메뉴 건너뛰기




Volumn 31, Issue 12, 2010, Pages 2069-2079

Homocysteine promotes proliferation and activation of microglia

Author keywords

Activation; Homocysteine; Microglia; NAD(P)H oxidases; P38 MAPK; P47phox; Proliferation; Reactive oxygen species

Indexed keywords

CD11B ANTIGEN; HOMOCYSTEINE; MITOGEN ACTIVATED PROTEIN KINASE P38; OXIDOREDUCTASE; PROTEIN P47PHOX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

EID: 78649652220     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.11.007     Document Type: Article
Times cited : (47)

References (33)
  • 1
    • 17144403395 scopus 로고    scopus 로고
    • Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
    • Akasaka K., Akasaka N., Di Luozzo G., Sasajima T., Sumpio B.E. Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells. J. Vasc. Surg. 2005, 41:517-522.
    • (2005) J. Vasc. Surg. , vol.41 , pp. 517-522
    • Akasaka, K.1    Akasaka, N.2    Di Luozzo, G.3    Sasajima, T.4    Sumpio, B.E.5
  • 2
    • 33947538533 scopus 로고    scopus 로고
    • Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats
    • Blaise S.A., Nedelec E., Schroeder H., Alberto J.M., Bossenmeyer-Pourie C., Gueant J.L., Daval J.L. Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats. Am. J. Pathol. 2007, 170:667-679.
    • (2007) Am. J. Pathol. , vol.170 , pp. 667-679
    • Blaise, S.A.1    Nedelec, E.2    Schroeder, H.3    Alberto, J.M.4    Bossenmeyer-Pourie, C.5    Gueant, J.L.6    Daval, J.L.7
  • 3
    • 28844487137 scopus 로고    scopus 로고
    • Cannabinoid receptors in microglia of the central nervous system: immune functional relevance
    • Cabral G.A., Marciano-Cabral F. Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. J. Leukoc. Biol. 2005, 78:1192-1197.
    • (2005) J. Leukoc. Biol. , vol.78 , pp. 1192-1197
    • Cabral, G.A.1    Marciano-Cabral, F.2
  • 4
    • 17144403821 scopus 로고    scopus 로고
    • Retinoic acid inhibits expression of TNF-α and iNOS in activated rat microglia
    • Dheen S.T., Jun Y., Yan Z., Tay S.S., Ling E.A. Retinoic acid inhibits expression of TNF-α and iNOS in activated rat microglia. Glia 2005, 50:21-31.
    • (2005) Glia , vol.50 , pp. 21-31
    • Dheen, S.T.1    Jun, Y.2    Yan, Z.3    Tay, S.S.4    Ling, E.A.5
  • 5
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification
    • Guillemin G.J., Brew B.J. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J. Leukoc. Biol. 2004, 75:388-397.
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 7
    • 0036892748 scopus 로고    scopus 로고
    • Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage
    • Ho P.I., Ortiz D., Rogers E., Shea T.B. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J. Neurosci. Res. 2002, 70:694-702.
    • (2002) J. Neurosci. Res. , vol.70 , pp. 694-702
    • Ho, P.I.1    Ortiz, D.2    Rogers, E.3    Shea, T.B.4
  • 8
    • 33745497498 scopus 로고    scopus 로고
    • Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation
    • Koh J.M., Lee Y.S., Kim Y.S., Kim D.J., Kim H.H., Park J.Y., Lee K.U., Kim G.S. Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J. Bone. Miner. Res. 2006, 21:1003-1011.
    • (2006) J. Bone. Miner. Res. , vol.21 , pp. 1003-1011
    • Koh, J.M.1    Lee, Y.S.2    Kim, Y.S.3    Kim, D.J.4    Kim, H.H.5    Park, J.Y.6    Lee, K.U.7    Kim, G.S.8
  • 9
    • 0034666267 scopus 로고    scopus 로고
    • Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
    • Kruman I.I., Culmsee C., Chan S.L., Kruman Y., Guo Z., Penix L., Mattson M.P. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 2000, 20:6920-6926.
    • (2000) J. Neurosci. , vol.20 , pp. 6920-6926
    • Kruman, I.I.1    Culmsee, C.2    Chan, S.L.3    Kruman, Y.4    Guo, Z.5    Penix, L.6    Mattson, M.P.7
  • 11
    • 22244470745 scopus 로고    scopus 로고
    • Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
    • Li J., Baud O., Vartanian T., Volpe J.J., Rosenberg P.A. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:9936-9941.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 9936-9941
    • Li, J.1    Baud, O.2    Vartanian, T.3    Volpe, J.J.4    Rosenberg, P.A.5
  • 12
    • 33847678000 scopus 로고    scopus 로고
    • Synergistic effects of S-adenosylhomocysteine and homocysteine on DNA damage in a murine microglial cell line
    • Lin P.-Y., Yang T.-H., Lin H.-G., Hu M.-L. Synergistic effects of S-adenosylhomocysteine and homocysteine on DNA damage in a murine microglial cell line. Clin. Chim. Acta 2007, 379:139-144.
    • (2007) Clin. Chim. Acta , vol.379 , pp. 139-144
    • Lin, P.-Y.1    Yang, T.-H.2    Lin, H.-G.3    Hu, M.-L.4
  • 14
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • Liu B., Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 2003, 304:1-7.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 15
    • 37548999379 scopus 로고    scopus 로고
