Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse

Pharmacology and Therapeutics

Volumn 129, Issue 2, 2011, Pages 149-171

  Breese, George R ^a   Sinha, Rajita ^b   Heilig, Markus ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Adaptation; Alcohol; Alcoholism; Brain imaging; Brain sites; Corticotropin releasing factor; Cytokines; Relapse; Stress; Substance P

Indexed keywords

ALCOHOL; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BACLOFEN; BUSPIRONE; LY 686017; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROTRANSMITTER; UNCLASSIFIED DRUG;

ALCOHOL ABSTINENCE; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ALLOSTASIS; ANXIETY; ARTICLE; DRUG MECHANISM; EMOTIONAL STRESS; HUMAN; KINDLING; NEGATIVE SYNDROME; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; WITHDRAWAL SYNDROME;

EID: 79151484610     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2010.09.007     Document Type: Review

References (334)

1. R.N. Achur, W.M. Freeman, and K.E. Vrana Circulating cytokines as biomarkers of alcohol abuse and alcoholism J Neuroimmune Pharmacol 5 2010 83 91
2. B. Adinoff, K. Junghanns, F. Kiefer, and S. Krishnan-Sarin Suppression of the HPA axis stress-response: implications for relapse Alcohol Clin Exp Res 29 2005 1351 1355
3. B. Adinoff, S.R. Krebaum, P.A. Chandler, W. Ye, M.B. Brown, and M.J. Williams Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 1: adrenocortical and pituitary glucocorticoid responsiveness Alcohol Clin Exp Res 29 2005 517 527
4. B. Adinoff, S.R. Krebaum, P.A. Chandler, W. Ye, M.B. Brown, and M.J. Williams Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone Alcohol Clin Exp Res 29 2005 528 537
5. M. Adler, E. Geller, X. Chen, and T. Rogers Viewing chemokines as a third major system of communication in the brain AAPS J 7 2006 E865 E870
6. M. al'Absi, D. Hatsukami, and G.L. Davis Attenuated adrenocorticotropic responses to psychological stress are associated with early smoking relapse Psychopharmacology 181 2005 107 117
7. H.L. Altschuler, P.E. Phillips, and D.A. Feinhandler Alteration of alcohol self-administration by naltrexone Life Sci 26 1980 679 688
8. H. Anisman Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder Rev Psychiatry Neurosci 34 2009 4 20
9. H. Anisman, and Z. Merali Cytokines, stress and depressive illness: brain-immune interactions Ann Med 35 2003 2 11
10. H. Aujla, R. Martin-Fardon, and F. Weiss Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence Neuropsychopharmacology 33 2008 1818 1826
11. E. Badrick, M. Bobak, A. Britton, C. Kirschbaum, M. Marmot, and M. Kumari The relationship between smoking status and cortisol secretion J Clin Endocrinol Metab 92 2007 819 824
12. H.A. Baldwin, S. Rassnick, J. Rivier, G.F. Koob, and T.K. Britton CRF antagonist reverses the "anxiogenic" response to alcohol withdrawal in the rat Psychopharmacology 103 1991 227 232
13. T.L. Bale, and W.W. Vale CRF and CRF receptors: role in stress responsivity and other behaviors Ann Rev Pharmacol Toxicol 44 2004 525 557
14. J.C. Ballenger, and R.M. Post (1978) Kindling as a model for alcohol withdrawal syndromes Br J Psychiatry 133 1978 1 14
15. C.S. Barr, R.L. Dvoskin, M. Gupte, and G.F. Grant The impact of a family history of alcoholism on the relationship between age of onset of alcohol use and DSM-IV alcohol dependence: results of the National Longitudinal Alcohol Epidemiological Survey Alcohol Health Res World 22 1998 144 147
16. C.S. Barr, R.L. Dvoskin, M. Gupte, W. Sommer, and H. Sun Functional CRH variation increases stress-induced alcohol consumption in primates Proc Natl Acad Sci 25 106 2009 14593 14598
17. S. Bauer, B.J. Kerr, and P.H. Patterson The neuropoietic cytokine family in development, plasticity, disease and injury Nat Neurosci Rev 8 2007 221 232
18. H.C. Becker, and R.L. Hale Repeated episodes of alcohol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal "kindling" Alcohol Clin Exp Res 17 1993 94 98
19. H.C. Becker, and M.F. Lopez Increased alcohol drinking after repeated chronic alcohol exposure and withdrawal experience in C57BL/6 mice Alcohol Clin Exp Res 28 2004 1829 1838
20. J.B. Becker, L.M. Monteggia, T.S. Perrot-Sinal, R.S. Romeo, J.R. Taylor, and R. Yehuda Stress and disease: is being female a predisposing factor? J Neurosci 27 2007 11851 11855
21. H. Begleiter Alcohol consumption subsequent to physical dependence Adv Exp Med Biol 59 1975 373 378
22. H. Begleiter, and B. Porjesz Persistence of brain hyperexcitability following chronic alcohol exposure in rats Adv Exp Med Biol 85B 1977 209 222
23. S. Behrendt, H.U. Wittchen, M. Höfler, R. Lieb, N.C. Low, J. Rehm, and K. Beesdo Risk and speed of transitions to first alcohol dependence symptoms in adolescents: a 10-year longitudinal community study in Germany Addiction 103 2008 1638 1647
24. J. Besheer, R.A. Stevenson, and C.W. Hodge mGlu5 receptors are involved in the discriminative stimulus effects of self-administered alcohol in rats Eur J Pharmacol 551 2006 71 75
25. J. Besheer, J.J. Grondin, R. Cannady, A.C. Sharko, S. Faccidomo, and C.W. Hodge Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of alcohol self-administration in a rat genetic model of high alcohol intake Biol Psychiatry 87 2010 812 822
26. L.J. Bierut, A. Agrawal, K.K. Bucholz, K.F. Doheny, C. Laurie, and E. Pugh A genome-wide association study of alcohol dependence Proc Natl Acad Sci 107 2010 5082 5087
27. B.M. Booth, and F.C. Blow The kindling hypothesis: further evidence from a U.S. national study of alcohol men Alcohol Alcohol 28 1993 593 598
28. C. Bouza, M. Angeles, A. Munoz, and J.M. Amate Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review Addiction 99 2004 811 828
29. C.M. Bradizza, P.R. Stasiewicz, and N.D. Paas Relapse to alcohol and drug use among individuals diagnosed with co-occurring mental health and substance use disorders: a review Clin Psych Rev 26 2006 162 178
30. K.T. Brady, S.E. Back, A.E. Waldrop, A.L. McRae, R.F. Anton, and H.P. Upadhyaya Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorder Alcohol Clin Exp Res 30 2006 938 946
31. K.T. Brady, A.E. Waldrop, A.L. McRae, S.E. Back, M.E. Saladin, and H.P. Upadhyaya The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response J Stud Alcohol 67 2006 700 706
32. D.F. Braus, J. Wrase, S. Grüsser, D. Hermann, M. Ruf, and H. Flor Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics J Neural Transm 108 2001 887 894
33. G. Breese, K. Chu, C. Dayas, D. Funk, D. Knapp, and G. Koob Stress enhancement of craving during sobriety: risk of relapse Alcohol Clin Exp Res 29 2005 185 195
34. G.R. Breese, S. Coyle, A.C. Towle, R.A. Mueller, T.J. McCown, and G.D. Frye Alcohol-induced locomotor stimulation in rats following thyrotropin releasing hormone J Pharmacol Exp Ther 229 1984 731 737
35. G.R. Breese, D.J. Knapp, M. Huang, T.A. Wills, R. Angel, S.E. Sinnett, and B.A. Whitman Stress between cycles of access to voluntary ethanol increases both ethanol intake and sensitizes anxiety-like behavior in alcohol preferring p rats Alcohol Clin Exp Res 34 2010 200A
