tail domain. Direct moduation by homocysteine. J Biol Chem 273: 9987-9993.
    • (1998) J Biol Chem , vol.273 , pp. 9987-9993
    • Hajjar, K.A.1    Mauri, L.2    Jacovina, A.T.3    Zhong, F.4    Mirza, U.A.5    Padovan, J.C.6    Chait, B.7
  • 42
    • 34548017218 scopus 로고    scopus 로고
    • Extended storage of whole blood with 3-deazaadenosine for homocysteine assay
    • Hansrani M, Stansby G (2007) Extended storage of whole blood with 3-deazaadenosine for homocysteine assay. Ann Clin Biochem 44: 388-390.
    • (2007) Ann Clin Biochem , vol.44 , pp. 388-390
    • Hansrani, M.1    Stansby, G.2
  • 43
    • 64849100782 scopus 로고    scopus 로고
    • Characterization of cysteine and homocysteine bound to human serum transthyretin
    • Hanyu N, Shimizu T, Yamauchi K, Okumura N, Hidaka H (2009) Characterization of cysteine and homocysteine bound to human serum transthyretin. Clin Chim Acta 403: 70-75.
    • (2009) Clin Chim Acta , vol.403 , pp. 70-75
    • Hanyu, N.1    Shimizu, T.2    Yamauchi, K.3    Okumura, N.4    Hidaka, H.5
  • 44
    • 0036892748 scopus 로고    scopus 로고
    • Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage
    • Ho PI, Ortiz D, Rogers E, Shea TB (2002) Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res 70: 694-702.
    • (2002) J Neurosci Res , vol.70 , pp. 694-702
    • Ho, P.I.1    Ortiz, D.2    Rogers, E.3    Shea, T.B.4
  • 46
    • 36849001753 scopus 로고    scopus 로고
    • Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-l-homocysteine and hydrogen peroxide: Analysis, quantification, and implications for hyperhomo-cysteinemia
    • Hong I, Fast W (2007) Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-l-homocysteine and hydrogen peroxide: analysis, quantification, and implications for hyperhomo-cysteinemia. J Biol Chem 282: 34684-34692.
    • (2007) J Biol Chem , vol.282 , pp. 34684-34692
    • Hong, I.1    Fast, W.2
  • 47
    • 33845533655 scopus 로고    scopus 로고
    • Bound homocysteine, cysteine, and cysteinylglycine distribution between albumin and globulins
    • Hortin GL, Seam N, Hoehn GT (2006) Bound homocysteine, cysteine, and cysteinylglycine distribution between albumin and globulins. Clin Chem 52: 2258-2264.
    • (2006) Clin Chem , vol.52 , pp. 2258-2264
    • Hortin, G.L.1    Seam, N.2    Hoehn, G.T.3
  • 48
    • 0035021823 scopus 로고    scopus 로고
    • Simultaneous determination of total plasma glutathione, homo-cysteine, cysteinylglycine, and methionine by high-performance liquid chromatography with electrochemical detection
    • Houze P, Gamra S, Madelaine I, Bousquet B, Gourmel B (2006) Simultaneous determination of total plasma glutathione, homo-cysteine, cysteinylglycine, and methionine by high-performance liquid chromatography with electrochemical detection. J Clin Lab Anal 15: 144-153.
    • (2006) J Clin Lab Anal , vol.15 , pp. 144-153
    • Houze, P.1    Gamra, S.2    Madelaine, I.3    Bousquet, B.4    Gourmel, B.5
  • 49
    • 64949116621 scopus 로고    scopus 로고
    • A highly selective phosphorescent chemodosimeter for cysteine and homocysteine based on platinum (II) complexs
    • Huang K, Yang H, Zhou Z, Chen H, Li F, Yi T, Huang C (2009) A highly selective phosphorescent chemodosimeter for cysteine and homocysteine based on platinum (II) complexs. Inorg Chim Acta 362: 2577-2580.
