Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function

American Journal of Physiology - Cell Physiology

Volumn 300, Issue 2, 2011, Pages

  Medikayala, S ^a   Piteo, B ^a   Zhao, X ^a   Edwards, J G ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Diabetes; DNA damage; Hyperglycemia; Mitochondria; Mitochondrial DNA damage; Topoisomerase

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; DNA TOPOISOMERASE; GLUCOSE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE;

APOPTOSIS; ARTICLE; CELL LINE; DIABETIC CARDIOMYOPATHY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CLEAVAGE; ENZYME ACTIVITY; HYPERGLYCEMIA; MITOCHONDRION; MYOTUBE; OXIDATIVE STRESS; PRIORITY JOURNAL; RISK FACTOR;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANNEXIN A5; APOPTOSIS; CELL LINE; CHRONIC DISEASE; DIABETIC CARDIOMYOPATHIES; DNA DAMAGE; DNA TOPOISOMERASES; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX IV; HYDROGEN PEROXIDE; HYPERGLYCEMIA; MITOCHONDRIA, HEART; MUSCLE FIBERS, SKELETAL; MYOCARDIUM; RATS; SUPEROXIDES; TOPOISOMERASE INHIBITORS;

EID: 79251590539     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00248.2010     Document Type: Article

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