36. G.R. Breese, D.J. Knapp, D.H. Overstreet, M. Navarro, T.A. Wills, and R.A. Angel Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize alcohol withdrawal-induced anxiety-like behavior Neuropsychopharmacology 33 2008 867 876
37. 1A agonist Neuropsychopharmacology 29 2004 470 482
38. G.R. Breese, D.H. Overstreet, and D.J. Knapp Conceptual framework for the etiology of alcoholism-a "kindling"/stress hypothesis Psychopharmacology 178 2005 367 380
39. 1A-receptor agonist Neuropsychopharmacology 30 2005 1662 1669
40. K.J. Brower Alcohol's effects on sleep in alcoholics Alcohol Res Health 25 2001 110 125
41. S.A. Brown, and S.F. Tapert Adolescence and the trajectory of alcohol use: basic to clinical studies Ann NY Acad Sci 1021 2004 234 244
42. S.A. Brown, P. Vik, J.R. McQuaid, T. Patterson, M.R. Irwin, and I. Grant Severity of psychosocial stress and outcome of alcoholism treatment J Abnorm Psychol 99 1990 344 348
43. S. Brown, P. Vik, T.L. Patterson, I. Grant, and M.A. Schuckit Stress vulnerability and adult alcohol relapse J Stud Alcohol 56 1995 538 545
44. R.J. Cadoret, C.A. Cain, and W.M. Grove Development of alcoholism in adoptees raised apart from alcoholic biologic relatives Arch Gen Psychiatry 37 1980 561 563
45. H. Cappel, and C.P. Herman Alcohol and tension reduction: a review Q J Stud Alcohol 33 1972 33 64
46. T.M. Chaplin, K. Hong, K. Bergquist, and R. Sinha Gender differences in response to emotional stress: an assessment across subjective, behavioral, and physiological domains and relations to alcohol craving Alcohol Clin Exp Res 32 2008 1242 1250
47. D.A. Charney, E. Zikos, and K.J. Gill Early recovery from alcohol dependence: factors that promote or impede abstinence J Subst Abuse Treat 38 2010 42 50
48. N. Chaudhri, L.L. Sahuque, W.W. Schairer, and P.H. Janak Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking Neuropsychopharmacology 35 2010 783 791
49. J.A. Chester, A.M. Blose, M. Zweifel, and J.M. Froehlich Effects of stress on alcohol consumption in rats selectively bred for high or low alcohol drinking Alcohol Clin Exp Res 28 2004 385 393
50. K. Chu, G.F. Koob, M. Cole, E.P. Zorrilla, and A.J. Roberts Dependence-induced increases in alcohol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout Pharmacol Biochem Behav 86 2007 813 821
51. R. Ciccocioppo, D.R. Gehlert, A. Ryabinin, S. Kaur, A. Cippitelli, and A. Thorsell Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond Alcohol 43 2009 491 498
52. A. Cippitelli, R. Damadzic, A.C. Hansson, E. Singley, W.H. Sommer, R. Eskay, A. Thorsell, and M. Heilig Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking Psychopharmacology 208 2010 417 426
53. R.L. Clapper, S.L. Buka, E.C. Goldfield, L.P. Lipsitt, and M.T. Tsuang Adolescent problem behaviors as predictors of adult alcohol diagnoses Int J Addict 30 1995 507 523
54. C.R. Cloninger, M. Bohman, and S. Sigvardsson Inheritance of alcohol abuse. Cross-fostering analysis of adopted men Arch Gen Psychiatry 38 1981 861 868
55. K.C. Collimore, R.N. Carleton, S.G. Hofmann, and G.J. Asmundson Posttraumatic stress and social anxiety: the interaction of traumatic events and interpersonal fears Depress Anxiety 27 2010 1017 1026
56. J.J. Conger The effects of alcohol on conflict behavior in the albino rat Q J Stud Alcohol 12 1951 1 29
57. J.J. Conger Alcoholism: theory, problem, and challenge. II. Reinforcement theory and the dynamics of alcoholism Q J Stud Alcohol 17 1956 296 305
58. K.P. Conway, W. Compton, F.S. Stinson, and B.F. Grant Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions J Clin Psychiatry 67 2006 247 257
59. C.J. Cook Stress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala Physiol Behav 82 2004 751 762
60. N.L. Cooney, M.D. Litt, P.A. Morse, L.O. Bauer, and L. Gaupp Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men J Abnorm Psychol 106 1997 243 250
61. M.L. Cooper, M. Russell, J.B. Skinner, M.R. Frone, and P. Mudar Stress and alcohol use: moderating effects of gender, coping and alcohol expectancies J Abnorm Psychol 101 1992 139 152
62. N.S. Cotton The familial incidence of alcoholism: a review J Stud Alcohol 40 1979 89 116
63. D.A. Dawson, R.B. Goldstein, S.P. Chou, W.J. Ruan, and B.F. Grant Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders Alcohol Clin Exp Res 32 2008 2149 2160
64. D.A. Dawson, R.B. Goldstein, and B.F. Grant Rates and correlates of relapse among individuals in remission from DSM-IV alcohol dependence: a 3-year follow-up Alcohol Clin Exp Res 31 2007 2036 2045
65. T. Deak, K. Bordner, N. McElderry, C. Barnum, P. Blandino Jr., M. Deak, and S. Tammariello Stress-induced increases in hypothalamic IL-1: systematic analysis of multiple stressor paradigms Br Res Bull 64 2005 541 556
66. S. del Cerro, and J. Borrell Interleukin-1 affects the behavioral despair response in rats by an indirect mechanism which requires endogenous CRF Brain Res 528 1990 162 164
67. J.A. Deutsch, and H.S. Koopmans Preference enhancement for alcohol by passive exposure Science 179 1973 1242 1243
68. E.J. Devor, and C.R. Cloninger Genetics of alcoholism Annu Rev Genet 23 1989 19 36
69. D.J. DeWit, E.M. Adlaf, D.R. Offord, and A.C. Ogborne Age at first alcohol use: a risk factor for the development of alcohol disorders Am J Psychiatry 157 2000 745 750
70. R. Dhaher, D. Finn, C. Snelling, and R. Hitzemann Lesions of the extended amygdala in C57BL/6J mice do not block the intermittent alcohol vapor-induced increase in alcohol consumption Alcohol Clin Exp Res 32 2008 197 208
71. D.M. Dick, and L.J. Bierut The genetics of alcohol dependence Curr Psychiatry Rep 8 2006 151 157
72. S.P. Drummond, J.C. Gillin, T.L. Smith, and A. Demodena The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse Alcohol Clin Exp Res 22 1998 1796 1802
73. A.J. Dunn, and C.W. Berridge Physiological and behavioral response to corticotropin-releasing factor administration: is CRF a mediator of anxiety-like behavior or stress responses? Brain Res Rev 15 1990 71 100
74. A.J. Dunn, A.H. Swiergiel, and R. de Beaurepaire Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev 29 2005 891 909
75. K. Ebner, N.M. Rupniak, A. Saria, and N. Singewald Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats Proc Natl Acad Sci 101 2004 4280 4285
76. D. Economidou, L. Mattioli, C. Cifani, M. Perfumi, M. Massi, and V. Cuomo Effect of the cannabinoid CB1 receptor antagonist SR-141716A on alcohol self-administration and alcohol-seeking behaviour in rats Psychopharmacology 183 2006 394 403
77. H.J. Edenberg, and T. Foroud The genetics of alcoholism: identifying specific genes through family studies Addict Biol 11 2006 386 396
78. G. Fein, and B. Landman Treated and treatment-naive alcoholics come from different populations Alcohol 36 2005 19 26
79. D.A. Finn, C. Snelling, A.M. Fretwell, M.A. Tanchuck, L. Underwood, M. Cole, J.C. Crabbe, and A.J. Roberts Increased drinking during withdrawal from intermittent alcohol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41) Alcohol Clin Exp Res 31 2007 939 949