    • (2009) Inorg Chim Acta , vol.362 , pp. 2577-2580
    • Huang, K.1    Yang, H.2    Zhou, Z.3    Chen, H.4    Li, F.5    Yi, T.6    Huang, C.7
  • 50
    • 4344683549 scopus 로고    scopus 로고
    • Homo-cysteine induced impairement of nitric oxide-dependent vasorelaxation is reversible by the superoxide dismutase mimetic TEMPOL
    • Hucks D, Thuraisingham RC, Raftery MJ, Yagoob MM (2004) Homo-cysteine induced impairement of nitric oxide-dependent vasorelaxation is reversible by the superoxide dismutase mimetic TEMPOL. Nephrol Dial Transpl 19: 1999-2005.
    • (2004) Nephrol Dial Transpl , vol.19 , pp. 1999-2005
    • Hucks, D.1    Thuraisingham, R.C.2    Raftery, M.J.3    Yagoob, M.M.4
  • 51
    • 38349181044 scopus 로고    scopus 로고
    • Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-κB activation
    • Hwang S-Y, Woo CWH, Au-Yeung KKW, Siow YL, Zhu TY, Karmin O (2008) Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-κB activation. Am J Physiol-Renal 294: F236-244.
    • (2008) Am J Physiol-Renal , vol.294
    • Hwang, S.-Y.1    Woo, C.W.H.2    Au-Yeung, K.K.W.3    Siow, Y.L.4    Zhu, T.Y.5    Karmin, O.6
  • 52
    • 70349480989 scopus 로고    scopus 로고
    • A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma
    • Ichinose S, Nakamura M, Maeda M, Ikeda R, Wada M, Nakazato M, Ohba Y, Takamura N, Maeda T, Aoyagi K, Nakashima K (2009) A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma. Biomed Chromatogr 23: 935-939.
    • (2009) Biomed Chromatogr , vol.23 , pp. 935-939
    • Ichinose, S.1    Nakamura, M.2    Maeda, M.3    Ikeda, R.4    Wada, M.5    Nakazato, M.6    Ohba, Y.7    Takamura, N.8    Maeda, T.9    Aoyagi, K.10    Nakashima, K.11
  • 53
    • 0034022607 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and oxidative stress: Time for a reality check?
    • Jacobsen DW (2000) Hyperhomocysteinemia and oxidative stress: time for a reality check? Arterioscl Throm Vas 20: 1182-1184.
    • (2000) Arterioscl Throm Vas , vol.20 , pp. 1182-1184
    • Jacobsen, D.W.1
  • 54
    • 0001640331 scopus 로고
    • Limited capacity for homocysteine catabolism in vascular cells and tissues: A pathophysiologic mechanism for arterial damage in hyperhomocysteinemia?
    • Jacobsen DW, Savon SR, Stewart RW, Robinson K, Kottke-Marchant K, Di Corleto PE (1995) Limited capacity for homocysteine catabolism in vascular cells and tissues: a pathophysiologic mechanism for arterial damage in hyperhomocysteinemia? Circulation 91: 29-33.
    • (1995) Circulation , vol.91 , pp. 29-33
    • Jacobsen, D.W.1    Savon, S.R.2    Stewart, R.W.3    Robinson, K.4    Kottke-Marchant, K.5    Di Corleto, P.E.6
  • 55
    • 0031035742 scopus 로고    scopus 로고
    • Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels
    • Jakubowski H (1997) Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels. J Biol Chem 272: 1935-1942.
    • (1997) J Biol Chem , vol.272 , pp. 1935-1942
    • Jakubowski, H.1
  • 56
    • 0032778517 scopus 로고    scopus 로고
    • Protein homocysteinylation: Possible mechanism underlying pathological consequences of elevated homocysteine levels
    • Jakubowski H (1999) Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 13: 2277-2283.
    • (1999) FASEB J , vol.13 , pp. 2277-2283
    • Jakubowski, H.1
  • 57
    • 0034635449 scopus 로고    scopus 로고
    • Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation
    • Jakubowski H (2000) Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation. J Biol Chem 275: 3957-3962.
