Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 579-587

  D'Hooghe, Matthias ^a   Kenis, Sara ^a   Vervisch, Karel ^a   Lategan, Carmen ^b   Smith, Peter J ^b   Chibale, Kelly ^c   De Kimpe, Norbert ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Antimalarial agents; Aziridines; Aziridinium salts; Ring opening; Triaminopropanes

Indexed keywords

1 (4 CHLOROPHENYL)METHYL 2 [(2,4 DIOXO 5 METHYLPYRIMIDIN 1 YL)METHYL]AZIRIDINE; 1 (4 CHLOROPHENYL)METHYL 2- [(N,N DIETHYLAMINO)METHYL]AZIRIDINE; 1 (4 METHOXYPHENYL)METHYL 2 [(1,2,4 TRIAZOL 1 YL)METHYL]AZIRIDINE; 1 (6 AMINOPURIN 9 YL) 2 [(4 CHLOROPHENYL)METHYL]AMINO 3 DIETHYLAMINOPROPANE; 1 (6 AMINOPURIN 9 YL) 3 DIETHYLAMINO 2 (PHENYLMETHYL)AMINOPROPANE; 1 (6 AMINOPURIN 9 YL) 3 DIETHYLAMINO 2 [(4 METHOXYPHENYL)METHYL]AMINOPROPANE; 1,2,3 TRIAMINOPROPANE; 1,3 BIS(DIETHYLAMINO) 2 (PHENYLMETHYL)AMINOPROPANE; 1,3 BIS(DIETHYLAMINO) 2 [(4 METHOXYPHENYL)METHYL]AMINOPROPANE; 2 (2,4 DIOXO 5 METHYLPYRIMIDIN 1 YL)METHYL 1 [(4 METHOXYPHENYL)METHYL]AZIRIDINE; 2 (6 AMINOPURIN 9 YL)METHYL 1 (PHENYLMETHYL)AZIRIDINE; 2 (6 AMINOPURIN 9 YL)METHYL 1 [(4 CHLOROPHENYL)METHYL]AZIRIDINE; 2 (6 AMINOPURIN 9 YL)METHYL 1 [(4 METHOXYPHENYL)METHYL]AZIRIDINE; 2 (AMINOMETHYL)AZIRIDINE; 2 (N,N DIETHYLAMINO)METHYL 1 (PHENYLMETHYL)AZIRIDINE; 2 (N,N DIETHYLAMINO)METHYL 1 [(4 METHOXYPHENYL)METHYL]AZIRIDINE; 2 (N,N DIETHYLAMINOMETHYL)AZIRIDINE; 2 [(1,2,4 TRIAZOL 1 YL)METHYL]AZIRIDINE; 2 [(4 CHLOROPHENYL)METHYL]AMINO 1,3 BIS(DIETHYLAMINO); 2 [(4 CHLOROPHENYL)METHYL]AMINO 3 DIETHYLAMINO 1 (1,2,4 TRIAZOL 1 YL)PROPANE; 2 [(4 CHLOROPHENYL)METHYL]AMINO 3 DIETHYLAMINO 1 (2,4 DIOXO 5 METHYLPYRIMIDIN 1 YL)PROPANE; 3 DIETHYLAMINO 1 (2,4 DIOXO 5 METHYLPYRIMIDIN 1 YL) 2 [(4 METHOXYPHENYL)METHYL]AMINOPROPANE; 3 DIETHYLAMINO 2 (PHENYLMETHYL)AMINO 1 (1,2,4 TRIAZOL 1 YL)PROPANE; 3 DIETHYLAMINO 2 [(4 METHOXYPHENYL)METHYL]AMINO 1 (1,2,4 TRIAZOL 1 YL)PROPANE; ACETONITRILE; ANTIMALARIAL AGENT; AZIRIDINE DERIVATIVE; DIETHYLAMINE; PROPYLAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG SCREENING; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; RING OPENING; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; AZIRIDINES; MICROWAVES; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROPYLAMINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79151482875     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.037     Document Type: Article

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