80. H.C. Fox, K.L. Bergquist, K.I. Hong, and R. Sinha Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals Alcohol Clin Exp Res 31 2007 395 403
81. H.C. Fox, C. D'Sa, and R. Sinha Altered cytokine responses are associated with enhanced stress-induced craving in alcohol dependent individuals Alcohol Clin Exp Res 34 2010 46A Supplement
82. H.C. Fox, K.I. Hong, K. Siedlarz, R. Sinha, K. Bergquist, G. Anderson, M.J. Kreek, and R. Sinha Sex-specific dissociations in autonomic and HPA responses to stress and cues in alcohol-dependent patients with cocaine abuse Alcohol Alcohol 44 2009 575 585
83. H.C. Fox, E.D. Jackson, and R. Sinha Difficulties in emotion regulation and impulse control in recently abstinent alcoholics compared with social drinkers Psychoneuroendocrinology 34 2009 1198 1207
84. H. Fox, M. Talih, R. Malison, G. Anderson, M. Kreek, and R. Sinha Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues Psychoneuroendocrinolgy 30 2005 880 891
85. G.D. Frye, T.J. McCown, and G.R. Breese Characterization of susceptibility to audiogenic seizures in alcohol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum J Pharmacol Exp Ther 227 1983 663 670
86. 2 agonist administered into the central nucleus of the amygdala decreases alcohol self-administration in alcohol-dependent rats Brain Res 1155 2007 172 178
87. D. Funk, Z. Li, and A.D. Lê Effects of environmental and pharmacological stressors on c-fos and corticotropin-releasing factor mRNA in rat brain: relationship to the reinstatement of alcohol seeking Neuroscience 138 2006 235 243
88. C.K. Funk, L.E. O'Dell, E.F. Crawford, and G.F. Koob Corticotropin- releasing factor within the central nucleus of the amygdala mediates enhanced alcohol self-administration in withdrawn, alcohol-dependent rats J Neurosci 26 2006 11324 11332
89. C.K. Funk, E.P. Zorrilla, M.J. Lee, K.C. Rice, and G.F. Koob Corticotropin-releasing factor 1 antagonists selectively reduce alcohol self-administration in alcohol-dependent rats Biol Psychiatry 61 2007 78 86
90. T. Furmark, L. Appel, A. Michelgard, K. Wahlstedt, F. Ahs, S. Zancan, and E. Jacobsson Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo Biol Psychiatry 58 2005 132 142
91. G.J. Gatto, W.J. McBride, J.M. Murphy, L. Lumeng, and T.K. Li Alcohol self-infusion into the ventral tegmental area by alcohol-preferring rats Alcohol 11 1994 557 564
92. D.R. Gehlert, A. Cippitelli, A. Thorsell, A.D. Lê, P.A. Hipskind, and C. Hamdouchi 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2, 6-dimethyl-imidazo[1, 2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism J Neurosci 27 2007 2718 2726
93. L. Gentry, J. Chung, N. Aung, S. Keller, K. Heinrich, and J. Maddock Gender differences in stress and coping among adults living in Hawaii Cal J Health Promotion 5 2007 89 102
94. M.S. George, R.F. Anton, C. Bloomer, C. Teneback, D.J. Drobes, J.P. Lorberbaum, Z. Nahas, and D.J. Vincent Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues Arch Gen Psychiatry 58 2001 345 352
95. D.T. George, J. Gilman, J. Hersh, A. Thorsell, D. Herion, and C. Geyer Neurokinin 1 receptor antagonism as a possible therapy for alcoholism Science 319 2008 1536 1539
96. R. Gilbertson, R. Prather, and S.J. Nixon The role of selected factors in the development and consequence of alcohol dependence Alcohol Res Health 31 2008 389 399
97. J.M. Gilman, and D.W. Hommer Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients Addict Biol 13 2008 423 434
98. J.M. Gilman, V.A. Ramchandani, M.B. Davis, J.M. Bjork, and D.W. Hommer Why we like to drink: a functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol J Neurosci 28 2008 4583 4591
99. N.W. Gilpin, H.N. Richardson, and G.F. Koob Effects of CRF1-receptor and opioid-receptor antagonist on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats Alcohol Clin Exp Res 32 2008 1535 1542
100. N.W. Gilpin, H.N. Richardson, L. Lumeng, and G.F. Koob Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats Alcohol Clin Exp Res 32 2008 1688 1696
101. B.S. Givens, and G.R. Breese Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by alcohol in the rat medial septal area J Pharmacol Exp Ther 254 1990 528 538
102. B.F. Grant, and D.A. Dawson Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey J Subst Abuse 9 1997 103 110
103. B.R. Grant, F.S. Stinson, D.A. Dawson, S.P. Chou, M.C. Dufour, and W. Compton Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders results from the national epidemiologic survey on alcohol and related conditions Arch Gen Psychiatry 61 2004 807 816
104. S.M. Grüsser, J. Wrase, S. Klein, D. Hermann, M.N. Smolka, M. Ruf, W. Weber-Fahr, H. Flor, K. Mann, D.F. Braus, and A. Heinz Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics Psychopharmacology 175 2004 296 302
105. J.J. Haddad Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects Biochem Biophys Res Commun 323 2004 361 371
106. A.C. Hansson, A. Cippitelli, W.H. Sommer, R. Ciccocioppo, and M. Heilig Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol Addict Biol 12 2007 30 34
107. A.C. Hansson, A. Cippitelli, W.H. Sommer, A. Fedeli, K. Björk, L. Soverchia, A. Terasmaa, M. Massi, M. Heilig, and R. Ciccocioppo Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress Proc Natl Acad Sci 103 2006 15236 15241
108. R.L. Hauger, V. Risbrough, R.H. Oakley, J.A. Olivares-Reyes, and F.M. Dautzenberg Role of CRF receptor signaling in stress vulnerability, anxiety, and depression Ann NY Acad Sci 1179 2009 120 143
109. S. Hayley, M.O. Poulter, Z. Merali, and H. Anisman The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity Neuroscience 135 2005 659 678
110. J. He, and F.T. Crews Increased MCP-1 and microglia in various regions of the human alcoholic brain Exp Neurol 210 2008 349 358
111. M. Heilig Molecular biology teases out two distinct forms of alcoholism Scientist 22 2008 31 35
112. M. Heilig, and M. Egli Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms Pharmacol Ther 111 2006 855 876
113. M. Heilig, and G.F. Koob A key role for corticotropin-releasing factor in alcohol dependence Trends Neurosci 30 2007 399 406
114. M. Heilig, G.F. Koob, R. Ekman, and K.T. Britton Corticotropin-releasing factor and neuropeptide Y: role in emotional integration Trends Neurosci 17 1994 80 85
115. M. Heilig, M. Egli, J.C. Crabbe, and H.C. Becker Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addict Biol 15 2010 169 184
116. M. Heilig, A. Thorsell, W.H. Sommer, A.C. Hansson, V.A. Ramchandani, and D.T. George Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues Neurosci Biobehav Rev 35 2010 334 344
117. 18F]DMFP PET study in detoxified alcoholic patients Am J Psychiatr 162 2005 1515 1520
118. 2 receptors in the ventral striatum and central processing of alcohol cues and craving Am J Psychiatry 161 2004 1783 1789
119. R.L. Higgins, and G.A. Marlatt Effects of anxiety arousal on the consumption of alcohol by alcoholics and social drinkers J Consult Clin Psychol 41 1973 426 433