    • Homocysteine induces connective tissue growth factor expression in vascular smooth muscle cells
    • Liu X., Luo F., Li J., Wu W., Li L., Chen H. Homocysteine induces connective tissue growth factor expression in vascular smooth muscle cells. J. Thromb. Haemost. 2008, 6:184-192.
    • (2008) J. Thromb. Haemost. , vol.6 , pp. 184-192
    • Liu, X.1    Luo, F.2    Li, J.3    Wu, W.4    Li, L.5    Chen, H.6
  • 16
    • 30744455267 scopus 로고    scopus 로고
    • Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase
    • Mander P.K., Jekabsone A., Brown G.C. Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase. J. Immunol. 2006, 176:1046-1052.
    • (2006) J. Immunol. , vol.176 , pp. 1046-1052
    • Mander, P.K.1    Jekabsone, A.2    Brown, G.C.3
  • 17
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • Mattson M.P., Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003, 26:137-146.
    • (2003) Trends Neurosci. , vol.26 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 18
    • 3542996239 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor augments β-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells
    • Murphy G.M., Yang L., Cordell B. Macrophage colony-stimulating factor augments β-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells. J. Biol. Chem. 1998, 273:20967-20971.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20967-20971
    • Murphy, G.M.1    Yang, L.2    Cordell, B.3
  • 19
    • 0036953725 scopus 로고    scopus 로고
    • Microglia in diseases of the central nervous system
    • Nelson P.T., Soma L.A., Lavi E. Microglia in diseases of the central nervous system. Ann. Med. 2002, 34:491-500.
    • (2002) Ann. Med. , vol.34 , pp. 491-500
    • Nelson, P.T.1    Soma, L.A.2    Lavi, E.3
  • 20
    • 35448972133 scopus 로고    scopus 로고
    • Vascular oxidant stress and inflammation in hyperhomocysteinemia
    • Papatheodorou L., Weiss N. Vascular oxidant stress and inflammation in hyperhomocysteinemia. Antioxid. Redox. Signal. 2007, 9:1941-1958.
    • (2007) Antioxid. Redox. Signal. , vol.9 , pp. 1941-1958
    • Papatheodorou, L.1    Weiss, N.2
  • 23
    • 33747262660 scopus 로고    scopus 로고
    • Homocysteine stimulates phosphorylation of NADPH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation
    • Siow Y.L., Au-Yeung K.K., Woo C.W.O.K. Homocysteine stimulates phosphorylation of NADPH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation. Biochem. J. 2006, 398:73-82.
    • (2006) Biochem. J. , vol.398 , pp. 73-82
    • Siow, Y.L.1    Au-Yeung, K.K.2    Woo, C.W.O.K.3
  • 24
    • 0028473441 scopus 로고
    • Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol
    • Stolk J., Hiltermann T.J., Dijkman J.H., Verhoeven A.J. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am. J. Respir. Cell. Mol. Biol. 1994, 11:95-102.
    • (1994) Am. J. Respir. Cell. Mol. Biol. , vol.11 , pp. 95-102
    • Stolk, J.1    Hiltermann, T.J.2    Dijkman, J.H.3    Verhoeven, A.J.4
  • 25
    • 7444239650 scopus 로고    scopus 로고
    • Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation
    • Tjiattas L., Ortiz D.O., Dhivant S., Mitton K., Rogers E., Shea T.B. Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell 2004, 3:71-76.
    • (2004) Aging Cell , vol.3 , pp. 71-76
    • Tjiattas, L.1    Ortiz, D.O.2    Dhivant, S.3    Mitton, K.4    Rogers, E.5    Shea, T.B.6
  • 29
    • 14944384253 scopus 로고    scopus 로고
    • Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia
    • Wang G., Dai J., Mao J., Zeng X., Yang X., Wang X. Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia. Atherosclerosis 2005, 179:395-402.
    • (2005) Atherosclerosis , vol.179 , pp. 395-402
    • Wang, G.1    Dai, J.2    Mao, J.3    Zeng, X.4    Yang, X.5    Wang, X.6
  • 30
    • 0037336095 scopus 로고    scopus 로고
    • Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells
    • Yang Z.Z., Zou A.P. Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells. Kidney. Int. 2003, 63:1012-1020.
    • (2003) Kidney. Int. , vol.63 , pp. 1012-1020
    • Yang, Z.Z.1    Zou, A.P.2
  • 31
    • 0042878460 scopus 로고    scopus 로고
    • Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes
    • Zeng X., Dai J., Remick D.G., Wang X. Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ. Res. 2003, 93:311-320.
    • (2003) Circ. Res. , vol.93 , pp. 311-320
    • Zeng, X.1    Dai, J.2    Remick, D.G.3    Wang, X.4
  • 32
    • 0034772002 scopus 로고    scopus 로고
    • Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism
    • Zhang Q., Zeng X., Guo J., Wang X. Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism. Cardiovasc. Res. 2001, 52:328-336.
    • (2001) Cardiovasc. Res. , vol.52 , pp. 328-336
    • Zhang, Q.1    Zeng, X.2    Guo, J.3    Wang, X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.