    • (2000) J Biol Chem , vol.275 , pp. 3957-3962
    • Jakubowski, H.1
  • 58
    • 0037163003 scopus 로고    scopus 로고
    • Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease
    • Jakubowski H (2002a) Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease. J Biol Chem 277: 30425-30428.
    • (2002) J Biol Chem , vol.277 , pp. 30425-30428
    • Jakubowski, H.1
  • 59
    • 0036750807 scopus 로고    scopus 로고
    • The determination of homocysteine-thiolactone in biological samples
    • Jakubowski H (2002b) The determination of homocysteine-thiolactone in biological samples. Anal Biochem 308: 112-119.
    • (2002) Anal Biochem , vol.308 , pp. 112-119
    • Jakubowski, H.1
  • 60
    • 33646788784 scopus 로고    scopus 로고
    • Pathophysiological consequences of homo-cysteine excess
    • Jakubowski H (2006) Pathophysiological consequences of homo-cysteine excess. J Nutr 136: 1741S-1749S.
    • (2006) J Nutr , vol.136
    • Jakubowski, H.1
  • 61
    • 64049095638 scopus 로고    scopus 로고
    • The pathophysiological hypothesis of homo-cysteine thiolactone-mediated vascular disease
    • Jakubowski H (2008a) The pathophysiological hypothesis of homo-cysteine thiolactone-mediated vascular disease. J Physiol Pharmacol 59: 155-167.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 155-167
    • Jakubowski, H.1
  • 62
    • 47749089308 scopus 로고    scopus 로고
    • New method for the determination of protein N-linked homocysteine
    • Jakubowski H (2008b) New method for the determination of protein N-linked homocysteine. Anal Biochem 380: 257-261.
    • (2008) Anal Biochem , vol.380 , pp. 257-261
    • Jakubowski, H.1
  • 63
    • 57349180605 scopus 로고    scopus 로고
    • Mutations in cystath-ionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans
    • Jakubowski H, Boers GHJ, Strauss KA (2008) Mutations in cystath-ionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans. FASEB J 22: 4071-4076.
    • (2008) FASEB J , vol.22 , pp. 4071-4076
    • Jakubowski, H.1    Boers, G.H.J.2    Strauss, K.A.3
  • 66
    • 4644257043 scopus 로고    scopus 로고
    • Homocysteine: It is a clinically important cardiovascular risk factor?
    • Lentz SR, Haynes WG (2004) Homocysteine: It is a clinically important cardiovascular risk factor? Clev Clin J Med 71: 729-734.
    • (2004) Clev Clin J Med , vol.71 , pp. 729-734
    • Lentz, S.R.1    Haynes, W.G.2
  • 68
    • 0028910633 scopus 로고
    • Determination of total plasma homocysteine and related aminothiols by gas chromatography with flame photometric detection
    • Kataoka H, Takagi K, Makita M (1995) Determination of total plasma homocysteine and related aminothiols by gas chromatography with flame photometric detection. J Chromatogr B Biomed Appl 664: 421-425.
    • (1995) J Chromatogr B Biomed Appl , vol.664 , pp. 421-425
    • Kataoka, H.1    Takagi, K.2    Makita, M.3
  • 70
    • 0034666267 scopus 로고    scopus 로고
    • Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
    • Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 20: 6920-6926.
    • (2000) J Neurosci , vol.20 , pp. 6920-6926
    • Kruman, I.I.1    Culmsee, C.2    Chan, S.L.3    Kruman, Y.4    Guo, Z.5    Penix, L.6    Mattson, M.P.7
  • 71
    • 32844469944 scopus 로고    scopus 로고
    • Rapid micro-scale assay for homocysteine by liquid chromatography-tandem mass spectrometry
    • Kuhn J, Gotting C, Kleesiek K (2006) Rapid micro-scale assay for homocysteine by liquid chromatography-tandem mass spectrometry. Clin Biochem 39: 164-166.