120. R.L. Higgins, and G.A. Marlatt Fear of interpersonal evaluation as a determinant of alcohol consumption in male social drinkers J Abnorm Psychol 84 1975 644 645
121. R.W. Hingson, T. Heeren, and M.R. Winter Age at drinking onset and alcohol dependence: age at onset, duration, and severity Arch Peiatr Adolesc Med 160 2006 739 746
122. S.M. Hölter, and R. Spanagel Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term alcohol-experienced rats Psychopharmacology 145 1999 360 369
123. C.J. Hopfer, T.J. Crowley, and J.K. Hewitt Review of twin and adoption studies of adolescent substance use J Am Acad Child Adolesc Psychiatry 42 2003 710 719
124. M. Huang, D.H. Overstreet, D.J. Knapp, R. Angel, T.A. Wills, and M. Navarro Corticotropin releasing factor (CRF) sensitization of alcohol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization J Pharmacol Exp Ther 332 2010 298 307
125. C.L. Hubbell, S.A. Czirr, G.A. Hunter, C.M. Beaman, N.C. LeCann, and L.D. Reid Consumption of alcohol solution is potentiated by morphine and attenuated by naloxone persistently across repeated daily administrations Alcohol 3 1986 39 54
126. W.A. Hunt, L.W. Barnett, and L.G. Branch Relapse rates in addiction programs J Clin Psychol 27 1971 455 456
127. B.E. Hunter, D.W. Walker, and J.N. Riley Dissociation between physical dependence and volitional alcohol consumption: role of multiple withdrawal episodes Pharmacol Biochem Behav 2 1974 523 529
128. T. Imaki, T. Shibasaki, M. Hotta, and H. Demura Intracerebroventricular administration of corticotropin releasing factor induces c-fos mRNA expression in brain regions related to stress responses: comparison with pattern of c-fos mRNA induction by stress Brain Res 616 1993 114 125
129. K. Junghanns, J. Backhaus, U. Tietz, W. Lange, J. Bernzen, and T. Wetterling Impaired serum cortisol stress response is a predictor of early relapse Alcohol Alcohol 38 2003 189 193
130. M. Keller On the loss-of-control phenomenon in alcoholism Br J Addict Alcohol Other Drugs 67 1972 153 166
131. R.C. Kessler, K.A. McGonagle, M. Swartz, D.G. Blazer, and C.B. Nelson Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence J Affect Disord 29 1993 85 96
132. R.C. Kessler, K.A. McGonagle, S. Zhao, C.B. Nelson, M. Hughes, and S. Eshleman Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey Arch Gen Psychiatry 51 1994 8 19
133. F. Kiefer, H. Jahn, M. Schick, and K. Wiedemann Alcohol intake, tumor necrosis factor-α, leptin and craving: factors of possible vicious circle? Alcohol Alcohol 37 2002 401 404
134. D. Knapp, D. Overstreet, S. Moy, and G. Breese SB242084, flumazenil, and CRA1000 block alcohol withdrawal-induced anxiety Alcohol 32 2004 101 111
135. D. Knapp, D. Overstreet, and G. Breese Modulation of alcohol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/GABA ligands Alcohol Clin Exp Res 29 2005 553 563
136. D. Knapp, D. Overstreet, and G. Breese Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and alcohol withdrawal Alcohol Clin Exp Res 31 2007 582 595
137. D.J. Knapp, D.H. Overstreet, R.A. Angel, M. Navarro, and G.R. Breese The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic alcohol or repeated stress Alcohol Clin Exp Res 31 2007 1872 1882
138. L. Kofoed, M.J. Friedman, and R. Peck Alcoholism and drug abuse in patients with PTSD Psychiat Q 64 1993 151 171
139. G.F. Koob Alcoholism: allostasis and beyond Alcohol Clin Exp Res 27 2003 232 243
140. G.F. Koob A role of brain stress systems in addiction Neuron 59 2008 11 34
141. G.F. Koob Neurobiological substrates for the dark side of compulsivity in addiction Neuropharmacology 56 Suppl 1 2009 18 31
142. G.F. Koob, and S.C. Heinrichs A role of corticotropin releasing factor and urocortin in behavioral responses to stressors Brain Res 848 1999 141 152
143. G.F. Koob, and M. Le Moal Drug abuse: hedonic homeostatic dysregulation Science 278 1997 52 58
144. G.F. Koob, and M. Le Moal Drug addiction, dysregulation of reward, and allostasis Neuropsychopharmacology 24 2001 97 129
145. G.F. Koob, and M. Le Moal Plasticity of reward neurocircuitry and the 'dark side' of drug addiction Nat Neurosci 8 2005 1442 1444
146. G.F. Koob, and M. Le Moal Addiction and the brain antireward system Annu Rev Psychol 59 2008 29 53
147. S.M. Korte, J.M. Koolhaas, J.C. Wingfield, and B.S. McEwen The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease Neurosci Biobehav Rev 29 2005 3 38
148. J.H. Krystal, E. Webb, N.L. Cooney, H.R. Kranzler, S.W. Southwick, G.R. Heninger, and D.S. Charney Serotonergic and noradrenergic dysregulation in alcoholism: m-chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects Am J Psychiatry 153 1996 83 92
149. B.M. Kudielka, and C. Kirschbaum Sex differences in HPA axis responses to stress: a review Biol Psychol 69 2005 113 132
150. A.D. Lê, S. Harding, W. Juzytsch, P.J. Fletcher, and Y. Shaham The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol J Neurosci 22 2002 7844 7849
151. A.D. Lê, S. Harding, W. Juzytsch, D. Funk, and Y. Shaham Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats Psychopharmacology 179 2005 366 373
152. A.D. Lê, S. Harding, W. Juzytsch, J. Watchus, U. Shalev, and Y. Shaham The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats Psychopharmacology 150 2000 317 324
153. A.D. Lê, C.X. Poulos, S. Harding, J. Watchus, W. Juzytsch, and Y. Shaham Effects of naltrexone and fluoxetine on alcohol self-administration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress Neuropsychopharmacology 21 1999 435 444
154. A.D. Lê, B. Quan, W. Juzytsch, P.J. Fletcher, N. Joharchi, and Y. Shaham Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats Psychopharmacology 135 1998 169 174
155. A.D. Lê, and Y. Shaham Neurobiology of relapse to alcohol in rats Pharmacol Ther 94 2002 137 156
156. A.D. Lê, A. Wang, S. Harding, W. Juzytsch, and Y. Shaham Nicotine increases alcohol self-administration and reinstates alcohol seeking behavior in rats Psychopharmacology 168 2003 216 221
157. R. Lechtenberg, and T.M. Worner Relative kindling effect of detoxification and non-detoxification admissions in alcoholics Alcohol Alcohol 26 1991 221 225
158. L. Li, C. Power, S. Kelly, C. Kirschbaum, and C. Hertzman Lifetime socioeconomic position and cortisol patterns in mid-life Psychoneuroendocrinology 32 2007 824 833
159. T.L. Lindquist, L.J. Beilin, and M.W. Knuiman Influence of lifestyle, coping, and job stress on blood pressure in men and women Hypertension 29 1997 1 7
160. M.D. Litt, N.L. Cooney, and P. Morse Reactivity to alcohol-related stimuli in the laboratory and in the field: predictors of craving in treated alcoholics Addiction 95 2000 889 900
161. L. Liu, M.R. Hutchinson, J.M. White, A.A. Somogyi, and J.K. Coller Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence Pharmacogenet Genomics 19 2009 869 876
162. X. Liu, and F. Weiss Additive effect of stress and drug cues on reinstatement of alcohol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms J Neurosci 22 2002 7856 7861
