ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma

International Journal of Cancer

Volumn 107, Issue 2, 2003, Pages 202-208

  Guan, Xin ^a   Sagara, Junji ^a   Yokoyama, Taro ^a   Koganehira, Yoko ^b   Oguchi, Misae ^b   Saida, Toshiaki ^b   Taniguchi, Shun'ichiro ^a,c  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SHINSHU UNIVERSITY   (Japan)

Author keywords

ASC; CARD; Melanoma; Methylation; PYD

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADAPTOR PROTEIN; ASC PROTEIN; ENZYME ACTIVATOR; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MELANOCYTIC NEVUS; MELANOMA; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; AZACITIDINE; BLOTTING, WESTERN; CASPASE 1; CPG ISLANDS; CYTOSKELETAL PROTEINS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA PRIMERS; DNA, NEOPLASM; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MELANOMA; NEVUS, PIGMENTED; POLYMERASE CHAIN REACTION; PROTEINS; SKIN NEOPLASMS; SULFITES; TUMOR CELLS, CULTURED;

EID: 0141857814     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11376     Document Type: Article

References (30)

1. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992;69:915-26.
2. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999;99:247-57.
3. Bird AP, Wolffe AP. Methylation-induced repression belts, braces, and chromatin. Cell 1999;99:451-4.
4. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-6.
5. Robertson KD, Jones PA. DNA methylation: past, present and future directions. Carcinogenesis 2000;21:461-7.
6. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000;16:168-74.
7. Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999;21:163-7.
8. Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST, Vertino PM. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res 2000;60:6236-42.
9. Stimson KM, Vertino PM. Methylation-mediated silencing of TMS1/ASC is accompanied histone hypoacetylation and CpG island-localized changes in chromatin architecture. J Biol Chem 2002;277:4951-8.
10. Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, Hidaka E, Katsuyama T, Higuchi T, Sagara J. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 1999;274:33835-8.
11. Bertin J, DiStefano PS. The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. Cell Death Differ 2000;7:1273-4.
12. Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci 2001;26:85-7.
13. Martinon F, Hofmann K, Tschopp J. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol 2001;11:118-20.
14. Staub E, Dahl E, Rosenthal A. The DAPIN family: a novel domain links apoptotic and interferon response proteins. Trends Biochem Sci 2001;26:83-5.
15. Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 2002;277:21119-22.
16. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417-26.
17. Dinarello CA. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann NY Acad Sci 1998;856:1-11.
18. McConnell BB, Vertino PM. Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. Cancer Res 2000;60:6243-7.
19. Chin L, Merlino G, DePinho RA. Malignant melanoma: modern black plague and genetic black box. Genes Dev 1998;12:3467-81.
20. Laemmli UK. Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature 1974;227:680-5.
21. Masumoto J, Taniguchi S, Nakayama J, Shiohara M, Hidaka E, Katsuyama T, Murase S, Sagara J. Expression of apoptosis associated speck-like protein containing a caspase recruitment domain, a Pyrin N-terminal homology domain-containing protein, in normal human tissues. J Histochem Cytochem 2001;49:1269-75.
22. Luo D, Chen H, Searles G, Jimbow K. Coordinated mRNA expression of c-kit with tyrosinase and TRP-1 in melanin pigmentation of normal and malignant human melanocyte and transient activation of tyrosinase by kit/SCF-R. Melanoma Res 1995;5:303-9.
23. Kikuchi A, Shimizu H, Nishikawa T. Expression and ultrastructural localization of HMB-45 antigen. Br J Dermatol 1996;135:400-5.
24. Rice L, Wainwright M. Phoenix DA. Phenothiazine photosensitizers III. Activity of methylene blue derivatives against pigmented melanoma cell lies. J Chemother 2000;1294-104.
25. Nozawa S, Ohta H, Tsukazaki K, Udagawa Y, Kurihara S, Kano S. A newly established melanoma cell line (GAK) with 5-S-cysteinyldopa phenotype. Nippon Sanka Fujinka Gakkai Zasshi 1984;36:883-92.
26. Gili A, Thomas PD, Ota M, Jimbow K. Comparison of in vitro cytotoxicity of n-acetyl and N-propionyl derivatives of phenolic thioether amines in relationship to tyrosinase and tyrosine hydroxylase enzyme activity. Melanoma Res 2000;10:9-15.
27. Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L, Sekut L, Talanian R, Paskind M, Wong W, Kamen R, et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997;386:619-23.
28. Micallef MJ, Yoshida K, Kawai S, Hanaya T, Kohno K, Arai D, Tanimoto T, Torigoe K, Fujii M, Ikeda M, Kurimoto M. In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngenic Meth A sarcoma malignant ascites. Cancer Immunol Immunother 1997;43:361-7.
29. Osaki T, Peron JM, Cai O, Okamura H, Robbins PD, Kurimoto M, Lotze MT, Tahara H. IFN-gamma-inducing factor/interleukin-18 administration mediates IFN-gamma and IL-12-independent antitumor effects. J Immunol 1998;160:1742-9.
30. Hashimoto W, Osaki T, Okamura H, Robbins PD, Kurimoto M, Nagata S, Lotze MT, Tahara H. Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively. J Immunol 1999;163:583-9.