    • (2006) Clin Biochem , vol.39 , pp. 164-166
    • Kuhn, J.1    Gotting, C.2    Kleesiek, K.3
  • 72
    • 77953133802 scopus 로고    scopus 로고
    • Efficacy of homo-cysteine-lowering therapy with folic acid in stroke prevention
    • Lee M, Hong K-S, Chang S-C, Saver JL (2010) Efficacy of homo-cysteine-lowering therapy with folic acid in stroke prevention. Stroke 41: 1205-1212.
    • (2010) Stroke , vol.41 , pp. 1205-1212
    • Lee, M.1    Hong, K.-S.2    Chang, S.-C.3    Saver, J.L.4
  • 73
    • 0042919553 scopus 로고    scopus 로고
    • Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: A multicenter case-control study in china
    • Li Z, Sun L, Zhang H, Liao Y, Wang D, Zhao B, Zhu Z, Zhao J, Ma A, Han Y, Wang Y, Shi Y, Ye J, Hui R (2003) Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a multicenter case-control study in china. Stroke 34: 2085-2090.
    • (2003) Stroke , vol.34 , pp. 2085-2090
    • Li, Z.1    Sun, L.2    Zhang, H.3    Liao, Y.4    Wang, D.5    Zhao, B.6    Zhu, Z.7    Zhao, J.8    Ma, A.9    Han, Y.10    Wang, Y.11    Shi, Y.12    Ye, J.13    Hui, R.14
  • 75
    • 0031437426 scopus 로고    scopus 로고
    • Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. Implications for homocystinuria
    • Liu G, Nellaiappan K, Kagan H (1997) Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. Implications for homocystinuria. J Biol Chem 272: 32370-32377.
    • (1997) J Biol Chem , vol.272 , pp. 32370-32377
    • Liu, G.1    Nellaiappan, K.2    Kagan, H.3
  • 79
    • 0033050869 scopus 로고    scopus 로고
    • Plasma total homocysteine measurement by ion-paired reversed-phase HPLC with electrochemical detection
    • Martin SC, Hilton AC, Bartlett WA, Jones AF (1999) Plasma total homocysteine measurement by ion-paired reversed-phase HPLC with electrochemical detection. Biomed Chromatogr 13: 81-82.
    • (1999) Biomed Chromatogr , vol.13 , pp. 81-82
    • Martin, S.C.1    Hilton, A.C.2    Bartlett, W.A.3    Jones, A.F.4
  • 80
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26: 137-146.
    • (2003) Trends Neurosci , vol.26 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 82
    • 0036165216 scopus 로고    scopus 로고
    • Determination of homocysteine thiolactone and homocysteine in cell cultures using high-performance liquid chromatography with fluorescence detection
    • Mukai Y, Togawa T, Suzuki T, Ohata K, Tanabe S (2002) Determination of homocysteine thiolactone and homocysteine in cell cultures using high-performance liquid chromatography with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 767: 263-268.
    • (2002) J Chromatogr B Analyt Technol Biomed Life Sci , vol.767 , pp. 263-268
    • Mukai, Y.1    Togawa, T.2    Suzuki, T.3    Ohata, K.4    Tanabe, S.5
  • 84
    • 0345535616 scopus 로고    scopus 로고
    • Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
    • Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin R (1999) Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 94: 959-967.
    • (1999) Blood , vol.94 , pp. 959-967
    • Outinen, P.A.1    Sood, S.K.2    Pfeifer, S.I.3    Pamidi, S.4    Podor, T.J.5    Li, J.6    Weitz, J.I.7    Austin, R.8
  • 85
    • 0036468241 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate
    • Patel KB, Stratford MR, Wardman P, Everett SA (2002) Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate. Free Radical Biol Med 32: 203- 211.