163. X. Liu, and F. Weiss Reversal of alcohol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously alcohol-dependent versus nondependent rats J Pharmacol Exp Ther 300 2002 882 889
164. X. Liu, and F. Weiss Stimulus conditioned to foot-shock stress reinstates alcohol-seeking behavior in an animal model of relapse Psychopharmacology 168 2003 184 191
165. M.F. Lopez, and H.C. Becker Effect of pattern and number of chronic alcohol exposures on subsequent voluntary alcohol intake in C57BL/6J mice Psychopharmacology 181 2005 688 696
166. W.R. Lovallo, S.L. Dickensheets, D.A. Myers, T.L. Thomas, and S.J. Nixon Blunted stress cortisol response in abstinent alcoholic and polysubstance- abusing men Alcohol Clin Exp Res 24 2000 651 658
167. E.G. Lowery, M. Spanos, M. Navarro, A.M. Lyons, C.W. Hodge, and T.E. Thiele CRF-1 antagonist and CRF-2 agonist decrease binge-like alcohol drinking in C57BL/6J mice independent of the HPA axis Neuropsychopharmacology 35 2010 1241 1252
168. A.M. Ludwig, A. Wikler, and L.H. Stark The first drink: psychobiological aspects of craving Arch Gen Psychiatry 30 1974 539 547
169. W.J. Lynch, M.G. Kushner, J.M. Rawleigh, J. Fiszdon, and M.E. Carroll The effects of restraint stress in voluntary ethanol consumption in rats Exp Clin Psychopharmacol 7 1999 318 323
170. J.R. Mantsch, D.A. Baker, D.M. Francis, E.S. Katz, M.A. Hoks, and J.P. Serge Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats Psychopharmacology 195 2008 591 603
171. P.W. Marinelli, D. Funk, W. Juzytsch, S. Harding, K.C. Rice, Y. Shaham, and A.D. Lê The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats Psychopharmacology 195 2007 345 355
172. G. Marlatt, and J. Gordon Determinants of relapse: implications for the maintenance of behavioral change P. Davidson, S. Davidson, Behavioral Medicine: Changing health lifestyles 1980 Brunner/ Mazel New York 410 452
173. G.A. Marlatt, C.F. Kosturn, and A.R. Lang Provocation to anger and opportunity for retaliation as determinants of alcohol consumption in social drinkers J Abnorm Psychol 84 1975 652 659
174. D. Martinez, R. Gil, M. Slifstein, D.R. Hwang, Y. Huang, and A. Perez Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum Biol Psychiatry 58 2005 779 786
175. D. Martinez, J.H. Kim, J. Krystal, and A. Abi-Dargham Imaging the neurochemistry of alcohol and substance abuse Neuroimaging Clin N Am 17 2007 539 555
176. R. Martin-Fardon, R. Ciccocioppo, M. Massi, and F. Weiss Nociceptin prevents stress-induced alcohol- but not cocaine-seeking behavior in rats NeuroReport 11 2000 1939 1943
177. R. Martin-Fardon, E.P. Zorrilla, R. Ciccocioppo, and F. Weiss Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin Brain Res 1314 2010 145 146
178. W.J. McBride, J.A. Schultz, M.W. Kimpel, J.N. McClintick, M. Wang, J. You, and Z.A. Rodd Differential effects of alcohol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study Pharmacol Biochem Behav 92 2009 304 313
179. T.J. McCown, and G.R. Breese Multiple withdrawals from chronic alcohol "kindles" inferior collicular seizure activity: evidence for kindling of seizures associated with alcoholism Alcohol Clin Exp Res 14 1990 394 399
180. T.J. McCown, G.D. Frye, and G.R. Breese Evidence for site specific alcohol actions in the CNS Alcohol Drug Res 6 1985 423 429
181. T.J. McCown, L.J. Moray, J.S. Kizer, and G.R. Breese Interactions between TRH and alcohol in the medial septum Pharmacol Biochem Behav 24 1986 1269 1274
182. B.S. McEwen Allostasis and allostatic load: implications for neuropsychopharmacology Neuropsychopharmacology 22 2000 108 124
183. B.S. McEwen, and J.C. Wingfield The concept of allostasis in biology and biomedicine Horm Behav 43 2003 2 15
184. M. McGue, and W.G. Iacono The adolescent origins of substance use disorders Int J Methods Psychiatry Res 17 1 suppl 2008 S30 S38
185. J.R. McKay, C. Foltz, R.C. Stephens, P.J. Leahy, E.M. Crowley, and W. Kissin Predictors of alcohol and crack cocaine use outcomes over a 3-year follow-up in treatment seekers J Subst Abuse Treat 28 Suppl 1 2005 S73 S82
186. D.S. McLeod, K.C. Koenen, J.M. Meyer, M.J. Lyons, S. Eisen, W. True, and J. Goldberg Genetic and environmental influences on the relationship among combat exposure, posttraumatic stress disorder symptoms, and alcohol use J Trauma Stress 14 2001 259 275
187. R.A. Meisch Relationship between physical dependence on alcohol and reinforcing properties of alcohol in animals NIAAA Res Monogr 13 1983 27 32
188. R.A. Meisch, and R.B. Stewart Alcohol as a reinforcer: a review of laboratory studies of non-human primates Behav Pharmacol 5 1994 425 440
189. R.I. Melendez, L.D. Middaugh, and P.W. Kalivas Development of an alcohol deprivation and escalation effect in C57BL/6J mice Alcohol Clin Exp Res 30 2006 2017 2025
190. E. Merlo-Pich, M. Lorang, M. Yeganeh, F.R. deFonseca, J. Raber, G.F. Koob, and F. Weiss Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and alcohol withdrawal as measured by microdialysis J Neurosci 15 1995 5439 5447
191. A. Michelgard, L. Appel, A. Pissiota, O. Frans, B. Langstrom, M. Bergstrom, and M. Fredrikson Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system Biol Psychiatry 61 2007 1002 1006
192. W.R. Miller, V.S. Westerberg, R.J. Harris, and J.S. Tonigan What predicts relapse? Prospective testing of antecedent models Addiction 91 1996 155 171 (Suppl.)
193. M. Minami, Y. Kuraishi, T. Yamaguchi, S. Nakai, Y. Hirai, and M. Satoh Immobilization stress induces interleukin-1 beta mRNA in the rat hypothalamus Neurosci Lett 123 1991 254 256
194. J.G. Modell, and J.M. Mountz Focal cerebral blood flow change during craving for alcohol measured by SPECT J Neurophysiol 7 1995 15 22
195. J.G. Modell, J.M. Mountz, and T.P. Beresford Basal ganglia/limbic striatal and thalamocortical involvement in craving and loss of control in alcoholism J Neuropsychiat Clin Neurosci 2 1990 123 144
196. P.M. Monti, J.A. Binkoff, D.B. Abrams, W.R. Zwick, T.D. Nirenberg, and M.R. Liepman Reactivity of alcoholics and nonalcoholics to drinking cues J Abnorm Psychol 96 1987 122 126
197. C.A. Munro, L.M. Oswald, E.M. Weerts, M.E. McCaul, and G.S. Wand Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependence Alcohol Clin Exp Res 29 2005 1133 1138
198. R.D. Myers, W.P. Stoltman, and G.E. Martin Effects of alcohol dependence induced artificially in the rhesus monkey on the subsequent preference for ethyl alcohol Physiol Behav 9 1972 43 48
199. H. Myrick, R.F. Anton, X. Li, S. Henderson, D. Drobes, K. Voronin, and M.S. George Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving Neuropsychopharmacology 29 2004 393 402
200. R. Nadal, A.M. Chappell, and H.H. Samson Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration Alcohol Clin Exp Res 22 1998 1190 1198
201. N.H. Naqvi, and A. Bechara The hidden island of addiction: the insula Trends Neurosci 32 2009 56 67
202. E.C. Nelson, A. Agrawal, M.L. Pergadia, J.C. Wang, J.B. Whitfield, and F.S. Saccone H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence Addict Biol 15 2010 1 11
