Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity

Journal of Medicinal Chemistry

Volumn 52, Issue 13, 2009, Pages 4058-4062

  D'hooghe, Matthias ^a   Dekeukeleire, Stijn ^a   Mollet, Karen ^a   Lategan, Carmen ^b   Smith, Peter J ^b   Chibale, Kelly ^c   De Kimpe, Norbert ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYLOXY 1 ISOPROPYL 4 PHENYLAZETIDIN 2 ONE; 5 BENZYLOXY 3 ISOBUTYL 4 (4 METHYLPHENYL) 1,3 OXAZINANE; 5 BENZYLOXY 3 ISOPROPYL 4 PHENYL 1,3 OXAZINANE; AMINOALCOHOL; ANTIMALARIAL AGENT; FORMALDEHYDE; SYN 2 BENZYLOXY 3 (N ISOBUTYL N METHYLAMINO) 3 (4 METHYLPHENYL)PROPAN 1 OL; SYN 2 BENZYLOXY 3 ISOPROPYLAMINO 3 PHENYLPROPAN 1 OL; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM;

AMINO ALCOHOLS; ANIMALS; ANTIMALARIALS; INHIBITORY CONCENTRATION 50; OXAZINES; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROPANOLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649977138     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9002632     Document Type: Article

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