    • (2002) Free Radical Biol Med , vol.32
    • Patel, K.B.1    Stratford, M.R.2    Wardman, P.3    Everett, S.A.4
  • 87
    • 77952294286 scopus 로고    scopus 로고
    • Paraoxonase 1 protects against protein N-homocysteinylation in humans
    • Perla-Kajan J, Jakubowski H (2010) Paraoxonase 1 protects against protein N-homocysteinylation in humans. FASEB J 24: 931-936.
    • (2010) FASEB J , vol.24 , pp. 931-936
    • Perla-Kajan, J.1    Jakubowski, H.2
  • 89
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG (1995) Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 346: 1395- 1398.
    • (1995) Lancet , vol.346
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 90
    • 33847176190 scopus 로고    scopus 로고
    • Homocysteine and cerebral ischemia: Pathogenic and therapeutical implications
    • Pezzini A, Del Zotto E, Padovani A (2007) Homocysteine and cerebral ischemia: pathogenic and therapeutical implications. Curr Med Chem 14: 249-263.
    • (2007) Curr Med Chem , vol.14 , pp. 249-263
    • Pezzini, A.1    Del Zotto, E.2    Padovani, A.3
  • 91
    • 0035810980 scopus 로고    scopus 로고
    • Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: Implications for vascular disease
    • Poddar R, Sivasubramanian N, DiBello PM, Robinson K, Jacobsen DW (2001) Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation 103: 2717-2723.
    • (2001) Circulation , vol.103 , pp. 2717-2723
    • Poddar, R.1    Sivasubramanian, N.2    Dibello, P.M.3    Robinson, K.4    Jacobsen, D.W.5
  • 92
    • 67650484107 scopus 로고    scopus 로고
    • Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death
    • Poddar R, Paul S (2009) Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death. J Neurochem 110: 1095-1106.
    • (2009) J Neurochem , vol.110 , pp. 1095-1106
    • Poddar, R.1    Paul, S.2
  • 94
    • 5444220704 scopus 로고    scopus 로고
    • High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells
    • Raposo B, Rodriguez C, Martinez-Gonzalez J, Badimon L (2004) High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells. Atherosclerosis 177: 1-8.
    • (2004) Atherosclerosis , vol.177 , pp. 1-8
    • Raposo, B.1    Rodriguez, C.2    Martinez-Gonzalez, J.3    Badimon, L.4
  • 96
    • 0033822684 scopus 로고    scopus 로고
    • Total homocysteine determination in clinical practice
    • Rasmussen K, Moller J (2000) Total homocysteine determination in clinical practice. Ann Clin Biochem 37: 627-648.
    • (2000) Ann Clin Biochem , vol.37 , pp. 627-648
    • Rasmussen, K.1    Moller, J.2
  • 98
    • 2442472190 scopus 로고    scopus 로고
    • Performance characteristics of a recombinant enzymatic cycling assay for quantification of total homocysteine in serum or plasma
    • Roberts RF, Roberts WL (2004) Performance characteristics of a recombinant enzymatic cycling assay for quantification of total homocysteine in serum or plasma. Clin Chim Acta 344: 95-99.
    • (2004) Clin Chim Acta , vol.344 , pp. 95-99
    • Roberts, R.F.1    Roberts, W.L.2
  • 99
    • 0032758245 scopus 로고    scopus 로고
    • Stability of blood homocysteine and other thiols: EDTA or acidic citrate?
    • Salazar J-F, Herbeth B, Siest G, Leroy P (1999) Stability of blood homocysteine and other thiols: EDTA or acidic citrate? Clin Chem 45: 2016-2019.
    • (1999) Clin Chem , vol.45 , pp. 2016-2019
    • Salazar, J.-F.1    Herbeth, B.2    Siest, G.3    Leroy, P.4
  • 100
    • 65249094749 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy and stroke risk, severity, and disability. Additional findings from the HOPE 2 Trial
    • Saposnik G, Ray JG, Sheridan P, McQueen M, Lonn E (2009) Homocysteine-lowering therapy and stroke risk, severity, and disability. Additional findings from the HOPE 2 Trial. Stroke 40: 1365-1372.