203. E.J. Nestler, M. Barrot, R.J. DiLeone, A.J. Eisch, S.J. Gold, and L.M. Monteggia Neurobiology of depression Neuron 34 2002 13 25
204. K.T. Nguyen, T. Deak, S.M. Owens, T. Kohno, M. Fleshner, L.R. Watkins, and S.F. Maier Exposure to acute stress induces brain IL-1β protein in the rat J Neurosci 18 1998 2239 2246
205. S. Nolen-Hoeksema Sex differences in unipolar depression: evidence and theory Psych Bull 101 1987 259 282
206. R. Numan Multiple exposures to alcohol facilitate intravenous self-administration of alcohol by rats Pharmacol Biochem Behav 15 1981 101 108
207. L.E. O'Dell, A.J. Roberts, R.T. Smith, and G.F. Koob Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcohol Clin Exp Res 28 2004 1676 1682
208. S.S. O'Malley, A.J. Jaffe, G. Chang, R.S. Schottenfeld, R.E. Meyer, and B. Rounsaville Naltrexone and coping skills therapy for alcohol dependence: a controlled study Arch Gen Psychiatry 49 1992 881 887
209. C.P. O'Brien Anticraving medications for relapse prevention: a possible new class of psychoactive medications Am J Psychiatry 162 2005 1423 1431
210. K.A. O'Connor, J.D. Johnson, M.K. Hansen, J.L. Wieseler Frank, E. Maksimova, and L.R. Watkins Peripheral and central proinflammatory cytokine response to a severe acute stressor Brain Res 991 2003 123 132
211. M.F. Olive, H.N. Koenig, M.A. Nannini, and C.W. Hodge Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake Pharmacol Biochem Behav 72 2002 213 220
212. M.F. Olive, K.K. Mehmert, R. Camarini, J.A. Kim, C.J. Ou, and C.W. Hodge A role for corticotropin releasing factor (CRF) in alcohol consumption, sensitivity, and reward as revealed by CRF-deficient mice Psychopharmacology 165 2003 181 187
213. 2c ligands Psychopharmacology 187 2006 1 12
214. D. Overstreet, D. Knapp, and G. Breese Accentuated decrease in social interaction in rats subjected to repeated multiple alcohol withdrawals Alcohol Clin Exp Res 26 2002 1259 1268
215. 1 receptors Pharmacol Biochem Behav 77 2004 405 413
216. D. Overstreet, D. Knapp, and G.R. Breese Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from alcohol Pharmacol Biochem Behav 78 2004 459 464
217. D.H. Overstreet, D.J. Knapp, and G.R. Breese Pharmacological modulation of repeated alcohol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats Pharmacol Biochem Behav 81 2005 122 130
218. D.H. Overstreet, D.J. Knapp, and G.R. Breese Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats Alcohol Clin Exp Res 31 2007 1473 1481
219. 2C antagonist reduce social interaction deficit induced by multiple withdrawals in rats Psychopharmacology 167 2003 344 352
220. M.S. Park, J.H. Sohn, J.A. Suk, S.H. Kim, S. Sohn, and R. Sparacio Brain substrates of craving to alcohol cues in subjects with alcohol use disorder Alcohol Alcohol 42 2007 417 422
221. T.J. Payne, R.G. Rychtarik, N.B. Rappaport, P.O. Smith, M. Etscheidt, T.A. Brown, and C.A. Johnson Reactivity to alcohol-relevant beverage and imaginal cues in alcoholics Addict Behav 17 1992 209 217
222. G.S. Peng, Y.C. Chen, T.P. Tsao, M.F. Wang, and S.J. Yin Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele Pharmacogenet Genomics 17 2007 845 855
223. E.C. Penick, B.J. Powell, E.J. Nickel, M.R. Read, W.F. Gabrielli, and B.I. Liskow Examination of Cloninger's type I and type II alcoholism with a sample of men alcoholics in treatment Alcohol Clin Exp Res 14 1990 623 629
224. I.L. Petrakis, G. Gonzalez, R. Rosenheck, and J.H. Krystal Comorbity of alcoholism and psychiatric disorders Alcohol Res Health 26 2002 81 89
225. S.P. Pirkola, S.P. Pirkola, E. Isometsä, J. Suvisaari, H. Aro, and M. Joukamaa DSM-IV mood-, anxiety- and alcohol use disorders and their comorbidity in the Finnish general population-results from the Health 2000 Study Soc Psychiatry Psychiatr Epidemiol 40 2005 1 10
226. L.A. Pohorecky Interaction of alcohol and stress: research with experimental animals-an update Alcohol Alcohol 25 1990 263 276
227. B. Porjesz, and H. Begleiter Human evoked brain potentials and alcohol Alcohol Clin Exp Res 5 1981 304 317
228. C.A. Prescott, and K.S. Kendler Age at first drink and risk for alcoholism: a noncausal association Alcohol Clin Exp Res 23 1999 101 107
229. M.L. Pucak, and A.L. Kaplin Unkind cytokines: current evidence for the potential role of cytokines in immune-mediated depression Int Rev Psychiatry 17 2005 477 483
230. C.L. Raison, L. Capuron, and A.H. Miller Cytokines sing the blues: inflammation and the pathogenesis of depression Trends Immunol 27 2006 24 31
231. Ramchandani, V. A., Umhau, J., Pavon, F. J., Ruiz-Velasco, V., Margas, W., Sun, H., et al. (in press). A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry.
232. M. Rangaswamy, K.A. Jones, B. Porjesz, D.B. Chorlian, A. Padmanabhapillai, C. Kamarajan, S. Kuperman, J. Rohrbaugh, S.J. O'Connor, L.O. Bauer, M.A. Schuckit, and H. Begleiter Delta and theta oscillations as risk markers in adolescent offspring of alcoholics Int J Psychophysiol 63 2007 3 15
233. D.D. Rasmussen, M.A. Raskind, and G.F. Koob alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for alcohol Alcohol 42 2008 91 97
234. S. Rassnick, S.C. Heinrichs, K.T. Britton, and G.F. Koob Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of alcohol withdrawal Brain Res 605 1993 25 32
235. J. Rehm, C. Mathers, S. Popova, M. Thavorncharoensap, Y. Teerawattananon, and J. Patra Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders Lancet 373 2009 2223 2233
236. A receptors in the nucleus accumbens mediate moderate intake of alcohol J Neurosci 29 2009 543 549
237. R. Rimondini, C. Arlinde, W. Sommer, and M. Heilig Long-lasting increase in voluntary alcohol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol FASEB J 16 2002 27 35
238. R. Rimondini, W. Sommer, R. Dall'Olio, and M. Heilig Long-lasting tolerance to alcohol following a history of dependence Addict Biol 13 2008 26 30
239. R. Rimondini, W. Sommer, and M. Heilig A temporal threshold for induction of persistent alcohol preference: behavioral evidence in a rat model of intermittent intoxication J Stud Alcohol 64 2003 445 449
240. R. Rimondini, A. Thoirsell, and M.J. Heilig Suppression of alcohol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence Neurosci Lett 375 2005 129 133
241. M. Roberto, M.T. Cruz, N.W. Gilpin, V. Sabino, P. Schweitzer, and M. Bajo Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biol Psychiatry 67 2010 831 839
242. A.J. Roberts, C.J. Heyser, M. Cole, P. Griffin, and G.F. Koob Excessive alcohol drinking following a history of dependence: animal model of allostasis Neuropsychopharmacology 22 2000 581 594
243. Z.A. Rodd, R.L. Bell, K.A. Kuc, J.M. Murphy, L. Lumeng, T.K. Li, and W.J. McBride Effects of repeated alcohol deprivations on operant alcohol self-administration by alcohol-preferring (P) rats Neuropsychopharmacology 28 2003 1614 1621
244. Z.A. Rodd, R.I. Melendez, R.L. Bell, K.A. Kuc, Y. Zhang, J.M. Murphy, and W.J. McBride Intracranial self-administration of alcohol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons J Neurosci 24 2004 1050 1057
