Early adaptations to training: Upregulation of α-myosin heavy chain gene expression

Medicine and Science in Sports and Exercise

Volumn 39, Issue 1, 2007, Pages 75-82

  Rafalski, Karolina ^a   Abdourahman, Aicha ^a   Edwards, John G ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Adaptation; Exercise; Myocardial contractile proteins; Transcription; YY1

Indexed keywords

ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; CYTOCHROME C OXIDASE; GLYCERALDEHYDE DEHYDROGENASE; MESSENGER RNA; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; OXIDOREDUCTASE; TRANSCRIPTION FACTOR YY1; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXERCISE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HEART DEVELOPMENT; HEART LEFT VENTRICLE CONTRACTILITY; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; MALE; NONHUMAN; NORTHERN BLOTTING; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITTING; TRAINING; UPREGULATION; WESTERN BLOTTING;

ANIMALS; GENE EXPRESSION; MYOSIN HEAVY CHAINS; PHYSICAL CONDITIONING, ANIMAL; RATS; UNITED STATES; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR MYOSINS;

EID: 33846244548     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/01.mss.0000240324.08406.3d     Document Type: Article

References (46)

1. ALVAREZ-SALAS, L. M., M. L. BENITEZ-HESS, and J. A. DIPAOLO. YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. Int. J. Oncol. 26:259-266, 2005.
2. BUCCINO, R. A., J. F. SPANN Jr., E. H. SONNENBLICK, and E. BRAUNWALD. Effect of thyroid state on myocardial contractility. Endocrinology 82:191-192, 1968.
3. BUTTRICK, P., M. KAPLAN, L. LEINWAND, and J. SCHEUER. Alterations in gene expression in the rat heart after chronic pathologic and physiologic loads. J. Mol. Cell. Card. 26:61-67, 1994.
4. BUTTRICK, P., A. MALHOTRA, and J. SCHEUER. Effects of systolic and swim training on cardiac mechanics and biochemistry in rats. J. Appl. Physiol. 64:1466-1471, 1988.
5. CALDERONE, A., N. TAKAHASHI, N. J. IZZO Jr., C. M. THAIK, and W. S. COLUCCI. Pressure- and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and differential induction of peptide growth factor mRNAs. Circulation 92:2385-2390, 1995.
6. 2, and high intravascular pressure. Circulation 111:2364-2372, 2005.
7. DIFFEE, G. M., and E. CHUNG. Altered single cell force-velocity and power properties in exercise-trained rat myocardium. J. Appl. Physiol. 94:1941-1948, 2003.
8. DIFFEE, G. M., and D. F. NAGLE. Regional differences in effects of exercise training on contractile and biochemical properties of rat cardiac myocytes. J. Appl. Physiol. 95:35-42, 2003.
9. DIFFEE, G. M., E. A. SEVERSEN, T. D. STEIN, and J. A. JOHNSON. Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles. Am. J. Physiol. Heart Circ. Physiol. 284:H830-H837, 2003.
10. EDWARDS, J. G. Swim training increases ventricular atrial natriuretic factor (ANF) gene expression as an early adaptation to chronic exercise. Life Sciences 70:2753-2768, 2002.
11. FITZSIMONS, D. P., P. W. BODELL, R. E. HERRICK, and K. M. BALDWIN. Left ventricular functional capacity in the endurance-trained rodent. J. Appl. Physiol. 69:305-312, 1990.
12. GOLDMAN, P. S., V. K. TRAN, and R. H. GOODMAN. The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog. Horm. Res. 52:103-119, 1997.
13. GOODMAN, J. M., P. P. LIU, and H. J. GREEN. Left ventricular adaptations following short-term endurance training. J. Appl. Physiol. 98:454-460, 2005.
14. GUPTA, M., V. SUEBLINVONG, J. RAMAN, V. JEEVANANDAM, and M. P. GUPTA. Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. J. Biol. Chem. 278:44935-44948, 2003.
15. HADDAD, F., P. W. BODELL, A. X. QIN, J. M. GIGER, and K. M. BALDWIN. Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching. J. Biol. Chem. 278:37132-37138, 2003.
16. HAINSEY, T., T. CSISZAR, S. SUN, and J. G. EDWARDS. Cyclosporin A does not block exercise-induced cardiac hypertrophy. Med. Sci. Spt. Exer. 34:1249-1254, 2002.
17. HERRON, T. J., and K. S. MCDONALD. Small amounts of alphamyosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments. Circ. Res. 90:1150-1152, 2002.
18. HEWETT, T., I. GRUPP, G. GRUPP, and J. ROBBINS. Alpha-skeletal actin is associated with increased contractility in the mouse heart. Circ. Res. 74:740-746, 1994.
19. HICKSON, R. Time course of development of cardiac hypertrophy with endurance training. Med. Sci. Sports Exerc. 8:55, 1976.