    • (2009) Stroke , vol.40 , pp. 1365-1372
    • Saposnik, G.1    Ray, J.G.2    Sheridan, P.3    Mcqueen, M.4    Lonn, E.5
  • 102
    • 3042767565 scopus 로고    scopus 로고
    • Homocysteine increases the production of asymmetric dimethylarginine in cultured neurons
    • Selley ML (2004) Homocysteine increases the production of asymmetric dimethylarginine in cultured neurons. J Neurosci Res 77: 90-93.
    • (2004) J Neurosci Res , vol.77 , pp. 90-93
    • Selley, M.L.1
  • 103
    • 27644521579 scopus 로고    scopus 로고
    • Vitamin intervention for stroke prevention trial: An efficacy analysis
    • Spence JD, Bang H, Chambless LE, Stampfer MJ (2005) Vitamin intervention for stroke prevention trial: an efficacy analysis. Stroke 36: 2404-2409.
    • (2005) Stroke , vol.36 , pp. 2404-2409
    • Spence, J.D.1    Bang, H.2    Chambless, L.E.3    Stampfer, M.J.4
  • 105
    • 3142729014 scopus 로고    scopus 로고
    • Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine
    • Stipanuk MH (2004) Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24: 539-577.
    • (2004) Annu Rev Nutr , vol.24 , pp. 539-577
    • Stipanuk, M.H.1
  • 106
    • 0031239784 scopus 로고    scopus 로고
    • Betain-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene
    • Sunden SL, Renduchintala MS, Park EI, Miklasz SD, Garrow TA (1997) Betain-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys 345: 171-174.
    • (1997) Arch Biochem Biophys , vol.345 , pp. 171-174
    • Sunden, S.L.1    Renduchintala, M.S.2    Park, E.I.3    Miklasz, S.D.4    Garrow, T.A.5
  • 107
    • 0022999801 scopus 로고
    • Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat
    • Syardal A, Refsum H, Ueland PM (1986) Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat. J Biol Chem 261: 3156-3163.
    • (1986) J Biol Chem , vol.261 , pp. 3156-3163
    • Syardal, A.1    Refsum, H.2    Ueland, P.M.3
  • 108
    • 51649102863 scopus 로고    scopus 로고
    • A highly sensitive single-enzyme homocysteine assay
    • Tan Y, Hoffman RM (2008) A highly sensitive single-enzyme homocysteine assay. Nat Protoc 3: 1388-1394.
    • (2008) Nat Protoc , vol.3 , pp. 1388-1394
    • Tan, Y.1    Hoffman, R.M.2
  • 109
    • 40949149821 scopus 로고    scopus 로고
    • Dietary homocysteine promotes atherosclerosis in apoE-deficient mice by inducing scavenger receptors expression
    • Thampi P, Stewart BW, Joseph L, Melnyk SB, Hennings LJ, Nagarajan S (2008) Dietary homocysteine promotes atherosclerosis in apoE-deficient mice by inducing scavenger receptors expression. Atherosclerosis 197: 620-629.
    • (2008) Atherosclerosis , vol.197 , pp. 620-629
    • Thampi, P.1    Stewart, B.W.2    Joseph, L.3    Melnyk, S.B.4    Hennings, L.J.5    Nagarajan, S.6
  • 110
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The vitamin intervention for stroke prevention (VISP) randomized controlled trial
    • Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang C-H, Stampfer M (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (VISP) randomized controlled trial. JAMA 291: 565-575.
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3    Spence, J.D.4    Pettigrew, L.C.5    Howard, V.J.6    Sides, E.G.7    Wang, C.-H.8    Stampfer, M.9
  • 112
    • 65549159487 scopus 로고    scopus 로고
    • Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway
    • Tyagi N, Gillespie W, Vacek JC, Sen U, Tyagi SC, Lominadze D (2009) Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. J Cell Physiol 220: 257-266.