245. Z.A. Rodd-Henricks, D.L. McKinzie, J.M. Murphy, W.J. McBride, L. Lumeng, and T.K. Li The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations Alcohol Clin Exp Res 24 2000 747 753
246. Z.A. Rodd-Henricks, D.L. McKinzie, S.R. Shaikh, J.M. Murphy, W.J. McBride, L. Lumeng, and T.K. Li Alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after repeated deprivations Alcohol Clin Exp Res 24 2000 8 16
247. W. Rostène, P. Kitabgi, and S.M. Parsadaniantz Chemokines: a new class of neuromodulator? Nat Rev Neurosci 8 2007 895 903
248. T.J. Sajdyk, S.D. Fitz, and A. Shekhar The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor mediated behavioral stress response in the rat Stress 9 2006 21 28
249. H.H. Samson Initiation of alcohol reinforcement using a sucrose-substitution procedure in food and water sated rats Alcohol Clin Exp Res 10 1986 436 442
250. H.H. Samson, and J.L. Falk Alteration of fluid preference in alcohol-dependent animals J Pharmacol Exp Ther 190 1974 365 376
251. C. Sanchis-Segura, and R. Spanagel Behavioral assessment of drug reinforcement and addictive features in rodents: an overview Addict Biol 11 2006 2 38
252. M.A. Sayette, S. Shiffman, S.T. Tiffany, R.S. Niaura, C.S. Martin, and W.G. Shadel The measurement of drug craving Addiction 95 Supplement 2 2000 S189 S210
253. F. Schneider, U. Habel, M. Wagner, P. Franke, and J.B. Sallaoum Subcortical correlates of craving in recently abstinent alcoholic patients Am J Psychiatry 158 2001 1075 1083
254. M.A. Schuckit Alcohol-induced changes in body sway in men at high alcoholism risk Arch Gen Psychiatry 42 1985 375 379
255. M.A. Schuckit Reactions to alcohol in sons of alcoholics and controls Alcohol Clin Exp Res 12 1988 465 470
256. M.A. Schuckit The 1994 Isaacson Award Lecture: a prospective study of sons of alcoholics Alcohol Alcohol Suppl 2 1994 1 6
257. M.A. Schuckit Comorbidity between substance use disorders and psychiatric conditions Addiction 101 2006 76 88
258. M.A. Schuckit An overview of genetic influences in alcoholism J Subst Abuse Treat 36 2009 S5 S14
259. M.A. Schuckit Alcohol use disorders Lancet 373 2009 492 501
260. M.A. Schuckit, T.K. Li, C.R. Cloninger, and R.A. Deitrich Genetics of alcoholism Alcohol Clin Exp Res 9 1985 475 492
261. G. Schulteis, P. Hyytiä, S.C. Heinrichs, and G.F. Koob Effects of chronic alcohol exposure on oral self-administration of alcohol or saccharin by Wistar rats Alcohol Clin Exp Res 20 1996 164 171
262. A.D. Schweinsburg, M.P. Paulus, V.C. Barlett, L.A. Killeen, L.C. Caldwell, and Pulido An FMRI study of response inhibition in youths with a family history of alcoholism Ann NY Acad Sci 1021 2004 391 394
263. D. Seo, C. Lacadie, T.C. Constable, K.T. Bergquist, and R. Sinha Disrupted ventromedial prefrontal cortex function during stress and neutral relaxed states is predictive of alcohol relapse outcomes Alcohol Clin Exp Res 34 2010 161A Supplement:
264. Y. Shaham, and B.T. Hope The role of neuroadaptations in relapse to drug seeking Nat Neurosci 8 2005 1437 1439
265. Y. Shaham, U. Shalev, L. Lu, H. De Wit, and J. Stewart The reinstatement model of drug relapse: history, methodology and major findings Psychopharmacology 168 2003 3 20
266. L.M. Shin, and I. Liberzon The neurocircuitry of fear, stress, and anxiety disorders Neuropsychopharm Rev 35 2010 169 191
267. F. Shintani, T. Nakaki, S. Kanba, R. Kato, and M. Asai Role of interleukin-1 in stress responses. A putative neurotransmitter Mol Neurobiol 10 1995 47 71
268. F. Shintani, T. Nakaki, S. Kanba, K. Sato, G. Yagi, M. Shiozawa, S. Aiso, R. Kato, and M. Asai Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat J Neurosci 15 1995 1961 1970
269. R. Shivani, R.J. Goldsmith, and R.M. Anthenelli Alcoholism and psychiatric disorder Alcohol Res Health 26 2002 90 98
270. K. Shizuya, T. Komori, R. Fujiware, S. Miyahara, M. Ohmori, and J. Nomura The influence of restraint stress on the expression of mRNAs for IL-6 and the IL-6 receptor in the hypothalamus and midbrain of the rat Life Sci 61 1997 135 140 PL
271. I. Sillaber, and M.S. Henniger Stress and alcohol drinking Ann Med 36 2004 596 605
272. I. Sillaber, G. Rammes, S. Zimmermann, B. Mahal, W. Zieglgänsberger, and W. Wurst Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors Science 296 2002 931 933
273. J.D. Sinclair Drugs to decrease alcohol drinking Ann Med 22 1990 357 362
274. J.D. Sinclair Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism Alcohol Alcohol 36 2001 2 10
275. J.D. Sinclair, and R.J. Senter Development of an alcohol-deprivation effect in rats Q J Stud Alcohol 29 1968 863 867
276. R. Sinha How does stress increase risk of drug abuse and relapse Psychopharmacology 158 2001 343 359
277. R. Sinha The role of stress in addiction relapse Curr Psychiatry Rep 9 2007 388 395
278. R. Sinha Chronic stress, drug use, and vulnerability to addiction Ann N Y Acad Sci 1141 2008 105 130
279. R. Sinha Chronic alcohol related neuroadaptations in stress responses: effects on compulsive alcohol seeking and relapse outcomes Alcohol Clin Exp Res 32 2008 341a
280. R. Sinha Modeling stress and drug craving in the laboratory: implications for addiction treatment development Addict Biol 14 2009 84 98
281. R. Sinha, H.C. Fox, K.A. Hong, K. Bergquist, Z. Bhagwagar, and K.M. Siedlarz Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals Neuropsychopharmacology 34 2009 1198 1208
282. R. Sinha, M. Garcia, P. Paliwal, M.J. Kreek, and B.J. Rounsaville Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes Arch Gen Psychiatry 63 2006 324 331
283. R. Sinha, C. Lacadie, C.S.R. Li, V. Milivojevic, and K.T. Bergquist Altered corticostriatal-limbic responses to stress, alcohol-related and neutral relaxing cues in abstinent alcoholics compared to controls Alcohol Clin Exp Res 31 2007 453A Supplement:
284. R. Sinha, and C.S. Li Imaging stress and cue-induced drug and alcohol craving: association with relapse and clinical implications Drug Alcohol Rev 26 2007 25 31
285. R. Sinha, and S.S. O'Malley Craving for alcohol: findings from the clinic and the laboratory Alcohol Alcohol 34 1999 223 230
286. R. Sinha, K.A. Hong, D. Seo, H.C. Fox, and K. Berguist Neural and endocrine predictions of alcohol relapse risk Clin Exp Res 34 Supplement: 290A 2010
287. W.H. Sommer, R. Rimondini, A.C. Hansson, P.A. Hipskind, D.R. Gehlert, C.S. Barr, and M.A. Heilig Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence Biol Psychiatry 63 2008 139 145
288. M. Soyka, and S. Rösner Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review Curr Drug Abuse Rev 1 2008 280 291
289. R. Spanagel Alcoholism: a systems approach from molecular physiology to addictive behavior Physiol Rev 80 2009 649 705
290. R. Spanagel, and S.M. Hölter Pharmacological validation of a new animal model of alcoholism J Neural Transm 107 2000 669 680
291. A. Steptoe, and M. Ussher Smoking, cortisol and nicotine Int J Psychophysiol 59 2006 228 235
292. E. Suzuki, F. Shintani, S. Kanba, M. Asai, and T. Nakaki Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions Cell Mol Neurobiol 17 1997 557 562