20. HICKSON, R., G. HAMMONS, and J. HOLLOSZY. Development and regression of exercise induced hypertrophy in rats. Am. J. Physiol. 236:H268-H272, 1979.
21. HIROMURA, M., C. H. CHOI, N. A. SABOURIN, H. JONES, D. BACHVAROV, and A. USHEVA. YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation). J. Biol. Chem. 278:14046-14052, 2003.
22. HOLLOSZY, J. O. Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J. Biol. Chem. 242:2278-2282, 1967.
23. HONGO, F., H. GARBAN, S. HUERTA-YEPEZ, et al. Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation. Biochem. Biophys. Res. Commun. 336:692-701, 2005.
24. IEMITSU, M., T. MIYAUCHI, S. MAEDA, et al. Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats. Am. J. Physiol. Heart Circ. Physiol. 286:H1696-H1705, 2004.
25. IZUMO, S., B. NADAL-GINARD, and V. MAHDAVI. Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc. Natl. Acad. Sci. U. S. A. 85:339-343, 1988.
26. KATZEFF, H. L., K. M. OJAMAA, and I. KLEIN. Effects of exercise on protein synthesis and myosin heavy chain gene expression in hypothyroid rats. Am. J. Physiol. 267:E63-E67, 1994.
27. KAWADA, H., C. NISHIYAMA, A. TAKAGI, et al. Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes. J. Invest. Dermatol. 124:1206-1214, 2005.
28. KINUGAWA, K., K. YONEKURA, R. C. RIBEIRO, et al. Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ. Res. 89:591-598, 2001.
29. KO, L., and W. W. CHIN. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase. J. Biol. Chem. 278:11471-11479, 2003.
30. LAFRAMBOISE, W. A., J. F. WATCHKO, B. S. BROZANSKI, M. J. DAOOD, and R. D. GUTHRIE. Myosin heavy chain expression in respiratory muscles of the rat. Am. J. Respir. Cell Mol. Biol. 6:335-339, 1992.
31. LEE, Y., B. NADAL-GINARD, V. MAHDAVI, and S. IZUMO. Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the alpha-cardiac myosin heavy-chain gene. Mol. Cell Biol. 17:2745-2755, 1997.
32. MAR, J., and C. ORDAHL. M-CAT binding factor, a novel transacting factor governing muscle-specific transcription. Mol. Cell Biol. 10:4271-4283, 1990.
33. MCNALLY, E. M., R. KRAFT, M. BRAVO-ZEHNDER, D. A. TAYLOR, and L. A. LEINWAND. Full-length rat alpha and beta cardiac myosin heavy chain sequences. Comparisons suggest a molecular basis for functional differences. J. Mol. Biol. 210:665-671, 1989.
34. MIYATA, S., W. MINOBE, M. R. BRISTOW, and L. A. LEINWAND. Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ. Res. 86:386-390, 2000.
35. MOLKENTIN, J., J. LU, C. ANTOS, et al. A calcineurin dependent transcriptional pathway for cardiac hypertrophy. Cell 93:215-228, 1998.
36. PATTEN, M., W. WANG, S. AMINOLOLAMA- SHAKERI, M. BURSON, and C. S. LONG. IL-1 beta increases abundance and activity of the negative transcriptional regulator yin yang-1 (YY1) in neonatal rat cardiac myocytes. J. Mol. Cell Cardiol. 32:1341-1352, 2000.
37. SCHAIBLE, T., A. MALHOTRA, G. CIAMBRONE, P. BUTTRICK, and J. SCHEUER. Combined effects of hypertension and chronic running program on rat heart. J. Appl. Physiol. 63:322-327, 1987.
38. SCHAIBLE, T., A. MALHOTRA, G. CIAMBRONE, P. BUTTRICK, and J. SCHEUER. Effect of hypertension on hearts of rats trained by swimming. J. Appl. Physiol. 62:328-334, 1987.
39. SHORT, K. R., J. L. VITTONE, M. L. BIGELOW, et al. Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training. J. Appl. Physiol. 99:95-102, 2005.
40. SUCHAROV, C. C., S. M. HELMKE, S. J. LANGER, M. B. PERRYMAN, M. BRISTOW, and L. LEINWAND. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Mol. Cell Biol. 24:8705-8715, 2004.
41. SUCHAROV, C. C., P. MARINER, C. LONG, M. BRISTOW, and L. LEINWAND. Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter. J. Biol. Chem. 278:31233-31239, 2003.
42. SWARTMAN, J. R., P. B. TAYLOR, and B. COOK. Effect of exercise on amino acid incorporation into myocardial contractile proteins. Pflugers Arch 391:319-323, 1981.
43. TARDIFF, J. C., T. E. HEWETT, S. M. FACTOR, K. L. VIKSTROM, J. ROBBINS, and L. A. LEINWAND. Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominantnegative functional effects. Am. J. Physiol. Heart Circ. Physiol. 278:H412-H419, 2000.
44. VON HARSDORF, R., J. EDWARDS, R. KUDEJ, et al. Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload. J. Clin. Invest. 100:1294-1304, 1997.
45. WILKINS, B. J., Y. S. DAI, O. F. BUENO, et al. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ. Res. 94:110-118, 2004.
46. YAO, Y. L., W. M. YANG, and E. SETO. Regulation of transcription factor YY1 by acetylation and deacetylation. Mol. Cell Biol. 21:5979-5991, 2001.