Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients

Annals of the New York Academy of Sciences

Volumn 1011, Issue , 2004, Pages 193-204

  Nomiyama, Takashi ^a   Tanaka, Yasushi ^a,c   Piao, Lianshan ^b   Hattori, Nobutaka ^c   Uchino, Hiroshi ^a   Watada, Hirotaka ^a   Kawamori, Ryuzo ^a   Ohta, Shigeo ^d  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b YANBIAN UNIVERSITY   (China)

^c JUNTENDO UNIVERSITY   (Japan)

^d NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Atherosclerosis; Diabetes; Mitochondrial DNA; Oxidative stress; Somatic mutation

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ATHEROSCLEROSIS; BLOOD SAMPLING; CAROTID ARTERY; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MARKER; DNA EXTRACTION; FEMALE; GENE MUTATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; POINT MUTATION; POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SOMATIC MUTATION;

EID: 2342485822     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1293.020     Document Type: Conference Paper

References (21)

1. Leu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet. 1: 368-371.
2. KADOWAKI, T. 1994. A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. N. Engl. J. Med. 330: 962-968.
3. KOBAYASHI, Y. 1990. A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes). Biochem. Biophys. Res. Commun. 173: 816-822.
4. MUNSCHER, C. 1993. Human aging is associated with various point mutations in tRNA gene of mitochondrial DNA. Biol. Chem. Hoppe-Seyler 374: 1099-1104.
5. CORRAL-DEBRINSKI, M. 1992. Mitochondrial DNA deletion in human brain: regional variability and increase with advanced age. Nat. Genet. 2: 324-329.
6. OZAWA, T. 1995. Mechanism of somatic mitochondrial DNA mutations associated with age and diseases. Biochem. Biophys. Acta 1271: 177-189.
7. KADENBACH, B. 1995. Human aging is associated with stochastic somatic mutations of mitochondrial DNA. Mutat. Res. 338: 161-172.
8. DANDONA, P. 1996. Oxidative damage to DNA in diabetes mellitus. Lancet 347: 444-445.
9. HINOKIO, Y. 1999. Oxidative damage in diabetes mellitus: its association with diabetic complications. Diabetologia 42: 995-998.
10. KAWAMORI, R. 1995. Asymptomatic hyperglycemia and early atherosclerotic changes. Diabetes Res. Clin. Pract. 40 (Suppl.): S35-S42.
11. NISHIKAWA, T. 2000. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage. Nature 404: 787-790.
12. CAMBIEN, F. 1992. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 359: 641-644.
13. VIEDT, C. 2000. Differential activation of mitogen-activated protein kinases in smooth muscle cells by angiotensin II: involvement of P22phox and reactive oxygen species. Arterioscler. Thromb. Vasc. Biol. 20: 949-948.
14. HAYASHI, J. 1994. Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects. J. Biol. Chem. 269: 6878-6883.
15. INOUE, N. 1998. Polymorphism of the NADH/NADPH oxidase p22phox gene in patients with coronary artery disease. Circulation 97: 135-137.
16. KOGAWA, K. 1997. Effect of polymorphism of apoplipoprotein E and angiotensis-converting enzyme genes on arterial wall thickness. Diabetes 46: 682-687.
17. LIANG, P. 1997. Increased prevalence of mitochondrial DNA deletions in skeletal muscle of older individuals with impaired glucose tolerance: possible marker of glycemic stress. Diabetes 46: 920-923.
18. FUKAGAWA, N.K. 1999. Aging and high concentrations of glucose potentiate injury to mitochondrial DNA. Free Radic. Biol. Med. 27: 1437-1443.
19. SUZUKI, S. 1999. Oxidative damage to mitochondrial DNA and its relationship to diabetic complications. Diabetes Res. Clin. Pract. 45: 161-168.
20. NOMIYAMA, T. 2002. Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients. Diabetologia 45: 1577-1583.
21. PIAO, L.S. 2002. Combined genotypes of ACE and NADPH oxidase p22phox associated with somatic mutation of mtDNA and carotid intima-media thickness in Japanese patients with type 2 diabetes mellitus. Curr. Ther. Res. 12: 842-852.