293. L.K. Tamres, D. Janicki, and V.S. Helgeson Sex differences in coping behavior: a meta-analytic review and an examination of relative coping Pers Soc Psychol Rev 6 2002 2 30
294. S.F. Tapert, G.G. Brown, S.S. Kindermann, E.H. Cheung, L.R. Frank, and S.A. Brown fMRI measurement of brain dysfunction in alcohol-dependent young women Alcohol Clin Exp Res 25 2001 236 245
295. S.F. Tapert, E.H. Cheung, G.G. Brown, L.R. Frank, M.P. Paulus, and A.D. Schweinsburg Neural response to alcohol stimuli in adolescents with alcohol use disorder Arch Gen Psychiatry 60 2003 727 735
296. S. Tate, J. McQuaid, and S. Brown Characteristics of life stressors predictive of substance treatment outcomes J Subst Abuse Treat 29 2005 107 115
297. A. Thorsell, J.R. Schank, E. Singley, S.P. Hunt, and M. Heilig Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice Psychopharmacology 209 2010 103 111
298. J.E. Toalston, S.M. Oster, K.A. Kuc, T.J. Pommer, J.M. Murphy, and L. Lumeng Effects of alcohol and saccharin deprivations on concurrent alcohol and saccharin operant self-administration by alcohol-preferring (P) rats Alcohol 42 2008 277 284
299. A.V. Turnbull, and C.L. Rivier Regulation of the hypothalamic-pituitary- adrenal axis by cytokines: actions and mechanisms of action Physiol Rev 79 1999 1 71
300. M. Uddin, A.E. Aiello, D.E. Wildman, K.C. Koenen, G. Pawelec, R. de Los Santos, E. Goldmann, and S. Galea Epigenetic and immune function profiles associated with posttraumatic stress disorder Proc Natl Acad Sci 107 2010 9470 9475
301. M. Uhart, and G.S. Wand Stress, alcohol, and drug interaction: an update of human research Addict Biol 14 2008 43 64
302. J. Ulrichsen, B. Bech, P. Allerup, and R. Hemmingsen Diazepam prevents progression of kindled alcohol withdrawal behaviour Psychopharmacology 121 1995 451 460
303. J. Ulrichsen, S. Haugbøl, C.F. Brandt, P. Allerup, and R. Hemmingsen Irreversibility of kindled alcohol-withdrawal behavior in rats Alcohol Alcohol 33 1998 230 243
304. J. Ulrichsen, D.P. Woldbye, T.M. Madsen, L. Clemmesen, S. Haugbøl, C.H. Olsen, H. Laursen, T.G. Bolwig, and R. Hemmingsen Electrical amygdala kindling in alcohol-withdrawal kindled rats Alcohol Alcohol 33 1998 244 254
305. G.R. Valdez, and G.F. Koob Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism Pharmacol Biochem Behav 79 2004 671 679
306. G.R. Valdez, A.J. Roberts, K. Han, H. Davis, M. Brennan, E.P. Zorrilla, and G.F. Koob Increased alcohol self-administration and anxiety-like behavior during acute alcohol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor Alcohol Clin Exp Res 26 2002 1494 1501
307. G.R. Valdez, V. Sabino, and G.F. Koob Increased anxiety-like behavior and alcohol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation Alcohol Clin Exp Res 28 2004 865 872
308. G.R. Valdez, E.P. Zorrilla, A.J. Roberts, and G.F. Koob Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted alcohol abstinence Alcohol 29 2003 55 60
309. W. Vale, J. Spiess, C. Rivier, and J. Rivier Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotrophin and beta-endorphin Science 213 1981 1394 1397
310. V. Vengeliene, S. Siegmund, M.V. Singer, J.D. Sinclair, T.K. Li, and R. Spanagel A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake Alcohol Clin Exp Res 27 2003 1048 1054
311. F.J. Vocci, J. Acri, and A. Elkashef Medication development for addictive disorders: the state of the science Am J Psychiatry 162 8 2005 1432 1440
312. N.D. Volkow, G.J. Wang, F. Telang, J.S. Fowler, J. Logan, and A.R. Childress Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction J Neurosci 26 2006 6583 6588
313. J. Volpicelli, A.I. Alterman, M. Hayashida, and C.P. O'brien Naltrexone in the treatment of alcohol dependence Arch Gen Psychiatry 49 1992 876 880
314. B.M. Walker, and G.F. Koob Pharmacological evidence for a motivational role of K-opioid systems in alcohol dependence Neuropsychopharmacology 33 2008 643 652
315. B.M. Walker, D.D. Rasmussen, M.A. Raskind, and G.F. Koob alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for alcohol Alcohol 42 2008 91 97
316. G. Wand The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism J Clin Investig 115 2005 2762 2773
317. G.S. Wand, and A.S. Dobs Alterations in the hypothalamic-pituitary- adrenal axis in actively drinking alcoholics J Clin Endocrinol Metab 72 1991 1290 1295
318. W. Wang, P. Ji, and K.E. Dow CRF induces proliferation and TNFα release in cultured rat microglia via MAP-kinase signaling pathways J Neurochem 84 2003 189 195
319. W. Wang, P. Ji, R.J. Riopelle, and K.E. Dow Functional expression of CRH receptor 1 in cultured rat microglia J Neurochem 80 2002 287 294
320. F. Weiss Neurobiology of craving, conditioned reward and relapse Curr Opin Pharmacol 5 2005 9 19
321. F. Weiss, R. Ciccocioppo, L.H. Parsons, S. Katner, X. Liu, and E.P. Zorrilla Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors Ann NY Acad Sci 937 2001 1 26
322. A. Wikler Recent progress in research on the neurophysiological basis of morphine addiction Am J Psychiatry 105 1948 329 338
323. G. Winger Effects of alcohol withdrawal on alcohol-reinforced responding in rhesus monkeys Drug Alcohol Depend 22 1988 235 240
324. J. Wolffgramm, and A. Heyne From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat Behav Br Res 70 1995 77 94
325. D.F. Wong, H. Kuwabara, D.J. Schretlen, K.R. Bonson, Y. Zhou, and A. Nandi Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving Neuropsychopharmacology 31 2006 2716 2727
326. J. Wrase, S.M. Grüsser, S. Klein, C. Diene, D. Hermann, and H. Flor Development of alcohol-associated cues and cue-induced brain activation in alcoholics Eur Psychiatry 17 2002 287 291
327. R. Yehuda Biology of post-traumatic stress disorder J Clin Psychiatry 62 Suppl 17 2001 41 46
328. G.K. Yoon, S.W. Kim, P. Thuras, and J.E. Grant Alcohol craving in outpatients with alcohol dependence: rate and clinical correlates J Stud Alcohol 67 2006 770 777
329. Z. Zhang, A.C. Morse, G.F. Koob, and G. Schulteis Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent alcohol intoxication in rats Alcohol Clin Exp Res 31 2007 1811 1819
330. Y. Zhao, C.V. Dayas, H. Aujla, M.A. Baptista, R. Martin-Fardon, and F. Weiss Activation of Group II metabotropic glutamate receptors attenuates both stress and cue-induced alcohol-seeking and modulates c-fos expression in the hippocampus and amygdala J Neurosci 26 2006 9967 9974
331. A.W. Zobel, T. Nickel, H.E. Künzel, N. Ackl, A. Sonntag, M. Ising, and F. Holsboer Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated J Psychiatr Res 34 2000 171 181
332. E.P. Zorrilla, and G.F. Koob The therapeutic potential of CRF1 antagonists for anxiety Expert Opin Investig Drugs 13 2004 799 828
333. E.P. Zorrilla, G.R. Valdez, and F. Weiss Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats Psychopharmacology 158 2001 374 381
334. W.H. Zywiak, V.S. Westerberg, G.J. Connors, and S.A. Maisto Exploratory findings from the Reasons for Drinking Questionnaire J Subst Abuse Treat 25 2003 287 292