    • (2009) J Cell Physiol , vol.220 , pp. 257-266
    • Tyagi, N.1    Gillespie, W.2    Vacek, J.C.3    Sen, U.4    Tyagi, S.C.5    Lominadze, D.6
  • 113
    • 23244456667 scopus 로고    scopus 로고
    • Homocysteine in micro-vascular endothelial cell barrier permeability
    • Tyagi SC, Lominadze D, Roberts AM (2005) Homocysteine in micro-vascular endothelial cell barrier permeability. Cell Biochem Biophys 43: 37-44.
    • (2005) Cell Biochem Biophys , vol.43 , pp. 37-44
    • Tyagi, S.C.1    Lominadze, D.2    Roberts, A.M.3
  • 114
    • 37549056545 scopus 로고    scopus 로고
    • Gamma-ami-nobutiric acid A receptor mitigates homocysteine-induced endothe-lial cell permeability
    • Tyagi N, Moshal KS, Tyagi SC, Lominadze D (2007) Gamma-ami-nobutiric acid A receptor mitigates homocysteine-induced endothe-lial cell permeability. Endothelium 14: 315-323.
    • (2007) Endothelium , vol.14 , pp. 315-323
    • Tyagi, N.1    Moshal, K.S.2    Tyagi, S.C.3    Lominadze, D.4
  • 115
    • 0033822337 scopus 로고    scopus 로고
    • Assay methods for the measurement of total homocyst(e)ine in plasma
    • Ubbink JB (2000) Assay methods for the measurement of total homocyst(e)ine in plasma. Semin Thromb Hemost 26: 233-241.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 233-241
    • Ubbink, J.B.1
  • 116
    • 0036270587 scopus 로고    scopus 로고
    • Protein-bound homocystamide measured in human plasma by HPLC
    • Uji Y, Motomiva Y, Hanyu N, Ukaji F, Okabe H (2002) Protein-bound homocystamide measured in human plasma by HPLC. Clin Chem 48: 941-944.
    • (2002) Clin Chem , vol.48 , pp. 941-944
    • Uji, Y.1    Motomiva, Y.2    Hanyu, N.3    Ukaji, F.4    Okabe, H.5
  • 117
    • 2542618547 scopus 로고    scopus 로고
    • Autoantibodies against N-homocysteinylated proteins in humans: Implications for atherosclerosis
    • Undas A, Perla J, Lacinski M, Trzeciak W, Kazmierski R, Jakubowski H (2004) Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis. Stroke 35: 1299-1304.
    • (2004) Stroke , vol.35 , pp. 1299-1304
    • Undas, A.1    Perla, J.2    Lacinski, M.3    Trzeciak, W.4    Kazmierski, R.5    Jakubowski, H.6
  • 120
    • 0036464601 scopus 로고    scopus 로고
    • Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition
    • Wang H, Jiang XH, Yang F, Chapman GB, Durante W, Sibinga NES, Schafer AI (2002) Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Blood 99: 939-945.
    • (2002) Blood , vol.99 , pp. 939-945
    • Wang, H.1    Jiang, X.H.2    Yang, F.3    Chapman, G.B.4    Durante, W.5    Sibinga, N.E.S.6    Schafer, A.I.7
  • 121
    • 34249730020 scopus 로고    scopus 로고
    • Efficacy of folic acid supplementation in stroke prevention: A meta-analysis
    • Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, Sun N, Liu L, Xu X (2007) Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 369: 1876-1882.
    • (2007) Lancet , vol.369 , pp. 1876-1882
    • Wang, X.1    Qin, X.2    Demirtas, H.3    Li, J.4    Mao, G.5    Huo, Y.6    Sun, N.7    Liu, L.8    Xu, X.9
  • 122
    • 0345169177 scopus 로고    scopus 로고
    • Influence of hyperhomocysteinemia on the cellular redox state - impact on homocysteine-induced endothelial dysfunction
    • Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF, Loscalzo J (2003) Influence of hyperhomocysteinemia on the cellular redox state - impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med 41: 1455-1461.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1455-1461
    • Weiss, N.1    Heydrick, S.J.2    Postea, O.3    Keller, C.4    Keaney, J.F.5    Loscalzo, J.6
  • 123
    • 27444444053 scopus 로고    scopus 로고
    • Automated assay for the determination of methylmalonic acid, total homo-cysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry
    • Windelberg A, Arseth O, Kvalheim G, Ueland PM (2005) Automated assay for the determination of methylmalonic acid, total homo-cysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem 51: 2103-2109.
    • (2005) Clin Chem , vol.51 , pp. 2103-2109
    • Windelberg, A.1    Arseth, O.2    Kvalheim, G.3    Ueland, P.M.4
  • 124
    • 0034624251 scopus 로고    scopus 로고
    • Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface
    • Yamamoto M, Hara H, Adachi T (2000) Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface. FEBS Lett 486: 159-162.
    • (2000) FEBS Lett , vol.486 , pp. 159-162
    • Yamamoto, M.1    Hara, H.2    Adachi, T.3
  • 126
    • 0042878460 scopus 로고    scopus 로고
    • Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes
    • Zeng X, Dai J, Remick DG, Wang X (2003) Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ Res 93: 311-320.
    • (2003) Circ Res , vol.93 , pp. 311-320
    • Zeng, X.1    Dai, J.2    Remick, D.G.3    Wang, X.4
  • 127
    • 0035929641 scopus 로고    scopus 로고
    • Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response
    • Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 276: 35867-35874.
    • (2001) J Biol Chem , vol.276 , pp. 35867-35874
    • Zhang, C.1    Cai, Y.2    Adachi, M.T.3    Oshiro, S.4    Aso, T.5    Kaufman, R.J.6    Kitajima, S.7
  • 128
    • 72449210573 scopus 로고    scopus 로고
    • Hyperhomo-cysteinemia promotes infammatory monocyte generation and accelerates atherosclerosis in transgenic cystathione b-synthase-deficient mice
    • Zhang D, Jiang X, Fang P, Yan Y, Song J, Gupta S, Schafer AI, Durante W, Kruger WD, Yang X, Wang H (2009) Hyperhomo-cysteinemia promotes infammatory monocyte generation and accelerates atherosclerosis in transgenic cystathione b-synthase-deficient mice. Circulation 120: 1893-1902.
    • (2009) Circulation , vol.120 , pp. 1893-1902
    • Zhang, D.1    Jiang, X.2    Fang, P.3    Yan, Y.4    Song, J.5    Gupta, S.6    Schafer, A.I.7    Durante, W.8    Kruger, W.D.9    Yang, X.10    Wang, H.11
  • 129
    • 0842303105 scopus 로고    scopus 로고
    • Comparing the ESA HPLC total homocysteine assay with electrochemical detection to the CDC in-house HPLC assay with fluorescence detection
    • Zhang M, Pfeiffer CM (2004) Comparing the ESA HPLC total homocysteine assay with electrochemical detection to the CDC in-house HPLC assay with fluorescence detection. Clin Chim Acta 340: 195-200.
    • (2004) Clin Chim Acta , vol.340 , pp. 195-200
    • Zhang, M.1    Pfeiffer, C.M.2
  • 130
    • 0033066640 scopus 로고    scopus 로고
    • Prostaglandin endoperoxide-de-pendent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase
    • Zou M, Jendral M, Ullrich V (1999) Prostaglandin endoperoxide-de-pendent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. Br J Pharmacol 126: 1283-1292.
    • (1999) Br J Pharmacol , vol.126 , pp. 1283-1292
    • Zou, M.1    Jendral, M.2    Ullrich, V.3
  • 132
    • 17644409326 scopus 로고    scopus 로고
    • Homocysteine and redox signaling
    • Zou CG, Banerjee R: Homocysteine and redox signaling (2005) Anti-oxid Redox Sign 7: 547-559.
    • (2005) Anti-oxid Redox Sign , vol.7 , pp. 547-559
    • Zou, C.G.1    Banerjee, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.